Discover Food
·
2025
·Vol. 5
·期 1
·428
·
IF 3.7
Gui Xinchen,Chen Yaozhong,Cao Shihai,Yu Yadong
To address the limitations of conventional packaging materials, this work synthesized the curcumin-loaded γ-cyclodextrin-metal-organic frameworks, Cur@CD-MOF, which was subsequently combined with the zein-chitosan (ZC) matrix to form the Cur@CD-MOF/ZC film. The structure, physiochemical property, curcumin release behavior, antibacterial/antioxidant activity and strawberry preservation performance of the Cur@CD-MOF/ZC film were investigated. Results confirmed that Cur@CD-MOF was successfully incorporated into the ZC matrix. The incorporation of Cur@CD-MOF made the Cur@CD-MOF/ZC films own smoother and denser microstructures, and have a lower water vapor permeability and light transmittance. The tensile strength of Cur@CD-MOF/ZC film (5.99 ± 0.55 MPa) was significantly higher than that of ZC film (3.37 ± 0.15 MPa). The release of curcumin from the Cur@CD-MOF/ZC film was delayed in humid environments, and interestingly, it became faster under acidic conditions compared to that under neutral conditions. Cur@CD-MOF significantly improved the antioxidant activity of Cur@CD-MOF/ZC film and its inhibitory effects against Escherichia coli and Staphylococcus aureus . Fruit preservation experiments showed that Cur@CD-MOF/ZC film effectively reduced the decay of strawberry. Moreover, Cur@CD-MOF/ZC film exhibited excellent preservation performances on other fruits and vegetables as well (winter jujube, broccoli, white mushroom, etc.), confirming their broad application potentials for the perishable produce preservation.
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产品关联
DOI
高影响因子
JOURNAL OF FOOD PROCESSING AND PRESERVATION
·
2025
·Vol. 2025
·期 1
·7504108
·
IF 2.5
Xinyao Quan,Jiajia Ma,Lingxiang Sun,Guili Huang,Siyao Sui,Haocong Li,Qianshuo Shao,Su Yan,Yuning Wang,Xiaoqing Wang
To address the demand for sustainable postharvest preservation, this study developed a chitosan-based composite film integrated with γ -cyclodextrin ( γ -CD) microcapsules encapsulating proanthocyanidins and cinnamaldehyde. The primary objectives were to evaluate the film’s physicochemical properties and assess its efficacy in mitigating quality deterioration in citrus fruits during storage. Results demonstrated that the composite film significantly reduced weight loss (5.78%), maintained firmness (≥ 80% retention), and delayed changes in total soluble solids (TSSs) and pH compared to uncoated controls. Furthermore, it inhibited vitamin C degradation (≤ 35% loss) and extended shelf life to 40 days at 15°C by suppressing microbial growth and oxidative stress. The synergistic effects of chitosan’s film-forming capacity and the sustained release of bioactive compounds from γ -CD microcapsules, among which proanthocyanidins had good antioxidant function and cinnamaldehyde had good antibacterial property, played a key role in the preservation of citrus fruits.
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产品关联
DOI
高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
·
2025
·
IF 6.8
Xinlin Zhu,Yi Dong,Ya Zhang,Chenghai Gao,Lijian Ding,Yonghong Liu,Zhiran Ju
Gouty arthritis, driven by monosodium urate (MSU) crystal deposition and dysregulated inflammation, remains a therapeutic challenge due to the limitations of current treatments. Here, we investigate Herdmanine D (HDD), a marine-derived alkaloid from the ascidian Herdmania momus. It was optimized via structure–activity relationship (SAR) studies and computational modeling to enhance its binding to peroxisome proliferator-activated receptor γ (PPAR-γ), which regulates the PPAR-γ/NF-κB signaling pathway in gout pathogenesis. The optimized HDD derivative 9a demonstrated potent PPAR-γ binding affinity and pharmacokinetic properties, effectively suppressing NF-κB-driven pro-inflammatory cytokines in vitro. In murine MSU-induced gouty arthritis models, 9a alleviated synovial inflammation and tissue damage. Mechanistically, 9a activated PPAR-γ to inhibit NF-κB and attenuate NLRP3 inflammasome assembly. This work highlights HDD as a unique marine scaffold for next-generation antigout therapeutics, merging marine natural product safety with rational design to address unmet clinical needs.
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DOI
PubMed
高影响因子
BRITISH JOURNAL OF HAEMATOLOGY
·
2021
·Vol. 195
·期 2
·267-275
·
IF 6.998
Zaoke He,Xiaoqin Sun,Shixiang Wang,Dongsheng Bai,Xiangyu Zhao,Ying Han,Piliang Hao,Xue-Song Liu
Summary The expression of GGCT (γ-glutamyl cyclotransferase) is upregulated in various human cancers. γ-glutamyl cyclotransferase enzyme activity was originally purified from human red blood cells (RBCs), but the physiological function of GGCT in RBCs is still not clear. Here we reported that Ggct deletion in mice leads to splenomegaly and progressive anaemia phenotypes, due to elevated oxidative damage and the shortened life span of Ggct −/− RBCs. Ggct −/− RBCs have increased reactive oxygen species (ROS), and are more sensitive to H 2 O 2 -induced damage compared to control RBCs. Glutathione (GSH) and GSH synthesis precursor l -cysteine are decreased in Ggct −/− RBCs. Our study suggests a critical function of Ggct in RBC redox balance and life span maintenance through regulating GSH metabolism.
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DOI
PubMed
高影响因子
JOURNAL OF THE ENERGY INSTITUTE
·
2021
·
IF 6.186
Hao Xu,Xing Fan,Guo-Sheng Li,Yang-Yang Xu,Wen-Long Mo,Peter N. Kuznetsov,Feng-Yun Ma,Xian-Yong Wei
Co-Mo/γ-Al 2 O 3 bimetallic catalyst was prepared by incipient wetness impregnation and the physicochemical properties were obtained by a series of characterization methods. The active components are mainly MoS 2 and Co-Mo-S existing on γ-Al 2 O 3 , the support. Meanwhile, the activity of catalyst in hydroconversion of four coal-related model compounds (CRMCs), dibenzyl ether, furan, thiophene and quinoline, was investigated. Hydroconversion products were analyzed by gas chromatography/mass spectrometry (GC/MS) and the possible reaction pathways were proposed according to the GC/MS data. Oxygen was removed from dibenzyl ether via the direct cleavage of C alk -O bridge bond to produce benzylium cation followed by the combination with H − to generate toluene. The hydroconversion of furan can be realized by the direct cleavage of C ar -O bond and direct hydrogenation, respectively. For thiophene, H + directly transferred to sulfur atom, leading to the cleavage of C ar -S bond to produce H 2 S and 1,3-butadiene, which abstracted active hydrogen to yield butane. Another indirect desulfurization pathway for thiophene is hydrogenating to form tetrahydrothiophene and C–S bond cracking to produce butane. Hydroconversion of quinoline started with either N-ring or benzene ring , and the first one was the main pathway.
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高影响因子
POLYMER INTERNATIONAL
·
2022
·Vol. 71
·期 11
·1278-1286
·
IF 3.213
Miao Dai,Siyuan Li,Yan Cui,Wei Zhang,Hui Shi,Kai Pan,Wei Wei,Xiaoya Liu,Xiaojie Li
Although magnesium (Mg) and its alloys are promising biodegradable materials for orthopedic implants, rapid and uncontrollable degradation of Mg is still a challenge for clinical applications. In this work, electroactive polymer coatings were prepared to improve the corrosion resistance and cytocompatibility of Mg alloys. Amphiphilic electroactive tetraaniline (TANi)-conjugated poly( γ -glutamic acid) ( γ -PGA) with various TANi modification rates ( γ -PGA–TANi 10 , γ -PGA–TANi 20 , γ -PGA–TANi 27 ) were first synthesized. γ -PGA–TANi colloidal particles, prepared by a self-assembly method, were then coated on Mg alloys by electrophoretic deposition. The prepared γ -PGA–TANi coatings showed a homogeneous surface and good adhesion on AZ31 Mg alloys. Electrochemical analysis and in vitro immersion tests revealed that γ -PGA–TANi-coated Mg exhibited superior corrosion resistance, which was mainly attributed to the electroactivity of the γ -PGA–TANi coatings, leading to the rapid formation of a passivation layer to prevent the further corrosion of Mg alloys. Furthermore, the γ -PGA–TANi alloy coatings efficiently regulated Mg 2+ release and pH value of coated Mg alloy during immersion for 40 days. In comparison with bare Mg alloy, the coated Mg alloy also showed better cytocompatibility, where L929 cells emerged with a good cell adhesion and viability. These results indicate that electroactive γ -PGA–TANi coatings have promising potential for corrosion resistance of Mg alloys. © 2022 Society of Industrial Chemistry.
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高影响因子
GREEN CHEMISTRY
·
2017
·Vol. 19
·期 16
·3869-3879
·
IF 9.125
Shurong Wang,Yuan Zhao,Haizhou Lin,Jingping Chen,Lingjun Zhu,Zhongyang Luo
For the purpose of building a green reaction system to produce furfural (FF), the conversion of two important pentoses from hemicellulose, namely xylose and arabinose, was investigated in an aqueous reaction system including a Lewis acidic ionic liquid as a catalyst and renewable γ-valerolactone (GVL) as a co-solvent. The results showed that the introduction of GVL greatly improved the reactivity of pentose and inhibited the secondary decomposition reaction of FF compared to a pure-water reaction system. NMR analysis suggested that the composition of pentose conformers was greatly altered towards a reactive distribution. The highest FF yields were 79.76% (from xylose) and 58.70% (from arabinose), which were obtained at 140 °C. The influence of reaction parameters on pentose conversion was also studied. A comparison between different reaction conditions suggested that arabinose had less reactivity than xylose, leading to its lower conversion rate and FF yield. Furthermore, xylan and real biomass materials were tested in the proposed reaction system, and decent FF yields of up to 69.66% (from xylan) and 47.96% (from corn stalk) were obtained.
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DOI
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2023
·
IF 5.9
Huan Xu,Shuhua Mo,Qi Peng,Minsheng Lu
Efficient fractionation of lignocellulosic biomass offers the possibility of converting it into high value-added products. This paper presents a strategy for one-pot fractionation of eucalyptus in an AlCl 3 -catalyzed γ-valerolactone (GVL)/H 2 O system. Under the suitable conditions, 90.7% of hemicellulose and 92.5% of lignin were dissolved in the aqueous and organic phases, respectively, while 86.2% of cellulose was retained. Enzymatic hydrolysis of the cellulose-rich solid residue resulted in a 86.2% yield of glucose. In addition, 82% of the original xylan was recovered from the aqueous phase as xylose and low levels of inhibitors were generated. The recovered lignin appeared as spherical nanoparticles with high purity (95.2%), low dispersity (1.32), low molar mass, making it well-suited for biomaterials preparation. The proposed strategy is novel and promising for lignocellulosic biomass fractionation, which improves the downstream processability and facilitates the complete exploitation of biomass, thus providing a viable route for biorefinery.
研究领域:
生物化学
·
可再生资源与环境科学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2020
·
IF 5.162
Hesaam Hajilou,Mohammad Reza Farahpour,Hamed Hamishehkar
This study was conducted to design and evaluate a wound dressing based on a polycaprolactone (PCL) nanofiber coated with gamma oryzanol (GO) and chitosan (CS) in mice model. All the dressings were prepared by electrospinning method, and their morphology and physical properties were investigated. The mice were divided into five groups and treated with I) PCL-sole (PCL), III) PCL-mupirocin (PCL-M), IV) PCL-GO, IV) PCL-CS, and V) PCL-CS-GO. Wound area, total bacterial count, histopathological parameters, and expressions of IL-1β, TNF-α, IL-10, MMP-9, EGF, and VEGF were assessed. The fibers were randomly distributed in PCL group, but loading CS and GO increased the complexity and placing on the dressings. PCLs loaded with GO and CS showed lower viscosity, surface tension, and fiber diameter and higher conductivity and water contact angle compared to unloaded PCLs ( P < 0.05). The treatment with PCLs loaded with mupirocin, CS, and GO significantly reduced wound area and total bacterial count ( P < 0.05). Loading PCLs with mupirocin, CS, and GO decreased the expressions of IL-1β, TNF-α, MMP-9, but increased the expressions of IL-10 and VEGF compared to the unloaded PCL group ( P < 0.05). The most optimal responses to wound healing and physical parameters belonged to the PCL-CS-GO group.
研究领域:
生物材料学
·
医学
·
药理学
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DOI
高影响因子
POLYMER COMPOSITES
·
2020
·Vol. 41
·期 5
·2046-2053
·
IF 2.265
Chuyuan Jia,Runze Zhang,Chengce Yuan,Zhenyu Ma,Yunzhe Du,Li Liu,Yudong Huang
The 3-aminopropyltriethoxysilane (APS) grafted aramid fibers were prepared by γ-ray irradiation and chemical treatment to improve the interfacial properties between aramid fibers and epoxy matrix. The functionalization process of aramid fibers was investigated by scanning electron microscopy, X-ray photoelectron spectroscopy, and Fourier transform infrared spectrum. After grafted with APS, the surface roughness of aramid fibers increased obviously, and the element content and composition of functional groups changed significantly in the modification process. Dynamic contact analysis indicated the wettability, and surface free energy of the fibers were greatly improved after the APS treatment. Monofilament pull-out measurement showed that the interfacial shear strength of aramid fiber reinforced composite increased by 51.03%, from 36.33 to 54.87 MPa after the surface modification. Moreover, benefited from the appropriate radiation and the APS grafting, the functionalization process did not damage fiber tensile strength.
研究领域:
材料科学
·
复合材料工程
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DOI
高影响因子
Sustainable Energy & Fuels
·
2020
·Vol. 4
·期 6
·3102-3114
·
IF 5.503
Jian He,Yufei Xu,Zhaozhuo Yu,Hu Li,Wenfeng Zhao,Hongguo Wu,Song Yang
The effective and economically feasible tandem synthesis of γ-valerolactone (GVL), a renowned bio-based platform molecule with great promising applications in the production of drop-in chemicals, liquid fuels and polymers, is significantly vital and challenging. Herein, we for the first time describe a direct and effective catalytic system based on ZrOCl2·8H2O capable of facilitating the one-pot one-step tandem synthesis of GVL from bio-based furfural or furfuryl alcohol in 2-propanol by integrating sequential transfer hydrogenation, ring-opening, and transfer hydrogenation–cyclization reactions. A maximum GVL yield of 63.3% and 52.1% was achieved from furfuryl alcohol and furfural at 200 °C, respectively. The synergistic effect of [ZrO(OH)2]n·xH2O species and Brønsted acid species H+, derived from in situ hydrolysis of ZrOCl2·8H2O, is accountable for its remarkable catalytic performance. Moreover, calcination of the leftover solid after tandem synthesis of GVL could fabricate a hollow microrod ZrO2 material, in which the formation of a microrod morphology and hollow structure was probably attributed to the electrostatic repulsion forces among particles in the alcohol solution and removal of generated humins/coke during the reactions within collected solids via calcination, respectively. Importantly, hollow microrod ZrO2 innovatively featuring a high BET surface area, a large amount of acid–base sites and facile active-site accessibility thereby exhibited a superior performance in the catalytic transfer hydrogenation of biomass-derived aldehydes or ketones to ZrO2 prepared by the precipitation method.
研究领域:
化学工程
·
材料科学
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DOI
高影响因子
Journal of Hazardous Materials Advances
·
2023
·
IF 0
Abdul Haleem,Shengqi Chen,Jianming Pan,He Weidong
γ − radiation is a clean, fast and efficient synthetic route for polymeric materials. it is very powerful tool to generate free radicals during polymerization without any need of initiator and accelerator in both hydrophilic and hydrophobic media. Here in this work, for the first time, we fabricated acrylamide-methyl-propane sulfonic acid based-single and double network hydrophilic cryogels via γ − radiation at low pH. pH highly effects the synthesis of acrylamide-methyl-propane sulfonic acid based cryogels using redox initiation method. Along with pH, the effect of radiation time and radiation dose rate on cryo-polymerization was also studied. Gold hybrid cryogels (single and double network) were fabricated via self-reduction method at ambient conditions. Fourier transform infrared spectroscopy was implemented for chemical structure analysis of the synthesized material. The surface morphology of single and double network cryogels was observed via scanning electron microscopy. For the hybrid cryogels materials analysis x-ray diffraction, thermal gravimetric analysis, energy dispersive x-ray analysis, x-ray photoelectron spectroscopy and transmission electron microscopy and was used to confirm the presence of nanoparticles in the polymer network. The fabricated hybrid cryogels (0.15 g) were used for the degradation of Congo red (50 mL) as model dye in the presence of NaBH 4 (0.02 g) with efficient and fast degradation activity. The apparent rate constant value (K app ) for single and double network hybrid cryogels was 0.3652 min −1 and 0.2268 min −1 , respectively. The activation energy, enthalpy and entropy was calculated (34.44 kJ.mol −1 , –30.85 kJ.mol −1 and –146.30 J·mol −1 k −1 , respectively) using Arrhenius and Eyring equations for the fabricated catalyst. The catalyst was tasted in the tap water system and its efficiency was satisfied in real world too. The fabricated double wall hybrid catalyst will have a significant importance in the environmental field.
研究领域:
材料科学
·
环境科学
·
化学工程
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危险品化学品经营许可证（带存储）