查找使用阿拉丁产品的科研文献

Trace Determination of Arsenite With an Ionophore-Coated Selective Micro Sensor

Li Wang,Wenshuai Lu,Gaoshan Jing,Tianhong Cui

Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation

Liang Huiyi,Peng Bo,Dong Cong,Liu Lixin,Mao Jiaji,Wei Song,Wang Xinlu,Xu Hanshi,Shen Jun,Mao Hai-Quan,Gao Xiaohu,Leong Kam W.,Chen Yongming

Cell-free DNA (cfDNA) released from damaged or dead cells can activate DNA sensors that exacerbate the pathogenesis of rheumatoid arthritis (RA). Here we show that ~40 nm cationic nanoparticles (cNP) can scavenge cfDNA derived from RA patients and inhibit the activation of primary synovial fluid monocytes and fibroblast-like synoviocytes. Using clinical scoring, micro-CT images, MRI, and histology, we show that intravenous injection of cNP into a CpG-induced mouse model or collagen-induced arthritis rat model can relieve RA symptoms including ankle and tissue swelling, and bone and cartilage damage. This culminates in the manifestation of partial mobility recovery of the treated rats in a rotational cage test. Mechanistic studies on intracellular trafficking and biodistribution of cNP, as well as measurement of cytokine expression in the joints and cfDNA levels in systemic circulation and inflamed joints also correlate with therapeutic outcomes. This work suggests a new direction of nanomedicine in treating inflammatory diseases.

Synthesis of an energetic polynorbornene with pendant bis-azidoacetyloxymethyl groups (PNBAA)

Kun Jiang,Han-Lin Deng,Qi Zhang,Shuifeng Wang,Hao Wu,Yan Liu,Chunpeng Chai,Mu-Hua Huang

A novel energetic polynorbornene with pendant bisazidoacetyloxymethyl (named PNBAA) was designed, by combining its intrinsic energetic properties, potential good mechanical properties, its compatibility with a plasticizer and odourless polynorbornene in one polymer. A green synthesis of PNBAA was achieved starting from easily available materials, by using the solvent-free Diels–Alder reaction, chloroacetylation of norbornene dimethanol in water, solvent-free ring opening metathesis polymerization (ROMP), azidation in aqueous 3-pentanone and tandem ROMP and azidation in one pot. In addition, the Nuclear Magnetic Resonance (NMR) technique was utilized to investigate the key ROMP and azidation steps in situ. PNBAA as an energetic polymer was demonstrated by measuring its TG-IR, DSC and mechanical sensitivity. The strategy reported in this paper will lead to the general green synthesis of diverse energetic polymers in the future.

Diphenidine: a dissociative NPS makes an entrance on the drug scene

Katselou Maria,Papoutsis Ioannis,Nikolaou Panagiota,Misailidi Nektaria,Spiliopoulou Chara,Athanaselis Sotiris

Purpose Diphenidine is a potent synthetic dissociative anesthetic drug that has recently emerged in drug markets of Europe, Japan and America. The aim of this review is to summarize the current knowledge about this drug concerning its chemistry, synthesis, prevalence, pharmacology, toxicology and metabolism, as well as its legal status. Analytical methodologies developed for the determination of diphenidine in biological specimens and published diphenidine-related intoxications, fatal or not, are also presented. Methods All the reviewed information was gathered through a detailed search of PubMed and the World Wide Web using proper keywords. Results Diphenidine is not approved for medical or veterinary use, but it is used illicitly around the world for recreational purposes or as a substitute of other controlled dissociative drugs. It is available through the Internet in powder form for oral administration, smoking or vaporization. Since its first appearance in the drug market in 2013, seizures have been reported worldwide and its abuse has already caused intoxications and deaths in Europe and Japan, thus leading to its scheduling in the United Kingdom and Canada during the second semester of 2016. Conclusions Diphenidine is a harmful dissociative drug that recently gained serious concern for public health. International and local authorities should take all the appropriate actions and measures to avoid the expansion of this new threat.

Gelatin-Based Hydrogels Blended with Gellan as an Injectable Wound Dressing

Yueyuan Zheng,Yuqing Liang,Depan Zhang,Xiaoyi Sun,Li Liang,Juan Li,You-Nian Liu

Injectable scaffolds are of great interests for skin regeneration because they can fill irregularly shaped defects through minimally invasive surgical treatments. In this study, an injectable hydrogel from biopolymers is developed and its application as wound dressings is examined. Gelatin-based hydrogels were successfully prepared at body temperature upon blending with low content of gellan, and the synergetic effect on the gel formation was carefully characterized through rheological methods. The electrostatic complexation between gelatin and gellan was confirmed to contribute a continuous hydrogel network. The obtained blend hydrogel demonstrates remarkable shear-thinning and self-recovering properties. For antibacterial purpose, tannic acid was incorporated into the blend hydrogel. In addition, tannic acid-loaded blend hydrogel was verified to accelerate the wound healing on the mice model, significantly than the control groups. Thus, this paper presents a facile approach without chemical modification to construct injectable gelatin-based hydrogels, which have great potential as a wound dressing or tissue scaffold at body temperature.

Hyperbranched PdRu nanospine assemblies: an efficient electrocatalyst for formic acid oxidation

Hongjing Wang,Yinghao Li,Chunjie Li,Ziqiang Wang,You Xu,Xiaonian Li,Hairong Xue,Liang Wang

Highly branched Pd-based nanocrystals are very attractive materials for electrocatalytic formic acid oxidation (FAO). Herein, a very simple synthetic method is proposed for preparing unique bi-metallic PdRu nanospine assemblies (PdRu NSAs) in high yield. The self-supported PdRu NSAs assembled by staggered nanospines show superior catalytic activity and durability for FAO, owing to their hyperbranched nanoarchitectures and bimetallic compositions. Different from the traditional multi-step routes, the proposed one-step synthetic method is very valuable for fabricating hyperbranched Pd-based catalysts with designed compositions and desired performances.

Ovalbumin as an Outstanding Pickering Nanostabilizer for High Internal Phase Emulsions

Yan-Teng Xu,Chuan-He Tang,Tong-Xun Liu,Ruihai Liu

There is still a debate about the effectiveness of native globular proteins to perform as Pickering-like stabilizers for oil-in-water high internal phase emulsions (HIPEs). In the work, we report one native globular protein (ovalbumin) with strong structural integrity and high refolding ability, exhibits an outstanding Pickering stabilization for HIPEs. Ultrastable gel-like HIPEs can be formed through a facile one-pot homogenization even at a concentration as low as 0.2 wt %. The HIPEs formed in the protein-poor regime are a kind of self-supporting and remoldable hydrogel consisting of bridging droplets. The formed HIPEs also exhibit other unique characteristics, such as extraordinary coalescence stability (against prolonged storage or heating), susceptibility to freeze–thawing, enhanced oxidation stability (to encapsulated bioactives), and inhibited vaporization of volatile oils. The findings would be of importance for extending the HIPEs to be applied in food, cosmetic, and petroleum industries.

An architectural exfoliated-graphene carbon aerogel with superhydrophobicity and efficient selectivity

Yutong Lu,Huiqing Wang,Yun Lu

In the study, in order to completely utilize the advantages of graphene monolayer, nano-fibrillated cellulose with cations from polyethyleneimine (PEI) was used as the intercalator to efficiently exfoliate the reduced graphene oxide into a single layer with a thickness about 0.47 nm by means of ionic attraction. After the high-temperature treatment (800 °C), the carbon aerogel (NC-GO@NFC) with an architectural structure was manufactured by combining 2D monolayer graphene with 1D nano-fibrillated cellulose. The pore volume (0.55 cm 3 /g) and specific surface area (441 m 2 /g) of NC-GO@NFC were about two times higher than those of GO carbon aerogel. Particularly, the buoyant porous aerogel showed superhydrophobicity with a large water contact angle (155.5°) due to the increase of -NH- and C C as well as the pyrolysis of hydrophilic groups. The superhydrophobicity endows the aerogel with an exceptional oil/water separation performance. The carbon aerogels exhibited the adsorption capability towards many organic phases (including lubricating oil and some organic solvents). In addition, the efficient continuous removal and collection of organic solvents (methylbenzene) from water surface was achieved by a designed water/oil pump device. Therefore, the recyclable 3D porous composite aerogel had the application potential as organic solvent adsorbents and oil/water separation agents.

Magnetochromic Photonic Hydrogel for an Alternating Magnetic Field-Responsive Color Display

Wentao Wang,Xiaoqiao Fan,Feihu Li,Jinjing Qiu,Malik Muhammad Umair,Wenchen Ren,Benzhi Ju,Shufen Zhang,Bingtao Tang

As an external stimulus for stimuli-responsive chromic materials, a magnetic field has the benefits of contactless control, instant action, and ease of integration into electronic devices. Hence, the development of a magnetically responsive photonic crystal provides a new platform for color displays. However, magnetically controlled display systems have been primarily limited to liquid systems of colloidal crystals; their application to solid chromic systems has been difficult because the ordered array structure is fixed by a polymer network. A novel solid magnetochromic photonic hydrogel is developed that enables colorimetric responses to an alternating magnetic field (AMF). This notable magnetochromic performance is attributed to the superior magnetothermal effect of 1D aggregates of magnetic chains fixed in a thermosensitive hydrogel. The AMF-responsive magnetic hydrogel exhibits excellent stability for repeated use. This study presents a basis for the development of responsive solid materials with new optical effects for future chromatic applications.

An ultrasensitive electrochemical immunosensor for Cry1Ab based on phage displayed peptides

Xin Lu,Dong-jian Jiang,Jia-xiang Yan,Zhen-e Ma,Xiu-er Luo,Tai-long Wei,Yang Xu,Qing-hua He

The rapid and widespread adoption of Bacillus thuringiensis (Bt) proteins in genetically modified (GM) crops has raised concerns about the impact of GM crops on environment and food safety. A sensitive and specific method for detecting Bt proteins in GM crops is of great significance for environment and food risk assessment. In this study, using Cry1Ab as a model Bt protein, an ultrasensitive electrochemical immunosensor for Cry1Ab protein has been developed based on phage displayed peptide. Phage displayed peptides against Cry1Ab protein were obtained from a phage displayed peptide library without animal immunization process through biopanning-elution strategy. After modification of electrode with gold nanoparticles, selected phage displayed peptide was applied to electrochemical immunosensor for Cry1Ab. Under the optimized conditions, the peptide-based immunosensor showed a dynamic range of 0.01–100   ng/mL and a limit detection of 7   pg/mL. Specific measurement of this established method was conducted by testing cross-reactivity of Cry1Ac (88% amino acid sequence homology to Cry1Ab protein), and the result showed that peptide-based immunosensor has negligible cross-reactivity with analogue. In addition, the accuracy and reproducibility of this established immunosensor was evaluated by testing the recovery of spiked samples and assay coefficients of variation, respectively. The results showed that the average recovery of corn and wheat sample was 90–120% and 86.7–120%, respectively; the intra-assay coefficient of variation was 7.4% (n = 6), and the inter-assay coefficient of variation was 6.9% (n = 6) at 1   ng/mL Cry1Ab solution. Furthermore, the novel concept of peptide-based immunosensor may provide a potential application in general method for the ultrasensitive detection of various Bt proteins.

Isoindigo as an electron−deficient unit for high−performance polymeric electrochromics

Hua Gu,Shouli Ming,Kaiwen Lin,Shuai Chen,Ximei Liu,Baoyang Lu,Jingkun Xu

Isoindigo has been found to be an excellent electron-accepting building block towards electroactive conjugated polymers with remarkable optoelectronic properties for organic electronics due to its ease of scalable synthesis with high yields. Isoindigo-based conjugated polymers have been successfully applied in organic photovoltaics and organic field effect transistors most recently, yet have attracted surprisingly scant attention in polymeric electrochromics despite their potential advantages. Herein, to evaluate the electrochromic performances of isoindigo-based materials, we synthesized two donor–acceptor–donor (D–A–D) type precursors of isoindigo moiety end-capped with 3,4-ethylenedioxythiophene (EDOT), ( E )-6,6′-bis(2,3-dihydrothieno[3,4- b ] [1,4]dioxin-5-yl)-1,1′-dihexyl-[3,3′-biindolinylidene]-2,2′-dione (IDOHE) and ( E )-6,6′-bis(2,3-dihydrothieno[3,4- b ] [1,4]dioxin-5-yl)-1,1′-didodecyl-[3,3′-biindolinylidene]-2,2′-dione (IDODE) by Stille coupling, and electropolymerized them to get the corresponding polymer films. These p and n -dopable low band-gap polymers (∼1.26 eV) revealed electrochromic nature from green color in the neutral state to blue upon oxidation . Further kinetic investigation demonstrated isoindigo-EDOT polymers exhibited outstanding electrochromic performances especially in the NIR region, including high coloration efficiency of 362 cm 2  C −1 at 1050 nm, fast switching time of 0.5 s, and high optical contrast of 59% at 1500 nm, and excellent redox stability (<8% after 4000 cycling). Based on these findings, isoindigo-EDOT polymers possessed competitive electrochromic parameters suffice for device fabrication and commercial applications and can be further explored towards indoor electrochromic products and flexible NIR displays. Overall, isoindigo and its derivatives can be regarded as a series of promising acceptors for synthesizing high-performance D-A type NIR electrochromic polymers.

A Flexible Multifunctional Sensor Based on an AgNW@ZnONR Composite Material

Hao Lv,Xue Qi,Yuxin Wang,Yang Ye,Peike Wang,Ao Yin,Jingjing Luo,Zhongqi Ren,Haipeng Liu,Suzhu Yu,Jun Wei

A multifunctional sensor comprising flexible and transparent ultraviolet (UV) photodetectors (PDs) with strain gauges based on Ag nanowire (AgNW)@ZnO nanorods (ZnONRs) was fabricated using a cost-effective, simple, and efficient method. High-aspect ratio silver nanowires were synthesized using the polyol method. An AgNW@ZnONR composite was formed via the hydrothermal method to ensure the multifunctional capability of the flexible sensors. After refining the process parameters, the size of the ZnO nanorods was decreased to fabricate pliable multifunctional sensors using AgNW@ZnONRs. At a deposition of 0.207 g of AgNW@ZnONRs, the sensor achieves its maximum switching ratio and fastest response time under conditions of 2000 μW/cm2UV optical power density. With a ton(rise time) of 2.7 s and a toff(fall time) of 2.3 s, the ratio of Ionto Ioffcurrent is 1151. Additionally, the sensor’s maximum optical current value correlates linearly with UV light’s power density. The maximum response current increased from 222.5 pA to 588.1 pA, an increase of 164.3%, when the bending angle was increased from 15° to 90° for the sensor with a deposition of 0.276 g of AgNW@ZnONRs. There was no degradation in the response of the sensors after 10,000 bending cycles, as they have excellent stability and repeatability, which means they can meet the requirements of wearable sensor applications. Therefore, there is great potential for the practical application of multifunctional AgNW@ZnONRs in flexible sensors.