Communications Biology
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2026
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IF 5.8
Zhang Han,Gu Xinsheng,Sun Yidan,Chen Pengcheng,Hu Qiangsheng,Li Hao
The roles of glutamic-oxaloacetic transaminase 2 (GOT2) in malate-aspartate shuttle (MAS), fatty acid binding/trafficking, and peroxisome proliferator-activated receptor (PPAR) delta axis have been documented. However, its function in ferroptosis remains unexplored. Here, we report that GOT2 promotes ferroptosis by disturbing mitochondrial redox homeostasis through inhibiting the synthesis of radical scavenger coenzyme Q10 (CoQ 10 ). Mechanism, by fueling MAS, GOT2 increases net influx of NADH into mitochondria and enhances aerobic respiration, increasing cellular ATP generation. The high ATP/ADP ratio inactivates adenosine 5′-monophosphate-activated protein kinase (AMPK) and PPARα, downregulating the transcription of core enzymes in CoQ 10 synthesis pathway (FDPS, PDSS1/2, COQ3/5/6). In lung adenocarcinoma (LUAD), high expression of GOT2 restrains tumor progression by activating ferroptosis and igniting antitumor immunity. Whereas, the activation of GOT2-mediated ferroptosis exacerbates lesion in atherosclerosis disease. Our study reveals that GOT2-AMPK-PPARα-CoQ 10 axis is a novel pro-ferroptosis pathway, and modulating GOT2-mediated ferroptosis suggests an intriguing method to treat LUAD and atherosclerosis. The alternative text for this image may have been generated using AI.
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高影响因子
Chinese Medicine
·
2026
·Vol. 21
·期 1
·146
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IF 7.4
Yang Junfa,Shu Min,Fang Hui,Yang Fan,Li Jiahe,Sun Yuansong,Li He,Xu Tao
Background Liver fibrosis is a representative scarring response that can ultimately lead to liver cancer. However, relevant antifibrotic drugs for the effective treatment of liver fibrosis in humans have not yet been identified. 6-Shogaol is derived from natural products and exhibits multiple biological activities, including anti-inflammatory and antioxidant properties; however, its efficacy and potential mechanism of action against liver fibrosis remains unclear. This study aimed to examine the anti-fibrotic properties and potential mechanisms of action of 6-Shogaol. Methods Two liver fibrosis mouse models (carbon tetrachloride (CCl 4 ) and bile duct ligation (BDL)) were constructed to evaluate the anti-fibrotic properties of 6-Shogaol in vivo . Transforming growth factor-β1 (TGF-β1)-induced human hepatic stellate cells (HSCs) LX-2 cells were used as in vitro models. Network pharmacology analysis was introduced to explore the key targets of 6-Shogaol regarding the mechanisms on liver fibrosis. Molecular docking, molecular dynamics simulations, drug affinity reactivity target stability (DARTS) and isothermal titration calorimetry (ITC) were used to detect the affinity and binding between 6-Shogaol and its target. Additionally, we invested the mechanism of 6-Shogaol through RNA sequencing combined with Western blotting, oxygen consumption rate (OCR), extracellular acidification rate (ECAR), immunofluorescence co-localization, histopathology, immunohistochemical staining and RT-qPCR. Results The results showed that 6-Shogaol remarkably alleviated CCl 4 - and BDL-induced liver fibrosis in mice, including observations of improved liver function, decreased activity of HSCs, and decreased extracellular matrix (ECM) deposition. In an in vitro model, 6-Shogaol suppressed TGF-β1-induced LX-2 activation. Mechanistically, RNA sequence analysis revealed that the effect of 6-Shogaol on liver fibrosis is linked to glycolytic reprogramming. 6-Shogaol suppressed HSCs glycolysis by decreasing glycolytic enzymes (HK2, PKM2, and GLUT1) and glycolytic metabolite levels (lactic acid and pyruvic acid). Furthermore, network pharmacology suggested HIF-1α as a potential 6-Shogaol target. Molecular docking, molecular dynamics simulations, DARTS, and ITC confirmed that 6-Shogaol could directly bind to HIF-1α. Interestingly, we demonstrated that HIF-1α knockout significantly inhibited HSCs glycolysis and activation, whereas the overexpression of HIF-1α increased HSCs glycolysis and activation. Moreover, specific knockout of HIF-1α did not enhance the suppressive effect of 6-Shogaol on HSCs activation or fibrosis-associated protein expression in vivo . Conclusion These findings showed that 6-Shogaol ameliorated liver fibrosis by modulating the expression of HIF-1α associated with glycolysis reprogramming and validate 6-Shogaol as a promising therapeutic strategy for liver fibrosis. Graphical
The alternative text for this image may have been generated using AI.
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高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Wang Weilin,Hu Qiaoying,Wu Chunyan,Ding Jiayue,Zhu Chuanxiu,Wen Jiayao,Li Yingchao,Yang Menghan,Wang Yujie,Sun Deqing,Zhai Guangxi,Zhang Yanan
Ferroptosis and sonodynamic therapy (SDT) have both been recognized as powerful weapons in cancer treatment, especially in non-small-cell lung carcinoma (NSCLC) recently. However, the lack of effective sono-sensitizer and ferroptosis regulator limited their usage. In order to overcome the limitation, a novel nanoplatform of DTX-CS/ART/PFCA@RGD (cRCAPD) was fabricated based on SDT and ferroptosis. Nanoparticles, under the action of c(RGDfk) cyclic peptides and their skeleton chondroitin sulfate (CS), could specifically target αvβ3 and CD44 receptors, respectively, thereby targeting tumor sites. Meanwhile, the peroxy-bridge structure of ART disrupted the intracellular iron homeostasis while generating highly toxic reactive oxygen species (ROS) under the SDT. Docetaxel (DTX) in nanoparticles led to the excellent apoptosis of A549 cells. Oxygen carried by PFCA alleviated the tumor hypoxic microenvironment, downregulated HIF-1α, and provided substrates for SDT. Further, the nanoparticles showed a strong immunogenic cell death (ICD) effect, modulating the number of T cells and dendritic cells in tumor-bearing mice. In summary, the proposed therapeutic strategy based on SDT and ferroptosis holds promising potential for synergistic treatment of lung cancer in future clinical applications. Graphical The alternative text for this image may have been generated using AI.
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高影响因子
FOOD SCIENCE AND BIOTECHNOLOGY
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2026
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IF 3.9
Li Jie,Perera Vindya,Cao Shihao,Zhang Mengluo,Ding Yuheng,Tang Minmin,Zhu Tingting
Edible composite films were developed by incorporating Clausena lansium leaf essential oil (CLEO) into chitosan (CS) matrix to enhance the functionality of food-contact films. The optimal formulation (2.0% CS, 1.5% glycerol and 0.4% CLEO) was determined using principal component analysis and response surface methodology. The optimized films exhibited favorable physicochemical, mechanical, and barrier properties. Fourier transform infrared spectroscopy and SEM verified successful CLEO incorporation into the polymer matrix without compromising structural integrity. Furthermore, CLEO significantly enhanced antioxidant and antibacterial activities, with DPPH and ABTS⁺ scavenging rates of 49.15 ± 1.25 and 52.25 ± 3.33%, respectively, and inhibition rates of 72.84 to 98.63% against tested pathogenic bacteria. Preliminary biological evaluation indicated good cytocompatibility, with cell viability above 90%; however, this does not constitute a comprehensive food safety assessment. Overall, CLEO represents a promising natural functional additive for chitosan-based edible films, although further validation in real food systems is required to confirm practical preservation efficacy.
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高影响因子
Nature Communications
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2026
·
IF 18.1
Jia Ning,Ji Yuan,Wang Wei,Wang Shichang,Wu Hong,Guo Shaoyun,Qiu Jianhui
Mesophase pitch-based carbon fibers (CFs) with ultrahigh axial thermal conductivity can significantly enhance through-plane heat transfer in thermal interface materials by vertical alignment, yet raise short-circuiting and electromagnetic interference (EMI) risks. Although incorporating insulating fillers or coating CFs can suppress electron migration, it often compromises thermal performance. Herein, we engineer multi-functionally trunk-branch hierarchical heterostructures to address above limitations. Vertically aligned trunk-like CF scaffolds ensure superior through-plane heat transfer. Branch-like boron nitride (BN) networks optimize impedance matching by enhancing electrical insulation and consequently improve electromagnetic wave (EMW) absorption. Meanwhile, in situ BN networks interconnect CF scaffolds, extending bidirectional thermally conductive and EMW propagation paths. At only 20.17 vol% filler, the composite exhibits a through-plane thermal conductivity of 57.96 W·m −1 ·K −1 (specific thermal conductivity enhancement of 1431.62 %·(vol%) −1 ) and an in-plane thermal conductivity of 2.93 W·m −1 ·K −1 , together with excellent electrical insulation and absorption-dominated EMI shielding, addressing the challenge of thermal-electrical-electromagnetic coupling for next-generation electronics.
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Nature Communications
·
2026
·Vol. 17
·期 1
·4120
·
IF 18.1
Song Yun,Zhu Zhaohua,Das Tridip,Riasati Aarya D.,Su Jianjun,Guo Weihua,Liu Yong,Li Geng,Xin Yinger,Zhang Qiang,He Mingming,Wang Ruixuan,Xue Rui,Zhao Shenlong,Xia Chuan,Tang Ben Zhong,Robert Marc,Wang Xin,Goddard William A.,Ye Ruquan
Formaldehyde (FA) electrolysis is attractive for paired production of value‑added chemicals. However, conventional electrolysis adopts alkaline electrolytes, which triggers FA self-disproportionation and severe feed loss. Here we introduce a sustainable and selective strategy for valorizing FA through electrochemically mediated disproportionation in acidic electrolytes. By leveraging a dual-electrode system consisting of a hydrophobic copper tetraminophthalocyanine layer (CuTAPc-layer) cathode and a Pt 2 Ru bimetallic anode, we efficiently convert FA into methanol and formic acid at high Faradaic efficiencies of 93.2% and 91.3%, respectively. Compared with alkaline FA oxidation, which can lose up to 76% FA and complicate downstream separation, the acidic system suppresses side reactions to ensure high product purity. Mechanism studies reveal that the hydrophobic microenvironment of CuTAPc-layer suppresses hydrogen evolution, while the stronger oxophilicity of Pt 2 Ru enhances FA activation and lowers the key deprotonation barrier for FA oxidation. The integrated device demonstrates application potential in polyoxymethylene upgrading, delivering 374.2 mA at 4 V with ~90% single-pass conversion, establishing a scalable and eco-friendly electrochemical pathway for chemical upcycling.
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Nature Communications
·
2026
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IF 18.1
Han Xiaoxiao,He Ning,Yuan Dandan,Li Na,Zhu Wei,Zhu Xiaolong,Li Jing,Yuan Xun,Wang Wenxin,Gu Xingshi,Chen Feng,Wang Wei
Engineering functional soft tissue constructs remains difficult because scaffolds must meet the mechanical, physicochemical, and biological requirements simultaneously. Here, we present a cell-laden hydrogel gyroid scaffold designed to support vascularisation, long-term multicellular culture, and implantation for the development of 3D tissue constructs. The scaffold is structurally optimised to balance nutrient transport and mechanical stability, and is fabricated with high fidelity by mitigating cell-induced light scattering. The gyroid architecture supports the formation of dense microvascular networks throughout the 3D construct, and its curved Gaussian curvature promotes endothelial self-assembly. The scaffold also enables high-density co-culture of HepG2 cells and HUVECs without active perfusion, resulting in a vascularised 3D liver tumour model with enhanced tissue-specific function. Upon subcutaneous implantation in mice, the constructs show enhanced neovascularisation and facilitate tumour formation. These findings identify the gyroid scaffold as a biologically favourable architecture for generating bulk vascularised constructs, with potential applications in disease modelling, drug screening and regenerative medicine.
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JOURNAL OF SOILS AND SEDIMENTS
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2026
·Vol. 26
·期 9
·342
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IF 3.3
Zhang Nan,Duan Xin-yi,Zhou Xiao-tao,Li Xiang,Yue Wen-kai,Ye Xiao-xin
Purpose Nitrogen (N) addition significantly impacts greenhouse gas emissions, yet differential response mechanisms between natural wetlands and paddy ecosystems remain poorly understood. This study elucidates these ecosystem-specific variations and their underlying driving factors. Methods A 28-day laboratory incubation was conducted using soils from Shengjin Lake natural wetlands and adjacent paddy fields across four N levels: 0.00, 3.90, 7.80, and 15.60 g·m − 2 ·yr − 1 . Cumulative methane (CH 4 ), carbon dioxide (CO 2 ), and nitrous oxide (N 2 O) emissions were measured, and Structural Equation Modeling was used to identify regulatory pathways for comprehensive global warming potential (CGWP). Results Paddy soils exhibited higher cumulative CH 4 and CGWP than natural wetlands. N addition suppressed CO 2 emissions in wetlands but induced a priming effect in paddies. N 2 O emissions increased linearly in wetlands but showed significant temporal lags in paddies. SEM indicated that wetland CGWP was primarily regulated by nitrate nitrogen via pH and urease. In contrast, paddy CGWP was driven by a multifactorial network characterized by intensive nitrogen transformations involving pH dynamic fluctuations, soil organic matter and nitrate nitrogen, while cellulase activity showed a significant negative correlation with CGWP. Conclusion Paddy ecosystems exhibit higher sensitivity to N input and greater climate feedback risks. These findings support differentiated N management and precision agriculture to mitigate climate pressure while preserving the ecological resilience of natural wetlands. Graphical
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CHINESE JOURNAL OF POLYMER SCIENCE
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2026
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IF 4.6
Jia Hui-Wen,Lv Xue,Ma Yan-Ming,Xu Wang,Yang Xiao-Ning
Conductive hydrogels with high mechanical strength, good adhesion, and high sensitivity are highly demanded for wearable electronics. A multifunctional hydrogel based on 2-acrylamido-2-methylpropanesulfonic acid (AMPS) and acrylic acid (AA) was synthesized via free-radical polymerization. The system incorporates dynamic hydrogen bonds from guanine–cytosine (G–C) base pairs and homogeneously dispersed carbon nanotubes (CNTs) modified using a dual-ionic liquid strategy. Short-chain (C 4 ) and long-chain (C 12 ) imidazole-based ionic liquids act synergistically to exfoliate and stabilize CNTs, facilitating uniform dispersion and strong interfacial bonding. Owing to the continuous conductive pathways formed by the CNTs, the hydrogel exhibited enhanced electrical conductivity with a gauge factor of 5.61, together with excellent short-term cyclic stability and responsiveness for monitoring dynamic human motions. The combination of covalent cross-linking, reversible hydrogen bonding, and reinforced nanofillers endows the hydrogel with high stretchability, good adhesion (5.5 kPa), and superior fatigue resistance, showing great potential for use in flexible wearable bioelectronics.
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BMC BIOTECHNOLOGY
·
2026
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IF 4.8
Zhou Zhenhua,Huo Huanglin,Zhou Li,Zeng Huicong,Chen Yuchun,Zhang Jinyi,Li Menghan,Zhao Dongyu,Zhou Qian,Li Bo
Diabetic wounds (DW) are one of the most serious complications of diabetes mellitus and remain a major public health challenge, typified by an extremely complex microenvironment featuring hyperglycemia-related hypoxia, oxidative stress, endothelial dysfunction, vascular injury, and microbial invasion. Herein, a hollow mesoporous manganese dioxide (HM) nanozyme was fabricated with the template method, then loaded with berberine (BBR) and artepillin C (APC) and coated with polydopamine to form a multifunctional nanoplatform (HMBAP) for DW healing. As expected, HMBAP showed excellent antibacterial effects due to its high photothermal conversion efficiency. Additionally, HMBAP could efficiently decompose hydrogen peroxide to generate oxygen in the acidic pH environment of DW, which regulated the microenvironment and relieved local hypoxia. Meanwhile, the shell of HMBAP was also degraded by the above process, which accelerated the release of BBR and APC to achieve synergistic anti-inflammatory and glucose metabolism-promoting effects. HMBAP treatment also alleviated H₂O₂-impaired migration and tube formation in HUVECs. In a full-thickness DW model, HMBAP reduced TNF-α and hypoxia-inducible factor-1α expression and promoted collagen deposition, resulting in rapid wound closure. HMBAP also exhibited excellent biological safety due to polydopamine endowing the nanozyme with superior biocompatibility. Overall, this microenvironment responsive and photothermal nanoplatform demonstrates potential as a therapeutic agent for DW. Graphical
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POLYMER BULLETIN
·
2026
·Vol. 83
·期 11
·615
·
IF 4.2
Li Jiayi,Liu Shu,Ning Hao,Jiang Chengshao,Liu Hongying,Ni Yingzhe,Kong Weibo,Bao Lixia,Wang Jiliang
Acrylonitrile-butadiene-styrene (ABS) is widely used but inherently flammable, and conventional flame retardants often suffer from poor compatibility, high migration tendency, or compromised mechanical properties. Herein, a novel nitrogen-phosphorus (N/P) synergistic flame retardant, ammonium 1,3,5-triazine-2,4,6-triyl tri(phosphate) (ATTP), was synthesized, and a nanoscale core-shell flame retardant (NCSFR) with ATTP as the core and crosslinked polyacrylates as the shell was constructed via a supramolecular lock-shell strategy. This unique supramolecular encapsulation not only transforms micron-sized rod-like ATTP into 300–900 nm nanoparticles but also enhances interfacial affinity with ABS. At 40 wt% loading, NCSFR/ABS achieved a limiting oxygen index (LOI) of 24.8% (vs. 17.1% for pure ABS) and superior combustion inhibition (peak heat release rate reduced by 46.2% vs. pure ABS), outperforming ATTP/ABS. TG-IR and SEM confirmed a N/P synergistic biphasic mechanism, that is, gas-phase release of non-flammable gases and phosphorus radicals, and condensed-phase formation of a dense char layer. Benefiting from the supramolecular lock-shell structure, NCSFR/ABS exhibited better mechanical properties than ATTP/ABS at the same 40 wt% loading (tensile strength: 25.3 MPa vs. 21.9 MPa), excellent high-temperature aging resistance (96.77% LOI retention after 100 ℃/2 h aging), and migration resistance (13.33% mass loss after 80 ℃ water immersion, versus 40% for ATTP/ABS). This work highlights the superiority of supramolecular encapsulation in balancing flame retardancy, mechanical performance, and durability for ABS, addressing key bottlenecks of traditional additives. Graphical abstract
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JOURNAL OF POLYMER RESEARCH
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2026
·Vol. 33
·期 9
·379
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IF 3.5
Li Hao,Ma Xinyi,Chen Jian,Li Xiaohong,Vishneuski Kanstantsin,Wang Shun,Wu Yadong,Jin Huile
This study synthesizes dendritic mesoporous silica nanoparticles (DMSN) via an anion-assisted templating method, utilizing sheet-like micelles formed from anion-cation complexes to direct silica condensation, followed by calcination. The obtained high-surface-area DMSN were incorporated as a filler into fluororubber (FKM) to fabricate FKM/DMSN composites. The extensive interface and mesoporous structure of DMSN provide sufficient areas for polymer chain adsorption, enhancing mechanical interlocking with the FKM matrix, significantly improving the composite’s properties. At an optimal loading of 10 phr, the composite demonstrates a tensile strength of 15.7 MPa, elongation at break of 300%, modulus at 100% strain of 3.8 MPa, and Shore A hardness of 68, representing increases of 292%, 36%, 217%, and 28%, respectively, over pure FKM. Additionally, the composite exhibits enhanced thermal stability with an initial decomposition temperature of 440 ℃, improved accelerated thermal transport, and retained electrical insulation alongside stable vulcanization characteristics. These superior mechanical and thermal properties make the DMSN-reinforced FKM composite a promising material for advanced sealing applications in aerospace, automotive, and energy sectors.
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