IMMUNITY
·
2024
·
IF 25.5
Rui Ding,Xiaoyan Yu,Zhilin Hu,Yu Dong,Haiyan Huang,Yuerong Zhang,Qiaoqiao Han,Zhi-Yu Ni,Ren Zhao,Youqiong Ye,Qiang Zou
RNA splicing is involved in cancer initiation and progression, but how it influences host antitumor immunity in the metabolically abnormal tumor microenvironment (TME) remains unclear. Here, we demonstrate that lactate modulates Foxp3-dependent RNA splicing to maintain the phenotypic and functional status of tumor-infiltrating regulatory T (Treg) cells via CTLA-4. RNA splicing in Treg cells was correlated with the Treg cell signatures in the TME. Ubiquitin-specific peptidase 39 (USP39), a component of the RNA splicing machinery, maintained RNA-splicing-mediated CTLA-4 expression to control Treg cell function. Mechanistically, lactate promoted USP39-mediated RNA splicing to facilitate CTLA-4 expression in a Foxp3-dependent manner. Moreover, the efficiency of CTLA-4 RNA splicing was increased in tumor-infiltrating Treg cells from patients with colorectal cancer. These findings highlight the immunological relevance of RNA splicing in Treg cells and provide important insights into the environmental mechanism governing CTLA-4 expression in Treg cells.
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PubMed
高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
·
2025
·Vol. 27
·期 2
·1-11
·
IF 2.6
Zhang Enlei,Chen Jiaojiao,Xu Rui,Song Xiaowen,Zhang Bengui,Wang Guosheng
In this work, the different shaped CoSn(OH) 6 nanocrystallines were prepared by hydrothermal method. The morphology, microstructure, and composition of the prepared nanocrystallines were characterized with X-ray diffraction (XRD), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and other methods. The optical properties of CoSn(OH) 6 nanocrystallines with different morphologies were analyzed using UV–vis DRS. With the reduction of 4-nitrophenol as a model reaction, the photocatalytic performance of CoSn(OH) 6 nanocrystallines with the different morphologies was investigated. The results show that the CoSn(OH) 6 nanorings significantly improved the photocatalytic reduction 4-nitrophenol performance. The conversion rate of 4-nitrophenol reached 94% within 6 min. Finally, a potential mechanism for the photocatalytic process of CoSn(OH) 6 nanorings is discussed.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Shenyi Tang,Chenglian Luo,Zhi Wang,Xinlei Liu
A defect-free and stable metal–organic framework (MOF) membrane is a promising candidate for the separation of methanol/methyl tertiary butyl ether (MeOH/MTBE) mixtures. In this work, a structural-integrity and low-thickness (∼400 nm) UiO-66 membrane was fabricated by regulating the metal ion/ligand molar ratio in the synthesis solution and optimizing the preparation process using the secondary growth method with safer and more environment-friendly Zr(n-OPr)4 metal source. Based on the effective pore size and inherent amphiphilic structure of UiO-66, the membrane exhibits exceptional pervaporation (PV) performance. For the separation of MeOH/MTBE (5:95 wt/wt %) mixtures, the membrane displays an outstanding separation performance with an average separation factor of 2.23 × 104 and an average total flux of 3.61 kg·m–2·h–1 at 40 °C, which is superior to most membranes reported for the PV separation of MeOH/MTBE mixtures. In addition, a 72 h PV process was used to further confirm the structural stability of the membrane.
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高影响因子
SOLAR ENERGY MATERIALS AND SOLAR CELLS
·
2024
·
IF 6.3
Yu He,Chenxi Zhao,Zecheng Lu,Ning Guo,Hongmei Luan,Yanchun Yang,Ruijian Liu,Chengjun Zhu
Indium tin oxide (ITO) and intrinsic ZnO (i-ZnO) are usually used as the window layer of Cu 2 ZnSn(S,Se) 4 (CZTSSe) solar cells within a typical structure. The optoelectronic properties of the window layer play a crucial role in determining the efficiency of solar cells. In this work, two types of CZTSSe solar cells with and without i-ZnO layers were fabricated using dimethyl sulfoxide (DMSO) and dimethylformamide (DMF) as solvents, respectively. The impact of the window layer on the performance of CZTSSe solar cells was investigated. The results suggest that the device without i-ZnO still exhibits a high power conversion efficiency (PCE) compared to conventional bilayer i-ZnO/ITO structures. By removing i-ZnO and optimizing the thickness of ITO, the highest power conversion efficiency (PCE) of DMSO and DMF-based CZTSSe solar cells has been up to 10.17% and 10.27%, respectively, with an increase in open-circuit voltage (V OC ) of 15 mV (in DMSO system) and 10 mV (in DMF system), as well as an enhancement in fill factor (FF) by ∼5 percentage points. These performance improvements are mainly attributed to the reduction of series resistance (R s ) of the window layer due to the removal of i-ZnO layer. Further analysis shows that the generation and collection of photon-generated carriers in CZTSSe solar cells can be affected by the optimized window layer due to optical interference effects and its resistance. Our research may provide insights for the preparation of high efficient CZTSSe solar cells with new structures of the i-ZnO free window layer.
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高影响因子
Frontiers in Molecular Neuroscience
·
2017
·
IF 5.076
Du Si-Hao,Qiao Dong-Fang,Chen Chuan-Xiang,Chen Si,Liu Chao,Lin Zhoumeng,Wang Huijun,Xie Wei-Bing
Methamphetamine (METH) is an amphetamine-typed stimulant drug that is increasingly being abused worldwide. Previous studies have shown that METH toxicity is systemic, especially targeting dopaminergic neurons in the central nervous system (CNS). However, the role of neuroinflammation in METH neurotoxicity remains unclear. We hypothesized that Toll-like receptor 4 (TLR4) and Caspase-11 are involved in METH-induced astrocyte-related neuroinflammation. We tested our hypothesis by examining the changes of TLR4 and Caspase-11 protein expression in primary cultured C57BL/6 mouse astrocytes and in the midbrain and striatum of mice exposed to METH with western blot and double immunofluorescence labeling. We also determined the effects of blocking Caspase-11 expression with wedelolactone (a specific inhibitor of Caspase-11) or siRNA on METH-induced neuroinflammation in astrocytes. Furthermore, we determined the effects of blocking TLR4 expression with TAK-242 (a specific inhibitor of TLR4) or siRNA on METH-induced neuroinflammation in astrocytes. METH exposure increased Caspase-11 and TLR4 expression both in vitro and in vivo, with the effects in vitro being dose-dependent. Inhibition of Caspase-11 expression with either wedelolactone or siRNAs reduced the expression of inflammasome NLRP3 and pro-inflammatory cytokines. In addition, blocking TLR4 expression inhibited METH-induced activation of NF-κB and Caspase-11 in vitro and in vivo, suggesting that TLR4-Caspase-11 pathway is involved in METH-induced neuroinflammation. These results indicate that Caspase-11 and TLR4 play an important role in METH-induced neuroinflammation and may be potential gene targets for therapeutics in METH-caused neurotoxicity.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2018
·Vol. 53
·期 11
·8059-8066
·
IF 2.993
Lv Yu-Kai,Duan Shao-Feng,Zhao Zhi-Hao,Kang Xin-Yu,Ge Rui-Fang,Wang Hongqiang,Dai Yejing
By the traditional solid-state reaction method, Bi 0.5 (Na 0.8 K 0.2 ) 0.5 Ti 1− x (Fe 0.5 Nb 0.5 )
x
O 3 (marked as BNKT- x FN; x = 0.00, 0.01, 0.02, 0.03 and 0.04) piezoelectric ceramics were fabricated, and the effects of FN substitution on the dielectric, ferroelectric, piezoelectric and electric field-induced strain performance were investigated. The relative dielectric permittivity and loss tangent reveal that the phase transition temperature between ferroelectric and ergodic relaxor phase is reduced from 90 °C to room temperature (RT), even below RT, with increasing FN content. Temperature dependence of polarization–electric field loops and strain-electric field curves exhibits that the ferroelectric order is disturbed gradually, and the ergodic relaxor phase forms with increasing FN content. A large unipolar strain of 0.42% and corresponding d 33 * (= S max / E max ) of 642 pm/V for the sample with x = 0.04 are obtained under 6.5 kV/mm due to the phase transition from ergodic relaxor to ferroelectric. These results indicate that the (Fe 0.5 Nb 0.5 ) 4+ complex ion-modified BNKT-based ceramics would have great potentials for lead-free electromechanical actuator applications.
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高影响因子
CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Xinyi Chen,Yitong Ding,Mingjiao Li,Hao Wu,Ze Kan,Zhibo Li
Chemically synthesized poly(4-hydroxybutyrate) (P4HB) is a new generation of biomass-derived and degradable semi-crystalline polymer with good comprehensive properties, but high costs limit its application. Starch, as an inexpensive natural polymer , can reduce the cost of P4HB products. However, starch lacks thermoplastic behavior and has poor compatibility with P4HB, thus its extensive use will inevitably impair the mechanical properties of P4HB. In this study, the ball-milling starch grafting process is adopted, which can simultaneously solve the two major deficiencies of starch, and the prepared ball-milling starch-g-polycaprolactone (BSt-g-PCL) has thermoplasticity and better compatibility with P4HB. BSt-g-PCL can melt near 55 °C, and the interweaving of its molecular chains with P4HB reduces the binding energy ( E interaction ) of both, making the phase interface blurred or even disappear. Therefore, the elongation at break retention ( R EB ) of P4HB/BSt-g-PCL can increase from 37.1 % to 74.3 % compared to P4HB/starch at the same filling (70 Phr). Additionally, BSt-g-PCL can exert the effect of accelerating P4HB degradation and still make it maintain excellent anti-aging ability. The ball-milling starch graft process provides a simple and effective method for the preparation of inexpensive fully biodegradable P4HB composite films with excellent mechanical properties.
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高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Chuanxiang Cheng,Yujie Lei,Tiantian Min,Yushan Zhang,Jin Yue
4-Terpineol (4-TA), a typical monocyclic monoterpene essential oil compound with important biological activities, poor stability and solubility severely hamper its biological activities. To date, β-cyclodextrin (β-CD) encapsulating essential oil to form inclusion complexes (ICs) is considered as a satisfactory treatment. Nevertheless, the detailed inclusion mechanism of β-CD for 4-TA especially the behavior of 4-TA during inclusion formation have not available yet. Herein, 4-TA/β-CD ICs were successfully synthesized by the co-precipitation method, and hydrogen bonds and hydrophobic interactions played a key role in the formation of ICs, and the isopropyl of 4-TA entered the cavity through the wide rim of β-CD. Moreover, the release profile demonstrated that high RH (85 % and 99 %) triggered the release of TA from ICs. This study suggests the great potential of cyclodextrin inclusion strategy for improving the stability and sustained release of 4-TA in food preservation application.
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高影响因子
Catalysts
·
2025
·Vol. 15
·期 3
·263
·
IF 4
Kaijie Li,Qin Wang,Qifan Zhao,Hongbo Yu,Hongfeng Yin
In this article, Pt-SnxOyhybrid nanoparticles encaged in porous silica nanospheres (Pt-SnxOy@PSNs) were prepared by using 1-dodecanethiol (C12-SH) as a coordination agent to confine Pt and Sn ions in a microemulsion system, which is formed by cetyltrimethylammonium bromide (CTAB) and C12-SH as co-surfactants in water. Compared with Pt@PSNs, when different molar ratios of SnxOywere introduced into Pt@PSNs to form Pt-SnxOy@PSNs, the catalytic efficiency of 4-nitrophenol (4-NP) reduction with NaBH4can be significantly enhanced. At molar ratios of 4-NP/Pt of 150/1, the 4-NP conversion reached 100% over Pt-SnxOy@PSNs with Pt/Sn molar ratios of 1/0.75 in 8 min. This catalytic performance showed a slight decrease after six reaction cycles. This enhanced catalytic efficiency can be ascribed to the synergistic effect between Pt and SnxOy,and the protection of porous silica nanostructures can effectively improve the stability of the catalyst.
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高影响因子
Journal of Materials Chemistry A
·
2024
·
IF 10.7
Tao Chen,Yulong Li,Fangpei Ma,Mingdong Sun,Ping Fu,Xiaoling Liu,Yu Zhou,Jun Wang
Paired electrocatalytic systems have emerged as a promising approach for the synthesis of high-value-added fine chemicals from renewable resources like biomass, however, a high-performing bifunctional catalyst is urgent to reduce the overall cell voltage and enhance the current efficiency. Herein, amino-tethered Ni3S2/MoS2 heterojunction (NiMoSx-NH2) was constructed as the bifunctional catalyst simultaneously for the anodic 5-Hydroxymethylfurfural oxidation into furan dicarboxylic acid and cathodic 4-nitrophenol hydrogenation into P-aminophenol, providing the high conversion/yield/Faradic efficiency above 98% on both electrodes. Amino-tethered Ni3S2/MoS2 heterojunction, on the one hand, accelerated the electron transfer, and on the other hand, promoted the catalysts’ proton-coupled electron transfer process to generate NiIII-O(OH)ad at the anode and H* desorption at the cathode. A highly efficient paired electrolyzer with NiMoSx-NH2 as a bifunctional catalyst was assembled, showing an extremely low cell voltage of 0.89 V at 10 mA cm-2 and ~200% current efficiency at 1.75 V for the overall reaction.
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高影响因子
JOURNAL OF MATERIALS CHEMISTRY
·
2012
·Vol. 22
·期 28
·14155-14159
·
IF 5.968
Yonghua Zhou,Xingyun Li,Xiulian Pan,Xinhe Bao
Carbon has been widely used as a catalyst support and adsorbent in industry. However, it suffers from poor stability due to its limited mechanical strength, particularly under high pressures and temperatures. We report here a carbide derived carbon (CDC) layer on a porous SiC surface, which has the properties of high mechanical strength and is easy to shape. The CDC exhibits an amorphous structure and contains mainly mesopores with a BET surface area of 125 m2 g−1. The CDC–SiC composite yields a comparable performance to coconut activated carbon (AC) as a catalyst support in the probe reaction hydrogenation of 4-carboxybenzaldehyde. The further introduction of TiO2 nanoparticles enhances the activity and stability significantly because of the improved dispersion of Pd particles on CDC–SiC. The activity is 4 times higher than the Pd/AC catalyst. Pd–TiO2/CDC–SiC shows great promise as an alternative to the current AC supported Pd catalyst for the crude terephthalic acid hydropurification industry.
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高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Yuhong Li,Mengting Zhang,Yutian Huang,Pengcheng Zhao,Jinyao Zhao,Junjie Fei,Yixi Xie
4-Aminophenol (4-AP) is an environmental pollutant that is harmful to aquatic organisms and can cause long-term adverse effects in the aquatic environment. Herein, a Zn,N-γ-CD/GCE sensing platform was constructed by utilizing the complexation of Zn ions with γ-cyclodextrin (γ-CD), along with the composite of N-doped γ-cyclodextrin (N-γ-CD) and ZnCl 2 , for the detection of 4-AP. The presence of pore structures and hydrogen bonding groups in N-γ-CD enables effective capture of the target analyte through host–guest interactions, thereby enhancing the detection efficiency. The doping of Zn metal significantly improves the sensitivity of the sensing platform. After optimization, the detection limit of the Zn,N-γ-CD/GCE sensor was as low as 29.1 nM. Moreover, the sensor exhibits reliable repeatability, reproducibility, and stability. The practical feasibility of detecting 4-AP in real samples using this sensor demonstrated a recovery rate of 94.3 %–105.5 %, providing a new method for the accurate detection of 4-AP.
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