MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 6
·393
·
IF 5.4
Li Mengqiu,Xu Dongpo,Zhuang Wenfang,Cheng Zien,Sun Yiqian,Qiu Jingxuan,Liu Caiyun,Li Jia,Wang Xin
Carcinoembryonic antigen (CEA) is a key tumor biomarker, and its sensitive detection is critical for early diagnosis and treatment monitoring. This work presents a novel “turn-on” fluorescent aptasensor for sensitive and cost-effective detection of CEA, based on a FAM-labeled CEA aptamer (FAM-Aptamer) as the recognition unit, and Ce-UiO-66 nanoparticles as an efficient quenching platform. The Ce-UiO-66 material was synthesized and comprehensively characterized by SEM, TEM, XPS, FT-IR, Raman and XRD, demonstrating a high quenching efficiency (QE) of 99.95% toward the fluorescent aptamer. This exceptional quenching performance is attributed to a synergistic mechanism involving FRET, PET, DQE and SQE. After systematic optimization of key parameters (Ce-UiO-66 concentration: 66.67 µg/mL; quenching time: 30 min; pH: 7.6; incubation temperature: 25 ℃; incubation time: 60 min), the aptasensor achieved a wide dual-linear response across 1-10 ng/mL and 10-100 ng/mL, respectively, with a detection limit of 13.78 pg/mL. Validation in diluted serum samples confirmed its accuracy and precision for CEA quantification, with recoveries of 95.50-109.60% and RSDs below 5.07%. The proposed aptasensor provides a reliable, cost-effective, and sensitive platform for CEA detection, serving as a proof-of-concept biosensing platform, with a certain potential for clinical application. Graphical The alternative text for this image may have been generated using AI.
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DOI
PubMed
高影响因子
Results in Chemistry
·
2022
·
IF 0
Xia Zhang,Lili Sun,Yangang Sun,Meng Zhou,Siqi Wang,Zihao Cao,Xueying Zhang,Yajun Wei,Yuandong Xu
Developing electroactive materials with superior sensitivity, selectivity, and so on is an important issue for target ions detection. Hierarchically heterostructured nanomaterials represent a kind of promising active materials for electrochemical sensors due to the synthetic effect between different components and the high surface area. Herein, heterostructured UIO-66-NH 2 /CNTs nanocomposites have been successfully synthesized via the solvothermal method and investigated for the detection of Pb 2+ ions. The SEM, TEM, XRD and FTIR collectively confirmed that the UIO-66-NH 2 was successfully loaded on the surface of the CNTs. The specific surface areas of the UIO-66-NH 2 /CNTs are 4–7 times higher than that of activated CNTs and more mesoporous structures appear in composite materials. The electrochemical impedance spectroscopy measurements showed that the concentration of CNTs could influence the electron mobility and the UIO-66-NH 2 /CNTs-15 exhibits the lowest charge transfer resistance and the highest capacitive property. The cyclic voltammetry study towards K 3 [Fe(CN) 6 ] further demonstrated that the CNTs can improve the conductivity of the composites especially for the UIO-66-NH 2 /CNTs-15, which was conducive to the sensing behavior confirmed by follow-up performance experiments. Under the optimized condition, UIO-66-NH 2 /CNTs-15 exhibits the best sensing performance towards Pb 2+ . Correspondingly, a high sensitivity of 1.64 μA (μmol/L) −1 and a low detection limitation of 0.206 μmol/L (S/N = 3) are achieved. Meanwhile, a wide detection range, excellent selectivity, repeatability, and stability are also obtained. The recovery experiment by standard addition method is also carried out and a satisfactory result has been attained indicating a promising sensor for practical application.
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NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 47
·期 5
·2257-2263
·
IF 3.925
Shiyu Nie,Fengfeng Chen,Tianbo Shen,Tingting Wang,Ningyu Di,Junkuo Gao
Adjusting the internal porous environment of MOFs to enhance their adsorption properties is considered an effective strategy to improve their gas separation performance. Herein, 1-ethyl-3-methyl-imidazolium acetate ([Emim][Ac]) was encapsulated in UiO-66 by an impregnation method for the improvement of carbon dioxide (CO2) capture performance. The synthesis and detailed characterizations of the developed [Emim][Ac]@UiO-66 are reported, and the effect of the loading amount of [Emim][Ac] on the CO2 separation performance was also studied. The obtained [Emim][Ac]@UiO-66 could efficiently show the synergistic effect of the adsorption of CO2 between [Emim][Ac] and UiO-66. The optimized [Emim][Ac]@UiO-66 exhibited a much higher CO2 adsorption capacity at 298 K and 1.0 bar, affording 2 times the CO2 uptake than its original UiO-66. In addition, the CO2/N2 selectivity and CO2/CH4 selectivity of [Emim][Ac]@UiO-66-3.5% are significantly higher than those of UiO-66. This study for designing various MOF-encapsulated ionic liquids potentially paves the way for the development of highly efficient absorbents for gas separations.
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高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2022
·
IF 10.53
Shuting Tian,Yang Bai,Shuangshuang Li,Zuoming Chen,Liyun Zhang,Hongjie Li,Peng Zhou,Yi He
Microsphere layers/nanofibrous membranes decorated with UiO-66-NH 2 as a metal-organic framework (MOF) were successfully obtained by one-step coaxial electrospinning. The coaxially spun dense microsphere/wire-like structure and UiO-66-NH 2 hydrophilic components with excellent hydration ability enabled the prepared membrane to have excellent static and dynamic adsorption capacity for dyes and oil-in-water emulsion separation performance (adsorption capacity >247 mg/g; separation efficiency >99%). What's more, the membrane can purify complex wastewater dynamically and efficiently (separation efficiency >99%). After the membrane was desorbed in ethanol and methanol, the reversible recovery rate was as high as 98%, indicating its excellent recyclability. In a word, the as-prepared membrane has broad prospects in the remediation of complex polluted water bodies containing dyes-oil.
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高影响因子
ADVANCES IN POLYMER TECHNOLOGY
·
2022
·
IF 2.502
Qing-Chun Chen,Yu Bang,Lu Li,Hui-Yu Deng
Owing to the specific porous structure which could provide additional passage channel for some molecules, metal organic frameworks are attractive candidates for enhancing permeability and selectivity of membranes in pervaporation, reverse osmosis, and gas separation. In this experiment, Ag@UiO-66-NH2 was introduced into polyamide separation layer by interfacial polymerization of triethylenetetramine and 1,3,5-benzenetricarboxylic acid chloride for nanofiltration. The results indicated that Ag@UiO-66-NH2 nanoparticles did endow the membranes with rapid diffusion pathways for water molecules. When the content of Ag@UiO-66-NH2 was 0.03 g, the prepared membrane (NF-Ag-3) showed high flux about 47.3 L·m-2·h-1 at 0.6 MPa, which is about 2-fold higher than that of polyamide membrane without Ag@UiO-66-NH2, while the MgSO4 rejection rate remained about 87.4%. The membrane also showed excellent antifouling properties, and the water flux recovery ratio was 95.6% after filtration BSA solution. When it was applied for 50 mg/L bisphenol A removal, the rejection rate reached 94.6%, and the flux is about 49.1 L·m-2·h-1. Moreover, Ag particles on UiO-66-NH2 rendered the membrane with good inhibition for Escherichia coli. The antibacterial rate of the membranes is above 95% when the loading of Ag@UiO-66-NH2 is more than 0.03 g.
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高影响因子
EUROPEAN POLYMER JOURNAL
·
2022
·
IF 5.546
Shuang Han,Yuzhuo Song,Shiwei Liu,Le Zhao,Ruonan Sun
The preparation of synthetic drug delivery systems free of antibody modifications that can effectively recognize tumor sites and control drug delivery is essential for cancer therapy. In this study, UiO-66 metal–organic framework (MOF) modified with amino and phenylboronic acid groups was used as substrate to load the anti-cancer drug doxorubicin (DOX). Then a molecularly imprinted polymer (UiO-66-DOX@MIP) with sialic acid (SA) as the template molecule was further prepared on the surface of the synthesized nanoparticles using surface molecular imprinting technique (MIT). This polymer combines the excellent properties of UiO-66 and molecularly imprinted polymer (MIP). It was simple to prepare, economical and easy to obtain, and had a regular morphology. UiO-66-DOX@MIP containing molecularly imprinted binding sites that match the template molecule SA, could specifically recognize target tumor cells. The imprinted layer prevented drug leakage in normal body fluids while degrading and drug release under tumor microenvironment, with pH and glutathione (GSH) dual-responsive drug release properties. The UiO-66-DOX@MIP showed excellent biocompatibility and great cellular uptake efficiency to cancer cells without influence of interfering substances.
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高影响因子
LANGMUIR
·
2022
·
IF 4.331
Lan Ma,Yan Wan,Teng Wang,Yaling Liu,Ying Yin,Liyun Zhang
Developing the high-anti-fouling membrane has kept continuous attention in oil/water emulsion treatment. However, the majority of works on anti-fouling membranes mainly focused on low-viscosity oils, which greatly limited the development and application of a membrane to face the real crude oil wastewater. Inspired by the hydrophilicity of sodium carboxymethyl cellulose (CMC) and zirconium base metal–organic frame (Zr-MOF), an anti-oil-fouling CMC/UiO-66-NH2 composite membrane was constructed by a self-assembly method. Profiting from the hydrophilicity and micro-nanostructure of the CMC/UiO-66-NH2 layer, the obtained CMC/UiO-66-NH2 membranes displayed underwater superoleophobicity and desired oil resistance. It could display the effective separation capability with 1282 ± 62 to 6160 ± 81 L/(m2·h·bar) and above 99.08% toward the different light oil emulsions. More importantly, the CMC/UiO-66-NH2 membrane displayed ultralow crude oil adhesion behaviors toward the crude oil emulsions, which could achieve a considerably high flux (746 ± 60 to 5224 ± 87 L/(m2·h·bar)). Furthermore, electrostatic interaction and physical enwinding–wrapping between CMC and UiO-66-NH2 also endowed the composite membranes with outstanding stability. After immersing the as-prepared membranes into the harsh environments for 24 h, the membranes still maintained high underwater–oil contact angles (UWOCA > 155°) and separation ability (oil rejection was above 99.0%). Therefore, CMC/UiO-66-NH2 composite membranes could demonstrate promising prospects in real oily emulsion treatment.
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PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2022
·
IF 4.326
Xuesheng Liu,Junsu Jin,Hong Meng
In this study, we successfully synthesized a novel composite material UiO-66/polyacrylate (UiO/PA) by suspension polymerization and in situ growth of metal–organic frameworks (MOFs). Due to the control of heterogeneous nucleation and firm growth, nano-UiO-66 with a diameter of only 400 nm has been reduced by about 90%, resulting in lower transfer resistance, effective separation of photogenerated carriers, and more catalytic active sites exposed. Under visible light irradiation, UiO/PA with 48.7% loading can almost completely degrade rhodamine B (RhB) in 120 min and the corresponding degradation rate constant of RhB reached 0.0203 min–1 from 0 min–1. After easy filtration and five cycles, the degradation rate is still above 85%. This study can provide new insights into effectively improving the photocatalytic performance of MOFs.
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高影响因子
TALANTA
·
2022
·
IF 6.556
Yi Wu,Keren Lu,Fubin Pei,Yanghao Yan,Shasha Feng,Qingli Hao,Mingzhu Xia,Wu Lei
The wide clinical application of d -penicillamine (D-PA) makes it inevitably accumulates in the environment, seriously threatening human health and the ecological environment. To better supervisory control D-PA, a highly sensitive and reliable photoelectrochemical (PEC) sensor based on gold nanoparticles (Au NPs) loaded on graphitic carbon nitride sheet and hexagonal NH 2 -UiO-66 composite (g-C 3 N 4 /Au/NH 2 -UiO-66) was synthesized. Tactfully using the strong bonding between D-PA and Au NPs and the effective carrier separation of Z-scheme heterojunction, the designed g-C 3 N 4 /Au/NH 2 -UiO-66 PEC sensor without an extra recognition unit exhibited a selective and sensitive photocurrent to D-PA. With the aid of UV diffuse reflectance spectra (UV-DRs), electron paramagnetic resonance (EPR) characterization, and free radical capture experiments, the electron transfer path of the PEC sensing system was deduced. The proposed g-C 3 N 4 /Au/NH 2 -UiO-66 PEC-based sensor achieved a low detection limit of 0.0046 μM (S/N = 3) with a wide linear response ranging from 10 nM to 400 μM. In addition, its good stability and selectivity also laid a good foundation for practical applications.
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PubMed
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2022
·
IF 24.319
Rong Shang,Qizhao Zhang,Peng Lin,Bang Gu,Qinghu Tang,Qiue Cao,Wenhao Fang
Direct oxidative coupling of alcohols and amines is an environmental-benign and atomic-economy approach for imine synthesis. We disclosed that UiO-66 framework successfully confined Ru to single-atom scale with assistance of oxophilic Zn 2+ promoter. This RuZn@UiO-66 catalyst showed a highest TOF of 78 h -1 among all Ru catalysts in literature and attained > 99% yield to benzylideneaniline in the model reaction in an O 2 atmosphere at a low temperature without alkaline additives. In addition, this catalyst demonstrated satisfying gram-scale imine synthesis, wide substrate scope and stable reusability. Kinetic investigations and in situ characterizations allowed getting insights to active sites, amphoteric carrier and reaction mechanism. Dynamic interactions between Ru and Zn based on their ratios induced electron-deficient Ru 0 active sites promoted by oxophilic Zn 2+ species. Hence, primary alcohols can be efficiently converted to the corresponding aldehydes using molecular O 2 , i.e. , the rate-determining step. Besides, Zr 4+ -O 2- pairs on UiO-66 provided adequate acidic-basic sites for the tandem catalysis.
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高影响因子
ANALYST
·
2022
·Vol. 147
·期 17
·3867-3875
·
IF 5.227
Fangfang Yu,Yihan Wang,Tengfei Liu,Xiaohui Liu,Hui Jiang,Xuemei Wang
Hypochlorite plays a vital role in biological systems and our daily life. The rapid and convenient detection of hypochlorite is imperative and significant for disease treatment and human health. In this work, EY/UiO-66-NH2 (EY = eosin Y) was prepared through a hydrothermal process and could be applied to the detection and bioimaging of hypochlorite as a self-calibrating sensing nanoprobe. EY/UiO-66-NH2 features two emissions at 432 nm and 533 nm, and the emission intensity of 533 nm is enhanced with increasing ClO− concentration. EY/UiO-66-NH2 could be utilized as a ratiometric fluorescence sensor of ClO−. The linear range of EY/UiO-66-NH2 towards ClO− is 0.1–200 μM and its detection limit is 46.4 nM. In comparison with previously reported probes for ClO−, EY/UiO-66-NH2 has the advantages of a wide linear range, low detection limit, turn-on fluorescence and ratiometric response. This work provides a new method for ClO− detection in living cells.
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PubMed
高影响因子
JOURNAL OF SOLID STATE CHEMISTRY
·
2021
·
IF 3.498
Zhi-Juan Zhang,Peng-Wei Li,Lu-Ping Liu,Li-Hua Ru,Han-Xiao Tang,Wei-Sheng Feng
The analysis of breath VOC biomarkers is an efficient method for the early diagnosis of lung cancer. In this work, the zirconium UiO-66 was post-synthetically modified by using methylamine (MA), ethylenediamine (ED) and N,N′ -dimethylethylenediamine (MMEN), respectively. The modified UiO-66 materials were thoroughly characterized, including PXRD , FTIR, TGA , physical adsorption at 77 K by nitrogen and photoluminescence analysis. The sensing properties of the modified UiO-66 materials toward the selected five potential breath VOC biomarkers were investigated. Results showed that after modification, the BET surface area and total pore volume all decreased, and followed the order: UiO-66 > UiO-66-MA > UiO-66-MMEN > UiO-66-ED. Furthermore, the N–H group was successfully grafted into the modified UiO-66 samples. In comparison with UiO-66, the fluorescence intensities of UiO-66-MA, UiO-66-ED and UiO-66-MMEN toward hexanal , styrene and isoprene all obviously increased, while the fluorescence intensities of the modified UiO-66 materials toward 1-propanol and ethylbenzene all decreased a lot, accompanied by the frequency shift. In addition, the LOD of hexanal on UiO-66-MA was calculated to be as low as 12 ppm, which was obviously lower than that of UiO-66 (31 ppm). The fluorescence quenching of hexanal was mainly due to the FRET mechanism. The results of this study would provide information for the development of early breath diagnosis of lung cancer.
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高影响因子
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