MATERIALS LETTERS
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2017
·
IF 2.572
Xue Yang,Yanjiao Zhao,Hassan Mussana,Mengistu Tessema,Lifang Liu
The chitosan (CS)/cellulose nanocrystal (CNC) (0, 0.2. 0.5, 0.8 and 1 wt%) nanocomposites were applied as modifier, and then deposited on the surface of cotton fabric via a pad-dry-cure method. The morphology, mechanical, hydrophilicity and ultraviolet (UV)-blocking properties of prepared fabrics were carefully investigated. The results showed that CS/CNC could obviously enhance the UV-blocking property of cotton fabric. CS/CNC0.5 fabric exhibited the most excellent UV-blocking property as well as good washing durability after 30 times water laundering, indicating CS/CNC could be used as efficient and durable UV blocker for cotton fabric. In addition, CS/CNC also can increase the mechanical property of cotton fabric; while decrease the hydrophilicity of cotton fabric.
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高影响因子
IONICS
·
2017
·Vol. 24
·期 3
·845-859
·
IF 2.062
Xiao Qi,Feng Mengmeng,Liu Yi,Lu Shuangyan,He Yingzi,Huang Shan
A sensitive and selective electrochemical sensor based on carboxyl graphene (CG), polypyrrole (PPy), and chitosan (CS) nanocomposite-modified glassy carbon electrode (GCE) has been developed for nitrite determination. The electrochemical performances of CG/PPy/CS/GCE were characterized by cyclic voltammetry and electrochemical impedance spectroscopy. Under the optimum experimental conditions, CG/PPy/CS/GCE exhibited excellent differential pulse voltammetry (DPV) response of nitrite. A linear relationship between DPV peak current and the concentration of nitrite was obtained in the range of 0.2 to 1000 μM. The limit of detection of nitrite was estimated to be 0.02 μM. Using such modified electrodes, our method is quite reproducible for nitrite determination, even for real water samples.
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高影响因子
MOLECULES
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2016
·Vol. 22
·期 1
·12
·
IF 2.465
Ping Li,Yangyang Gao,Zijia Sun,Dan Chang,Ge Gao,Alideertu Dong
In response to the wide spread of microbial contamination induced by bacterial pathogens, the development of novel materials with excellent antibacterial activity is of great interest. In this study, novel antibacterial chitosan (CS) and polyhexamethylene guanidine hydrochloride (PHGC) dual-polymer-functionalized graphene oxide (GO) (GO-CS-PHGC) composites were designed and easily fabricated. The as-prepared materials were characterized by Fourier transform infrared (FTIR), X-ray photoelectron spectrometer (XPS), field emission scanning electron microscopy (FE-SEM), transmission electron microscope (TEM), thermogravimetric analysis (TGA) and Raman spectroscopy. Their antibacterial capability towards bacterial strains was also studied by incubating both Gram-negative bacteria and Gram-positive bacteria in their presence. More significantly, the synergistic antibacterial action of the three components was assayed, and the findings implied that the as-prepared GO-CS-PHGC shows enhanced antibacterial activity when compared to its single components (GO, CS, PHGC or CS-PHGC) and the mixture of individual components. Not only Gram-negative bacteria but also Gram-positive bacteria are greatly inhibited by GO-CS-PHGC composites. The minimum inhibitory concentration (MIC) value of GO-CS-PHGC againstE. coliwas 32 μg/mL. With the powerful antibacterial activity as well as its low cost and facile preparation, GO-CS-PHGC has potential applications as a novel antibacterial agent in a wide range of biomedical uses.Keywords:graphene oxide;chitosan;polyhexamethylene guanidine hydrochloride;antibacterial activity
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PubMed
高影响因子
Nanoscale
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2013
·Vol. 5
·期 9
·3982-3991
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IF 6.233
Xiangsheng Liu,Haoyuan Huang,Gongyan Liu,Wenbo Zhou,Yangjun Chen,Qiao Jin,Jian Ji
Surface engineering of nanoparticles plays an essential role in their colloidal stability, biocompatibility and interaction with biosystems. In this study, a novel multidentate zwitterionic biopolymer derivative is obtained from conjugating dithiolane lipoic acid and zwitterionic acryloyloxyethyl phosphorylcholine to the chitosan oligosaccharide backbone. Gold nanoparticles (AuNPs) modified by this polymer exhibit remarkable colloidal stabilities under extreme conditions including high salt conditions, wide pH range and serum or plasma containing media. The AuNPs also show strong resistance to competition from dithiothreitol (as high as 1.5 M). Moreover, the modified AuNPs demonstrate low cytotoxicity investigated by both MTT and LDH assays, and good hemocompatibility evaluated by hemolysis of human red blood cells. In addition, the intracellular fate of AuNPs was investigated by ICP-MS and TEM. It showed that the AuNPs are uptaken by cells in a concentration dependent manner, and they can escape from endosomes/lysosomes to cytosol and tend to accumulate around the nucleus after 24 h incubation but few of them are excreted out of the cells. Gold nanorods are also stabilized by this ligand, which demonstrates robust dispersion stability and excellent hemocompatibility. This kind of multidentate zwitterionic chitosan derivative could be widely used for stabilizing other inorganic nanoparticles, which will greatly improve their performance in a variety of bio-related applications.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2012
·
IF 2.453
Zaiqian Qi,Juan Xu,Zhiliang Wang,Jun Nie,Guiping Ma
Photopolymerizable chitosan derivative was synthesized by chitosan and methyl acroloyl glycine (MAG). The chemical structures and physical properties were characterized by FT-IR, 1 H NMR, XRD and TGA . The thermal stability of chitosan derivative was lower than chitosan. The chitosan derivative was amorphous compared with the high degree crystallization of chitosan. The hydrogels were prepared based on chitosan derivative via photopolymerization with different concentrations of photoinitiator 2959. The surface of hydrogel showed porous network and the pore size distribution tended to become homogeneous with the increase of the concentration of 2959, while the swelling property decreased due to more crosslinking.
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Journal of Materials Chemistry B
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2015
·Vol. 3
·期 45
·8884-8891
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IF 4.726
Xiaoman Li,Bing Han,Xiaoyan Wang,Xuejun Gao,Fuxin Liang,Xiaozhong Qu,Zhenzhong Yang
The treatment of apical periodontitis (AP) remains challenging because traditional root canal therapy (RCT) outcomes are limited by the complexity of the root canal system, drug toxicity, and host immune factors. It is necessary to develop methods to prepare controlled drug release vehicles with improved biocompatibility for treatment of AP. Herein, calcium hydroxide microcapsules with chitosan and ethylcellulose coated (CS–EC@Ca(OH)2 microcapsules) were prepared and the presence of hydrogen bonding between shell materials was observed by FT-IR. Through release assessment and biological assays, we showed that the microcapsules had enhanced controlled-release performance and biocompatibility. In particular, drug release from the microcapsules was pH-triggered. The cumulative release of drugs in pH 5.0 buffer was 8-fold higher than that in pH 7.0 buffer. Furthermore, the microcapsules exhibited prolonged antibacterial activity against refractory strains of Enterococcus faecalis. Additionally, the CS–EC@Ca(OH)2 microcapsules reduced inflammation and promoted osteogenesis, which could be beneficial for the healing of AP with bone defects. Therefore, CS–EC@Ca(OH)2 microcapsules improve the innate properties of Ca(OH)2 and hold potential for AP treatment.
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高影响因子
Nanomaterials
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2015
·Vol. 5
·期 3
·1379-1396
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IF 2.076
Li Zhang,Tingxian Liu,Yanan Xiao,Dexin Yu,Na Zhang
Molecular imaging is essential to increase the sensitivity and selectivity of cancer diagnosis especially at the early stage of tumors. Recently, polyionic nanocomplexes (PICs), which are composed of polyanions and opposite polycations, have been demonstrated to be a promising strategy for biomedical applications. In this work, chitosan-hyaluronic acid nanoparticles (GCHN) were developed to deliver Gd-DTPA as MRI contrast agents for tumor diagnosis. The Gd-labeled conjugates (CS-DTPA-Gd) were successfully synthesized by carbodiimide reaction, and then GCHN were prepared by ionic gelation using the obtained CS-DTPA-Gd and hyaluronic acid. The morphology of GCHN was spherical or ellipsoidal, which is observed by transmission electronic microscopy (TEM). The mean particle size and zeta potential of GCHN were 213.8 ± 2.6 nm and 19.92 ± 1.69 mV, respectively. The significant enhancement of signal intensity induced by GCHN was observed bothin vitroandin vivo. Also, compared with Magnevist, GCHN was witnessed for a prolonged imaging time in the B16 tumor-bearing mice model. Furthermore, GCHN were verified as below toxic bothin vitroandin vivo. These results indicated that GCHN could potentially be an alternative to current MRI contrast agents for tumor diagnosis.Keywords:tumor imaging;magnetic resonance imaging;hyaluronic acid;chitosan nanoparticles;Gd-DTPA
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JOURNAL OF APPLIED POLYMER SCIENCE
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2015
·Vol. 132
·期 37
·
IF 1.768
Hongqiu Wei,Fenghua Zhang,Dawei Zhang,Yanju Liu,Jinsong Leng
With aim of constructing a class of functional environmentally friendly materials, we electrospun chitosan (CS) blends with various contents of poly(ethylene oxide) (PEO) into a series of composite nanofibrous membranes exhibiting shape-memory behaviors. In the present composite system, CS and PEO served as hard and soft domains, respectively. The CS, presenting no thermal transition, and the PEO, with apparent melting–crystallization, were demonstrated by differential scanning calorimetry testing. Characterizations also revealed that the morphologies of the CS/PEO membranes were controlled by the mass ratios of CS/PEO. The composite fibrous membranes showed great mechanical performances and thermal stabilities as well. Moreover, CS/PEO possessed excellent shape-memory behaviors. Such fibrous membranes could complete their shape-recovery processes within 20 s at the temperature of 20°C above the melting transition temperature ( T m ). Both the shape fixity and shape-recovery ratios were higher than 90%, even after five cycles. The CS/PEO fibrous membranes present significant potential applications in the field of biotechnology and tissue engineering, such as in scaffolds and smart tubes. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 42532.
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PLoS One
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2015
·Vol. 10
·期 4
·e0121817
·
IF 3.234
Huiying Chen,Shaohui Cui,Yinan Zhao,Chuanmin Zhang,Shubiao Zhang,Xiaojun Peng
Modifying chitosan (CS) with polyethylenimine (PEI) grafts is an effective way to improve its gene transfection performance. However, it is still a challenge to conduct the grafting with fine control and high efficiency, particularly for the modification of water-insoluble CS. Herein, a novel method to graft CS with PEI (1.8 kDa, PEI-1.8) was developed by using ionic liquid 1-butyl-3-methyl imidazolium acetate ([BMIM]Ac) as a reaction solvent, water-insoluble CS as a reaction substrate and 1,1-carbonyldiimidazole (CDI) as a linking agent. The grafting reaction was greatly accelerated and the reaction time was largely shortened to 4 h by taking advantages of the good solubility of CS, the enhanced nucleophilicity of amino groups and the preferential stability of the activated complexes in the ionic liquid. The chitosan- graft -polyethylenimine (CS- g -PEI) products were characterized by 1 H NMR, FTIR and GPC. PEI-1.8 was quantitatively grafted to CS through urea linkages, and the grafting degree (GD) was conveniently tuned by varying the molar ratios of PEI-1.8 to D-glucosamine units of CS in the range of 9.0 × 10 -3 to 9.0 × 10 -2 . Compared with CS, the synthesized CS- g -PEI copolymers showed higher pDNA-binding affinity, which increased with the GD as shown in Agarose gel electrophoresis. The dynamic light scattering (DLS) experiment demonstrated that the CS- g -PEI/pDNA polyplexes had suitable particle sizes and proper ζ-potentials for cell transfection. The CS- g -PEI copolymer with a medium GD of 4.5% conferred the best gene transfection, with the efficiency 44 times of CS and 38 times of PEI-1.8 in HEp-2 cells. The cytotoxicity of CS- g -PEI was tested and found nearly as low as that of CS and much lower than that of PEI.
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高影响因子
RSC Advances
·
2015
·Vol. 5
·期 120
·98783-98795
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IF 3.84
Yong Lei,Wei Chen,Bin Lu,Qin-Fei Ke,Ya-Ping Guo
Both hydroxyapatite (HAP) and chitosan (CS) powders have good adsorption activity for Pb2+ ions, but it is difficult to separate the adsorbent powders from wastewaters. Herein, we report the bioinspired fabrication of nano-HAP/CS porous materials (HCPMs) according to the following steps: (i) freeze-drying fabrication of brushite (DCPD)/CS porous materials (BCPMs); and (ii) conversion of HCPMs from BCPMs by alkaline solution treatment. The HCPMs possess interconnected three-dimensional (3D) macropores with a pore size of 150–240 μm and a porosity of 93.0%. The nano-HAP rods with a length of ∼500 nm and a diameter of ∼20 nm disperse uniformly within the porous materials. As lead aqueous solutions flow through the HCPMs, the Pb2+ ions are chemically adsorbed on the adsorbents by forming lead hydroxyapatite (PbHAP, Pb10(PO4)6(OH)2) and CS–Pb complex. The conversion mechanism of HAP to PbHAP is a dissolution–precipitation reaction. Notably, the pH values of lead solutions have a great effect on the adsorption capacity of the HCPMs. On decreasing the pH values from 7.0 to 2.5, the experimental equilibrium adsorption amount increases from 208.0 to 548.9 mg g−1. Adsorption kinetics and adsorption isotherm studies reveal that the adsorption of Pb2+ ions on the HCPMs exhibits good compliance with pseudo-second-order kinetic and Langmuir isotherm models. Hence, the HCPMs can be used for the chemical adsorption of Pb2+ ions from wastewater.
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高影响因子
RSC Advances
·
2015
·Vol. 5
·期 38
·30303-30309
·
IF 3.84
Yangling Li,Ying Tan,Kun Xu,Cuige Lu,Xuechen Liang,Pixin Wang
An in situ hydrogel based on oxidation cholesterol starch (OCS) and O-carboxymethyl chitosan (CMCT) that is completely devoid of potentially cytotoxic small molecule cross-linkers and does not require complex manoeuvres or catalysis has been formulated and characterized. The network structure was created by Schiff base formation. The mechanical properties, internal morphology and swelling ability of the injectable hydrogel were examined. Rheological measurements demonstrated that increasing the concentration of the monomer improved the storage modulus. SEM showed that the hydrogel possessed a well-defined porous structure. In addition, the Schiff base reaction was acid sensitive. Under acid conditions, the hydrogel could hydrolyse quickly compared with high pH conditions. Doxorubicin (DOX) was used as a model drug to investigate the control and release properties of the hydrogel. The cytotoxic potential of the hydrogel was determined using an in vitro viability assay with L929 cells as a model and the results revealed that the hydrogel was non-cytotoxic.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2014
·
IF 3.096
Zhen-Hua Cheng,Jun Huang,Sheng Hu,Cheng-Jun Jiang,Qing Ge,Hong-Wu Lai,Jin-Yan Gong,Pei-Long Sun,Jian-Wei Mao,Le-He Mei
Chitosan was prepared by alkaline N -deacetylation of β-chitin and hydroxypropyl derivatives with different degrees of substitution (DS) were synthesized. It was characterized by Fourier transform infrared (FT-IR) and elemental analysis. The DS of hydroxypropyl chitosan (HPCS) calculated by an element analyzer were 0.42, 0.75, 1.20, 1.82 and 2.25. HPCS showed better foam capacity and stability than that of chitosan, and the effectiveness correlated well with the DS of HPCS. The highest bile acid-binding capacity of all five HPCS reached 56.02 mg/g, which was 4.0-fold higher than that of chitosan. The scavenging ability of HPCS against hydroxyl and ABTS radicals improved with increasing concentration. The correlation between the hydroxypropyl content (DS) of HPCS and scavenging ABTS radical ability was positive. The hydroxyl radicals scavenging activity of HPCS correlated well with its increasing concentration, and EC 50 values were below 12.5 mg/mL. These results indicated that hydroxypropylation is a possible approach to obtain chitosan derivatives with desirable physiochemical properties.
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