Nature Communications
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2026
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IF 18.1
Li Xiao,Lin Lizhou,Zhu Mingrui,Li Xiaolong,Yu Jifeng,Lu Dan,Li Shaoyue,Shen Yuting,Xiong Bing,Zhao Chongke,Zhou Boyang,Yin Haohao,Xu Huixiong,Guan Xin
Nociceptive hypersensitivity and prolonged wound healing due to the interaction of peripheral neuropathy and local immune disorders are key issues that need to be addressed in diabetic foot ulcer (DFU) regenerative repair. Here, we present a low-intensity focused ultrasound (LIFU)-activated piezoelectric gel bandage for DFU wound repair and neuropathic pain relief. Acting as an artificial “skin”, this self-powered, functionalized bandage not only temporarily shields tissue from external environment, but also serves as a drug reservoir that can in situ release nitric oxide upon LIFU to promote macrophage polarization, generate piezoelectric current to desensitize TRPV1 nociceptor for on demand neuropathic pain relief and produce reactive oxygen species to eliminate pathogens in male rodents. More importantly, this regimen can promote CGRP neuropeptides release from sensory neurons to invigorate M2-like macrophages-mediated protective cutaneous immunity. This LIFU-activated immune-nociceptor modulation strategy is potentially applicable to other non-healing tissue regeneration.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
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2026
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IF 4.4
You Mei,Zhou Zixuan,Yan Xinying,Xie Haotian,Chen Xueke,Zhang Jing,Liao Fusheng,Wei Guobing,Fan Hao,Yin Zhaojiang
In this study, we developed a fluorescent sensor based on a pyrene-derived covalent organic framework (PT 2 D-COFs) for the efficient and sensitive detection of copper ions (Cu 2+ ) and iron ions (Fe 3+ ). The PT 2 D-COFs are synthesized via a Schiff base reaction, exhibiting high crystallinity, excellent porosity, and remarkable chemical stability, which provide ideal coordination sites for the effective recognition of metal ions. The results demonstrate that the PT 2 D-COFs exhibit significant fluorescence quenching upon interaction with Cu 2 ⁺, with a detection limit (LOD) of 0.79 nM, while fluorescence enhancement is observed in the presence of Fe 3+ , with an LOD of 0.47 nM. and reproducibility in complex sample matrices. It was effectively utilized to quantify Cu 2+ and Fe 3+ in environmental water samples and traditional Chinese herbal medicines, achieving satisfactory recovery rates. This sensor demonstrates characterized by its low detection limits, strong anti-interference capability, and broad application potential, holds significant promise for applications in environmental monitoring and bioanalysis. Graphical abstract
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MACROMOLECULAR RESEARCH
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2026
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IF 3.7
Javan Almasi Mohammad,Gong Chenyang,Abdelhussein Abdelsalam,Xiong Dangsheng
This study first investigates the influence of precursor concentration on the properties of negatively charged poly (vinyl alcohol) (PVA)/poly (2-acrylamido-2-methylpropane sulfonic acid) (PAMPS) hydrogels using a Box–Behnken experimental design to optimize tribological, mechanical, and water content performance. Subsequently, carboxylated carbon nanotubes (CNT-COOH) were incorporated into the dual-network hydrogel to mimic the negatively charged structure of natural cartilage. Fourier transform infrared spectroscopy (FTIR) confirmed successful polymerization, while scanning electron microscopy (SEM) revealed a porous three-dimensional network structure. The optimized hydrogels exhibited an equilibrium swelling ratio of up to 1785%. Mechanical testing demonstrated improved tensile strength (TS) at intermediate CNT concentrations, with a maximum elongation at break of 229%. Tribological measurements under physiological conditions showed excellent lubrication performance, with a low coefficient of friction (COF) of approximately 0.0336 and enhanced wear resistance. Long-term friction testing (7200 cycles) indicated stable lubrication behavior with minimal surface damage. These results demonstrate that the PVA/PAMPS/CNT-COOH nanocomposite hydrogel exhibits tunable swelling behavior, enhanced mechanical resilience, and superior lubrication performance, making it a promising biomimetic material for underwater and bio-lubrication applications. Graphical
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Nature Communications
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2026
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IF 18.1
Zhao Lei,Gao Zhongqiang,Yuan Ze,Yang Xiaodie,Li Duxin,Ren Qian,Yu Yunli,Pan Jie,Zheng Yiran,Zhang Xinyun
Inducing antigen-specific regulatory T (T reg ) cells is a promising strategy for treating autoimmune diseases (AID). Here, we present dendritic cells-CD4⁺ T cells (DC-CD4) bispecific tolerogenic nanovesicles (NV) co-loaded with an antigenic peptide and rapamycin. We show that these NVs bring DCs and CD4⁺ T cells into close spatial proximity through CTLA4-CD80/86 and anti-CD4 (aCD4)-CD4 interactions, thereby promoting antigen-specific T reg cell generation. In a collagen-induced arthritis mouse model, the bispecific NVs display enhanced lymph node (LN) tropism and increase antigen-specific T reg cells in LNs and spleen, when administered in both therapeutic and prophylactic settings, resulting in robust efficacy against CIA. Furthermore, arthritogenic cell transfer and adoptive transfer of T reg cells into T reg -ablated mice confirm the pivotal role of bispecific NV-induced antigen-specific T reg cells in mediating the anti-inflammatory efficacy. Collectively, our data support DC-CD4 bispecific tolerogenic NVs as a platform to induce antigen-specific T reg cells for precise immune tolerance in AIDs.
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高影响因子
Nature Communications
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2026
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IF 18.1
Liu Di,Bai Haoyun,Chen Mingpeng,Peng Shuyang,Kang Jiaqian,Li Lun,Feng Ziwen,Liu Chunfa,Ip Weng Fai,Pan Hui
Geen ammonia synthesis through electrochemical nitrate reduction (e-NO 3 R) using cost-effective Co-based catalysts is promising, but the inevitable structural evolution induced by reductive potentials compromises long-term stability and hinders practical implementation. Focusing on β-Co(OH) 2 , which serves as the active phase in e-NO 3 R systems, this work combines experimental analysis and computational studies to reveal a dynamic surface *OH evolution process: *OH cleavage under negative potentials and *OH generation by the dissociation of NO 3 - . Notably, Ru nanoparticles anchored on β-Co(OH) 2 nanosheets promote structural evolution by facilitating *OH cleavage and generation, thereby sustaining a highly active and selective OH-terminated surface. Simultaneously, Ru provides moderate *H adsorption, accelerates the conversions from NO 3 − to NO 2 − and from NO 2 − to NH 3 , and thus enhances ammonia synthesis. The optimized Co(OH) 2 -Ru catalyst achieves an ammonia yield of 98 ± 0.91 mg·h -1 ·cm -2 with a Faradaic efficiency (FE) of 97.7 ± 0.90 % at −0.7 V versus reversible hydrogen electrode (vs. RHE), while maintaining NH 3 FEs above 95% across a broad potential window. This work elucidates structural evolution dynamics, offering a design principle for robust electrocatalysts.
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Scientific Reports
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2026
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IF 4.9
Jiang Qi,Weng Xiaoyu,Chai Yi,Ragan Katherine B.,Liu Zhengjin,Li Zhongwu,Wang Bonnie,Jin Olivia,Gopinath Ashwin,Zhang David Yu,Chen Wei
High-frequency longitudinal RNA sequencing has emerged as a powerful approach for capturing dynamic transcriptional responses to therapeutic interventions, yet traditional differential expression analysis fails to identify genes with temporal variability that lack static expression differences. We used our previously developed computational framework for identifying Temporally Varying Genes (TVGs) from daily blood samples collected over 10–21 days in Sprague–Dawley rats treated with hepatotoxic compounds including tetracycline, isoniazid, carbon tetrachloride, and valproate. Our methodology employs variance-based scoring to detect genes exhibiting significant temporal fluctuations under treatment conditions. Unsupervised hierarchical clustering of TVGs identified three distinct temporal patterns: early-transient responses, sustained activation, and late-phase upregulation, each enriched for specific biological processes. Principal component analysis demonstrated clear treatment-induced transcriptomic shifts from baseline “Healthy Region” clusters to treatment-adapted “Response Region” states, with sample trajectories reflecting dose-dependent temporal dynamics. Cross-compound analysis revealed 186 commonly regulated genes across all treatments, representing conserved hepatotoxicity signatures, while compound-specific responses highlighted distinct mechanistic pathways. This approach enables kinetic-pharmacodynamic modeling that distinguishes primary drug targets from secondary adaptive responses, advancing precision medicine applications through dynamic molecular portraits of drug action and individual treatment variability.
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Scientific Reports
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2026
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IF 4.9
Liu Siqi,Fang Fei,Jiang Yu
Chronic administration of glucocorticoids are being linked to an increased risk of osteoporosis. 5-Hydroxymethylfurfural (5-HMF) is a natural compound that possesses various biological activities, including osteogenic regulation. In this research, we sought to investigate the potential of 5-HMF to exert protective effects against glucocorticoid-induced osteoporosis. In cellular investigations, we deployed Western Blot (WB), Real-Time Quantitative real-time PCR (qRT-PCR), Alkaline phosphatase (ALP) and Alizarin S-red (ARS) staining to scrutinize the expression of osteogenic differentiation markers within MC3T3-E1 pre-osteoblasts and BMSCs. We used dexamethasone to establish a mouse model for glucocorticoid-Induced osteoporosis and administered 5-HMF to evaluate its influence on bone density and architecture through the use of micro-CT and histological analysis. In addition, we employed network pharmacology to elucidate the potential pathways and targets of 5-HMF. Finally, we explored the effect of AKT knockout on the treatment of 5-HMF. We found that 5-HMF significantly enhanced VEGFR2 phosphorylation, reestablishing angiogenesis and activating the PI3K/AKT pathway in vitro and in vivo. 5-HMF also inhibited Dexamethasone -induced apoptosis by regulating Bax and Bcl-2 expression. MK2206, an AKT inhibitor, abrogated 5-HMF’s protective properties against GCs. These results indicate that 5-HMF counteracts the negative effects of GCs on osteoblasts and has good bone-promoting differentiation effects.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
·Vol. 24
·期 1
·184
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IF 15
Li Qingchen,Chen Lixue,Sun Yi,Wang Changyuan,Sun Yilun,Lu Kangjun,Li Lei,Sun Huijun,Liu Mozhen
PANoptosis, a distinct type of inflammation-associated programmed cell death that integrates features of apoptosis, necroptosis and pyroptosis, is closely related to the pathogenesis and progression of articular cartilage degeneration in osteoarthritis (OA). Meanwhile, excessive reactive oxygen species (ROS), pro-inflammatory pathways, and inflammatory cytokines in the OA microenvironment mutually reinforce one another, exacerbating synovial inflammation. To simultaneously target these interconnected pathological drivers, we developed an injectable nanocomposite thermosensitive hydrogel (DHA-PRO@NMs@TSH). This hierarchical system was constructed by integrating a ROS-responsive dihydroartemisinin prodrug (DHA-PRO) into Soluplus/TPGS-based nanomicelles (NMs), which were subsequently embedded within a Poloxamer-based thermosensitive hydrogel (TSH). This hierarchical and smart drug delivery system enables stable dihydroartemisinin (DHA) delivery and demonstrates a graded, ROS-triggered release profile, achieving sustained DHA retention in OA joints. The formulated system demonstrated excellent injectability, thermosensitivity, and physicomechanical stability, achieving sustained drug retention in rat joints for over 7 days, as confirmed by in vivo imaging. In vitro studies demonstrated that DHA-PRO@NMs significantly suppressed PANoptosis in chondrocytes by downregulating key markers (e.g., Bax/Bcl-2, RIPK3/p-RIPK3, NLRP3/Caspase-1/GSDMD) and inhibited inflammation by blocking the NF-κB pathway and subsequent cytokine production (e.g., TNF-α, IL-1β). In a rat OA model, treatment with DHA-PRO@NMs@TSH robustly attenuated disease progression, as evidenced by near-complete restoration of gait function, marked inhibition of cartilage degradation, a remarkable nearly 90% reduction in the Mankin score, and a comprehensive suppression of PANoptosis and inflammation pathological markers. This work not only presents a promising translational strategy for OA but also pioneers a therapeutic paradigm of leveraging advanced drug delivery system to dual-targeting PANoptosis and inflammation. Graphical abstract
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高影响因子
Science China-Chemistry
·
2026
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IF 9.8
Fang Pengda,Yuan Han,Zhou Tao,Yuan Yongjiang,Zhang Jiale,Zhang Qiuhuan,Zhang Hao,Yu Qikun,Sun Zhe,Yan Feng
Anion exchange membrane fuel cells (AEMFCs), recognized as a cost-effective solution for hydrogen energy utilization, have been extensively investigated in thousands of research articles. However, the performance of the anion exchange membranes (AEMs) under operating conditions still falls short of practical requirements. The challenge resides in the current emphasis on analyzing the intrinsic properties of AEMs without explicitly linking these properties to the performance of terminal devices. We developed a comprehensive machine learning model for predicting and optimizing AEMFC power density, encompassing AEM properties, catalyst layer composition, and operating conditions. Having learned from extensive experimental data, the model demonstrates generalization capability, accurately predicting performance for unseen data with an overall error rate below 10%. By implementing the data-driven optimization strategy recommended by the model, the power density of AEMFCs improved by up to 20%. This approach effectively links material-level characteristics to system-level performance, offering a novel perspective on precision-oriented and systematic energy materials innovation.
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POLYMER BULLETIN
·
2026
·Vol. 83
·期 7
·401
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IF 4.2
Liu Deyu,Ba Xuan,Wu Shaoyuan,Hu Jinghan,Duan Jihong,Guan Xingyu,Zhou Guoyong,Wang Kui,Huang Weijiang,Yan Wei
Waterborne polyurethane (WPU) has the advantage of good flexibility in the coating film, high and low-temperature resistance, and the advantages of environmental protection. Currently, there is a high demand for flame-retardant WPU. Herein, a flame-retardantcomposites (WPU/BN@APP/DIDOPO) is successfully developed by incorporating ammonium polyphosphate (APP) modified boron nitride (BN@APP) and DOPO derivatives into WPU via simple casting technology.The results indicate that BN@APP formed the intended composite structure and was well dispersed in the WPU matrix. This system significantly enhanced the char residue at 700 ℃ from 0.23% to 5.22% and reducing the peak heat release rate (pHRR) and total heat release (THR) by 58.9% and 36.9%, respectively, compared to pure WPU. Performance analysis shows that during combustion, a dense and stable expanded carbon layer forms, effectively delaying heat and mass transfer. The mechanical properties of the WPU/0.5BN@APP/5DIDOPO composite material are optimal and its breaking strength and elongation at break are superior to those of components. This work demonstrates the potential of the BN@APP/DIDOPO composite system for enhancing flame retardancy in polymeric materials, providing valuable insights for designing advanced flame-retardant systems.
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MICROCHIMICA ACTA
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2026
·Vol. 193
·期 9
·605
·
IF 5.4
Yi Gui,Wang Wenyan,Xia Qi,Xiao Liqiong,Wang Dekai,Xie Lianwu,Qin Haijiao,Guo Yaping
Early detection of aflatoxins is crucial to safeguard food safety. In this study, a new azobenzene monomer was synthesized and its photo-isomerization behavior in methanol and dimethyl sulfoxide was studied. A photo-switchable molecularly imprinted polymer (PMIP) designed for selectively recognizing aflatoxin B1 (AFB1) was fabricated via a surface imprinting technique. A dummy template, 5,7-dimethoxycoumarin was incorporated during the polymerization process. The photo-responsive behaviors of candidate monomers were systematically evaluated in methanol and dimethyl sulfoxide. The resulting PMIP was used as an extraction adsorbent for pretreatment prior to high-performance liquid chromatography-mass spectrometry analysis with its adsorption capacity could be controlled by light irradiation (365 nm and 440 nm). The method demonstrated a linear calibration interval from 50 to 1000 ng·mL⁻¹ with detection limit of 5.1 ng·mL⁻¹, and exhibited favorable binding capacity values between 90.8% and 95.4% when used for the determination of AFB1 in corn, reflecting the strong recognition affinity of PMIP toward AFB1. Graphical
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JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
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2026
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IF 2.6
Li Shanjian,Ren Jie
Polydopamine (PDA) coatings have great potential for corrosion protection in harsh acidic industrial environments. However, their performance and failure mechanisms in strongly acidic media at identical H⁺ concentrations but with different anions remain unclear. This work systematically compares the corrosion inhibition behavior of PDA coatings on N80 steel in hydrochloric acid and sulfuric acid media using static weight-loss measurements, potentiodynamic polarization, electrochemical impedance spectroscopy (EIS), UV-Vis spectrophotometry, and surface characterization. The results demonstrate significant anion-dependent behavior. At 25 °C, the corrosion inhibition efficiency reached 96.55% in 0.05 mol L −1 H 2 SO 4 with a coating peeling rate of only 1.22%. In contrast, the efficiency was only 59.72% in 0.10 mol L⁻ 1 HCl with a peeling rate of 3.38%. The charge-transfer resistance was higher and the coating structure was more stable in H 2 SO 4 . Increasing the acid concentration or temperature reduced the protective performance of the coating, with faster degradation observed in HCl. The Mechanistic analysis indicates that small, highly mobile Cl⁻ ions penetrate the coating and disrupt intermolecular interactions, whereas SO 4 2 ⁻ interacts weakly with protonated PDA, thereby preserving coating integrity. These results provide a theoretical basis for designing PDA-based anticorrosion coatings for high-chloride acidic industrial environments.
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