ACS Applied Nano Materials
·
2025
·
IF 5.5
Jinyao Zheng,Juan Qin,Yuanhao Zhang,Zongjia Li,Miaomiao Zhang,Qianyu Guo,Ying Chen,Yu Chen,Wei Wei,Xiue Jiang,Jilin Tang
Infected wound healing is a multifaceted biological process, particularly in the context of the emergence of antibiotic-resistant bacteria that compromise the efficacy of conventional treatments, thereby rendering the management of infected wounds exceedingly challenging. Developing highly effective antibacterial materials to fight resistant bacteria and promote wound healing remains a major challenge. In this study, a graphene oxide (GO)-based synergistic multifunctional nanomaterial, GO-Ag-l-Arg, is developed to promote wound healing by effectively combating antibiotic-resistant bacterial infections and promoting angiogenesis. The excellent antibacterial activity of GO-Ag-l-Arg is attributed to the synergistic effect of highly dispersed silver nanoparticles (Ag NPs) and l-Arginine (l-Arg). GO-Ag-l-Arg can effectively avoid the aggregation of Ag NPs and fully exert the antibacterial ability of Ag NPs in GO-Ag-l-Arg. By precisely regulating the pH, l-Arg is further loaded onto the GO-Ag nanosheets through an esterification reaction between the hydroxyl on the surface of GO and l-Arg. The highly positively charged guanidyl in l-Arg can interact with negatively charged bacteria, improving the targeting ability between the nanocomposite and bacteria and further enhancing the antibacterial effect of GO-Ag-l-Arg. At the same time, GO-Ag-l-Arg can produce nitric oxide (NO) under the action of cells, thus effectively promoting angiogenesis. The in vivo experiments show GO-Ag-l-Arg exhibits an outstanding ability to accelerate the healing of bacterial-infected wounds by inhibiting bacterial growth and stimulating angiogenesis at the wound site, offering a promising strategy for the treatment of wounds infected by drug-resistant bacteria.
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产品关联
DOI
高影响因子
Bioactive Carbohydrates and Dietary Fibre
·
2021
·
IF 0
Lu-Yao Ma,Rou Xu,Hai-Feng Lin,Ming-Yong Xie,Shao-Ping Nie,Jun-Yi Yin
In this study, okra ( Abelmoschus esculentus (Linn.) Moench) pods (pericarp) obtained after removing seeds and flesh were applied for polysaccharide extraction. The 60 °C water extract polysaccharide (OPW-60) was obtained from okra peel at 60 °C, and then 100 °C water extract polysaccharide (OPW-100) was obtained from the residue at 100 °C. Acid extraction at 60 °C was finally used to obtain the polysaccharide by acid leaching at 60 °C (OPA-60). Then, structural characteristics and antioxidant activities investigations were performed on the extracted polysaccharides. The results showed that monosaccharide composition of three polysaccharides was different. OPW-60 was mainly type I rhamnogalacturonan (RG-I) pectin, while OPW-100 and OPA-60 consist of RG-I and homogalacturoan (HG) pectins. 1 H NMR analysis confirmed the existence of rhamnose and acetyl group among them. The structure diversity resulted in the difference of viscosity, molecular weight, surface morphology and antioxidant activities. OPW-60 exhibited the highest apparent viscosity, which might be attributed to the differences in molecular weight distribution and monosaccharide composition. OPW-60 was most effective in scavenging 2,2-Diphenyl-1-picrylhydrazyl radicals and chelating ferrous ion ability, while OPW-100 exhibited the highest hydroxyl radical scavenging activity. The results showed that polysaccharides with different structure and antioxidant ability could be obtained from okra under different extraction conditions.
研究领域:
食品科学
·
生物化学
·
植物学
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DOI
PROGRESS IN ORGANIC COATINGS
·
2026
·
IF 7.3
Linrui Liu,Kaiti Wang,Qiuyan Yan,Shuaishuai Yuan
Bacterial infections associated with indwelling catheters pose a significant clinical challenge, often leading to severe morbidity and mortality. The development of effective antibacterial coatings is thus of paramount importance. This study presents a novel polyurethane (PU) incorporating cationic epsilon-poly- l -lysine (CPL)/docusate sodium (DS). The incorporation of CPL/DS nanoparticles enhanced the hydrophilicity of the PU material. Among the PUs we prepared, PU-1.75 boasted optimized performances featuring high bactericidal efficiency against S. aureus and E. coli . Notably, in vitro tests confirmed that PU-1.75 maintains nearly 100 % bactericidal activity against S. aureus even after 21 days of incubation in physiological saline solutions. Furthermore, PU-1.75-coated urinary catheters effectively inhibit the growth of S. aureus and E. coli under static and dynamic flow conditions. The in vivo SD rat model approved the good biocompatibility of PU-1.75-coated catheters. These findings collectively indicate that PU-1.75 is a highly promising, safe, and durable antibacterial capable of providing long-term protection against catheter-associated infections.
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2013
·
IF 5.008
Wanyun Liu,Junchao Wei,Yiwang Chen,Ping Huo,Yen Wei
Photoluminescent fullerene nanoparticles/nanofibers have potential applications in bioimaging. A novel fluorescent nanofibrous material, consisting of fullerene nanoparticles and poly(L-lactide) (PLLA), was fabricated via a simple electrospinning method, and the composite nanofibers were characterized by various techniques such as scanning electron microscopy (SEM), laser scanning confocal microscopy (LSCM), and transmission electron microscopy (TEM). The nanofibers were uniform, and their surfaces were reasonably smooth, with the average diameters of fibers ranging from 300 to 600 nm. The fullerene nanoparticles were encapsulated within the composite nanofibers, forming a core–shell structure. The nanofiber scaffolds showed excellent hydrophilic surface due to the addition of water-soluble fullerene nanoparticles. The composite nanofibers used as substrates for bioimaging in vitro were evaluated with human liver carcinoma HepG2 cells, the fullerene nanoparticles signal almost displayed in every cell, implying the potential of fluorescent fullerene nanoparticles/PLLA nanofibers to be used as scaffolds for bioimaging application.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
·
生物成像
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高分子科学
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DOI
高影响因子
EUROPEAN JOURNAL OF MASS SPECTROMETRY
·
2011
·
IF 1.103
Shaohui Zhou,Genbai Chu,Lanlan Cao,Xiaobin Shan,Fuyi Liu,Ju-Guang Han,Liusi Sheng
The photoionization and photodissociation of L-valine are studied by tunable synchrotron vacuum ultraviolet photoionization mass spectrometry at the photon energy of 13 eV. The ionization energy of L-valine and the appearance energies of major fragments are measured by the photoionization efficiency spectrum in the photon energy range of 8–11 eV. Possible formation pathways of the major fragments, NH2CHC(OH)2+ (m/z = 75), NH2(CH3)2(CH)2+ (m/z = 72) and NH2CHCO+ (m/z = 57), are discussed in detail with the theoretical calculations at the B3LYP/6-31++G (d, p) level. Hydrogen migration is considered as the key way for the formation of NH2CHC(OH)2+ (m/z = 75) and NH2CHCO+ (m/z = 57). Further more, other fragments, NH2CHCOOH+ (m/z = 74), (C H3)2(C H)2+ (m/z = 56), C4H7+ (m/z = 55), NH2CHOH+ (m/z = 46), NH2CH2+ (m/z = 30) and m/z = 18, species are also briefly described.
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DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2015
·
IF 2.353
Lei Chen,Bing Yan
Zeolite L (ZL) is functionalized with inside-outside double modification paths (gas disperse (“ship in bottle”) and covalently grafting) with two kinds of luminescent lanthanide species (Tb 3+ complex of acetylacetone (AA), lanthanide polyoxometalate (NaLnW 10 O 36 ·32H 2 O, abbreviated as LnW 10 , Ln = Eu, Tb)) to prepare the hybrid materials. The prepared hybrids show the red and green luminescence, which provides a useful path to obtain multi-component lanthanide hybrids.
研究领域:
材料科学
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无机化学
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发光材料
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纳米复合材料
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DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2018
·
IF 6.434
Jingjing Du,Yuyan Zhang,Wei Guo,Ningyun Li,Chaoshuai Gao,Minghui Cui,Zhongdian Lin,Mingbao Wei,Hongzhong Zhang
Titanium dioxide (TiO 2 ) nanoparticles have been applied in diverse commercial products, which could lead to toxic effects on aquatic microbes and would inhibit some important ecosystem processes. The study aimed to investigate the chronic impacts of TiO 2 nanoparticles with different concentrations (5, 50, and 500 mg L −1 ) on Populus nigra L. leaf decomposition in the freshwater ecosystem. After 50 d of decomposing, a significant decrease in decomposition rates was observed with higher concentrations of TiO 2 nanoparticles. During the period of litter decomposition , exposure of TiO 2 nanoparticles led to decreases in extracellular enzyme activities, which was caused by the reduction of microbial especially fungal biomass. In addition, the diversity and composition of the fungal community associated with litter decomposition were strongly affected by the concentrations of TiO 2 nanoparticles. The diversity and composition of the fungal community associated with litter decomposition was strongly affected. The abundance of Tricladium chaetocladium decreased with the increasing concentrations of TiO 2 nanoparticles, indicating the little contribution of the species to the litter decomposition. In conclusion, this study provided the evidence for the chronic exposure effects of TiO 2 nanoparticles on the litter decomposition and further the functions of freshwater ecosystems.
研究领域:
环境毒理学
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水生生态学
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纳米材料
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微生物生态学
·
植物生理学
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DOI
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2018
·
IF 3.974
Yanmei Wang,Ruixi Yang,Jiaying Zheng,Zhenguo Shen,Xiaoming Xu
It was reported that fulvic acid (FA) has a positive effect on enhancing plant tolerance to various environmental stresses, including salinity stress and drought stress and so on. However, there is little study regarding the effects of FA on plants in response to heavy metal stress. Hence, the objective of this study was to investigate the potential effects of fulvic acid (FA) on cadmium (Cd) toxicity alleviation in lettuce seedlings. Our results showed that application of 0.5 g/L FA significantly mitigate Cd-induced toxic symptoms in lettuce seedlings. Cd stress triggered plant growth inhibition, photosynthetic pigment reduction, destruction of the photosynthesis apparatus, reactive oxygen species (ROS) accumulation, and nutrient elemental imbalance. We observed that FA promoted the growth in lettuce under Cd stress, mainly reflected in those alterations that the increase of biomass, chlorophyll content and photosynthesis capacity and reduction of the Cd content and lipid peroxidation in plant tissue. Foliar spraying of FA significantly alleviated these detrimental symptoms and facilitated nutrient element translocation from root to shoot, particularly the absorption of elements involved in photosynthesis, including iron (Fe), zinc (Zn), and manganese (Mn). In summary, foliar application of FA conferred Cd toxicity tolerance to lettuce by increasing ROS-scavenging capacity, inhibiting Cd uptake and the transport of elemental nutrients to shoots, which in turn protected the photosynthetic apparatus and promoted plant growth.
研究领域:
植物生理学
·
环境胁迫生物学
·
农业科学
·
重金属毒理学
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DOI
高影响因子
Journal of Macromolecular Science Part B-Physics
·
2017
·
IF 0.828
Shan Bai,Zhenzhong Ouyang
Direct graft copolymerization of maleic anhydride (MAH) onto poly(D,L-lactide-co-glycolide) (PLGA) was performed by use of benzoyl peroxide (BPO) as initiator. Fourier transform infrared spectra, nuclear magnetic resonance, titration analysis of maleation extent and water contact angle were employed to characterize the obtained MPLGA. The effects of monomer concentration, initiator concentration and reaction temperature on the degree of maleation were investigated. The MPLGA scaffold was obtained by using NaCl as the porogen. The results showed that maleic anhydride was successfully grafted onto the PLGA chains. The monomer and initiator concentrations played an important role in the graft copolymerization; the extent of maleation first increased with increasing content of MAH and BPO and then declined. The extent of maleation continuously increased with increasing temperature to 100°C, and then the rate of increase decreased. The extent of maleation could be controlled in the range from 0.15 to 0.71% by adjusting the graft copolymerization conditions. The introduction of anhydride enhanced the water contact angle of PLGA. The MPLGA scaffold showed a network of interconnected pores ranging from 50 to 300 μm.
研究领域:
高分子化学
·
生物材料科学
·
高分子改性
·
组织工程
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DOI
高影响因子
Polymers
·
2026
·Vol. 18
·期 13
·1568
·
IF 5.8
Yong-Hua Li,Li-Jie Zeng,Jin-Yun Wu,Jun Meng,Meng-Na Li,Jia-Yi Huang,Yan-Yan Huang,Feng-Song Liu
Natural polysaccharides fromSiegesbeckia orientalisL. have been reported to exhibit promising bioactivities. To enhance extraction efficiency, low-temperature plasma-assisted extraction was optimized forS. orientalisL. polysaccharides using single-factor experiments and response surface methodology. Column chromatography purified a homogeneous SIE-III fraction, followed by structural characterization. Optimal parameters were 80 kV discharge voltage, 153 Hz frequency, and 109 s treatment time, under which the polysaccharide yield reached 15.68%, significantly higher than that of the conventional hot water extraction method. Plasma treatment loosened the raw material’s surface, potentially facilitating polysaccharide release. SIE-III had a molecular weight of 20.831 kDa and comprised mainly galactose (51.7%), rhamnose (19.1%), arabinose (11.3%), and galacturonic acid (9.9%). It featured typical rhamnogalacturonan-I (RG-I) domains and a triple-helix conformation. Fourier transform infrared spectroscopy and nuclear magnetic resonance confirmed both α- and β- glycosidic linkages, and methylation analysis revealed a highly branched →3,4)-Galp-(1→ structure. This study provides an effective extraction method for plant polysaccharides and valuable insights into their potential applications in the food and other industries.
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2026
·
IF 5.1
Chao-min Cheng,Xiang-cheng Li,Tian-wei Shen,De-xu Liu,Guang-wen Chu,Yuan Le,Jian-feng Chen
High-throughput preparation of the specific size (20–50 μm) microspheres with narrowly distributed is of significant interest to the medical aesthetics market. This study developed a novel method for preparing this kind of poly(l-lactic acid) (PLLA) microspheres using high-gravity rotating packed bed (RPB) reactor. Investigated the effects of operating parameters, initial liquid distribution and wire mesh packing wettability on microspheres size distribution. The RPB system was configured with a composite jet for the initial liquid distribution and a modified wire mesh packing featuring a lotus-leaf-like self-cleaning surface to intensify liquid dispersion. The prepared PLLA microspheres is of D 50 = 31.27 μm, with a distribution span of 0.78. Employing a dimensionless group analysis, correlations were established to predict the average particle size and uniformity of the PLLA microspheres. The predicted values showed good agreement with experimental data, typically within a ± 10% deviation. Based on the obtained results, a large scale test was carried out, achieving a production capacity of 2 kg/h. The PLLA microspheres prepared on a large scale have a D 50 = 41.29 μm, with a distribution span of 0.70. High-gravity RPB, with its superior liquid–liquid heterogeneous mixing capability, should be a promising candidate for the large-scale production of polymeric microspheres.
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DOI
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2019
·
IF 3.579
Ning Zhang,Baoguo Sun,Xueying Mao,Haitao Chen,Yuyu Zhang
Fried allium oil has been widely used in traditional Chinese home cooking and recently has grown in popularity in the food manufacturing industry. Thus, physical and chemical changes during frying process were measured to investigate the flavor formation mechanism in green onion ( Allium fistulosum L.) deep-fried oil. With the increase of the oil temperature, important variations took place when the temperature rose above 140 °C during the whole frying process. A detailed study of these changes was made from both macro and micro aspects. From a macro perspective, sensory attributes including burnt, fried, oily, cooked vegetable and salty were strengthened. Meanwhile, the reference points of the oil samples on the fingerprint chart were distinguishable from others by electronic nose. In addition, contents of furans and furanones, sulfur-containing compounds, aldehydes and alcohols increased sharply according to SAFE-GC-MS analysis from a microscopic point of view, and contents of unsaturated fatty acids dropped remarkably while the saturated ones increased. These changes were considered to be caused by interactions between carbohydrates , proteins and fats in the deep-fried system and thermo degradations of sugars, amino acids and fats. The results indicated that the stage, when frying at temperatures ranging from 140 °C to 165 °C, was the most significant period for the flavor formation of the deep-fried oil.
研究领域:
食品科学
·
化学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）