Food Biophysics
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2025
·Vol. 20
·期 1
·1-10
·
IF 3.2
Zang Jiaxiang,Song Liling,Ge Chang,Zhang LanLan,Shah Bakht Ramin,Wei Xianling,Xu Wei
In this study, the preparation of hydrogel beads through electrostatic interactions between Ι-carrageenan (IC) and ε-polylysine (ε-PL) using a dropwise method is reported. As the concentration of ε-PL increased, the degree of swelling of the hydrogel beads decreased. FTIR and XRD analyses revealed shifts in the absorption peaks, suggesting the formation of hydrogen bonding, electrostatic interactions in the hydrogel beads. TGA showed that the mass loss of the IC/ε-PL hydrogel beads was significantly lower compared to that of pure ε-PL. These results indicate that the IC component has a protective stabilizing effect on the hydrogel structure. ε-PL concentration of 2% yielded the highest encapsulation efficiency of curcumin (Cur) in the hydrogel beads. In vitro release studies showed that the hydrogel beads sustained the release of Cur and the release kinetics followed the first-order and Hixson-Crowell models. Collectively, these findings demonstrate that these hydrogel beads have the potential to be effective carriers of hydrophobic substances. Graphical
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JOURNAL OF APPLIED POLYMER SCIENCE
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2025
·
IF 2.8
Zixuan Zou,Xuejing Wei,Jiayi Yao,Li Sun,Hua Wang,Shaohua Chen,Luoxin Wang
In order to improve the mechanical properties and UV resistance of polylactic acid (PLA) composites, a bio-based additive (ESO-CUR) was synthesized by one-pot method. A new environment-friendly toughening agent was synthesized by using epoxy soybean oil (ESO) as the core material and curcumin (CUR) as the curing agent. PLA composite material with toughening and UV resistance was prepared by melt blending process. Among them, the elongation at break of 6%ESO-CUR/PLA reached 20.26% in the tensile test, which was 11.8 times higher than that of pure PLA. In addition, 6%ESO-CUR/PLA has excellent UV resistance, and the UV protection factor (UPF) is increased from 3.1 to 15,485 of pure PLA. The results show that the new environmental protection toughening agent has a significant synergistic effect on improving the mechanical properties and UV protection properties of PLA. In order to reduce the white pollution caused by traditional plastics, it provides a new way to prepare biodegradable materials with excellent properties.
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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
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2021
·
IF 4.291
Ying Zhang,Hongjun Yan,Jiawen Tang,Peiyuan Li,Rixiang Su,Haiyi Zhong,Wei Su
Bacteria are becoming increasingly resistant to antibiotics because of their overuse. As a result, new therapies are urgently needed to replace traditional antibiotic therapies. Photodynamic therapy and photothermal therapy are considered to be effective sterilization methods instead of antibiotics to resist drug-resistant pathogens. In this work, silica-coated gold nanorods with photothermal conversion effects were employed as photothermal carriers, and curcumin was selected as photosensitizer, to form PTT/PDT dual-mode antibacterial nanocomposites (AuNRs@Cur). Comparing with their counterparts Cur and AuNRs, AuNRs@Cur exhibited higher singlet oxygen yield and photothermal conversion efficiency, which greatly improved the utilization rate of photosensitizer and consequently effectively enhanced the photoinactivation effect of bacteria. The inhibition rate of AuNRs@Cur on S. aureus and E. coli under 405 and 808 nm dual irradiation was higher than that of Cur or PDT alone. The changes of bacterial membrane structure were revealed by scanning electron microscopy (SEM) and confocal fluorescence imaging. The reactive oxygen species and thermal energy generated by dual-wavelength (405 + 808 nm) laser irradiation can cause the destruction of bacterial outer membrane structure, resulting in bacterial death. In addition, the cytotoxicity and hemolytic activity of AuNRs@Cur were negligible. AuNRs@Cur nanocomposites proved that photodynamic-photothermal synergistic treatment can greatly improve the bactericidal effect. Therefore, construction of AuNRs@Cur provides a new idea for pathogen infection caused by drug-resistant bacteria, and provides relevant nano-carrier experience for follow-up drugs.
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JOURNAL OF CONTROLLED RELEASE
·
2024
·
IF 10.5
Xiao Wang,Haoling Huo,Lin Cao,Yanming Zhong,Jin Gong,Zhidan Lin,Xiaobao Xie,Zhen Bao,Peng Zhang
Diabetic wound healing remains a challenge due to high levels of oxidative stress, excessive inflammation, and bacterial infection. Smart dressings loaded with natural active monomers are proving to be effective strategies for enhancing diabetic wound healing. Herein, the bio-composites (PTIGA-Cur and PTIGA-Cur-Ag) with curcumin (Cur) responsive release were reported for promoting angiogenesis and diabetic wound repair, showing excellent anti-inflammatory, antioxidant, and antibacterial properties. The integration of three-dimensional networks and chemical bonds endowed the bio-composites with superior thermodynamic, mechanical, and self-healing properties. Notably, pH-responsive Schiff base as well as ester groups in the matrix enable the Cur to be released in a controlled manner. A biosensor assembled from PTIGA-Cur-Ag demonstrated electronic conductivity based on in-situ synthesis of AgNPs, which enabled sensitive monitoring of blood glucose levels. In addition, the release of AgNPs enhanced the antibacterial and anti-inflammatory properties. Expectedly, the bio-composites exhibited remarkable biocompatibility, effectively promoting the polarization of macrophages to M2 phenotype, and reducing the expression of proinflammatory cytokines. The full-thickness diabetic wound model revealed that PTIGA-Cur and PTIGA-Cur-Ag were able to effectively promote collagen deposition, neovascularization, and granulation tissue regeneration through their anti-inflammatory, antioxidant, and antibacterial properties. This study provides evidence supporting the potential utility of bio-composites with both pro-healing properties and monitoring functions in the management of diabetic wounds.
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JOURNAL OF PHYSICAL CHEMISTRY B
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2020
·
IF 2.857
Wenjie Liu,Xiaochun Hu,Lulu Zhou,Ying Tu,Shuo Shi,Tianming Yao
Curcumin, a molecule of labile natural product, has multiplex pharmacological effects, including antioxidant, antimicrobial, and anticancer effects as well as anti-Alzheimer’s disease (AD) properties. However, the drawbacks of curcumin such as poor stability and bioavailability seriously limited its application in drug development. Numerous literature studies suggested the conversion of curcumin to metal complexes and explored the clearance of β-amyloid fibrils by curcumin conjugates. However, the research about the inhibition effect of curcumin complex on τ protein aggregation is progressing slowly, and its interactive orientation with the related proteins from the steric effect has been ignored. Inspired by the perspective on interactive orientation, we conjugated curcumin molecule on the positive-charged scaffold of Ru(II) complexes (bipyridine for Ru1, phenanthroline for Ru2) to construct an octahedral structure. After being conjugated with a ruthenium octahedral framework, curcumin exhibited a stronger ability to not only inhibit aggregation of R3, the τ peptide corresponding to the third repeat unit of the microtubule binding domain (residues 306–336 in full τ) (Ru1 with an IC50 of 0.5 μM and Ru2 with an IC50 of less than 3 μM) but also disaggregate R3 fibers with dose-dependence through an exothermic and dynamic process. Autodock simulation was applied to get a hairpin-docking mode in the inhibition of R3 aggregation. Herein, our results provide a rational strategy emphasizing the interactive orientation from an octahedral steric structure to design the anti-AD drugs with natural compound.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2016
·
IF 2.76
Jin Feng,Shanshan Wu,Hua Wang,Songbai Liu
Improved capability to inhibit degradation of trianionic curcumin has been realized in this study. The interaction between trianionic curcumin (Cur 3− ) and gemini dodecyl or tetradecyl O -glucoside micelles , tetradecyltrimethylammonium chloride (TTAC) or hexadecyltrimethylammonium bromide (CTAB) micelles as well as gemini alkyl O -glucosides (AGs)/alkyl trimethyl ammonium halides mixed micelles have been characterized. It is demonstrated that Cur 3− cannot be incorporated into gemini AGs micelles since the lack of electrostatic attraction and degraded as rapidly as in aqueous phase. Cur 3− tend to reside at palisade layer − water interface of TTAC or CTAB micelles due to the strong electrostatic interaction while moderate electrostatic interaction allows Cur 3− to locate more deeply in the palisade layer of mixed micelles. Additionally, mixed micelles tend to form a more compact and hydrophobic palisade layer than pure TTAC and CTAB ones. These factors bring about enhanced fluorescence intensity and blue − shift of emission maxima, improved fluorescence anisotropy and quantum yield, as well as reduced decay rate of Cur 3− in mixed micelles than in pure TTAC and CTAB ones.
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Biomaterials Science
·
2018
·Vol. 7
·期 3
·1011-1027
·
IF 5.831
Xiaoqun Shi,Yang Wang,Haiyan Sun,Yujuan Chen,Xingzhen Zhang,Jiangkang Xu,Guangxi Zhai
Graphene-based nanomaterials (GBNMs) have great potential in drug delivery and photothermal therapy owing to their unique physicochemical properties. However, inferior water solubility and biocompatibility related issues greatly restricted their further applications. Herein, to rectify the obstructive problems, we prepared uniform and smaller sized graphene oxide (GO) nanosheets (∼85 nm) via a modified Hummers’ method, which exhibited significantly improved hemocompatibility compared to random large sized GO nanosheets prepared by a common method. Then, we grafted unfractionated heparin (UFH) onto reduced graphene oxide (rGO) covalently using adipic acid dihydrazide (ADH) as a linker to fabricate biocompatible nanocomposites for the cellular delivery of curcumin (Cur). The novel nanocomposites showed quite a small size of 42 nm in average lateral dimension and exhibited a significantly stronger photothermal effect than GO nanosheets. Besides, in vitro cell experiments verified that the potential anticancer efficacy of Cur-loaded vehicles and cytotoxicity of rGO-UFH/Cur against MCF-7 and A549 cells could be further enhanced under 808 nm irradiation, suggesting the possibility of combinational chemotherapy and photothermal therapy. Moreover, consistent with the in vitro sustained drug release performance, an in vivo pharmacokinetics study also indicated that the retention time of Cur could be significantly prolonged when loaded on rGO-UFH nanocomposites than in free Cur solution. Notably, we firstly discussed the interaction between rGO and Cur, and demonstrated the meliorative biocompatibility of uniform rGO compared to GRO via a molecular dynamics simulation (MD) study. Thus, the in vitro, in vivo and computational study demonstrated that the small sized rGO-UFH nanocomposites had wide application prospects as drug delivery vehicles.
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Scientific Reports
·
2025
·Vol. 15
·期 1
·1-13
·
IF 3.9
Meng Zhuo-Nan,Chen Jian-Yuan,Yu Chong,Zheng Ai-hong,Reddy O. Sreekanth,Liu Kai-Yan,Su Yong-Rui,Zhang Shi-Tai,Wang Yin-Shuang,Gu Hang-Yu,Wang Fu-Wei,Xu Song-Cheng,Sun Li-Tao,Chen Bing-Chen,Lai Wing-Fu,Wu Guo-Qing,Zhang Da-Hong
Surgical resection of the tumor remains the preferred treatment for most solid tumors at an early stage, however, residual tumor cells after surgical resection poses a considerable obstacle in cancer treatment. Here, we developed a gel carrier using a cellulose-based gel-forming polymer (CT) combined with gelatin sponge (GS) to fill the resection cavity and delay postoperative residual tumor growth. The fabricated gel exhibited a porous nature along with gradual swelling and erosion over time. Curcumin (Cur) and apatinib (Apa) were loaded into CT gel (CT-CA), and a sustained release behavior was observed at pH 7.4 and 6.4 at 37 °C. The preclinical studies indicated that the mouse weight and tissue exhibited no apparent change after administration of the GS-CT compared with the control. The in vivo fluorescence images showed that GS-CT has the capability to regulate the release of Cur and Apa, facilitating the accumulation of these two agents at the surgical tumor site. Moreover, GS-CT loaded Cur and Apa (GS-CT-CA) delayed postoperative residual tumor growth in intraperitoneal and subcutaneous postoperative mouse models. These findings demonstrated that our gel carrier system significantly prevents postoperative residual tumor growth because of enhanced drug accumulation and sustained drug release at the tumor site.
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FOOD CHEMISTRY
·
2024
·
IF 8.5
Shumin Wang,Shengnan Wang,Lina Yang,Peng Wang,Hong Song,He Liu
Mesoporous silica microspheres (MSMs) possess poor biocompatibility . This study focuses on integrating MSMs with polymers to obtain hybrid materials with superior performance compared to the individual components and responsive release in specific environments. The synthesized MSMs were aminated, and subsequently, soybean hull polysaccharide (SHPs) was modified onto MSMs-NH 2 to produce MSMs-NH 2 @SHPs nanoparticles . The encapsulation rate, loading rate of curcumin (Cur), and in vitro release behavior were investigated. Results indicated that the encapsulation efficiency of Cur by MSMs-NH 2 @SHPs nanoparticles reached 75.58%, 6.95 times that of MSMs-NH 2 with a load capacity of 35.12%. It is noteworthy that these nanoparticles exhibit pH-responsive release capacity in vitro. The cumulative release rate of the three nanoparticles at pH 5.0 was higher than that at pH 7.4. MSMs-NH 2 @SHPs had a cumulative release rate of 56.55% at pH 7.4, increasing to 76.21% at pH 5.0. In vitro experiments have shown that MSMs-based nanoparticles have high delivery efficiency and can achieve pH-sensitive drug release, with a high release rate in a slightly acidic acid, highlighting the potential for controlled release of Cur.
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FOOD CONTROL
·
2025
·
IF 6.3
Zhifeng Cai,Tianyu Miao,Guiyu Meng,Yanan Li
N,S-doped carbon dots (N,S-CDs) were fabricated by utilizing m-phenylenediamine and β-mercaptoethylamine as precursors and designed as colorimetric/fluorometric dual-mode nanosensors. The curcumin (CUR) could quench the green fluorescence around 509 nm. The mechanism of fluorescence quenching was mainly attributed to the static quenching effect. Meanwhile, the color alterations of sensing solution were acquired with CUR contents changing from 0 to 50 μM. Thereby, the quantitative measurement of CUR could be materialized based on colorimetric and fluorometric dual-mode sensing methods. The wide linearity and low detection limit (LOD) were achieved through this dual-mode nanosensor. The feasibility of this system was continuously confirmed via the assay of CUR in fruit samples. Moreover, a portable smartphone-assisted detection system based on N, S-CDs suggested a facile, inexpensive, and efficient approach for detecting CUR in actual fruit samples.
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FOOD HYDROCOLLOIDS
·
2024
·
IF 11
Hanyu Li,Minghui Zhao,Jinghong Li,Jiaqi Wang,Huajiang Zhang,Jing Wang,Ning Xia,Zhongjiang Wang,Ahmed M. Rayan
The pH-driven method, recognized for its material safety and avoidance of organic solvents, is considered a promising approach for the encapsulation of hydrophobic active substances. However, the interaction mode and mechanism between carriers and receptors in two stages (alkalization and neutralization) remain underexplored. In this study, the hydrophilic globular protein ovalbumin (OVA) was utilized as a carrier to load curcumin (Cur) by the pH-driven method, with an alkalization pH of 8–12. The results indicated that the solubility of Cur and the degree of protein unfolding increased with increasing alkalization pH, with a transformation in the secondary structure observed at pH 12. During the alkalization stage at pH 11 and 12, the loading efficiency of Cur exceeded 90%, with binding constants reaching as high as 5.79 × 10 5 M −1 and 1.44 × 10 5 M −1 , respectively. The interactions transitioned through three phases in the alkalization process: electrostatic dominance to hydrophobic dominance, electrostatic assistance to hydrophobic dominance, and electrostatic repulsion hindrance. Notably, the generation of electrostatic repulsion and the potential loss of binding sites resulted in a decrease in the binding affinity between OVA and Cur at pH 12. In the neutralization stage, a stable structure dominated by hydrogen bonds and van der Waals forces was observed, with Cur encapsulated within the hydrophobic core of OVA. The mechanism proposed in this study elucidates the factors affecting the efficacy of the pH-driven method and helps to refine the application in hydrophobic active substance delivery systems.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-21
·
IF 10.6
Sun Junpeng,Du Jiaqun,Liu Xiaobang,An Jinyu,Hu Yu,Wang Jing,Zhu Fu,Feng Huicong,Cheng Shuai,Tian He,Mei Xifan,Wu Chao
Rheumatoid arthritis (RA) is a chronic autoimmune disease of yet undetermined etiology that is accompanied by significant oxidative stress, inflammatory responses, and damage to joint tissues. In this study, we designed chondroitin sulfate (CS)-modified tragacanth gum–gelatin composite nanocapsules (CS-Cur-TGNCs) loaded with curcumin nanocrystals (Cur-NCs), which rely on the ability of CS to target CD44 to accumulate drugs in inflamed joints. Cur was encapsulated in the form of nanocrystals into tragacanth gum–gelatin composite nanocapsules (TGNCs) by using an inborn microcrystallization method, which produced CS-Cur-TGNCs with a particle size of approximately 80 ± 11.54 nm and a drug loading capacity of 54.18 ± 5.17%. In an in vitro drug release assay, CS-Cur-TGNCs showed MMP-2-responsive properties. During the treatment of RA, CS-Cur-TGNCs significantly inhibited oxidative stress, promoted the polarization of M2-type macrophages to M1-type macrophages, and decreased the expression of inflammatory factors (TNF-α, IL-1β, and IL-6). In addition, it also exerted excellent anti-inflammatory effects, and significantly alleviated the swelling of joints during the treatment of gouty arthritis (GA). Therefore, CS-Cur-TGNCs, as a novel drug delivery system, could lead to new ideas for clinical therapeutic regimens for RA and GA. Graphical Abstract
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