FUEL
·
2018
·
IF 4.908
Qing-Qing Teng,Xian-Yong Wei,Yi-Bing Sun,Sheng-Kang Wang,Jing-Hui Lv,Zhan-Ku Li,Zhong-Qiu Liu,Zhi-Min Zong
Catalysts trifloromethanesulfonic acid (TFMSA)/treated attapulgite powder (TAP), Ni/TAP, and Ni-TFMSA/TAP with different Ni and TFMSA loadings were prepared. The typical catalysts were characterized with multiple instruments and used for catalyzing hydroconversion of di(1-naphthyl)methane (DNM), which was used as a coal-related model compound. The suitable loadings of Ni and TFMSA in Ni-TFMSA/TAP were determined to be 28.6% of Ni and 33% of TFMSA. Under optimal reaction conditions of 5 MPa of initial hydrogen pressure, 240 °C, and 4 h over Ni-TFMSA/TAP, DNM was completely converted, producing decalin and 1-methyldecalin as the main products. The result suggests that Ni-TFMSA/TAP is highly active for both cleaving the C ar -C alk bond in DNM and hydrogenating the resulting naphthalene and 1-methylnaphthalene under mild conditions. Based on the identification of reaction products, the catalytic mechanism for DNM hydroconversion was discussed.
✓ 已验证
DOI
高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2022
·
IF 5.876
Wanli Zhao,Yuanhui Long,Yunqing He,Jiabing Cai,Mingxian Liu
Highly stretchable hydrogel shows great potential for wearable strain sensors. However, the rapid propagation of bacteria while using wearable sensors may threaten health. In this work, HNTs@HKUST-1 composites were prepared by the incorporation of halloysite nanotubes (HNTs) during the synthesis of HKUST-1. HNTs depressed the crystal growth of the HKUST-1, which leads to the 2D nanosheet morphology. HNTs@HKUST-1 serves as a reinforcing agent for polyacrylamide (PAAm) hydrogels, and PAAm-HNTs@HKUST-1 has high tensile strain properties (elongation at break of 912.5% and tensile strength of 22.4 kPa). The Cu 2+ in HKUST-1 endows remarkable conductivity and excellent antibacterial properties to the composite. The composite hydrogels were then developed as human motion detection sensors with antibacterial property to prevent microbial infection, which show recyclability, high sensitivity, and fast responsiveness. So, they have great potential as flexible antibacterial materials to monitor movements of the human body in real-time.
✓ 已验证
DOI
高影响因子
CHEMOSPHERE
·
2023
·
IF 8.8
Wenshan He,Run Jiang,Siqi Li,Minglu Zhang,Tingting Zhang,Xiaobiao Zhu,Xiaohui Wang
Chlortetracycline (CTC), a widely used typical tetracycline antibiotic, has raised increasing concerns due to its potential health and environmental risks. Biodegradation is considered an effective method to reduce CTC in environment. In this study, a strain Aspergillus sp. LS-1, which can efficiently degrade CTC, was isolated from CTC-rich activated sludge . Under optimal conditions, the maximum removal efficiency of CTC could reach 95.41%. Temperature was the most significant factor affecting the degradation efficiency of LS-1. The 19 products were identified in the CTC degradation by strain LS-1, and three degradation pathways were proposed. All the degradation pathways for CTC exhibited ring-cleaving, which may accelerate the mineralization of CTC. To gain more comprehensive insights into this strain, we obtained the genome of LS-1, which had high GC content (50.1%) and completeness (99.3%). The gene annotation revealed that LS-1 contains some vital enzymes and resistance genes that may carry functional genes involved in the CTC degradation. In addition, other antibiotic resistance genes were found in the genome of LS-1, indicating that LS-1 has the potential to degrade other antibiotics. This study provides a more theoretical basis for the investigation of CTC degradation by fungi and new insights into the biodegradation of CTC.
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2020
·
IF 7.727
Mengshi Jiang,Wei Li,Chunqi Zhu,Xiang Li,Junlei Zhang,Zhenyu Luo,Bing Qin,Yongzhong Du,Lihua Luo,Jian You
The application of nanocarriers as drug delivery system for chemotherapeutic drugs has become a research hotspot in cancer treatment. Chemotherapy with high tumor-targeting accuracy and drug release specificity is the key to improve the efficacy of tumor chemotherapy and reduce the side effects caused by repeated doses drugs. Here, we synthesized a redox-sensitive nano-micelle formed by hyaluronic acid (HA) conjugated with d -α-tocopherol succinate (TOS) using a disulfide bond as the linker (HA-SS-TOS, HSST), which could actively accumulate to the tumor sites and metastasis cancer cells with high expression of CD44. The micelles could dissociate under the high GSH level in cancer cells, triggering a release of paclitaxel (PTX). Surprisingly, the precise chemotherapy instead induced a suppressive tendency of immune system, manifested by a significant increase in TGF-β, which weakened the therapeutic effect of micelles. Moreover, the high levels of TGF-β might be related to the increased drug-resistance of cancer cells. Research has shown that PD-1 pathway blockade can result in reduction in TGF-β expression, thus, a PLGA microsphere encapsulating PD-1 antagonist peptides A12 ( [email protected] ) was further prepared to activate the host immune response. Our data indicated that PTX-loaded HSST could accurately “find” the tumors as well as metastasis cancer cells, and efficiently kill most of them. The joining of a durable PD-1 blockage significantly boosted the efficacy of [email protected] on multiple tumor models, including lung metastatic tumors and even multidrug-resistant tumors. Thus, our work presented an optimal chemo-immunotherapy combined system, which shows profound significance for future cancer therapy in clinic.
✓ 已验证
DOI
PubMed
高影响因子
CELLULAR SIGNALLING
·
2026
·
IF 4.7
Qiu-shuang Ma,Xiao-man Zhao,Wan-ying Zhang,Li-jun Shao,Yi-fan Liu,Li-ya Feng,Xiao-xia Yang,Xiu-li Guo
Enolase 1 (ENO1) is overexpressed in hepatocellular carcinoma (HCC) and correlates with poor patient prognosis, as evidenced by TCGA and Kaplan-Meier (KM) analysis. This study demonstrates that targeting ENO1 with its specific inhibitor, ENOblock, markedly enhances the antitumor efficacy of sorafenib in HCC cells. The combination of sorafenib and ENOblock significantly suppresses cell proliferation, migration, invasion, and angiogenesis in vitro and in vivo . Mechanistically, sorafenib and ENOblock synergistically promote ferroptosis by concurrently regulating the Keap1/Nrf2/NQO1 and TFR1/C-MYC/NCOA4/FTH1/LC3 pathways, independent of xCT/GPX4 pathway. These effects are characterized by elevated levels of reactive oxygen species (ROS), iron ions, and malondialdehyde (MDA). In vivo tumorigenic models further confirm that the enhanced therapeutic effect of sorafenib by ENOblock. Our findings not only elucidate a novel ferroptosis-based mechanism underlying sorafenib response in HCC, but also position ENOblock-sorafenib combination as a promising preclinical proof- of-concept strategy targeting ENO1 for HCC intervention.
✓ 已验证
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2021
·
IF 5.279
Meng Zhang,Menglan Dou,Yingying Xia,Zhan Hu,Beijing Zhang,Yongxia Bai,Jia Xie,Qifeng Liu,Changping Xie,Dadong Lu,Shuai Hou,Jianguo He,Jun Tao,Ranfeng Sun
In the current work, a series of 1-trifluoromethyl cinnamyl alcohol derivatives were designed and synthesized and their antifungal activities were evaluated. The bioassay result showed that most compounds exhibited excellent antifungal activity in vitro at 10 μg mL–1. Next, photostable and easily synthesized compound 2 with broad-spectrum antifungal activity in vitro was selected as a potential candidate to evaluate its antibacterial and antifungal activities. The EC50 values of compound 2 against eight fungal plant pathogens in vitro ranged from 3.806 to 17.981 μg mL–1; at the same time, compound 2 could effectively control Podosphaera xanthii, Odium heveae Steinm, Puccinia striiformis West, and Puccinia sorghi in pot experiments. In addition, compound 2 exhibited excellent antibacterial activities in vitro and in vivo against Xanthomonas oryzae pv. oryzae. Furthermore, the absorption and translocation of compound 2 in wheat plants were determined by the high-performance liquid chromatography method. The result showed that compound 2 could be translocated acropetally as well as basipetally in wheat plants. Finally, it was found that compound 2 had no cross-resistance with carbendazim, azoxystrobin, and boscalid.
✓ 已验证
DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2021
·Vol. 9
·期 10
·6205-6213
·
IF 12.732
Jiacheng Xing,Danhua Yuan,Hanbang Liu,Yansi Tong,Yunpeng Xu,Zhongmin Liu
The synthesis of TS-1 zeolites is regarded as a milestone in zeolite history, and it has led to the revolution of the green oxidation system of using H2O2 as an oxidant, leaving only water as the byproduct. However, because of the highly hydrolyzable titanium source, the preparation of TS-1 requires complex synthesis conditions. Moreover, the difference in the hydrolysis rate between the silicon source and titanium source tends to increase the difficulty of titanium insertion into the framework, and it is easy to generate extra-framework Ti species during the synthesis. Here, a high-quality TS-1 zeolite with a large external surface area and free of extra-framework Ti species has been successfully synthesized by using a kind of novel polymer containing titanium and silicon. Due to the high hydrolysis resistance of the polymer reagent, a good matching of the hydrolysis rate between the silicon source and the titanium source is realized during crystallization, which facilitates the incorporation of titanium into the framework. Furthermore, the TS-1 zeolite exhibited excellent catalytic performance in n-hexane oxidation with hydrogen peroxide as the oxidant. This method of synthesizing zeolites from polymers is expected to be widely applied for the synthesis of other titanium-containing zeotype materials.
✓ 已验证
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2026
·
IF 6.6
Jiani Guo,Xin Song,Yan Su,Yiran Zou,Renke Kang,Shang Gao
Polarity-dependent CMP behavior of 4H-SiC Si-face and C-face is systematically investigated. • The C-face exhibits higher material removal rate and stronger oxidation tendency. • A thicker oxygen-rich reacted layer forms on the C-face during CMP. • Enhanced interfacial charge transfer promotes oxidant–surface interactions on the C-face. • First-principles calculations reveal the origin of polarity-dependent CMP behavior. Chemical mechanical polishing (CMP) of SiC is fundamentally limited by its high hardness and chemical inertness, as well as the pronounced polarity-dependent anisotropy between the Si-face (0 0 0 1) and C-face (0 0 0 −1). In this work, the intrinsic mechanism governing polarity-dependent oxidation and material removal of 4H-SiC is systematically investigated by combining CMP experiments, surface characterization, electrochemical analysis, and first-principles calculations.Under identical polishing conditions, the C-face exhibits a significantly higher material removal rate (1900 nm·h −1 ) and lower surface roughness (0.13 nm) compared to the Si-face (1000 nm·h −1 , 0.65 nm). Electrochemical results reveal faster oxidation kinetics on the C-face, which is further confirmed by the formation of a thicker oxide layer and enhanced oxygen-containing species. DFT calculations demonstrate that the C-face possesses higher surface energy, lower work function, and stronger charge transfer capability, leading to more favorable oxidant adsorption and interfacial reactions. These results reveal that the superior CMP performance of the C-face originates from its intrinsically enhanced electronic activity and oxidation-assisted removal capability. This work establishes a clear structure–property–performance relationship for polarity-dependent CMP of SiC and provides new insights for improving polishing efficiency and achieving wafer-level uniformity. Download: Download high-res image (234KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Yazhen Wu,Xiaoxiao Li,Zhengyu Jin,Birte Svensson,Yuxiang Bai
How to improve the solubility of linear dextrins (LD) and retain their characteristic helix amphiphilic cavities with flexible embedding capability, is a question worth exploring without adding new chemical groups. The strategy presented in this study is to attach a highly flexible (α-1 → 6) glucochain at the reducing end of LD by preparing a new type of dextrin, referred to as single-arm linear dextrin (SLD). In the actual synthesis, an (α-1 → 6) linked oligosaccharide of DP ¯ 10.7 (PDI = 1.28) was formed by extension of glucose units onto sucrose (2 M) by using L940W mutant of the glucansucrase GTF180-ΔN firstly. Next using γ-CD as glucosylation donor γ-CGTase extended this (α-1 → 6) glucochain with (α-1 → 4) bonds. SLD is a chimeric glucosaccharide comprising an (α-1 → 4) linked part ( DP ¯ 10.5) attached to the nonreducing end of an (α-1 → 6) glucochain as verified by enzyme fingerprinting and 1 H NMR. Furthermore, SLD was validated to show greatly improved solubility and dispersibility of resveratrol in water, as indicated by a 3.12-fold enhancement over the solubility in the presence of 0.014 M SLD. This study provided a new strategy for solving the solubility problem of LD and opens possibilities for new design of the fine structure of starch-like materials.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanomaterials
·
2022
·Vol. 12
·期 21
·3771
·
IF 5.719
Shizhuo Wang,Jikang Jiang,Minyan Gu,Yuanbo Song,Jiang Zhao,Zheng Shen,Xuefei Zhou,Yalei Zhang
To substitute fossil resources, it is necessary to investigate the conversion of biomass into 1,2-propanediol (1,2-PDO) as a high-value-added chemical. The Pt/deAl-Beta@Mg(OH)2catalytic system is designed to obtain a higher 1,2-PDO production yield. The optimal yield of 1,2-PDO is 34.1%. The unique shell-core structure of the catalyst demonstrates stability, with a catalytic yield of over 30% after three times of use. The primary process path from glucose to 1,2-PDO, glucose-hexitol-1,2-PDO, is speculated by the experiments of intermediate product selectivity. The alkaline catalytic mechanism of the reaction process is elucidated by studying catalyst characterization and analyzing different time courses of products. The introduction of Mg(OH)2improves the target yield by promoting the isomerization from glucose to fructose and retro-aldol condensation (RAC) conversion, with pseudo-yield increases of 76.1% and 42.1%, respectively. By studying the processes of producing lactic acid and 1,2-PDO from glucose, the glucose hydrogenolysis flow chart is improved, which is of great significance for accurately controlling 1,2-PDO production in industrial applications. The metal, acid, and alkali synergistic catalytic system constructed in this paper can provide a theoretical basis and route reference for applying biomass conversion technology in practice.Keywords:1,2-propanediol;alkaline modification;core–shell catalyst
研究领域:
生物化学
·
催化化学
✓ 已验证
DOI
PubMed
高影响因子
Communications Biology
·
2024
·Vol. 7
·期 1
·1-11
·
IF 5.2
Qin Danhui,Song Hui,Wang Caiwei,Ma Xiaojie,Fu Yu,Zhao Chunyuan,Zhao Wei,Zhang Lei,Zhang Weifang
Stimulator of interferon genes (STING) is vital in the cytosolic DNA-sensing process and critical for initiating the innate immune response, which has important functions in host defense and contributes to the pathogenesis of inflammatory diseases. Zinc finger CCCH-type antiviral protein 1 (ZC3HAV1) specifically binds the CpG dinucleotides in the viral RNAs of multiple viruses and promotes their degradation. ZAPS (ZC3HAV1 short isoform) is a potent stimulator of retinoid acid-inducible gene I (RIG-I) signaling during the antiviral response. However, how ZC3HAV1 controls STING signaling is unclear. Here, we show that ZC3HAV1 specifically potentiates STING activation by associating with STING to promote its oligomerization and translocation from the endoplasmic reticulum (ER) to the Golgi, which facilitates activation of IRF3 and NF-κB pathway. Accordingly, Zc3hav1 deficiency protects mice against herpes simplex virus-1 (HSV-1) infection- or 5,6-dimethylxanthenone-4-acetic acid (DMXAA)-induced inflammation in a STING-dependent manner. These results indicate that ZC3HAV1 is a key regulator of STING signaling, which suggests its possible use as a therapeutic target for STING-dependent inflammation.
研究领域:
免疫学
·
病毒学
·
炎症性疾病
✓ 已验证
DOI
PubMed
高影响因子
Frontiers in Pharmacology
·
2021
·
IF 5.811
Xiao Qing,Liu Qi-Meng,Jiang Ru-Chao,Chen Kai-Feng,Zhu Xiang,Ma Lei,Li Wei-Xi,He Fei,Huang Jun-Jun
Previous studies have indicated that α1D/1A antagonist naftopidil (NAF) suppresses prostate growth by decreasing cell proliferation without affecting apoptosis and prostate volume in benign prostatic hyperplasia (BPH). A NAF-derived α1D/1A antagonist 1- benzyl-N-(3-(4-(2-methoxyphenyl) piperazine-1-yl) propyl)-1H-indole-2- carboxamide (HJZ-12) has been reported from our laboratory, which exhibits high subtype-selectivity to both α1D- and α1A- AR (47.9- and 19.1- fold, respectively) with respect to a1B-AR in vitro. However, no further study was conducted. In the present study, a pharmacological evaluation of HJZ-12 in BPH was performed on an estrogen/androgen-induced rat BPH model and human BPH-1 cell line. In vivo, HJZ-12 exhibited better performance than NAF in preventing the progression of rat prostatic hyperplasia by not only decreasing prostate weight and proliferation (similar to NAF) but also, shrinking prostate volume and inducing prostate apoptosis (different from NAF). In vitro, HJZ-12 exhibited significant cell viability inhibition and apoptotic induction in BPH-1 cell line, without presenting cell anti-proliferation properties. Intriguingly, the role of HJZ-12 on cell viability and apoptosis was an α1-independent action. Furthermore, RNA-Seq analysis was applied to screen out six anti-apoptotic genes (Bcl-3, B-lymphoma Mo-MLV insertion region 1 [Bmi-1], ITGA2, FGFR3, RRS1, and SGK1). Amongst them, Bmi-1 was involved in the apoptotic induction of HJZ-12 in BPH-1. Overall, HJZ-12 played a remarkable role in preventing the progression of prostatic hyperplasia through α1-independent apoptotic induction, indicating that it will be a multi-target effective candidate for BPH treatment.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）