ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Faisal Ahmad,Yelan Xiao,Tong Shu,Guangyao Zhang,Xueji Zhang
Electrochemiluminescence (ECL) is rapidly emerging as an excellent electrochemical analytical technique for the specific and sensitive detection of various biomarkers and hazardous trace metals. Among ECL emitters, gold nanoclusters (AuNCs) have proven to be excellent luminophores due to their remarkable luminescent properties, stability, and biocompatibility. However, the low ECL efficiency of AuNCs precludes their application in ultrasensitive biosensing. One of the key reasons for the low ECL efficiency of AuNCs is the nonradiative energy transitions arising from intramolecular vibrations and rotations of the ligands on the surface of AuNCs. Herein, we explore the ECL of Zn2+/Au22(SG)18/PDA nanoclusters (NCs), where Zn2+ and 2,6-pyridinedicarboxaldehyde (PDA) activate the restriction of intramolecular motion (RIM) through aggregation-induced emission (AIE) to aggregation-induced enhanced emission (AIEE). This effect is achieved via cross-linking of Zn2+ and PDA with glutathione on the surface of Au22(SG)18, resulting in a significant enhancement of ECL emission compared to Au22(SG)18 NCs alone. A sensitive ECL sensing system was devised with Zn2+/Au22(SG)18/PDA as the ECL emitter, with triethylamine (TEA) as the coreactant, for the detection of Cu2+ and histidine in the linear ranges of 0.1 to 40 μM and 1 to 85 μM, respectively, with detection limits of 0.705 and 1.928 μM, respectively.
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PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2024
·
IF 5.7
Linxiu Zhao,Junli Shi,Yongzheng Liu,Mingfeng Han,Shengling Li,Duanlin Cao
Background In recent years, environmental pollution has been increasing due to the excessive emission of toxic ions, which has caused serious harm to human health and ecological environment. There are various methods for detecting Cu 2+ , S 2− and Zn 2+ , but the traditional ion detection methods have obvious disadvantages, such as poor selectivity and long detection time. Therefore, it is still crucial to develop simple, efficient and rapid detection methods. Results A fluorescent probe based on benzothiazole, ( E )- N '-(3-(benzo[ d ]thiazol-2-yl)-2-hydroxy-5-methylbenzylidene)-3,4,5-tris(benzyloxy)benzohydrazide ( BT ), was designed and synthesized. It was characterized using ESI-MS, 1 H NMR, and 13 C NMR. BT can be used as a chemosensor to detect Cu 2+ , S 2− and Zn 2+ in CH 3 CN/H 2 O (7:3, v/v, pH = 7.4, HEPES buffer: 0.1 M), with detection limits of 0.301 μM, 0.017 μM, and 0.535 μM, respectively. At an excitation wavelength of 320 nm, BT exhibits an “on-off-on” response to Cu 2+ /S 2− and enhanced fluorescence response to Zn 2+ , with a change in fluorescence color from orange to green. The coordination ratio of ions to the probe was determined to be 1:1 through Job's plot and hydrogen spectral titration. The recognition mechanism was discussed in conjunction with theoretical calculations. Furthermore, the probe has been successfully used in test strips and medical swabs colorimetry, as well as live cell imaging. Significance The probe BT lays the foundation for the design and synthesis of multifunctional fluorescent probes. As a portable detection method, probe BT was used to detect Cu 2+ , S 2− and Zn 2+ on strips. Furthermore, the probe was applied to biological cells to detect target ions with low cytotoxicity and excellent cell permeability. This indicating that it can be used as a potential candidate for tracking Cu 2+ and S 2− in clinical diagnostics and biological systems.
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PubMed
高影响因子
ChemistrySelect
·
2025
·Vol. 10
·期 36
·e03645
·
IF 2
Miaomiao Tian,Qingwen Zheng,Yuanyuan Pang,Fangjun Wang,Gang Liu
In this study, we developed a novel and facile fluorescent turn-on sensing method for the selective detection of Cu 2+ ions based on the specific oxidative reaction between Cu 2+ ions and 3-carboxyphenylboronic acid (3-CPBA). In this reaction, 3-CPBA was oxidized by Cu 2+ to form 3-hydroxybenzoic acid, which emitted strong fluorescence emission at 412 nm. The resulting product was characterized using comprehensive spectroscopic analyses, including proton nuclear magnetic resonance ( 1 H NMR), carbon-13 nuclear magnetic resonance ( 13 C NMR), and electrospray ionization mass spectrometry (ESI-MS). These analyses confirmed the formation of 3-hydroxybenzoic acid as the primary product. Under optimal conditions, the proposed method could detect Cu 2+ in the range of 0.1–3 µM with a detection limit of 10.2 nM. The developed method exhibited high sensitivity, ease of operation, practicality, and good selectivity toward Cu 2+ over other metal ions. Furthermore, the practical applicability of the method was validated by successfully detecting Cu 2+ in real water samples, with good recoveries of 94.0–105.0%. Graphical A fluorescence turn-on method for Copper ions (Cu 2+ ) detection via oxidative hydroxylation of 3-carboxyphenylboronic acid (3-CPBA) was developed. Under alkaline conditions, Cu 2+ converted non-fluorescent 3-CPBA into highly fluorescent 3-hydroxybenzoic acid (λ ex/e m = 315/412 nm). The method achieved a 10.2 nM detection limit with linear response (0.1–3 µM), superior selectivity over competing metal ions, and validated performance in environmental waters.
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高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2025
·
IF 4.1
Yu Rao,Penghua Liang,Chenxiao Guo,Xize Chen,Minglei Cao,Chuankun Zhang,Rui Tong,Kongjun Zhu
Metal sulfide is a promising anode material for lithium-ion batteries due to their unique layered structure and high theoretical specific capacity. However, the challenge lies in enhancing electronic conductivity and cycling stability. An effective method to enhance the rate capability and cycle performance of metal sulfide materials is to construct the hybrid structure. In this paper, the interfacial engineering of multiple sulfides is explored to develop ideal lithium-ion storage anode materials. Hence, the one-step mixed hydrothermal method was used to synthesize the Cu 2-x S/ZnS hybrid structure. The synthesized Cu 2-x S/ZnS hybrid structure exhibits better lithium storage performance and higher electronic conductivity compared with the single Cu 2-x S, which has resulted from the existence of the phase interface generating the built-in electric field and boosting Li + storage properties at the phase interfaces. In comparison with the single Cu 2-x S, the results display that the Cu 2-x S/ZnS hybrid structure shows enhanced rate capability and prominent long-term cycling performance (416.9 mAh g −1 at 1 A g −1 after 1300 cycles). This strategy demonstrates that the construction of hybrid structure can improve the electronic conductivity and structure stability for other advanced anode materials.
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高影响因子
TALANTA
·
2019
·
IF 4.916
Tao Luo,Lingli Bu,Siyu Peng,Yaya Zhang,Zhi Zhou,Guorui Li,Jing Huang
Carbon quantum dots (CQDs), owing to its unique optical properties , have achieved tremendous progress for the detection of different metal ions , organic small molecules, macromolecules , etc. Here we synthesized fluorescent CQDs by a simple one-step microwave-assisted method using 3,4-Dihydroxy- l -phenylalanine (levodopa) as the carbon resource. The CQDs proved to be a multifunctional probe which can be used for detection of various species including copper ion , biothiols and curcumin , via different mechanisms. The selective detection of copper ion was obtained by fluorescence quenching and the mechanism was proved to be static quenching by electrostatic interaction . The fluorescence of levoCQDs-Cu 2+ system can be recovered by biothiols (GSH, Cys and Hcy), implying levoCQDs-Cu 2+ system can also be applied for biothiols detection. The excitation spectrum of levoCQDs had a good overlap with the absorption peak of curcumin, making it as a suitable curcumin probe by fluorescence quenching via inner filter effect (IFE). Furthermore, the levoCQDs can also track the formation of Cu 2+ -Curcumin complexes by restoring the fluorescence of the CQDs in levoCQDs and Cu 2+ -Curcumin system, and this feature may be exploited in the mechanism study of Cu 2+ -Curcumin in the treatment of Alzheimer's disease. The fluorescent levoCQDs were finally used for Cu 2+ and curcumin detection in some real samples including different types of environmental water samples and human serum samples, providing a convenient strategy to monitor Cu 2+ and curcumin in environmental and biological samples.
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PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2021
·Vol. 45
·期 27
·11983-11991
·
IF 3.591
Wen Lu,Jiuzhou Shi,Jichao Chen,Lu Sun,Lingcen Shao,Hongyu Ren,Mengmeng Huang,Yanqin Wang,Shilong Yang,Xu Li
This study describes the synthesis of a coumarin-based reversible fluorescent probe BuCAC for the detection of Cu2+ and S2− in CH3CN : PBS (v/v = 8 : 2, pH = 7.4) solution. The resulting BuCAC exhibited high sensitivity (detection limit = 3.03 × 10−7 M) and selectivity towards Cu2+ through a 2 : 1 binding mode. In the presence of S2−, the BuCAC–Cu2+ recovered to BuCAC and CuS, which in turn perform the function of a sensitive probe with a lower detection limit of about 1.7 × 10−7 M. This “on–off–on” process can easily occur in 1 min with a repetition of at least 5 times. The sensing mechanism was confirmed by Job's plot analysis, MS, and density theory calculation. Besides, fluorescence imaging in zebrafish, HeLa cells, and soybean root tissue revealed that the probe BuCAC could serve as a valuable tool for monitoring and tracking intracellular Cu2+ and S2− while benefiting from its excellent fluorescence performance and lower cytotoxicity.
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高影响因子
Current Analytical Chemistry
·
2017
·Vol. 13
·期 3
·250-255
·
IF 1.306
Luan Feng,Lu Yuxi,Tang Lili,Liu Huitao
Background: The safety and level of heavy metal ions in the traditional Chinese medicine has become an important topic. Most of the metal ions are carcinogens and lead to serious health concerns by producing free radicals. It is of great significance to develop simple and effective
methods to determine heavy metal ions. The aim of this paper is to develop a CE-indirect UV method for the analysis of the four heavy metal ions for Chinese medicine Shuanghuanglian oral liquid. Methods: The alternative CE method for separation and test of metal ions was developed in
this paper, which can help control the safety and level of heavy metal ions in traditional Chinese medicine Shuanghuanglian oral liquid. And the developed HPCE method showed superior analytical performance, including high sensitivity and good selectivity. Results: The experimental conditions
of the CE separation method were: 5s hydrodynamic injection at 0.5 psi, 20 kV applied voltage, and UV detection at 218 nm. The results show that the migration time of all the four heavy metal ions was less than 6 min. The calibration curves for four heavy metal ions were linear in the range
of 0.5-35 μg mL-1 with linear correlation coefficients of 0.9984-0.9999. The limits of detection were in the range of 0.08-0.61 μg mL-1 along with the recoveries of 93.0% to 109.5%. Conclusion: A simple, rapid and sensitive HPCE method has been developed to separate four heavy metal
ions including Cd2+, Cr3+, Cu2+ and Zn2+ in traditional Chinese medicine Shuanghuanglian oral liquid. The comprehensive analysis performance is satisfactory. The proposed HPCE method provides shorter analysis time and lower detection limit. The results demonstrated that the developed CE method
can be potentially applied as an good alternative for quality control of TCM.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2016
·
IF 4.758
Chang Liu,Bing Yan
MIL-53-L was made from a metal-organic framework which was synthesized using pyrene-functionalized organic as building block. This ligand has framework construction, detecting and fluorophore parts. The flourescence property of MIL-53-L changed by space limitations within the metal organic frameworks structure to detect of Cu 2+ ion.
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高影响因子
LUMINESCENCE
·
2019
·Vol. 34
·期 2
·153-161
·
IF 1.691
Yi He,Qijing Bing,Yingjuan Wei,Heyang Zhang,Guang Wang
Two new twinborn benzimidazole derivates ( L and A ), which bonded pyridine via the ester space on the opposite and adjacent positions of the benzene ring of benzimidazole respectively, were designed and synthesized. Compound L displayed fluorescence quenching response only towards copper(II) ions (Cu 2+ ) in acetonitrile solution with high selectivity and sensitivity. However, compound A presented ‘on–off’ fluorescence response towards a wide range of metal ions to different degrees and did not have selectivity. Furthermore, compound L formed a 1:1 complex with Cu 2+ and the binding constant between sensor L and Cu 2+ was high at 6.02 × 10 4 M −1 . Job's plot, mass spectra, IR spectra, 1 H-NMR titration and density functional theory (DFT) calculations demonstrated the formation of a 1:1 complex between L and Cu 2+ . Chemosensor L displayed a low limit of detection (3.05 × 10 −6 M) and fast response time (15 s) to Cu 2+ . The Stern–Volmer analysis illustrated that the fluorescence quenching agreed with the static quenching mode. In addition, the obvious difference of L within HepG2 cells in the presence and absence of Cu 2+ indicated L had the recognition capability for Cu 2+ in living cells.
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高影响因子
BIOMATERIALS
·
2020
·
IF 10.317
Yuanlin Wang,Zhenglin Li,Ying Hu,Jing Liu,Mengyu Guo,Hengxiang Wei,Shanliang Zheng,Tingting Jiang,Xiang Sun,Zhuo Ma,Ye Sun,Flemming Besenbacher,Chunying Chen,Miao Yu
In vivo chemical reactions activated by the tumor microenvironment (TME) are particularly promising for antitumor treatments. Herein, employing Cu 2-x Se-Au Janus nanoparticles (NPs), photothermal conversion-coordinated Fenton-like and photocatalytic reactions are demonstrated in vitro/vivo . The amorphous form of Cu 2-x Se and the catalytic effect of Au benefit the OH generation, and the photo-induced electron‒hole separation of the Janus NPs produces additional OH. The plasmonic electrons of Au facilitate the conversion from Cu 2+ to Cu + . Both Cu 2-x Se and Au contributes to the efficient photothermal conversion, further promoting the reactions. As a result, the H 2 O 2 utilization rate is largely increased, and remarkable generation of reactive oxygen species is achieved by cell endogenous H 2 O 2 in vitro/vivo . A competent tumor inhibition effect is afforded, with high-contrast multimodal imaging. This work opens up the route synergistically integrating photothermal therapy with chemodynamic therapy and photocatalytic therapy into tri-combination antitumor therapy, simply by heterojunction of semiconductor and noble metal.
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高影响因子
APPLIED SURFACE SCIENCE
·
2018
·
IF 4.439
Zhuo Wang,Delong Kong,Ning Qiao,Nian Wang,Qi Wang,Huan Liu,Zhiyong Zhou,Zhongqi Ren
A novel surface ion-imprinted composite membrane was fabricated using layer-by-layer technology for selective adsorption separation of copper ion . The ion-imprinted multilayer was introduced on modified polyethersulfone substrates by electrostatic interaction. Photocrosslinking was initiated by adding 4,4′-diazostilbene-2,2′-disulfonic acid disodium salt and template ions were eluted by HAc solution. Effects of preparation and adsorption conditions, such as cationic polyelectrolyte species, crosslinking agent concentration, assembly layer number, pH and initial Cu(II) concentration, on adsorption behaviors were investigated. Fourier transform infrared spectroscopy, scanning electron microscopy, atomic force microscope and X-ray photoelectric spectroscopy were used for the characterization of the copper ion-imprinted membrane (Cu-IIM). Batch adsorption experiments for studies of adsorption kinetics , adsorption selectivity and stability were conducted. The maximum adsorption capacity reached up to 48.0 mg·g −1 when 3.5 bilayers were deposited on the surface of membrane under specific experimental conditions (C 0 = 200 mg·L −1 , pH 6.0, 400 mL, 25 °C). The Cu-IIM exhibited a higher selectivity for copper ions when competitive ions were present. In addition, the Cu-IIM showed good stability. Moreover, according to the observation of the surface color change of the Cu-IIM during the adsorption process, the membrane could be used for qualitative concentration detection of copper ions in aqueous solution.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Wenjie Zhao,Yujie Zhang,Haomiao Li,Yi Shen,Kangli Wang,Kai Jiang
Rechargeable Mg batteries with the merits of low cost, high safety and environmental compatibility are deemed as promising energy storage techniques for large-scale applications. However, the actual development of rechargeable Mg batteries is constantly hindered by the difficulty of finding suitable electrode materials to accommodate Mg 2+ . Cu 2-x Se has exceptionally high electrical conductivity and its unique crystal structure could be better compatible with Mg 2+ cations. Herein, a novel Cu 2-x Se hollow nanocube with extraordinarily high conductivity and unique structure was designed and synthesized by facile one-step template-directed selenation reaction methods. The excellent Mg electrochemical performance of Cu 2-x Se hollow nanocube cathodes was demonstrated based on rechargeable Mg batteries. The Cu 2-x Se NCs provide a high specific capacity of 232.5 mAh g - 1 at 100 mA g - 1 , superior cycling stability over 3700 cycles, and an excellent rate capacity of 163.1 mAh g - 1 at 3000 mA g - 1 . Furthermore, the two-step magnesiation/demagnesiation processes of the Cu 2-x Se NC cathodes were revealed, and the accelerating effects of the fast Mg 2+ diffusion in the unique hierarchical structure on magnesium storage performance were analyzed. The outcomes of this study not only provide simple methods for fabricating high-performance Cu 2-x Se cathodes but also propose valuable insights for exploring conversion-type Mg-storage materials.
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