PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
·
2020
·
IF 2.751
Jie Xiang,Dengyue Liu,Jixiang Chen,Deyu Hu,Baoan Song
In this study, thirty 1,3,4-oxadiazole sulfone derivatives containing 3,4-dichloroisothiazolamide moiety were designed and synthesized, and their antibacterial activities were evaluated. Bioassay results showed that some compounds exhibited excellent antibacterial activities against Xanthomonas oryzae pv. oryzae ( Xoo ) and Xanthomonas oryzae pv. oryzicola ( Xoc ) in vitro and in vivo . Notably, the EC 50 values of compounds 2 and 3 against Xoo were 0.79 and 0.85 μg/mL, respectively, which were superior to those of the control agents isotianil, bismerthiazol, and thiodiazole copper. In addition, in vivo antibacterial activities revealed that the compound 2 at 50 μg/mL possessed protective and curative activities of 43.99% and 41.06% against Xoo , respectively, which were better than positive controls. Furthermore, the preliminary mechanism study disclosed that compound 2 exhibited effective antibacterial activity against Xoo by inhibiting the formation of extracellular polysaccharides from Xoo , increasing cell permeability , and changing the shape of cells. This study suggested that 1,3,4-oxadiazole sulfone derivatives containing 3,4-dichloroisothiazolamide moiety displayed excellent antibacterial activity and could be further explored and developed as commercial pesticides.
研究领域:
植物病理学
·
农药化学
·
微生物学
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DOI
PubMed
高影响因子
JOURNAL OF ORGANIC CHEMISTRY
·
2025
·
IF 3.6
Yang Zhu,Guisheng Deng
The I2-catalyzed reaction of 1-(2-hydroxyphenyl)-propargyl alcohols with indoles and subsequent treatment with K2CO3 provided (benzofuran-3-yl)-1H-indoles in good to excellent yields with high regioselectivity. This one-pot and two-step strategy proved to be suitable for a wide range of substrates except for aliphatic alkynyl alcohols as well as the indoles bearing N-protected groups such as the Ts group possessing strong electron-withdrawing feature. The reaction procedure involved a cross-coupling and the construction of a benzofuran framework via 5-exo-dig cyclization.
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产品关联
DOI
PubMed
高影响因子
HIGH PERFORMANCE POLYMERS
·
2022
·
IF 1.73
Qi Li,Sung S Park,Chang-Sik Ha,Shuai Yuan,Liyi Shi
In this work, a copolyimide (Co-PI) film with high transparency was prepared by the copolymerization of hexafluoroisopropylidene)diphthalic anhydride (6FDA), 3,3′,4,4′-biphenyltetracarboxylic dianhydride (BPDA), 2,2′-Bis(trifluoromethyl)benzidine (TFMB) and adamantane-1,3-diamine (DAA). The effects of DAA monomers on the optical, thermal, and mechanical properties of the co-PIs were discussed in detail. We found that the preparation of polyimide (PI) based on the combination of two dianhydrides and two diamines could obtain the co-PI film with excellent comprehensive performance due to the synergy between the -CF3 group, the aliphatic ring and the aromatic structure. Through the structure and composition optimization, the co-PI film with 1.30% DAA (Q3) has a Tg of 374oC, T5 higher than 530oC, T430 of 82% and the tensile strength higher than 145 MPa. These results indicate that the Co-PI films can be successfully utilized in the development of novel heat-resistant plastic substrates for the optoelectronic engineering applications.
研究领域:
聚合物科学
·
材料科学
·
光电子学
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DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2021
·
IF 5.316
Yalin Qin,Peikun Yan,Fuxuan Han,Yongcheng Zhang,Zonglin Lv,Chunming Zhou
The enhancement of both transparency and piezoelectric properties in transparent ferroelectric ceramics is a challenge. In this work, we prepared transparent 0.75Pb(Mg 1/3 Nb 2/3 )O 3 -0.25PbTiO 3 : x Pr 3+ ceramics by oxygen atmosphere sintering together with hot pressing sintering. When x = 1.5 mol%, a transparency of 68% @ 900 nm (close to the theoretical value ~71%) was achieved, and the piezoelectric properties increased to twice as much as those in undoped ceramics ( x = 0). The small average domain size (below 200 nm) that far below the visible light wavelength was believed to benefit light transmittance. Meanwhile, the minute amount of tetragonal component induced by Pr 3+ irons, was supposed to be responsible for the improved piezoelectric properties. These merits make Pr 3+ -doped 0.75PMN-0.25PT transparent ceramics promising functional materials for transparent piezoelectric devices.
研究领域:
材料科学
·
物理学
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DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2019
·
IF 6.361
Jiadong Liu,Yijia Wang,Lei Wang
A polyvinylidene fluoride (PVDF) organic conductive membrane with photoelectric activity was successfully developed via printing of oxidant (FeCl 3 ·6H 2 O) layer by layer and then chemical vapor deposition (CVD) of Poly (3, 4-ethylenedioxythiophene) (PEDOT). Four kinds of membranes were prepared by changing the number of oxidant coatings layers. The structure and photoelectric properties of four membranes were well characterized. The photocurrent density of 3.7 × 10 −4 A indicated that the four-oxidant coating layers membrane achieved the best performance in photo-electricity activity. A comprehensive study of degradation efficiency under different photoelectric conditions was carried out. Results showed that the photoelectrocatalytic removal of tetracycline hydrochloride was 1.6 and 7.9 times higher than that of photocatalysis and photolysis, respectively, under a voltage of 3 V assisted with visible light irradiation. The anti-interference and stability tests in continuous filtration process demonstrated that the dissolved organic matters (DOMs) can result in a 30% fluctuation on removal rate. The streaming potential tests of DOMs adsorption on membrane surface indicated that the more obvious the adsorption phenomenon was, the degradation of tetracycline hydrochloride was weaker. The degradation intermediates were identified and pathways were proposed in this work. The photoelectrocatalysis of PEDOT modified PVDF membrane provided a new potential for water purification .
研究领域:
环境科学
·
材料科学
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DOI
高影响因子
CERAMICS INTERNATIONAL
·
2022
·
IF 5.532
Daokun Liu,Jinxue Guo,Yanfang Sun,Xiao Zhang
Sodium super-ionic conductor (NASICON) materials are believed as competitive cathodes for sodium-ion batteries, however, their practical application is still prohibited by the limited reversible capacity. In this study, the tri-metal NASICON structured Na 3 Mn 0.5 V 0.5 Ti(PO 4 ) 3 is designed to combine with reduced graphene oxide (NMVTP/rGO) as cathode material . Benefited from the multi-step redox couples of Mn, V, and Ti, NMVTP/rGO realizes high reversible capacity and wide operating voltage. The small sizes of Na 3 Mn 0.5 V 0.5 Ti(PO 4 ) 3 and rGO ensure the fast charge migration. The rGO inhibits the dissolution of electrode material. As a result, NMVTP/rGO exhibits large specific capacity of 284.6 mAh g −1 at 0.1C, high rate performance (170.2 mAh g −1 at 1C and 108.5 mAh g −1 at 5C), and good cyclic stability. This work demonstrates a new insight for designing tri-metal NASICON structured materials with high capacity for sodium-ion batteries.
研究领域:
材料科学
·
电化学
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DOI
高影响因子
Chinese Journal of Natural Medicines
·
2014
·
IF 0
De-Biao YAN,Dong-Ping ZHANG,Ming LI,Wen-Yuan LIU,Feng FENG,Bin DI,Qing-Long GUO,Ning XIE
To synthesize a series of 3-, 4-, and/or 11-trihydroxy modified bergenin derivatives and evaluated their cytotoxic activity in vitro . The phenolic hydroxyl groups of bergenin were protected by benzyl groups with benzyl bromide. Treatment of dibenzyl bergenin with the corresponding acid in the presence of EDC·HCl and DMAP in CH 2 Cl 2 , followed by hydrogenation over Pd/C catalysts, afforded derivatives of bergenin esters. All of the target compounds were identified by IR, MS, and 1 H NMR. Twenty-six novel and three known derivatives of bergenin esters were synthesized. Their cytotoxicity values were evaluated by the MTT assay on the inhibition of DU-145 and BGC-823 cells in vitro . Several triply-substituted ( 3a, 4a, 5a, 6a, 7a ) and doubly-substituted ( 8b, 9b ) bergenin derivatives exhibited higher cytotoxic activity than bergenin. The result showed that the size of substituents and the lipophilicity of the bergenin esters displayed an important role on their cytotoxic activity.
研究领域:
药物化学
·
肿瘤学
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DOI
PubMed
ACS Omega
·
2022
·
IF 4.132
Nan Zhang,Chaoren Yan,Changji Yin,Xiaoling Hu,Ping Guan,Yuan Cheng
Numerous therapeutic agents and strategies were designed targeting the therapies of Alzheimer’s disease, but many have been suspended due to their severe clinical side effects (such as encephalopathy) on patients. The attractiveness for small molecules with good biocompatibility is therefore restarted. Epigallocatechin-3-gallate (EGCG), extracted from green tea, is expected to be a promising small-molecule drug candidate, which can remodel the structure of preformed β-sheet-rich oligomers/fibrils and then effectively interfere with neurodegenerative processes. However, as the structure of non-fibrillary aggregates cannot be directly characterized, the atomic details of the underlying inhibitory and destructive mechanisms still remain elusive to date. Here, all-atom molecular dynamics simulations and experiments were carried out to elucidate the EGCG-induced remodeling mechanism of amyloid β (Aβ) fibrils. We showed that EGCG was indeed an effective Aβ fibril inhibitor. EGCG was capable of mediating conformational rearrangement of Aβ1–42 fibrils (from a β-sheet to a random coil structure) and triggering the disintegration of fibrils in a dose-dependent manner. EGCG redirected the structure of Aβ by breaking the β-sheet structure and hydrogen bonds between peptide chains within the Aβ protofibrils, especially the parallel β-strand (L17VFFAEDVGS26). Moreover, reduced solvent exposure and multisite binding patterns all tended to induce the conformation conversion of Aβ17–42 pentameric protofibrils, destroying pre-formed fibrils and inhibiting continued fibril growth. Detailed data analysis revealed that structural features of EGCG with abundant benzene ring and phenolic hydroxyl moieties preferentially interact with the parallel β-strands to effectually hinder the interaction of the interpeptide chain and the growth of the ordered β-sheet structure. Furthermore, experimental studies confirmed that EGCG was able to disaggregate the preformed fibrils and alter the protein structure. This study will enable a deeper understanding of fundamental principles for design of structural-based inhibitors.
研究领域:
神经科学
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分子生物学
·
药物发现
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DOI
PubMed
高影响因子
Journal of Advanced Research
·
2021
·
IF 10.479
Min Mu,Haifeng Chen,Rangrang Fan,Yuelong Wang,Xin Tang,Lan Mei,Na Zhao,Bingwen Zou,Aiping Tong,Jianguo Xu,Bo Han,Gang Guo
Introduction Numerous options for treatment of glioblastoma have been explored; however, single-drug therapies and poor targeting have failed to provide effective drugs. Chemotherapy has significant antitumor effect, but the efficacy of single-drug therapies in the clinic is limited over a long period of time. Thus, novel therapeutic approaches are necessary to address these critical issues. Objectives The present study, we investigated a tumor-specific metal-tea polyphenol-based cascade nanoreactor for chemodynamic therapy-enhanced chemotherapy. Methods HA-EGCG was synthesized for the first time by introducing epigallocatechin-3-gallate (EGCG) into the skeleton of hyaluronic acid (HA) with reducible disulfide bonds. A rapid and green method was developed to fabricate the metal-tea polyphenol networks (MTP) with an HA-EGCG coating ( [email protected] /HA-EGCG) based on Fe 3+ and EGCG for targeted delivery of doxorubicin hydrochloride (DOX). GL261 cells were used to evaluate the antitumor efficacy of the [email protected] /HA-EGCG nanoreactor in vitro and in vivo . Results [email protected] /HA-EGCG nanoreactors were able to disassemble, resulting in escape of their components from lysosomes and precise release of DOX, Fe 3+ , and EGCG in the tumor cells. HA-EGCG depleted glutathione to amplify oxidative stress and enhance chemodynamic therapy. The results of in vivo experiments suggested that [email protected] /HA-EGCG specifically accumulates at the CD44-overexpressing GL261 tumor sites and that sustained release of DOX and Fe 3+ induced a distinct therapeutic outcome. Conclusions The findings suggested the developed nanoreactor has promising potential as a future GL261 glioblastoma therapy.
研究领域:
肿瘤学
·
药剂学
·
纳米医学
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DOI
PubMed
高影响因子
FIBERS AND POLYMERS
·
2016
·Vol. 17
·期 11
·1741-1748
·
IF 1.022
Xu Bin,Li Qiaoping,Zhuang Linghua,Wang Qiang,Li Chao,Wang Guowei,Xie Fengwei,Halley Peter J.
3-methyl-1-(ethylacetyl)imidazolium chloride ([EtMIM]Cl), was synthesized for chitosan dissolution, and the dissolution and regeneration behaviors of chitosan in [EtMIM]Cl were thoroughly investigated. The solubility of chitosan in [EtMIM]Cl was measured at temperatures ranging from 40 °C to 110 °C, based on which the thermodynamic parameters of chitosan in [EtMIM]Cl were calculated. The polarizability and hydrogen bond accepting ability was determined by solvatochromic UV/vis spectroscopy. The regenerated chitosan from [EtMIM]Cl by adding methanol was characterized by thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and scanning electron microscopy (SEM). Density functional theory (DFT) computations were performed to study the interactions between [EtMIM]Cl and chitobiose. Five kinds of hydrogen bonds, C-H/O, O-H/O, O-H/Cl, C-H/Cl, N-H/Cl were found, suggesting strong interactions between [EtMIM]Cl and chitobiose. In particular, the oxygen atom and the active methylene group of carboxylic ester in [EtMIM] + , formed strong hydrogen bonding with chitobiose. The molecular simulation results indicated that both the Cl − anions and [EtMIM] + cation played important roles in the chitosan dissolution process, by the disruption of native hydrogen bonds of chitosan.
研究领域:
生物化学
·
材料科学
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DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2024
·
IF 5.7
Zhongyin Chen,Hui Cai,Xiao Zhang,Meng Zhang,Ge-Fei Hao,Zhichao Jin,Shichao Ren,Yonggui Robin Chi
To discover protoporphyrinogen oxidase (PPO) inhibitors with robust herbicidal activity and crop safety, three types of substituted 3-(pyridin-2-yl)phenylamino derivatives bearing amide, urea, or thiourea as side chain were designed via structure splicing strategy. Postemergence herbicidal activity assessment of 33 newly prepared compounds revealed that many of our compounds such as 6a, 7b, and 8d exhibited superior herbicidal activities against broadleaf and monocotyledon weeds to commercial acifluorfen. In particular, compound 8d exhibited excellent herbicidal activities and high crop safety at a dosage range of 37.5–150 g ai/ha. PPO inhibitory studies supported our compounds as typical PPO inhibitors. Molecular docking studies revealed that compound 8d provided effective interactions with Nicotiana tabacum PPO (NtPPO) via diverse interaction models, such as π–π stacking and hydrogen bonds. Molecular dynamics (MD) simulation studies and degradation studies were also conducted to gain insight into the inhibitory mechanism. Our study indicates that compound 8d may be a candidate molecule for the development of novel herbicides.
研究领域:
植物科学
·
农药化学
·
生物化学
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DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
·
2021
·Vol. 2021
·期 44
·4566-4571
·
IF 2.524
Wen-Dong Yao,Mei Yan,Xiao-Hui Li,Wenlong Liu,Ru-Ling Tang
Graphical A novel transition metal tellurite phosphate Cd 3 (PO 4 )(TePO 6 ) features a new type of {[TePO 6 ] 3− } ∞ chain was obtained by solid-state reactions, and its electronic structure and optical properties are studied systematically. New inorganic crystals containing multiple anions have received extensive attensions recently in view of their abilities to be potential multifunctional materials. Among them, tellurite-phosphates with simple chemical components are relatively rarely studied. Here, one novel tellurite phosphate Cd 3 (PO 4 )(TePO 6 ) was obtained through conventional soild-state reaction, and it is the first tellurite-phosphate only possessing d 10 transition metal. It crystallizes in the monoclinic space group P 2 1 / c , and its structure features an interesting {[TePO 6 ] 3− } ∞ chain constructed by corner-sharing connected PO 4 and TeO 4 tetrahedra. Meanwhile, we obtained a new phase of Cd 3 (PO 4 ) 2 and Cd 1.725 Mg 1.275 (PO 4 ) 2 in the exploration of tellurite-phosphates, and they also crystalize in the centric space group P 2 1 / c . Crystal structures, theoretical calculations on their electronic structure and birefringence have been studied, together with the IR and UV-vis-NIR diffuse reflectance spectra.
研究领域:
材料科学
·
化学
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DOI
高影响因子
危险品化学品经营许可证（带存储）