CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Weixia Zhi,Xinjie Guo,Yichu Nie,Lu Nie,Tingting He,Li Dai,Jing Xu,Xiangxin Zong,Jun Xu,Huaihong Cai,Yong Tang,Yanguang Cong,Jiang Pi,Youfeng Zhu,Pinghua Sun,Jialiang Guo,Huoqiang Chen,Xueqin Huang,Haibo Zhou
The current lack of rapid screening methods for Klebsiella pneumonia ( K. pneumonia ) poses a considerable threat to human health. Herein, we fabricated a multilayer Au@Au@Ag/Pt nanoparticle (NP) that made of the peroxidase-mimicking external shell and tunable plasmonic intra-nanogap as a versatile probe, and conjugated them with lateral flow immunoassay (LFIA) for colorimetric-catalytic-SERS (CM/CL/SERS) multi-model sensing K. pneumonia in complex biological matrix. After the optimization of several parameters, the limit of detection (LOD) of the target K. pneumonia were 10 3 CFU/mL for CL-LFIA and 38 CFU/mL for SERS-LFIA, both of which were over 10-fold and 200-fold more sensitive than the visual CM-LFIA (10 4 CFU/mL), respectively. The clinical validation of this multi-model LFIA was performed with the infected patients ( N = 6) and healthy subjects ( N = 3), among which 4 positive samples missed by conventional CM-LFIA were successfully identified by SERS-LFIA. More importantly, this LFIA has great specificity for the target bacteria, while showed no signal response to samples infected by other bacteria. Different from previous studies focusing on detection of protein and nucleic acid of K. pneumonia , our study shortened the sample-to-answer time with direct detection of K. pneumonia by LFIA, filling the diagnostic gap for point-of-care testing (POCT) of K. pneumonia infection. Overall, the great performance of our established LFIA suggested its substantial potential for diagnosis of K. pneumonia -induced nosocomial infection.
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DOI
高影响因子
Small
·
2025
·
IF 12.1
Mingyang Zhong,Tevin Li,Shouyi Yuan,Junwei Lucas Bao,Yonggang Wang
Small Quinone-based Organic Electrodes have received extensive attention. However, the rapid dissolution of small quinone electrode into electrolyte impede their practical applications. For example, Anthraquinone (AQ) and Phenanthrenequinone (PQ) molecules have been rarely reported for aqueous batteries due to the inferior electrochemical performance. Herein, a high-concentration hybrid electrolyte containing 1m Zn(OTF) 2 and 15m KOTF salts is introduced for small quinone electrode and investigate the redox behavior of PQ and AQ electrode is investigated in Zn 2+ /K + hybrid electrolyte. These findings reveal that AQ with carbonyl groups at para-position selectively stores proton rather than K + , while PQ with carbonyl group at ortho-position simultaneously stores proton and K + without selectivity. Moreover, the Zn(OTF) 2 salt serves as both proton buffer and binder to improve the cycle stability. Consequently, when PQ is paired with Zn metal anode for Zn || PQ batteries, the addition of potassium salt can improve the energy density of the Zn batteries. Moreover, when PQ is paired with Prussian blue cathode to assemble aqueous K-ion batteries, the addition of zinc salt in the electrolyte can improve the cycle stability via binding discharged PQ molecules with divalent-ions. This research provides an electrolyte engineering strategy to address the challenges facing PQ electrode for aqueous batteries.
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DOI
PubMed
高影响因子
ADVANCED MATERIALS
·
2023
·Vol. 35
·期 15
·2211311
·
IF 29.4
Dawei Sha,Yurong You,Rongxiang Hu,Xin Cao,Yicheng Wei,Heng Zhang,Long Pan,ZhengMing Sun
Anion vacancy engineering (AVE) is widely used to improve the Li-ion and Na-ion storage of conversion-type anode materials. However, AVE is still an emerging strategy in K-ion batteries, which are promising for large-scale energy storage. In addition, the role of anion vacancies on ion storage is far from clear, despite several proposed explanations. Herein, by employing VSe 2 as a model conversion-type anode material, Se vacancies are intentionally introduced (labeled as P-VSe 2− x ) to investigate their effect on K + storage. The P-VSe 2− x shows excellent cyclability in half cells (143 mA h g −1 at 3.0 A g −1 after 1000 cycles) and high energy density in coin-type full cells (206.8 Wh kg −1 ). By applying various electrochemical techniques, the effects of Se vacancies on the redox potentials of K-ion insertion/extraction and the K-ion diffusion in electrodes upon cycling are uncovered. In addition, the structural evolution of Se vacancies during potassiation/de-potassiation using various operando and ex characterizations is revealed. Moreover, it is demonstrated that Se vacancies can facilitate the breaking of V Se bonds upon the P-VSe 2− x conversion using theoretical calculations. This work comprehensively explains the role of anion vacancies in ion storage for developing high-performance conversion-type anode materials.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2025
·
IF 2.1
Wenfeng Huang,Yufeng Wei,Xiaocong Liu,Ruonan Li,Qiuxiang Yin,Lihong Jia
The equilibrium solubility of quetiapine fumarate was determined in twelve individual solvents and one binary solvent mixture by the gravimetric method at atmospheric pressure over a temperature range of 283.15–323.15 K. The results showed that the solubility increases with increasing temperature in all selected solvents. The solubility order is tetrahydrofuran–water (mole fraction of tetrahydrofuran 0.8083) > tetrahydrofuran > n-propanol > dichloromethane > butanone > methyl isobutyl ketone > xylenes > ethyl formate > tert-butyl methyl ether > isopropyl acetate > toluene > hexane ≈ heptane. The modified Apelblat model, λh model, nonrandom two-liquid model, and van’t Hoff–Jouyban–Acree model were employed to correlate the experimental solubility. The four models provided satisfactory fits, as confirmed by the average relative deviation and the root-mean-square deviation. The modified Apelblat model showed the best performance among them. The accurate solubility data are essential for the design and optimization of the crystallization process of QF.
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高影响因子
COMPOSITES PART B-ENGINEERING
·
2025
·
IF 14.2
Xinhui Geng,Ping Hu,Yanchun Zhou,Xiaoguang Luo,Haitao Han,Fei Wang,Anqi Li,Chengfan Yuan,Wuju Wang,Xinghong Zhang
Ultra-high temperature thermal protection materials play key roles for protecting hypersonic flight, re-entry vehicles, and propulsion systems from thermal attack. However, even the top-level passive protection materials such as C f /HfB 2 -SiC composites are unable to withstand the long-term harsh-environment above 3100 K as they suffer severe ablations. To overcome this bottleneck, herein a synergistic active-passive strategy is proposed. Embed aligned cooling channels were fabricated via microelectrical discharge machining (Micro-EDM) in C f /HfB 2 -SiC composite and liquid water was used as the cooling medium, forming an integrated system combining the composite’s passive ablation resistance and the channels’ active temperature regulation capability. Benefiting from this novel strategy, the surface temperature was significantly reduced by 46% (from over 3100 K to below 1700 K). Furthermore, a qualitative leap in ablation resistance was achieved, e.g., the ablation rate was dropped from 5.12×10 -3 mm/s to a non-ablation state after 400 s at such a high temperature, with almost no surface oxidation. These achievements were believed to stem from the synergistic coupling of the “passive barrier” (high melting point, good ablation resistance) and the liquid water’s “active reinforcement” (enhanced surface heat transfer). Notably, for 0.4 mm-diameter channels, heat and mass transfer were optimized, blockages and pressure fluctuations were mitigated, ensuring the cooling stability. This work demonstrates that the 3100 K ablation resistance limit of thermal protection materials can be broken, providing a promising route for developing materials suitable for service at temperatures above 3100 K, and lays a solid foundation for upgrading thermal protection in next-generation propulsion systems.
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高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2020
·
IF 3.232
Lijuan Huang,Longyan Xiang,Yan Zhang,Yongan Wang,Zhiyong Nie
The simultaneous detection of K + and Tl + can serve as a toxicological diagnostic tool for thallium poisoning. Colorimetric-reaction-based nanoprobes have emerged as promising sensors for the rapid and ultrasensitive detection of molecular species in simple systems. However, the development of viable screening tools for multicomponent analysis in complex systems remains challenging owing to interference from coexisting materials in the media. Herein, a simple chemical sensor array based on the peroxidase-like activity of gold nanoparticles modified with single-stranded DNA (AuNPs-ssDNA) and chemometrics was developed for the simultaneous detection of K + and Tl + in aqueous solutions and serum. The use of a K + adapter conferred high selectivity to the developed method. Optimized AuNPs-ssDNAs were used to construct a sensor array, which together with chemometrics provided fingerprints that can facilitate the simultaneous analysis of multiple components. The developed colorimetric reaction in combination with the chemometrics assay was directly used as a biosensor array, which exhibited detection limits of 107.33 nM for K + and 19.26 nM for Tl + . The developed method could potentially serve as a diagnostic technique for investigating thallium poisoning and toxicology.
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PubMed
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2021
·
IF 2.694
Li Wang,Danning Li,Lingyu Wang,Hongxun Hao,Lina Zhou
In this research, the gravimetric method was utilized to measure the solubility of phenacetin from 283.15 to 323.15 K under atmospheric pressure in 12 solvents, including methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, ethyl formate, ethyl acetate, n-propyl acetate, N,N-dimethylacetamide, N,N-dimethylformamide, and acetonitrile. The solubility curves present an increasing trend with increasing temperature, and the mixing thermodynamic properties are also investigated in detail. Moreover, three thermodynamic models were used to correlate the experimental solubility data, and the fitting effect looks satisfactory as the average relative density is below 5%. The modified Apelblat model has the highest agreement with the experimental data compared with other models (λh model and NRTL model).
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高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2019
·
IF 2.298
Renjie Xu,Li Shen,Jie Xu,Xiang’an Lu,Xin Song
The equilibrium solubility of palmatine chloride in various mixed solvents consisting of ethanol (ethylene glycol (EG), isopropyl alcohol, and propylene glycol (PG)) plus water was experimentally obtained by static technology with environment conditions (283.15–328.15 K, 101.1 kPa). The measured data of palmatine chloride had a proportional relationship with temperature under the condition of fixed solvent composition, the same as increasing with the increasing the cosolvents of ethanol and EG except for the isopropyl alcohol and PG in four binary systems. The maximum solubility (0.01339 in mole fraction at 328.15 K) of palmatine chloride was obtained in neat ethanol. Under the same solvent composition and regular temperature, palmatine chloride was most soluble in a mixture of ethanol + water among all binary systems. X-ray powder diffraction and differential scanning calorimetry were employed to analyze palmatine chloride, which showed no significant change in the crystals before and after recrystallization. Three cosolvency models, the Jouyban–Acree model, van’t Hoff–Jouyban–Acree model, and Apelblat–Jouyban–Acree model were employed to correlate the measured data. In all calculation results, the largest RAD and RMSD were 1.80 × 10–2 and 6.80 × 10–5.
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高影响因子
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
·
2022
·Vol. 80
·期 5
·679-689
·
IF 3.271
Wang Na,Yang Yang,Wen Jing,Fan Xin-Rong,Li Jian,Xiong Bing,Zhang Jin,Zeng Bo,Shen Jian-Wu,Chen Gui-Lan
Tolterodine is a first-line antimuscarinic drug used to treat overactive bladder. Adverse cardiac effects including tachycardia and palpitations have been observed, presumably because of its inhibition of the Human Ether-à-go-go-Related gene (hERG) K+ channel.
However, the molecular mechanism of hERG channel inhibition by tolterodine is largely unclear. In this study, we performed molecular docking to identify potential binding sites of tolterodine in hERG channel, and two-microelectrode voltage-clamp to record the currents of hERG and its mutants
expressed in Xenopus oocytes. The results of computational modeling demonstrated that phenylalanine at position 656 (F656) and tyrosine at position 652 (Y652) on the S6 helix of hERG channel are the most favorable binding residues of tolterodine, which was validated by electrophysiological
recordings on Y652A and F656A hERG mutants. The Y652A and F656A mutations decreased inhibitory potency of tolterodine 345-fold and 126-fold, respectively. The Y652A mutation significantly altered the voltage dependence of channel inhibition by tolterodine. For both the wild-type and the mutant
channels, tolterodine reduced the currents in a time-dependent manner, and the blockade occurred with the channel activated. Tolterodine did not interfere with hERG channel deactivation, whereas channel inactivation greatly impaired its blocking effect. The inhibition of hERG channel by tolterodine
is independent of its action on muscarinic acetylcholine receptors. In conclusion, tolterodine is an open-state blocker of hERG K+ channel with nanomolar potency. Y652 and F656, 2 aromatic residues on the inner S6 helix, are responsible for the high-affinity binding of tolterodine
to hERG channel.
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DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2019
·
IF 4.561
Hui Guo,Yu Dong,Tiantian Ping,Xiaoqin Shi,Shufeng Shen
Densities and viscosities for the binary liquid mixtures of monoethanolamine (MEA) with 2-alkoxyethanols (2-ethoxyethanol (EGEE) and 2-butoxyethanol (EGBE)) were measured over the entire concentration range at temperatures of 293.15–353.15 K and atmospheric pressure. From the experimental results, the excess molar volume ( V E ), viscosity deviations (∆ η ) and excess Gibbs free energy of activation of viscous flow (∆ G ⁎E ) were calculated and the excess/deviations properties for the studied binary systems were fitted with the Redlich-Kister equation to estimate the binary interaction parameters. The results were analyzed in terms of intermolecular interactions between unlike molecules and intramolecular interactions within like associated molecules. The densities and viscosities of CO 2 -loaded solutions were also measured and correlated with the proposed correlations. The calculated values of density and viscosity for the binary/ternary systems are in good agreement with the experimental values, with AADs within 0.2% for density and 3.2% for viscosity. The FTIR spectral analysis for the binary mixtures of MEA with 2-alkoxyethanols at various concentrations suggests the presence of weak interactions between component molecules in the systems, and also supports the findings of excess properties.
研究领域:
物理化学
·
分子相互作用
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高影响因子
Journal of Materials Chemistry C
·
2017
·Vol. 5
·期 47
·12422-12429
·
IF 5.256
T. T. Deng,E. H. Song,Y. Y. Zhou,L. Y. Wang,Q. Y. Zhang
Three isotypic double perovskites A2BAlF6:Mn4+ (A = Rb, Cs; B = K, Rb) were synthesized via a facile co-precipitation method at room temperature. XRD Rietveld refinements and Raman spectra indicate that the neighboring smaller A-site or larger B-site cation in A2BAlF6:Mn4+ lowers structural stability, but suppresses the [AlF6] octahedron to increase the crystal field strength and bond strength of the Al–F bond. Cs2KAlF6:Mn4+ presents a sharp line red light and excellent moisture resistance, but experiences severe thermal quenching. In comparison, altering the A- or B-site cation to Rb, Rb2KAlF6:Mn4+ and Cs2RbAlF6:Mn4+ shows blue shifts in emission and declining water resistance, but enhancements in thermal stability. A combination of static and dynamic emission degradations demonstrates that the water resistance of Mn4+ emission mainly relies on the structural stability of the host matrix; meanwhile, the thermal stability highly depends on the rigidity of its local accommodation. The variations of the temperature-dependent white light-emitting diode (WLED) performances further evidence their sufficient thermal stability for LED applications. These findings suggest that neighboring-cation modulation might be a feasible guideline for exploiting stable Mn4+-activated fluoride red phosphors in warm WLED applications.
研究领域:
材料科学
·
光学
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高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2020
·
IF 2.369
Yanmin Shen,Wenju Liu,Paifeng Shi,Zehua Bao
In this work, solubility of exo-3,6-epoxy-1,2,3,6-tetrahydrophthalic anhydride (ETA) was measured and discussed in acetone + ethanol, methyl acetate + ethanol, 1,4-dioxane + ethanol, and ethyl acetate + ethanol mixture solvents in a temperature range from 278.15 to 323.15 K by a gravimetric method under 0.1 MPa. Experimental results indicated that solubility increased with temperature increasing and declined with the mass fraction increasing of ethanol in four kinds of mixture solvents. The solvent effect and Hansen solubility parameter were adopted to discuss the solubility behavior of ETA in selected solvents. Modeling correlation solubility data about ETA indicated that the Jouyban–Acree–Apelblat model (J–A–A) was more suitable than the Jouyban–Acree–Van’t Hoff model (J–A–V) and Ma and Sun model in mixture solvents. Processing of the dilution crystallization in acetone + ethanol system was chosen to separate and purify ETA on the basis of the solubility and solvent characteristics.
研究领域:
化学工程
·
物理化学
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高影响因子
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