THERMOCHIMICA ACTA
·
2016
·
IF 1.938
Lipeng Wang,Fucheng Zhang,Yongping Bai,Liping Ding
The kinetic of non-isothermal crystallization of Poly (ethylene terephthalate-co-sodium-5-sulfo- iso -phthalate) (PETI) was investigated using differential scanning calorimetry (DSC). Various macrokinetic models namely the Avrami, Tobin, Ozawa, and Ziabicki were used to describe the non-isothermal crystallization process of PETI. Both of the Avrami crystallization rate constant and the Tobin crystallization rate constant were observed to increase with increasing cooling rate. The Avrami model is better than the Tobin model to describe the non-isothermal crystallization process of PETI. The Ozawa crystallization rate K O was found to decrease with increasing cooling rate, while Ziabicki’s kinetic crystallizability parameter G Z was found to increase with increasing cooling rate. The effective energy barrier △E for non-isothermal crystallization process of PETI, analyzed based on the differential iso-conversional method of Friedman, was found to be an increasing function of the relative crystallinity.
研究领域:
高分子化学
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材料科学
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物理化学
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热分析
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聚合物结晶
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PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
·
2026
·
IF 7.8
Yongning Chen,Yin Wang,Xiaoxuan Guo,Jianan Li,Yijie Jiang,Wenbo Sun,Wenlong Sun,Chong Peng
The electrocatalytic oxidation of 5-hydroxymethylfurfural (HMF) is an effective method to produce high-value-added chemicals with low energy consumption. In this work, we prepared a highly efficient electrocatalyst by incorporating Cr-doped NiFe layered double hydroxide nanosheets supported on nickel foam (NiFeCr-LDH/NF). For the HMF oxidation reaction (HMFOR) in 1 M KOH electrolyte, the NiFeCr-LDH/NF catalyst achieves an exceptional current density of 100 mA cm -2 at a low potential of 1.47 V vs . reversible hydrogen electrode (RHE). Critically, it exhibits a high 2,5-furandicarboxylic acid (FDCA) yield of 93.8% and a Faradaic efficiency of 91.5%. Furthermore, in situ Fourier transform infrared spectroscopy (FTIR) studies and transient electrochemical measurements were carried out to investigate the mechanism in the HMFOR. Precisely controlled Cr doping can effectively modulate the synergistic adsorption equilibrium between HMF and hydroxyl intermediates, thereby enhancing electrocatalytic reaction efficiency via optimized interfacial charge transfer dynamics. This work illustrates heteroatom engineering as a powerful strategy for designing efficient electrocatalysts, enabling efficient biomass valorization.
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RUSSIAN JOURNAL OF GENERAL CHEMISTRY
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2026
·Vol. 95
·期 12
·3886-3902
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IF 0.8
Lv Yingmei,Shi Lele,Luo Xi,Huang Yuhang,Du Zhenting
Thiazolidine-2,4-dione (TZD), a privileged scaffold, is a versatile pharmacophore and outstanding sulphur-containing heterocyclic compound found in various drugs. In this work, forty-two substituted 5-arylidene-1,3-thiazolidine-2,4-diones derivatives have been designed and synthesized by introducing sulfonyl groups, benzoyl groups, and amide groups into 5-(3/4-hydroxybenzylidene)thiazolidine-2,4-dione through Knoevenagel condensation, and their antibacterial activities were evaluated in vitro. As a result, thirty-five compounds were new compounds, and seven compounds were known compounds. The in vitro assay results disclosed that compared with B/C-series, A-series compounds presented remarkable antimicrobial activity against S. aureus, E. faecalis , and E. faecium . All twenty-one synthesized A-series compounds exhibited excellent antibacterial activity against S. aureus (MIC 80 ≤ 128 µg/mL). Among these, three compounds demonstrated the highest anti- E. faecalis activities (MIC 80 = 8 µg/mL), while E. faecium showed antibacterial susceptibility to A-series compounds except two of the investigated compounds p -cyanophenyl and p -trifluoromethoxyphenyl substituted sulfonate esters. In contrast, the B-series displayed limited activity, with only three compounds showing measurable anti- S. aureus effects, among which substituted phenyl benzoates exhibited the best antibacterial action against E. faecium (MIC 80 = 64 µg/mL). The C-series compounds demonstrated the weakest activity profile, with two N -substituted acetamides ( N -phenyl and N -methylphenyl) displaying moderate anti- S. aureus activity (MIC 80 = 128 µg/mL), which merely compound N - o -nitrophenyl was sensitive to E. faecalis (MIC 80 = 256 µg/mL). SAR analysis revealed that synthetic TZD-derivatives with substituted sulfonyl groups significantly enhanced antibacterial activity against all tested Gram-positive bacterial strains. These molecules may serve as lead compounds for developing more effective and less toxic antibacterial agents.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.5
Liu Nianci,Li Te,Li Shunmei,Feng Xiaofan,Zhang Zhuorui,Jiang Guiquan
To address the low bioavailability of polymeric proanthocyanidins (PPCs) in larch tannin, we developed a bimetallic catalyst, (Pd 1 –Cu 1 ) 5 /ZrO 2 , to convert PPCs into bioactive oligomeric proanthocyanidins (OPCs) via catalytic depolymerization. SEM, XRD, and XPS characterization indicate a high specific surface area and Pd-Cu synergistic active sites; combined with ZrO 2 solid acid sites, these features enhance substrate adsorption and C C bond cleavage. Single-factor optimization showed that under 0.05 g catalyst, 4 MPa H 2 , 140 °C and 3 h, the average degree of polymerization decreased from 9.5 to 2.48, corresponding to a 74 % degradation rate. The degradation products exhibited markedly improved antioxidant activity in DPPH and ABTS + assays.
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DOI
PubMed
高影响因子
WATER SCIENCE AND TECHNOLOGY
·
2015
·Vol. 72
·期 5
·696-703
·
IF 1.106
Liu Yanfang,Zhao Junna,Li Zaixing,Li Guixia,Li Wei,Gao Xiang
Mixed manganese and cerium oxide supported on HZSM-5 were synthesized and used as heterogeneous catalysts for ozonation of bisphenol A (BPA) in aqueous solution. The prepared catalysts of Mn-Ce/HZSM-5 were characterized by X-ray diffraction, scanning electron microscopy and Fourier transform-infrared spectroscopy. The results indicated that Mn-Ce/HZSM-5 exhibits extraordinary catalytic activity for the degradation of BPA. Removal of 89.3% of BPA and 90.4% of total organic carbon (TOC) was achieved in 30 min, compared to non-catalytic ozonation, where only 50.5% BPA and 28.1% TOC removal were reached under the same conditions. Adsorption of BPA on HZSM-5 support and Mn-Ce/HZSM-5 catalysts was negligible. The strong inhibition of BPA removal by tert-butyl alcohol indicated that the attack of hydroxyl radicals was responsible for the improvement of catalytic ozonation. It was observed that at neutral pH, which is near the point of zero charge of the catalyst, the catalytic activity reached its maximum. Increasing the amount of Mn-Ce/HZSM-5 catalyst until it exceeded 3 g/L did not show a strong effect on BPA removal. The catalysts showed high stability and reusability.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Kang Guo,Chengliang Tang,Ling Cen,Lei Liu,Hanzi Liu,Zhiqiang Sun
Bimetallic CrGaO x /ZSM-5 catalyst balances activity-selectivity trade-off in propane dehydrogenation. • Ga species modulates the Cr-O-Cr coordination environment, facilitates C H bond activation and simultaneously stabilizes the Cr 6+ /Cr 3+ redox cycle. • In-situ DRIFTS reveals Cr Ga synergy promotes propyl intermediate formation at low temperature. • O 2 regeneration effectively restores Cr 6+ active sites and removes coke deposits, ensuring sustained catalytic performance. Developing highly active and stable catalysts for propane dehydrogenation (PDH) is crucial for propylene production, yet it is normally hampered by the trade-off between C 3 H 8 conversion and C 3 H 6 selectivity. Herein, we construct a series of bimetallic CrGaO x /ZSM-5 catalysts to mitigate this intrinsic challenge. The optimized Cr 3 Ga 3 O x /ZSM-5 catalyst achieves a propane conversion of 38.7% with a propylene selectivity of 84.3% at 600 °C and maintains stable propylene productivity over 40 h of continuous operation. Results reveal that Ga 3+ incorporation modifies the Cr-O-Cr coordination environment, thus enhancing propane activation and formation of propyl intermediates. The structural modification suppresses Cr 3+ over-reduction to Cr 0 , maintaining the Cr 6+ /Cr 3+ redox cycle over extended reaction periods. Furthermore, O 2 regeneration effectively removes coke deposits and restores active sites. This work provides mechanistic insights into the Cr Ga electronic and structural synergy and offers a design strategy for stable chromium-based PDH catalysts. The incorporation of Ga 3+ modulates the Cr-O-Cr coordination environment, facilitating C H bond activation while suppressing undesired C C bond cleavage, and simultaneously stabilizes the Cr 6+ /Cr 3+ redox cycle by preventing over-reduction of Cr 6+ to inactive Cr 0 . O 2 -mediated regeneration effectively restores active Cr 6+ sites and removes coke deposits, enabling a reversible deactivation-regeneration cycle. The optimized Cr 3 Ga 3 O x /ZSM-5(300) catalyst achieves a propane conversion of 38.7% with a propylene selectivity of 84.3% at 600 °C under standard conditions, and delivers a superior performance of 62.1% conversion with 90.6% selectivity under lower WHSV. Download: Download high-res image (126KB) Download: Download full-size image
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PEST MANAGEMENT SCIENCE
·
2026
·
IF 4.2
Chunlan Li,Yuandong Liu,Yuxin Huang,Fanqi Meng,Jing Zhang,Lixin Zhang
BACKGROUND Asian soybean rust caused by Phakopsora pachyrhizi ( P. pachyrhizi ) poses a serious threat to global soybean production, and resistance to conventional fungicides is increasing. Therefore, new fungicides with novel modes of action are urgently needed. This study aimed to design and optimize potent 5-(trifluoromethyl)-1,2,4-oxadiazole (TFMO) derivatives inspired by fungal histone deacetylase inhibition. RESULTS Forty-two TFMO derivatives were synthesized through bioisosteric modification and linker optimization. Among them, FM-17888 showed the highest activity against P. pachyrhizi , with an EC 50 value of 0.0583 mg·L −1 , approximately eightfold lower than that of flufenoxadiazam. Under the tested greenhouse conditions, FM-17888 also showed good crop safety and selective activity against Puccinia triticina . Molecular docking and DFT analyses suggested that its improved activity may be associated with favorable binding geometry, additional π -sulfur interactions, and a reduced HOMO-LUMO energy gap. CONCLUSION FM-17888 is a potent and selective TFMO lead compound for soybean rust control. Together with the greenhouse bioassay, docking, and DFT results, these findings support FM-17888 as a promising candidate for further development against rust diseases, while direct target-validation studies are still needed to confirm its precise mode of action. © 2026 Society of Chemical Industry.
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ACS Catalysis
·
2026
·
IF 13.6
Li Guixian,Jin Gang,Wang Chenjing,Zhong Dazhong,Li Jinping,Zhao Qiang
Cobalt-based catalysts have been reported to electrocatalyze the oxidation of 5-hydroxymethylfurfural (HMFOR) to high-value-added chemicals. However, generating highly active Co 3+ OOH at low potential remains a grand challenge. In this paper, we describe the electronegative metal-doped cobalt metal-organic frameworks (Co-MOFs) that facilitate the formation of Co 3+ OOH for efficient HMFOR. Electrochemical measurements and in situ characterization reveal that the introduction of electronegative metals and the use of MOF facilitate cobalt oxidation and enhance hydroxyl adsorption, thereby promoting C–OH bond activation and yielding more free water, contributing to the HMFOR performance. The obtained CoNi-BDC delivers a low potential of 1.14 V vs RHE at 10 mA cm –2 and a high current density of 560 mA cm –2 at 1.48 V vs RHE, with a Faradaic efficiency (FE) of 95% for 2,5-furandicarboxylic acid (FDCA), and favorable cycling stability. The work provides insight into promoting Co 3+ OOH formation for advancing the electrocatalytic conversion of biomass.
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Cell Reports
·
2025
·
IF 6.9
Weiben Xu,Ying Zhou,Haiying Ding,Mengqian Ye,Shujing Li,Linwei Xu,Xiangyu Jin,Zhajun Zhan,Lulu Song,Yuhua Zhang,Canming Wang,Zhengqin Zhu,Liefeng Ma,Libin Pan,Luo Fang
Pancreatic cancer is highly malignant, and while fluoropyrimidines (5-fluorouracil [5-FU] and capecitabine) are critical first-line treatments for metastatic cases, drug resistance remains a major challenge. In this study, we identified an association between Citrobacter enrichment in pancreatic tumors and poor overall survival in patients with pancreatic cancer, particularly in patients receiving fluoropyrimidine-based treatment. Co-culture of 5-FU with the Citrobacter freundii strain isolated from pancreatic cancer and intratumoral injection of this strain in xenograft models significantly reduce the antitumor efficacy of 5-FU. Subsequent analyses using mass spectrometry, bioinformatics, and gene knockout experiments revealed that C. freundii strain inactivates 5-FU via the PreTA, which is homologous to human dihydropyrimidine dehydrogenase (DPD). Gimeracil, a DPD inhibitor, preserves the efficacy of 5-FU by blocking PreTA activity. Other preTA -harboring bacteria also metabolized 5-FU, indicating broader bacteria-mediated 5-FU resistance. These findings reveal a potential microbiome-driven mechanism of chemotherapy failure and identify PreTA as a druggable target.
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DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2012
·Vol. 39
·期 4
·3915-3919
·
IF 1.751
Junxia Wang,Hengchang Nie,Chunfeng Lan,Genshui Wang,Xianlin Dong,Xuefeng Chen,Fei Cao,Hongliang He
Porous Pb (Zr 0.95 Ti 0.05 ) O 3 / x MgO (PZT/MgO, x =0, 0.1, 0.2, 0.5 and 1.0 wt%) ferroelectric ceramics were prepared with MgO nanoparticles as reinforcing phase. The effects of MgO nanoparticles on the phase, microstructure, electrical and mechanical properties of as-prepared ceramics were investigated. The results show that the grain size is reduced obviously when increasing the amount of MgO. Compared with pure porous PZT, T C of MgO-added PZT ceramics shifts to higher temperature. Moreover, dielectric, ferroelectric and piezoelectric properties show no much degradation. Further, PZT/MgO ceramics possess enhanced mechanical properties compared to pure porous PZT ceramics, the largest increment of the fracture toughness and hardness being 31.3% and 19.8%, respectively. The optimal electrical and mechanical properties are obtained with the addition of less than 0.5 wt% MgO nanoparticles.
研究领域:
材料科学
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无机非金属材料
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功能陶瓷
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电子材料
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固态物理
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纳米复合材料
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DOI
高影响因子
RENEWABLE ENERGY
·
2023
·
IF 8.7
Yixuan Yu,Huai Liu,Junhua Zhang,Heng Zhang,Yong Sun,Lincai Peng
Designing highly efficient non-noble metal catalyst for the selective hydrogenolysis of biomass derivatives to fuels and fine chemicals is a key pursuit for sustainable chemical industry but substantially challenging. In this contribution, we report, for the first time, the construction of amorphous bimetal Ni–Fe borides for efficient catalytic hydrogenolysis of biomass-derived 5-hydroxymethylfurfural (HMF) into 2,5-dimethylfuran (DMF) as a promising biofuel candidate. The as-prepared Ni 1.52 Fe 0.36 BO x catalyst afforded a near-quantitative DMF yield using ethanol as a green solvent under relatively mild operating conditions (1 MPa H 2 , 160 °C and 1 h), leading to an excellent DMF formation rate of 16.5 mmol DMF ·g cat −1 ·h −1 , which is 1.7–16.5 folds higher than the state-of-art nickel-based catalysts. Mechanistic investigations demonstrated that the Fe intervention is conductive to the generation of electron-enriched metal sites and powerful acidic sites in Ni 1.52 Fe 0.36 BO x catalyst, which favored the activation of hydrogen and the cleavage of C–O bond to accelerate the hydrogenolysis process. Moreover, Ni 1.52 Fe 0.36 BO x catalyst exhibited good recyclability as well as universality in the hydrogenolysis of various biomass-derived unsaturated aldehydes. This finding opens a new avenue for highly selective hydrodeoxygenation of renewable biomass feedstock to value-added chemicals with non-noble bimetal hybrids in a green and straightforward manner.
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GREEN CHEMISTRY
·
2023
·Vol. 25
·期 12
·4781-4792
·
IF 9.8
Chunxiao Gong,Zhaoyang Ju,Kuichuan Sheng,Ximing Zhang
Improper disposal of large quantities of crustacean shell waste from the food industry has caused serious environmental problems and waste of resources. Shell biorefinery is an emerging concept that upcycles the major components of crustacean shell waste, such as chitin, into value-added chemicals and materials. Producing biomass-derived 5-hydroxymethylfurfural (HMF) has been a hot topic over the past decades, while efficient conversion of shell-derived chitin into HMF is not available due to its water-insoluble and chemically-stable features. Herein, we develop a sustainable and efficient HMF production route from chitin. Chitin was treated with formic acid under mild conditions to synthesize formylated chitin (FC), which was subsequently converted to HMF in dimethyl sulfoxide (DMSO)–H2O media. Results showed that FC achieved a 53.2% HMF yield at 160 °C for 10 min catalyzed by AlCl3 in the co-solvent system (DMSO : H2O = 4 : 1, v/v), which is 11 times higher than the yield obtained from chitin under the same condition. The grafted formyl groups on FC significantly enhanced its noncovalent interactions with DMSO molecules, enhancing the accessibility and reactivity for HMF production. The reaction mechanisms were proposed and simulated with density functional theory calculations, and the intramolecular hydrogen migration is the rate-determining step in the reaction pathways. This study highlights a green and simple approach for chitin valorization.
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