JOURNAL OF MOLECULAR LIQUIDS
·
2022
·
IF 6.633
Mansoor Khan,Ozgur Ozalp,Muslim Khan,Mustafa Soylak
In this work, we report the preparation of Fe 3 O 4 -Ti 3 AlC 2 max phase impregnated with 2-(5-Bromo-2-pyridylazo-5-(diethylamino) phenol) and its implementation for the extraction of cadmium, lead and cobalt from water and food samples. Blended Fe 3 O 4 -Ti 3 AlC 2 max phase impregnated with 2-(5-Bromo-2-pyridylazo-5-(diethylamino) phenol) was characterized using different instrumental techniques like scanning electron microscopy (SEM), surface area analyser (SAA), energy dispersive X-rays (EDX), Fourier transform infrared spectroscopy (FT-IR) and X-rays diffraction (XRD) for surface morphology, surface region, elemental composition, functional group and crystallinity, respectively. Factors that impact the % recoveries of analyte i.e pH, sample volume, vortex time, desorption condition and matrix impact were optimized. Analytical parameters like limit of detection (LOD) (Cd: 0.093 µg/L, Pb: 0.297 µg/L, Co: 0.223 µg/L), limit of quantifications (LOQ) (Cd: 0.310 µg/L, Pb: 0.992 µg/L, Co: 0.744 µg/L) preconcentration factors (PF) (Cd = Pb = Co: 40), enrichment factors (EF) (Cd: 39.8, Pb: 39, Co: 40) and relative standard deviation (RSD) (Cd: 3.8, Pb: 5.98, Co: 4.0) were determined under optimized trial conditions. The proposed strategy was tested using certified reference materials like TMDA-64.3 natural water and tobacco leaves (INCT-OBTL-5) for trace metal analysis. The developed strategy was also applied effectively to natural water samples and food samples using the standard addition method with good recovery results.
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高影响因子
ELECTROCHIMICA ACTA
·
2017
·
IF 4.798
Zhonghua Xue,Xiaoxia Fu,Honghong Rao,Xibin Zhou,Xiuhui Liu,Xiaoquan Lu
As efficient electron transfer mediator, various nanomaterials with smart performance have been explored in non-enzymatic sensor fabrication. We herein present an electron transfer mediator actuated electrochemical non-enzymatic sensor to assay nitrite, enabled by electrochemical reduced graphene oxide (ERGO) and 1-(2-pyridylazo)-2-naphthol (PAN). The composites of PAN-ERGO coating on electrode surface were successfully fabricated through a facile and green cyclic voltammetry technique. With the aid of ERGO nanosheets on the electrode surface, the electron transfer mediator of PAN nanostructures was easily immobilized and hybridized with ERGO, resulting in a remarkably synergistic effect between ERGO sensing substrate and the electrodeposited PAN coating for target electron transfer. The results demonstrated that the electrocatalytic current increased linearly with the nitrite concentration in the range of 7.49–1752.6 μM and 1752.6–3500 μM, with a good detection limit of 0.67 μM and 1.44 μM (signal-to-noise ratio, S/N = 3), respectively. The present work provide some new insights for the smart design of high efficiency electrocatalytic materials that based on the composites of electrochemical reduced graphene oxide and other substances.
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Journal of Environmental Sciences
·
2016
·
IF 2.208
Jingjing Shao,Yan Cheng,Chunping Yang,Guangming Zeng,Wencan Liu,Panpan Jiao,Huijun He
Naphthalene-2-ol is a typical biologically recalcitrant pollutant in dye wastewater. Solvent extraction of naphthalene-2-ol from aqueous solutions using mixed solvents was investigated. Various extractants and diluents were evaluated, and the effects of volume ratio of extractant to diluent, initial pH, initial concentration of naphthalene-2-ol in aqueous solution, extraction time, temperature, volume ratio of organic phase to aqueous phase (O/A), stirring rate and extraction stages, on extraction efficiency were examined separately. Regeneration and reuse of the spent extractant were also investigated. Results showed that tributyl phosphate (TBP) achieved 98% extraction efficiency for naphthalene-2-ol in a single stage extraction, the highest among the 12 extractants evaluated. Extraction efficiency was optimized when cyclohexane and n -octane were used as diluents. The solvent combination of 20% TBP, 20% n -octanol and 60% cyclohexane ( V / V ) obtained the maximum extraction efficiency for naphthalene-2-ol, 99.3%, within 20 min using three cross-current extraction stages under the following extraction conditions: O/A ratio of 1:1, initial pH of 3, 25°C and stirring rate of 150 r/min. Recovery of mixed solvents was achieved by using 15% ( W / W ) NaOH solution at an O:A ratio of 1:1 and a contact time of 15 min. The mixed solvents achieved an extraction capacity for naphthalene-2-ol stably higher than 90% during five cycles after regeneration.
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高影响因子
JOURNAL OF SOLID STATE CHEMISTRY
·
2015
·
IF 2.133
Xiaoxiang Xu,Yinghao Xie,Shuang Ni,Abul K. Azad,Tongcheng Cao
Solid solutions of ZnGa 2− x Cr x O 4 (0≤ x ≤2) were successfully prepared by solid state reactions . Introducing Cr into ZnGa 2 O 4 crystal structure significantly improves its light absorption and greatly enhances its photocatalytic activity . An optimized Cr content ( x =1.5 for ZnGa 0.5 Cr 1.5 O 4 ) was found for the solid solutions with the highest photocatalytic hydrogen production rate (~775 μmol/h). Compositional analysis suggests there is a strong enrichment of Cr at the surface of sample ZnGa 0.5 Cr 1.5 O 4 compared with other samples. Theoretical calculations suggest their electronic structures involve spin-polarized conduction band (CB) and valence band (VB) that are mainly composed of Cr 3 d orbitals. The highest photocatalytic activity observed in ZnGa 0.5 Cr 1.5 O 4 is probably due to the higher Cr content at the surface that favors the Cr 3 d orbital overlapping.
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TURKISH JOURNAL OF CHEMISTRY
·
2022
·Vol. 45
·期 4
·1133-1145
·
IF 1.151
WANG DING-KAI,ZHAO WEI,CUI MING-YU,GUO TIAN-TIAN,FU SHUI-YUAN,LI WEI-GANG
A series of Zr(SO4)2/SiO2 solid acid catalysts with different Zr(SO4)2 loadings were prepared by water-soluble-impregnation method at room temperature. Then, the prepared catalysts were characterized by Fourier transform infrared spectroscopy, transmission electron microscopy and energy-dispersive X-ray spectrum, X-ray diffraction, adsorption/desorption of N2, and temperature-programmed desorption of NH3. The results showed that the active component Zr(SO4)2 was successfully adhered to the mesoporous SiO2, and the acid amount of Zr(SO4)2/SiO2 increased with the increasing of the Zr(SO4)2 loadings. Finally, the wheat stalk was used as raw material and depolymerized over Zr(SO4)2/SiO2 to produce ethyl levulinate (EL). The reaction mixture was separated and purified by filtration and vacuum distillation. The kinetic characteristics and the reaction pathway were also studied. A comparative study showed that 20 wt.% Zr(SO4)2/SiO2 exhibited higher catalytic activity. When reaction temperature, time, catalyst dosage and Zr(SO4)2 loadings were 190 °C, 50 min, 20 wt.% and 30 wt.%, the EL yield reached a maximum of 17.14%. The relative content of EL exceeded 90% after three steps of distillation.
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Processes
·
2026
·Vol. 14
·期 2
·242
·
IF 3.4
Yu Guo,Qisong Liu,Li Liang,Guihong Lan,Ming Duan
Hydrogen sulfide (H2S) prevalent in fuel gases such as natural gas and biogas necessitates removal prior to utilization or pipeline distribution. Biological desulfurization is considered a green purification technology employing sulfur-oxidizing bacteria (SOB) under ambient conditions to eliminate sulfur compounds, offering advantages including high efficiency, simplified equipment, and minimal chemical consumption. A highly efficient SOB TYWJ-2 was isolated in this study. Genomic analysis revealed that strain TYWJ-2 possesses a complete set of sulfur metabolism genes, enabling the metabolism of various inorganic sulfides, along with salt-tolerance genes that support adaptation to high osmolarity environments. The optimal conditions for desulfurization were determined through single-factor experiments and Box–Behnken response surface methodology. Long-term desulfurization performance demonstrated stable operational efficiency, with H2S removal rates consistently reaching 99.72~99.87%. System performance remained robust under varying sulfur loads, elevated salinity, and intermittent operational shutdowns, with no significant decline in desulfurization efficiency observed. These findings indicate that strain TYWJ-2 holds considerable potential for the biological desulfurization of sulfur-containing biogas and natural gas.
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Advanced Healthcare Materials
·
2026
·
IF 11
Minjiang Chen,Kun Zhang,Kai Li,Hui Xu,Jiayi Shi,Huilin Hu,Qianhui He,Liyun Zheng,Shiji Fang,Qiaoyou Weng,Min Xu,Zhongwei Zhao,Gaofeng Shu,Jiansong Ji
The acidic and immunosuppressive tumor microenvironment (TME) remarkably hampers the therapeutic efficacy of transcatheter arterial embolization (TAE) for hepatocellular carcinoma (HCC). Herein, uniform CaCO 3 nanoparticles encapsulated nickel–alginate microspheres (CaNPs/Ni-Alg MSs) were engineered using a microfluidic device, serving as an immune-regulated embolic agent to amplify TAE treatment of HCC. CaNPs/Ni-Alg MSs could adsorb His-tagged interleukin-2 (IL-2) and enable sustained release through coordination interactions between the His-tag and Ni 2 + , thereby reducing systemic cytokine elevation risk from IL-2 administration. IL-2-loaded microspheres (IL-2/CaNPs/Ni-Alg MSs) effectively neutralize intratumoral lactic acid (LA) via CaCO 3 , modulating the acidic TME. Proton neutralization restores IL-2 activity, enhancing T lymphocyte infiltration and proliferation. Additionally, lactate made available following acid neutralization may serve as a metabolic substrate, as supported by the calcium lactate and neutralization-mimicking experiments in vitro, contributing to CD8 + T-cell metabolic fitness. IL-2/CaNPs/Ni-Alg MSs could reprogram the TME into an immune-promoting milieu, synergizing with immune checkpoint blockade (ICB) therapy to suppress both primary and distant tumors. Not surprisingly, TAE with IL-2/CaNPs/Ni-Alg MSs combined with αPD-L1 achieved superior therapeutic efficacy without side effect in a rat orthotopic HCC model. Overall, this work presents a safe metabolism-reprogramming embolic strategy that repurposes LA to boost IL-2–mediated embolization-immunotherapy in HCC.
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高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2026
·Vol. 74
·期 32
·25119-25128
·
IF 6.7
Li Biao,Ying Rui-Ning,Wang Xian-Quan,Zhao Jing,Lin Hong-Yan,Wang Da-Wei,Yang Guang-Fu
4-Hydroxyphenylpyruvate
dioxygenase (HPPD) has become an attractive
target for herbicide development owing to the slow development and
low risk of resistance to its inhibitors. However, most available
HPPD inhibitors exhibit limited crop selectivity and poor efficacy
against grasses. Therefore, the exploration of novel molecular scaffolds
is of great research value. In this study, we adopted a ring-fusion
strategy to enhance π–π stacking interactions and
developed a structurally novel pyrazole-4-chloro-benzimidazolin-2-one
scaffold. Through systematic structural optimization, compound II-19 showed the strongest enzyme inhibitory activity, with
an IC 50 of 52 nM, about 6-fold higher potency than the
positive control, mesotrione. The crystal structure of At HPPD- II-19 revealed that the inhibitor engages in characteristic
chelation and π–π stacking interactions within
the active site, and the 3-NO 2 -benzyl group contributes
additional hydrophobic interactions and a possible weak water-mediated
interaction involving Gln293. Additionally, I-5 showed
excellent broad-spectrum weed control and good safety toward peanut
at 30 g a.i./ha. These results indicate that compound I-5 is a promising candidate for the development of new HPPD inhibitors
for weed control in peanut fields.
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PubMed
高影响因子
CHEMISTRY & BIODIVERSITY
·
2026
·Vol. 23
·期 6
·e71440
·
IF 2.9
Qun Wang,Shaoyan Shuang,Shaobin Xu,Huilu Sun,Jiaxuan He,Yuee Tian,Xiaobo Huang,Genqiang Chen,Zhiping Che
In order to discover highly bioactive Fenjuntong compounds, 10 2′-acyloxyfenjuntong derivatives ( 3a – j ) were synthesized by structural modification of Fenjuntong, and their structures were well characterized by 1 H NMR, 13 C NMR, and HRMS. Furthermore, the bioactivities of these compounds as anti-oomycete, antifungal, and nematicidal agents against three serious agricultural pests, Phytophthora capsici , Fusarium graminearum , and Heterodera glycines were evaluated. Among all tested compounds, first, compound 3a exhibited promising anti-oomycete against P. capsici , with an EC 50 value of 35.00 mg/L. Second, compounds 3d and 3f displayed promising antifungal against F. graminearum , with EC 50 values of 52.60 and 39.41 mg/L, respectively. Third, compounds 3g , 3i , and 3j showed significant nematicidal activity against H. glycines , with LC 50 values of 36.29, 30.19, and 35.43 mg/L, respectively. The results demonstrate that introducing acyloxy pharmacophores at the phenolic hydroxyl position of Fenjuntong not only significantly enhances its biological activity against P. capsici , F. graminearum , and H. glycines , but also yields target compounds that uniformly more active than Fenjuntong itself. Moreover, these important results lay the foundation for further optimization of Fenjuntong toward the development of potential new pesticides. Graphical
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高影响因子
BIORESOURCE TECHNOLOGY
·
2026
·
IF 8.2
Jie Qiao,Yibo Song,Nan Zhao,Peiyao Duan,Xiujuan Li
Acyltransferase MtMetA catalyzes the specific conversion of BHET to MHET. • Catalytic barrier-minimization strategy increased MHET yield by 3.13-fold. • The engineered mutants outperformed wild-type MtMetA in stability and activity. • Shortened nucleophilic attack distance governs the enhanced enzyme activity. The extensive use of polyethylene terephthalate (PET) has resulted in severe environmental pollution and ecological stress. Despite advances in PET recycling, current processes struggle to achieve high product value, as the complete conversion to terephthalic acid remains energetically demanding and economically inefficient. The catalytic promiscuity inherent in natural enzyme evolution holds great promise for providing novel candidates to accelerate PET biodegradation and upcycling. Herein, we report for the first time that the acyltransferase metA from Mycobacterium tuberculosis (MtMetA) catalyzes the conversion of bis(2-hydroxyethyl) terephthalate (BHET), an intermediate of PET hydrolysis, into the high-value monomer mono(2-hydroxyethyl) terephthalate (MHET). Guided by molecular dynamics (MD) simulations, we applied a catalytic barrier-minimization strategy to optimize the active-site environment of MtMetA, yielding engineered variants, notably ΔBarrier2 and ΔBarrier3. Specifically, ΔBarrier2 achieved a 3.1-fold increase in MHET yield, while ΔBarrier3 demonstrated a 3.2-fold enhancement in catalytic efficiency ( k cat / K M ) relative to the wild-type. The truncated MtMetA variants also exhibited enhanced robustness, showing improved thermostability (3.5-fold increase in residual activity at 60 °C for ΔBarrier3), as well as higher tolerance to metal ions and organic solvents. In particular, ΔBarrier2 displayed a 7.2-fold increase in product yield in Ca 2+ -containing systems, while ΔBarrier3 retained 2.3-fold higher residual activity in the presence of 50 % (v/v) isopropanol. MD simulations revealed that an enlarged active pocket and a shortened nucleophilic attack distance synergistically govern the enhanced catalytic activity and robustness. This work expands the enzymatic toolbox for PET recycling and targeted BHET degradation, advancing sustainable plastic waste management through biocatalytic innovations. Download: Download high-res image (113KB) Download: Download full-size image
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高影响因子
Pharmaceuticals
·
2023
·Vol. 16
·期 5
·767
·
IF 4.6
Jie Chen,Xiang Zhou,Lifeng Fu,Haiyu Xu
Drugs that cure COVID-19 have been marketed; however, this disease continues to ravage the world without becoming extinct, and thus, drug discoveries are still relevant. Since Mprohas known advantages as a drug target, such as the conserved nature of the active site and the absence of homologous proteins in the body, it receives the attention of many researchers. Meanwhile, the role of traditional Chinese medicine (TCM) in the control of epidemics in China has also led to a focus on natural products, with the hope of finding some promising lead molecules through screening. In this study, we selected a commercial library of 2526 natural products from plants, animals and microorganisms with known biological activity for drug discovery, which had previously been reported for compound screening of the SARS CoV-2 S protein, but had not been tested on Mpro. This library contains compounds from a variety of Chinese herbs, includingLonicerae Japonicae Flos,Forsythiae FructusandScutellariae Radix, which are derived from traditional Chinese medicine prescriptions that have been shown to be effective against COVID-19. We used the conventional FRET method for the initial screening. After two rounds of selection, the remaining 86 compounds were divided into flavonoids, lipids, phenylpropanoids, phenols, quinones, alkaloids, terpenoids and steroids according to the skeleton structures, with inhibition rates greater than 70%. The top compounds in each group were selected to test the effective concentration ranges; the IC50values were as follows: (−)–gallocatechin gallate (1.522 ± 0.126 μM), ginkgolic acid C15:1 (9.352 ± 0.531 μM), hematoxylin (1.025 ± 0.042 μM), fraxetin (2.486 ± 0.178 μM), wedelolactone (1.003 ± 0.238 μM), hydroxytyrosol acetate (3.850 ± 0.576 μM), vanitiolide (2.837 ± 0.225 μM), β,β–dimethylacrylalkannin (2.731 ± 0.308 μM), melanin (7.373 ± 0.368 μM) and cholesteryl sodium sulfate (2.741 ± 0.234μM). In the next step, we employed two biophysical techniques, SPR and nanoDSF, to obtain KD/Kobsvalues: hematoxylin (0.7 μM), (−)–gallocatechin gallate (126 μM), ginkgolic acid C15:1 (227 μM), wedelolactone (0.9770 μM), β,β–dimethylacrylalkannin (1.9004 μM,), cholesteryl sodium sulfate (7.5950 μM) and melanin (11.5667 μM), which allowed better assessments of the binding levels. Here, seven compounds were the winners. Then, molecular docking experiments were specially performed by AutoDock Vina to analyze the mode of interactions within Mproand ligands. We finally formulated the present in silico study to predict pharmacokinetic parameters as well as drug-like properties, which is presumably the step that tells humans whether the compounds are drug-like or not. Moreover, hematoxylin, melanin, wedelolactone, β,β–dimethylacrylalkannin and cholesteryl sodium sulfate are in full compliance with the “Lipinski” principle and possess reasonable ADME/T properties, they have a greater potential of being lead compounds. The proposed five compounds are also the first to be found to have potential inhibitory effects on SARS CoV-2 Mpro. We hope that the results in this manuscript may serve as benchmarks for the above potentials.Keywords:SARS CoV-2 Mpro;natural products;high-throughput screening;lead compounds;in silico study
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高影响因子
Journal of Materials Chemistry A
·
2026
·
IF 9.2
Chao Yang,Xiao-Li Pu,Qi Yin,Qing-Ping Huang,Lei Cai,Ping Liu,Zhi-Bin Fang
Elucidating properties of cocatalysts from all aspects endows them new roles as proactive regulators of light harvesting and reaction kinetics to promote the overall efficiency of photocatalysts. [Mo3S13]2- nanoclusters have served as one of the most efficient catalysts for hydrogen evolution reaction (HER), while their underlying photo-responsive behaviors within hybrid photocatalyst systems remain unexplored. Herein, we unveil the visible-light sensitization effect of [Mo3S13]2- nanoclusters, in the mode of hot electron injection, that drive apparent and sustainable photocatalytic HER. This effect was demonstrated by loading [Mo3S13]2- nanoclusters on wide-bandgap nanosized ZnS host. Detailed characterizations further clarified the photosensitization of [Mo3S13]2- nanoclusters by revealing the dependence of HER activity on the enhanced visible light responsivity and the light-induced nanocluster-to-host electron transfer. This work not only showcases the dual function of the advanced [Mo3S13]2- nanocluster cocatalysts but also provides guidance for the discovery and understanding of more multifunctional materials opening new opportunities for efficient and multi-mode photocatalysis.
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