ADVANCED ENGINEERING MATERIALS
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2016
·Vol. 19
·期 2
·1600601
·
IF 1.817
Haiquan Zhang,Yanping Yuan,Qinrong Sun,Xiaoling Cao
Development of a polyethylene glycol (PEG) phase change material (PCM) is a popular research topic. Chemical reactions between the PEG and additive degrade the energy storage density obviously. We prepare a PEG8000/copper-based oxide composite to solve this problem. FT-IR results show that the molecular structure of the PEG8000 polymer does not change, thereby, indicating that no chemical reactions occur. Crystallization temperature of the composite is increased by 4.8 °C, corresponding to the formation of the hydrogen bond during the exothermic process. Crystallization fraction (Fc) of the composites is over 100% on the role of the interface effect. The present study represents an important step toward the development of composite PCMs with highly comprehensive performance.
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ACS Sustainable Chemistry & Engineering
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2017
·
IF 5.951
Guo Jiang,Mengdi Zhang,Jian Feng,Shuidong Zhang,Xiaohui Wang
Bionanocomposites of poly(propylene carbonate) (PPC) enhanced by cellulose nanocrytals (CNCs) are prepared via a two-step process using polyethylene glycol (PEG) as a carrier. Interfacial interaction among PPC, PEG, and CNCs, dispersion of CNCs in bionanocomposites, thermal properties, mechanical behavior, oxygen barrier property, and rheological responses are investigated. The obtained PPC/PEG/CNC nanocomposites display obvious improvement of barrier properties by adding an extremely low loading of CNCs. O2 permeability is decreased by more than 76% at CNC loading of 0.3 wt %. The Cussler model works better to predict gas barrier for nanocomposites. TEM results show that CNC is well dispersed in the matrix, and the introduction of CNC remarkably increases the tensile strength and storage modulus of PPC. Interestingly, elongation at break of the PPC/PEG/CNC nanocomposite remains above 580%. Moreover, the inclusion of CNCs increases the thermal stability and initial decomposition temperature (T–5%) of nanocomposites. The T–5% for the PPC/PEG/0.7CNC nanocomposite is approximately 246.5 °C, which is increased by 17.1% compared with that of pure PPC (210.5 °C). This makes PPC/PEG/CNC nanocomposites a very promising degradable material for food packaging applications.
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RSC Advances
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2016
·Vol. 6
·期 100
·97684-97693
·
IF 3.289
Yongchao Yao,Deqiu Xu,Chang Liu,Yayuan Guan,Jiya Zhang,Yuling Su,Lili Zhao,Fancui Meng,Jianbin Luo
Biodegradable multi-blocked polyurethane (PU) based micelles with a hydrophilic PEG corona were extensively studied for anti-cancer drug delivery systems. The hydrophilic PEG segment usually incorporated as a soft segment or as an end capping reagent, which has difficulty forming a dense PEG coating with a brush like conformation due to the low mobility of the PEG domains at the soft segment and the low amount of the PEG at the end of PU chains. In the present study, biodegradable pH sensitive polyurethane micelles with a dense brush like coating of PEG were prepared by a new kind of PEG grafted polyurethanes (PEG-g-PU) which were synthesized using PEGylated diethanolamine (MPEG-DEAM) as a chain extender. The high mobility of pendant MPEG in PEG-g-PU results in the formation of a dense and brush like PEG corona on the PEG-g-PU micelles. Meanwhile the MPEG attached on the hard segment will transfer the diethanolamine (DEAM) to the surface of nanoparticles during the self-assembly process and the DEAM render the particles with positive charges which potentially enhances cellular uptake and endosomal escape. DLS, TEM and AFM showed that a dense PEG domain was formed on the surface of PEG-g-PU micelles while no obvious PEG microdomain was observed for the other two kinds of micelles. FTIR and DSC results demonstrated the enhanced microphase separation of PEG-g-PU micelles compared with PEG-g-PU bulk materials and the other two contrast PU micelles, i.e. PEG-b-PU and PEG-c-PU. Paclitaxel (PTX) was chosen as a model hydrophobic drug to evaluate the loading and pH-triggered release of the PU micelles. The enhanced cytotoxicity of PTX-loaded PEG-g-PU-3 micelles against H460 cancer cells reveals that they are more potent for intracellular delivery of PTX as compared to PEG-b-PU-3 and PEG-c-PU-3 micelles.
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ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Dong-Yang Zhang,Yue Zheng,Cai-Ping Tan,Jing-Hua Sun,Wei Zhang,Liang-Nian Ji,Zong-Wan Mao
The combination of photothermal therapy (PTT) and photodynamic therapy (PDT) can kill cancer cells more efficiently as compared with PTT or PDT treatment alone. In this work, we use nanohybrid rGO-Ru-PEG composed of reduced nanographene oxide (rGO) sheet and a phosphorescent polyethylene glycol modified Ru(II) complex (Ru-PEG) for combined PTT and PDT of cancer. Photosensitizer and imaging agent Ru-PEG is decorated onto delivery and PTT agent rGO via π–π stacking and hydrophobic interactions. The chemical structure and morphology have been characterized by various methods. The release of Ru-PEG from rGO surface is pH-dependent, and irradiation can increase the release rate considerably. The combined effects of PDT and PTT have been evaluated by cytotoxicity assay under serial irradiation at 808 nm (PTT) and 450 nm (PDT). Mechanism investigation shows that the nanohybrid can induce apoptosis through generation of reactive oxygen species (ROS) and cathepsin-initiated apoptotic signaling pathways under light excitation. rGO-Ru-PEG can be applied to in vivo photothermal imaging, and high treatment efficacy was achieved for in vivo antitumor experiments when irradiated with an 808 nm laser and a 450 nm laser. Our work provides an effective strategy for the construction of multifunctional imaging and phototherapeutic nanohybrids for the treatment of cancer.
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CHEMISTRY OF MATERIALS
·
2017
·
IF 9.466
Xing Wang,Changping Wang,Xinyu Wang,Yitong Wang,Qiang Zhang,Yiyun Cheng
Hydrogels have exhibited remarkable benefits in drug delivery such as local delivery, days or even weeks of continuous drug release with improved bioavailability, and minimized adverse effects. Here we report a polydopamine (PDA) nanoparticle-knotted poly(ethylene glycol) (PEG) hydrogel for on-demand drug delivery and combined chemo-photothermal therapy. Anticancer drugs such as 7-ethyl-10-hydroxycamptothecin (SN38) loaded on PDA nanoparticles via π–π interaction in the gel exhibit minimal leakage at physiological conditions and could be released in an on-demand fashion upon near-infrared light exposure. The hydrogel shows excellent biocompatibility and does not induce any foreign-body reaction over a four-month implantation. The in vivo results demonstrate that the PDA nanoparticle-knotted PEG hydrogel loaded with SN38 could efficiently suppress tumor growth by a combined chemo-photothermal therapy. This smart hydrogel would benefit a series of local treatments for diverse diseases.
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BIOMEDICINE & PHARMACOTHERAPY
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2017
·
IF 2.759
Fangfang Teng,Peizong Deng,Zhimei Song,Feilong Zhou,Runliang Feng
In order to enhance water-solubility and realize controlled release while keeping synergistic effects of ketoconazole and curcumin , drug-loaded methoxy poly (ethylene glycol)-b-poly (ε-caprolactone) micelles were prepared through thin membrane hydration method. Transmission electric microscopy and dynamitic light scattering characterization revealed the formation of ketoconazole- and curcumin-loaded micelles with an average size of 44.70 nm and 39.56 nm, respectively. The drug-loaded micelles endowed the two drugs’ slow controlled release with water-solubility enhanced to 85 and 82000 folds higher than the corresponding raw drugs, respectively. In vitro antifungal activity test, chequerboard test and inhibition zone test indicated that efficacy of ketoconazole-loaded micelles was improved by introduction of curcumin-loaded micelles with a low fractional inhibitory concentration index (0.073). Biofilm formation inhibition assay also demonstrated that participation of curcumin-loaded micelles obviously strengthened the inhibition of fungal biofilms formation induced by ketoconazole-loaded micelles. The high synergistic activity of combinations is encouraging and the MPEG-PCL micelle is a potential drug delivery system for the combination of ketoconazole and curcumin.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Ying Zhang,Hui Chen,Mingyang Bai,Ao Zhang,Zhicheng Zhang,Youming Dong,Haijiao Kang,Jianzhang Li
Despite renewable bamboo globally available and has been applied in industry, the bamboo modification still absents for achieving long-term anti-mildew, stability and desirable toughness, owing to its inherent hierarchical porous structures, that cannot fully insert and retain ideal drugs/polymers. Hence, a hyperbranched polymer (HPB) with polyether as backbone and phenylboronic acid as binding groups via epoxy ring-opening reactions with amino was designed, and subsequently in situ synthesized in the multi-scaled cellular structures in bamboo. It was demonstrated that the hyperbranched polyether chains filled and swollen the hierarchical bamboo cell walls, which could efficiently replace the inner hydroscopic water in bamboo and greatly improved the bamboo stability, resulted in the wet swelling and dry shrinkage rates reduced by 20.3 % and 14.8 %, respectively. Both the side groups of phenylboronic acid and epoxy on HPB outer layers could generate covalent bonding with bamboo cell walls, which twisted the easy-losing facts of boron and gained a 60.6 % retention rate, surpassed most reported modified bamboo literatures and conferred bamboo with good fire resistance and long-time anti-mildew performance. Importantly, with the cavitation effect of HPB to help stress transmission, the modified bamboo had not expensed bamboo strength, instead of reaching satisfied bending strength and toughness at 154.1 MPa of flexure strength and 10.8 % of bending strain, respectively. That expand the industrial application of bamboo.
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CHINESE CHEMICAL LETTERS
·
2017
·
IF 1.932
Lin Liu,Xiang-Mei Yu,Bao Zhang,Shu-Xian Meng,Ya-Qing Feng
The performance of dye-sensitized solar cells (DSSCs) consisting of anatase TiO 2 nanoparticles that were synthesized via a hydrothermal method was studied. The synthesized TiO 2 nanoparticles were characterized by X-ray diffraction (XRD), nitrogen sorption analysis, scanning electron microscopy (SEM), high resolution transmission electron microscopy (HRTEM), and UV–vis spectroscopy. Then the J - V curve, electrochemical impedance spectroscopy (EIS), and open-circuit voltage decay (OCVD) measurement were applied to evaluate the photovoltaic performance of DSSCs. Compared with the commercial TiO 2 nanoparticles (P25), the synthesized-TiO 2 nanoparticles showed better performance. By adding diethylene glycol (DEG) before the hydrothermal process, the synthesized TiO 2 nanoparticles (hereafter referred to as TiO 2 -DEG particles) shows narrower size distribution, larger specific surface area, higher crystallinity, and less surface defects than TiO 2 (DEG free) particles. The analysis of photovoltaic properties of DSSCs based on TiO 2 -DEG particles showed that the recombination of electron-hole pairs was decreased and the trapping of carries in grain boundaries restrained. It was believed that the photoelectrode fabricated with the as-prepared TiO 2 nanoparticles improved the loading amount of dye sensitizers (N719), and enhanced the photocurrent of the DSSCs. As a result, the TiO 2 -DEG particle based cells achieved a photo-to-electricity conversion efficiency ( η ) of 7.90%, which is higher than 7.53% for the cell based on TiO2 (DEG free) and 6.59% for the one fabricated with P25.
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Journal of Energy Storage
·
2025
·
IF 9.8
Yu Mao,Jing Li,Xu Yang,Keai Tao,Kuan Sun,Shanshan Chen,Yujie Zheng
The amphiphilic structure of the coupling agent, which is capable of combining two materials with disparate properties to enhance their interfacial compatibility, was employed to modify graphene aerogel for the preparation of a composite phase change material (CPCM), thereby expanding the scope of potential applications for the phase change material. The phase change enthalpy of the prepared CPCM is 163.07 J/g, with 90.02 % of the phase change enthalpy retained and 98.7 % of the heat storage capacity retained after 500 thermal cycles, which is indicative of excellent thermal stability and cycling stability. Concurrently, the coupling agent impedes the volume contraction of graphene aerogel through the formation of hydrogen bonds, thereby enhancing the loading capacity of the aerogel with respect to the phase change material. Furthermore, the incorporation of the coupling agent diminishes the interfacial thermal resistance by augmenting the interfacial interaction and phonon coupling. The thermal conductivity is augmented by 213.8 % in comparison to that of pure PEG. The composite phase change materials prepared exhibit optimal thermal management and thermal storage capacity.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Xiuqing Yu,Ruirui Yue,Shiyao Yang,Changqing Fu,Jinbing Shu,Liang Shen
Developing a novel catalyst with lower noble-metal loading and higher catalytic efficiency is significant for promoting the widespread application of direct alcohol fuel cells (DAFCs). In this work, poly(3,4-ethylenedioxythiophene) (PEDOT) supported the PdSn alloy (PdSn/PEDOT) were simply synthesized and their electrocatalytic performance toward the oxidation of ethylene glycol and ethanol (EGOR and EOR) were investigated in alkaline media, respectively. In comparison with other control catalysts, the optimized Pd 4 Sn 6 /PEDOT catalyst exhibits the highest mass activity (7125/4166 mA mg Pd −1 ) and specific activity (26/15 mA cm −2 ) towards EGOR/EOR. The mass activity of Pd 4 Sn 6 /PEDOT for EGOR and EOR are 11.9 and 10.9 times higher than commercial Pd/C, respectively. Moreover, chronoamperometry (CA) and successive cyclic voltammetry (CV) tests show that the CO resistance ability and durability of the Pd 4 Sn 6 /PEDOT catalyst were superior to Pd 4 Sn 6 , Pd/PEDOT and commercial Pd/C catalysts, which can be attributed to the d-band center of Pd can be effectively downshifted and the interface strain effect between electrons caused by the conjugated structure between PEDOT groups. This work provides an effective strategy for the development of highly efficient anode catalysts of DAFCs.
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BIOMACROMOLECULES
·
2024
·
IF 5.5
Zhimin Luo,Yunan Yuan,Ling Li,Dayang Xie,Chong Liu,Tong Li,Zhaopei Guo,Kai Hao,Yanhui Li,Huayu Tian
Poly(amino acid)s (PAAs) are one kind of favorable biopolymer that can be used as a drug or gene carrier. However, conventional ring-opening polymerization of PAAs is slow and needs a strict anhydrous environment with an anhydrous reagent as well as the product without enough high molecular weight (Mn), which limits the expanding of PAAs’ application. Herein, we took BLG-NCA as the monomer to quickly synthesize one kind of high Mn amphiphilic copolymer, poly(ethylene glycol)-b-poly(γ-benzyl-l-glutamic acid) (PEG-PBLG), by relay polymerization with a simple one-pot method within 3 h in mild conditions (open air, moisture insensitive). In the polymerization process, ring-opening polymerization-induced self-assembly in sodium bicarbonate aqueous solution first occurred to obtain low Mn PEG-PBLG seeds without purification. Then γ-benzyl-l-glutamate N-carboxyanhydride (BLG-NCA) dichloromethane solution was added into PEG-PBLG seeds directly and stirred vigorously to form am emulsion; during this process, the amphiphilic PEG-PBLG seeds will anchor on the interface of DCM and water to ensure the concentration of α-helix rigid PBLG in DCM to maintain the following relay polymerization. Then, high Mn PEG-PBLG was obtained in mild conditions in one pot. We found that the α-helix rigid structure was essential for relay polymerization by studying the synthetic speed of amphiphilic copolymer with different secondary structures. MOE simulation results showed that PBLG and BLG-NCA tended to form a double hydrogen bond, which was beneficial to relay polymerization because of higher local concentrations that can produce more double hydrogen bonds. Our strategy can quickly obtain high Mn PEG-PBLG (224.9 KDa) within 3 h from PEG-NH2 and BLG-NCA in one pot and did not need an extra initiator. After deprotection, the poly(ethylene glycol)-b-poly(l-glutamate acid) (PEG-PGA) with high Mn as a second product can be used as an excellent antitumor drug carrier. The high Mn PEG-PGA can achieve an encapsulation rate of 86.7% and a drug loading rate of 47.3%, which is twice that of the low Mn PEG-PGA. As a result, the synthesis of PEG-PBLG by relay polymerization simplified the process of PEG-PAA polymerization and increased the Mn. In addition, this method opened a way to obtain other kinds of high Mn PEG-PBLG values in the future.
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MOLECULES
·
2024
·Vol. 29
·期 22
·5435
·
IF 4.2
Xia Ding,Bing Yang,Zhaosheng Hou
Hydrogels have emerged as promising biomaterials due to their excellent performance; however, their biocompatibility, biodegradability, and absorbability still require improvement to support a broader range of medical applications. This paper presents a new biofunctionalized hydrogel based on in situ crosslinking between maleimide-terminated four-arm-poly(ethylene glycol) (4–arm–PEG–Mal) and poly(ε-lysine) (ε–PL). The PEG/ε–PL hydrogels, named LG–n, were rapidly formed via amine/maleimide reaction by mixing 4–arm–PEG–Mal and ε–PL under physiological conditions. The corresponding dry gels (DLG–n) were obtained through a freeze-drying technique.1H NMR, FT–IR, and SEM were utilized to confirm the structures of 4–arm–PEG–Mal and LG–n (or DLG–n), and the effects of solid content on the physicochemical properties of the hydrogels were investigated. Although high solid content could increase the swelling ratio, all LG–n samples exhibited a low equilibrium swelling ratio of less than 30%. LG–7, which contained moderate solid content, exhibited optimal compression properties characterized by a compressive fracture strength of 45.2 kPa and a deformation of 69.5%. Compression cycle tests revealed that LG–n demonstrated good anti-fatigue performance. In vitro degradation studies confirmed the biodegradability of LG–n, with the degradation rate primarily governing the drug (ceftibuten) release efficiency, leading to a sustained release duration of four weeks. Cytotoxicity tests, cell survival morphology observation, live/dead assays, and hemolysis tests indicated that LG–n exhibited excellent cytocompatibility and low hemolysis rates (<5%). Furthermore, the broad-spectrum antibacterial activity of LG–n was verified by an inhibition zone method. In conclusion, the developed LG–n hydrogels hold promising applications in the medical field, particularly as drug sustained-release carriers and wound dressings.
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