查找使用阿拉丁产品的科研文献

5-Bromocytidine protects against hyperuricemia-induced renal injury by suppressing TLR4/NF-κB-mediated inflammation

Menghan Wang,Liang Han,Dong Tian,Xinrui Meng,Zhanghui Guan,Zhuozhou Hu,Jia Kang,Xiaoshan Gao,Yixuan Zhang,Youquan Gu,Xiaohua Liu,Xinping Chen

Hyperuricemia (HUA), a prevalent metabolic disorder, is an independent risk factor for chronic kidney disease (CKD). Elevated serum uric acid (UA) level leads to renal UA deposition, causing kidney inflammation, impairing renal function, and accelerating HUA progression. In this study, an inflammation model in RAW264.7 cells induced by monosodium urate (MSU) was established to screen for compounds resistant to MSU-induced inflammation. Fortunately, 5-bromocytidine, a nucleic acid analogue, demonstrated potent anti-inflammatory activity in MSU-treated RAW264.7 cells and exhibited excellent therapeutic effects in HUA rats by reducing serum UA, creatinine (CRE) and blood urea nitrogen (BUN) amounts. Furthermore, we found that 5-bromocytidine blocked the activation of TLR4/NF-κB signaling pathway which mediated inflammation, and downregulated the expression of IL-1β and NLRP3. In summary, 5-bromocytidine may ameliorate HUA by suppressing the renal TLR4/NF-κB signaling pathway, suggesting a new candidate compound for HUA therapy.

Catalytic oxidation of 5-hydroxymethylfurfural to 2,5-furandicarboxylic acid over Ru/hydrotalcite with tunable basicity

Lin Li,Baichuan Wang,Jie Li,Zhiyong Su,Yunzhao Fan,Haimei Xu,Lu Lin,Yuanshuai Liu

The aerobic oxidation of biomass-derived 5-hydroxymethylfurfural (HMF) represents an efficient and sustainable approach to produce 2,5-furandicarboxylic acid (FDCA), which serves as a potential renewable building block in the manufacturing of bio-polymers. However, this process typically requires the use of homogeneous basic additives (e.g., NaHCO 3 , Na 2 CO 3 , NaOH, etc.), which compromises its efficiency and environmental sustainability. Alternatively, the use of solid-base catalysts integrates the advantages of heterogeneous catalysis and basic functionality, thus improving catalytic activity and enabling the efficient separation of products and catalysts. Herein, a series of hydrotalcite-supported Ru-based catalysts with different divalent metal cations (M = Mg, Ca, Zn) and M/Al molar ratios were prepared and then devoted to the “base-free” aerobic oxidation of HMF. The catalytic performance of the Ru/hydrotalcite catalysts was found to be significantly affected by the structural parameters of hydrotalcite. Notably, the optimized Ru/Mg 2 Al with Mg/Al molar ratio of 2 can afford ∼99.9% HMF conversion and ∼ 93.5% yield of FDCA at 100 °C and 5 MPa air, along with excellent stability. A systematic investigation revealed that appropriate amounts of basic sites in the Ru/hydrotalcite could effectively accelerate the oxidation of HMF and simultaneously minimize the over-oxidation of FDCA, leading to the high yield of FDCA.

Unveiling Multi-Component Synergy in a Multiphase Medium-Entropy Oxide for Efficient 5-Hydroxymethylfurfural Electrooxidation

Jianguo Dong,Ru Wan,Xuefei Wang,Hongting Liu,Ju Wang,Jing Li,Wenyi Tan,Xiaoyan He,Zhao Li,Lin Tian

Abstract The electrocatalytic oxidation of 5-hydroxymethylfurfural (HMFOR) offers a viable route for converting biomass derivatives into high-value chemicals. However, developing non-noble metal electrocatalysts that combine low onset potential, high current density, and long-term stability remains challenging. Herein, multiphase medium-entropy self-supported electrocatalysts NiCoWMoOx/NF, composed of NiO, Co3O4, WO3, and MoO3, was delicated designed and successfully constructed. The NiCoWMoOx/NF achieves an current density of 5 mA cm–2 at 1.23 V (vs RHE) and a maximum current density exceeding 800 mA cm–2. At 1.45 V vs RHE, NiCoWMoOx/NF delivers 98.8% HMF conversion, 97.67% FDCA selectivity, and 96.66% faradaic efficiency, while retaining over 90% of its initial activity after nine consecutive cycles. Combining ex-situ and in-situ characterization techniques, the synergistic roles of each component in the reaction were elucidated: NiO primarily contributes to optimizing the electronic state of Co; WO3 mainly improves the electrical conductivity; and the partial leaching of MoO3 during the electrocatalytic process facilitates the in-situ exposure of more Co active sites. The synergy of these three components enables the efficient conversion of low-valence Co into a highly active and stable CoOOH phase, thereby endowing NiCoWMoOx/NF with superior HMFOR performance. This work provides a referable material and mechanistic strategy for the rational design of high-performance biomass electrocatalysts.

Electrooxidation of 5-hydroxymethylfurfural and electroreduction of nitrobenzene by hollow CoFeP cubes/rGO/Ni foam

Xinheng Li,Lei Qi,Wanfei Li,Mei Wang,Jianbin Xue,Muzi Chen,Guixin Wang

Electrocatalytic oxidation of 5-hydroxymethylfurfural (HMF) into 2,5-furandicarboxylate (FDCA) has attracted great attention due to its potential for producing degradable plastics. But, HMF electrooxidation still faces challenges such as high overpotentials and sluggish kinetics. Meanwhile, H2 evolution at the cathode is less cost-effective than cathodic reactions producing valuable chemicals. In view of this, a MOF-derived CoFeP cube anchored on rGO-encapsulated nickel foam (NF) via a facile wet-chemical method is reported. The CoFeP–rGO catalyst delivers a low potential of 1.38 V at a current density of 100 mA cm−2 in 1 M KOH containing 10 mM HMF, achieving ∼100% conversion, a 96% yield of FDCA, and 100% Faraday efficiency (FE). It acts as a bifunctional catalyst, demonstrating electrocatalytic reduction of nitrobenzene (NB) at low overpotential with 91% conversion. In the proposed mechanism, the CoFeP–rGO interface is proved to play a crucial role in increasing the catalytic activity via promoting dispersion of the CoFeP nanocrystals on the substrate and accelerating the electron transfer rate across the interface.

Acid-degradable polymer-driven sustainable assembly of catalytically efficient single-crystalline hierarchical ZSM-5 zeolites

Lilong Zhang,Xiaoling Chen,Yuan Hu,Jie Shi,Jiajia Ding,Linyu Zhou,Qingyan Cui,Tiesen Li,Yuanyuan Yue

Despite single-crystalline hierarchical zeolites exhibit catalytic promise, their synthesis still necessitates energy-intensive and environmentally detrimental high-temperature calcination to remove organic templates. Herein, we introduce a sustainable approach for synthesizing large-sized single-crystalline hierarchical ZSM-5 using an acid-degradable polymer (ADP) as a versatile template. The ADP not only facilitates the formation of ZSM-5 with a broad range of n(SiO 2 )/n(Al 2 O 3 ) ratios and tunable mesoporosity but also undergoes complete removal from the zeolite during the Na-to-H acid exchange without calcination. Mechanistic investigations reveal that ADP induces the formation of ZSM-5 framework by interacting with hydroxyl groups and Q 2 /Q 4 Si species while simultaneously guiding the ordered assembly of nanocrystals to achieve a single-crystalline and hierarchical structure. Notably, ADP, acting as a hard template, remains embedded within the hierarchical pores during crystallization. Life cycle assessment (LCA) demonstrates that this strategy significantly reduces environmental impacts when compared to traditional synthesis methods. The resulting zeolite shows superior thermal stability and enhanced mass transport properties due to its unique single-crystalline and hierarchical structure, translating to exceptional catalytic performance in low-density polyethylene pyrolysis and methanol-to-propylene reactions. This work offers an eco-friendly paradigm for zeolite fabrication by leveraging ADP’s availability, low cost, and acid degradability, and aligns with green chemistry principles.

Selective formation of aromatics through CO2 hydrogenation over HZSM-5 cladded FeK core–shell catalyst

Haripal Singh Malhi,Bantayehu Uba Uge,Lenka Matějová

The selective hydrogenation of CO 2 to produce aromatics presents an intriguing approach for carbon utilization and the formation of high-value chemicals. This study presents a novel core–shell FeK@HZSM-5 catalyst, developed by cladding HZSM-5 zeolite onto a K-promoted Fe oxide core, to enable the direct conversion of CO 2 into aromatics. Under optimum reaction conditions (320 °C, 2.0 MPa, H 2 /CO 2  = 3), the FeK@HZSM-5 catalyst accomplishes 43.2 % selectivity for aromatics at 31.1 % conversion of CO 2 , outperforming the physically mixed FeK-HZSM-5 catalyst (aromatics selectivity: 31.8 %) while keeping CH 4 selectivity below 12 %. Mechanistic investigations reveal that the reaction follows a tandem RWGS-FTS pathway, with olefins serving as crucial intermediates. Robust interactions between Fe and zeolite enhance the stability of active Fe 5 C 2 phases and graphitic carbon, promoting olefin chain growth while inhibiting methanation. The appropriate density of Brønsted acid sites facilitates efficient aromatization, whereas an excess of acidity and increased shell thickness result in over-hydrocracking. The FeK@HZSM-5 catalyst exhibits a notable improvement in CO 2 adsorption capacity, attributed to the occurrence of increased oxygen vacancies and higher surface basicity, which facilitates effective CO 2 activation. The confinement effect of the zeolite shell further modulates intermediate diffusion and water retention. A FeK-to-HZSM-5 wt ratio of 1:2 provides the optimal structural and chemical balance. The catalyst exhibits remarkable stability after 100 h of operation with minimal coke deposition, emphasizing its promise for industrial CO 2 -to-aromatics conversion.

PreTA-mediated metabolism of 5-fluorouracil by intratumoral Citrobacter freundii drives chemoresistance in pancreatic cancer

Weiben Xu,Ying Zhou,Haiying Ding,Mengqian Ye,Shujing Li,Linwei Xu,Xiangyu Jin,Zhajun Zhan,Lulu Song,Yuhua Zhang,Canming Wang,Zhengqin Zhu,Liefeng Ma,Libin Pan,Luo Fang

Pancreatic cancer is highly malignant, and while fluoropyrimidines (5-fluorouracil [5-FU] and capecitabine) are critical first-line treatments for metastatic cases, drug resistance remains a major challenge. In this study, we identified an association between Citrobacter enrichment in pancreatic tumors and poor overall survival in patients with pancreatic cancer, particularly in patients receiving fluoropyrimidine-based treatment. Co-culture of 5-FU with the Citrobacter freundii strain isolated from pancreatic cancer and intratumoral injection of this strain in xenograft models significantly reduce the antitumor efficacy of 5-FU. Subsequent analyses using mass spectrometry, bioinformatics, and gene knockout experiments revealed that C. freundii strain inactivates 5-FU via the PreTA, which is homologous to human dihydropyrimidine dehydrogenase (DPD). Gimeracil, a DPD inhibitor, preserves the efficacy of 5-FU by blocking PreTA activity. Other preTA -harboring bacteria also metabolized 5-FU, indicating broader bacteria-mediated 5-FU resistance. These findings reveal a potential microbiome-driven mechanism of chemotherapy failure and identify PreTA as a druggable target.

DNA damage protection and 5-lipoxygenase inhibiting activity of areca (Areca catechu L.) inflorescence extracts

W Chen,C Zhang,Y Huang,F Cheng,S Zhao,Y Shen,J Liu

Pillar[5]arene-enabled dual regulation of interfacial polymerization for high-performance reverse osmosis membranes

Ziyang Guo,Weihao Zhang,Yue Sun,Chenchen Tan,Chen Zhao,Na Chang,Yanyan Liu,Qinglei Zhang,Haitao Wang

A macrocyclic pillar[5]arene is introduced as an interfacial polymerization regulator. • MPD diffusion is reduced while interfacial reactivity is suppressed. • Controlled polymerization yields a thinner and more compact PA layer. • Enhanced RO performance with maintained water permeance. The interfacial polymerization (IP) of m -phenylenediamine (MPD) and trimesoyl chloride (TMC) is widely used to fabricate polyamide (PA) reverse osmosis (RO) membranes, yet its ultra-fast and diffusion-limited nature leads to poor controllability of the PA structure. Herein, a dual kinetic and thermodynamic regulation strategy is proposed using a macrocyclic additive, per-sulfonated pillar[5]arene (P[5]-SO 3 ), to control the IP process. The introduction of P[5]-SO 3 lowers the aqueous-phase pH and alters the interfacial reaction equilibrium, while its bulky structure suppresses MPD diffusion. This dual regulation enables the formation of a thinner and more highly crosslinked PA layer. As a result, the optimized membrane achieves significantly improved NaCl rejection (99.51%) compared to the pristine membrane (95.65%) while maintaining higher permeance (3.81 L m −2  h −1  bar −1 ), along with enhanced antifouling performance. This work provides a new strategy for precise control of interfacial polymerization toward high-performance RO membranes.

Temperature-Responsive Deep Eutectic Solvents for Highly Selective Separation of 5-Hydroxymethylfurfural from Reaction Mixture

Dazhen Xiong,Yang Wang,Huihui Ma,Lige Lu,Qian Zhang,Yunlei Shi,Yang Zhao,Jianji Wang

5-Hydroxymethylfurfural (HMF) is a key biobased platform compound for the production of high-value chemicals and fuels. However, separation and purification of HMF is currently the bottleneck for HMF production. In this work, a novel class of temperature-responsive deep eutectic solvent (DES)–water systems have been explored to selectively separate HMF from reaction mixtures. The fructose dehydration reaction was conducted in homogeneous DES–H2O systems, and then, the produced HMF was migrated to the DES-rich phase while the unreacted fructose was retained in the H2O-rich phase upon cooling. Thus, selective separation of HMF was realized. It was found that water–water and DES–DES interactions predominate over DES–water interactions during cooling, thus resulting in upper critical solution temperature phase separation. Under optimal conditions, the partition coefficient and separation factor of HMF could reach up to 78 and 609, respectively, which is about 5 and 13 times those reported in ionic liquid-based aqueous biphasic systems. Furthermore, HMF could be removed from the DES-rich phase, giving a high recovery efficiency of 69%, which is much higher than the best value reported in the literature. At the same time, DES was regenerated and reused in the next process, and no obvious decrease in partition coefficient of HMF was observed after six cycles.

Highly Efficient and Selective Preparation of 5-Hydroxymethylfurfural from Concentrated Carbohydrates Using Deep Eutectic Solvents

Xusheng Guo,Haoxiang Zhu,Yuxi Si,Heng Ban,Xilei Lv,Youwei Cheng,Lijun Wang,Xi Li

Converting carbohydrates to 5-hydroxymethylfurfural (HMF) is an important goal for biorefinery. Although various deep eutectic solvents (DESs) have been reported for HMF production, the field lacks systematic research on the effect of cations and anions and an effective catalytic system for converting concentrated carbohydrates. Here, 12 kinds of DESs containing four cations and six anions were systematically evaluated and tetraethylammonium bromide (TEAB) was confirmed as the most effective DES, which provided HMF yields of 90 and 76% from fructose and glucose, respectively. The stable bromide-substituted intermediate may explain the positive effect of bromide based on the results of density functional theory calculation. A high concentration substrate has an adverse impact on the selectivity of HMF due to the HMF concentration caused by glucose, CrCl3·6H2O, and concentrated HMF. To inhibit the condensation, a biphasic system of TEAB/THF is developed to convert a highly concentrated glucose of 62.5 wt % (83.3 wt % with respect to TEAB), providing an excellent HMF yield of 72%. This study has revealed the impact of cations and anions of DESs on HMF production, which will serve as a base for designing task-specific DESs. Moreover, an efficient catalytic system to produce HMF from concentrated glucose was also provided.

Hierarchical gallium-modified ZSM-5@SBA-15 for the catalytic pyrolysis of biomass into hydrocarbons

Xiaocui Wei,Yanan Liu,Yang Cao,Jin Li,Xianghao Meng,Zhao Zhang,Zhongyi Jiang

The catalytic pyrolysis of biomass is a sustainable approach for biofuel production, contributing to replacing fossil resources with renewable resources . The ZSM-5 zeolite remains an attractive catalyst in the catalytic pyrolysis of biomass, and how to reduce the product diffusion resistance and regulate the surface acidity of ZSM-5 should be explored more deeply. Herein, a hierarchical gallium-modified ZSM-5@SBA-15 catalyst is fabricated through coating a mesoporous layered SBA-15 shell on a hollow ZSM-5 core with gallium modified on the surface, which is effective for increasing hydrocarbon production during the catalytic pyrolysis of biomass process. The synergistic effect of hollowness, mesoporosity, and activity in the hierarchical gallium-modified ZSM-5@SBA-15 catalysts is found to affect the yield and quality of bio-oil. Accordingly, the hierarchical gallium-modified ZSM-5@SBA-15 catalyst with 11 wt% Ga loading exhibits a superior deoxygenation ability, and the relative content of hydrocarbons in bio-oil reach to 49.76 area% which is much higher than that of ZSM-5 (35.30 area%). Furthermore, a possible catalytic pyrolysis mechanism of biomass was also proposed to clarify the potential application of hierarchical gallium-modified ZSM-5@SBA-15 catalysts.