TALANTA
·
2012
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IF 3.794
Xiaoyu Mu,Li Qi,Haizhi Zhang,Ying Shen,Juan Qiao,Huimin Ma
Ionic liquids (ILs) with l -proline ( l -Pro) as cations have been developed for the novel chiral ligands coordinated with Cu(II) in chiral ligand exchange capillary electrophoresis (CLE-CE). Four kinds of amino acid ionic liquids (AAILs), including [ l -Pro][CF 3 COO], [ l -Pro][NO 3 ], [ l -Pro][BF 4 ] and [ l -Pro 2 ][SO 4 ], were successfully synthesized. Among them, [ l -Pro][CF 3 COO] was selected as the model ligand to optimize the separation conditions. The influences of AAIL concentration, pH, and methanol concentration on efficiency of chiral separation were investigated. Then it has been testified that the optimal buffer solution consisted of 25.0 mM Cu(Ac) 2 , 50.0 mM AAIL and 20% (v/v) methanol at pH 4.0. The interesting thing is well enantioresolution could be observed with [ l -Pro][CF 3 COO] as the new chiral ligand and nine pairs of labeled d , l -AAs were successfully separated with the resolution ranging from 0.93 to 6.72. Meanwhile, the baseline separation of labeled d , l -AAs could be achieved with the other three kinds of AAILs as ligands. The results have demonstrated the good applicability of AAILs with AAs as cations for chiral separation in CLE-CE system. In addition, comparative study was also conducted for exploring the mechanism of the AAILs as new ligands in CLE-CE.
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Drug Delivery and Translational Research
·
2024
·
IF 5.7
Li Yang,Yu Qin,Lu Yi,Ma Yanyun,Qi Jianping,Chen Zhongjian,Zhu Quangang,Wu Wei
Psoriasis is a prevalent chronic disease affecting 2–3% of the global population. Cyclosporine A (CyA) has been widely used with great promise in the treatment of moderate to severe psoriasis despite various side effects associated with its systemic administration. Topical administration of CyA circumvents systemic side effects; however, the poor water solubility and large molecular weight of CyA pose challenges for dermal delivery. In this study, choline-based ionic liquids (ILs) were used to enhance the dermal delivery of CyA for the potential treatment of psoriasis. All four ILs tested significantly improved the solubility of CyA, which was greater than that of the control group with dimethyl sulfoxide (DMSO) as a solubilizer (20%, w/w). The saturated solubility of CyA in two of the ILs, choline geranate ([Ch][Ge]) and choline ricinoleate ([Ch][Ra]), reached more than 90 mg/mL, and the solubilization capability of the ILs except [Ch][Ci] was resistant to water dilution. The negligible change in CyA content determined by high-performance liquid chromatography and the secondary structure detected by circular dichroism spectroscopy confirmed the stability of CyA in the ILs. At 4 h in the in vitro penetration test, the amount of CyA retained in the skin in the IL groups was slightly greater than that in the control group (20% DMSO). The water content of the ILs significantly affected their penetration ability. When the water content increased from 10 to 70%, the dermal delivery of CyA first increased, peaked at a water content of 30%, and then decreased. The dermal delivery ability of [Ch][Ge] and [Ch][Ra] with a water content of 70% was still comparable to that of 20% DMSO. Moreover, CyA-loaded ILs (0.5%, w/w) significantly relieved the symptoms of psoriasis in an imiquimod (IMQ)-induced mouse model, and the levels of inflammatory factors, including tumor necrosis factor α, interleukin 22 and interleukin 17, in the affected area were reduced by 71.7%, 75.6%, and 89.3%, respectively. The IL tested, choline sorbate ([Ch][So]), showed low cytotoxicity to human immortalized epidermal cells (HaCaT). After 7 days of consecutive application, [Ch][So] did not cause significant irritation. In conclusion, ILs demonstrate promising potential for the dermal delivery of CyA for the treatment of psoriasis. Graphical Abstract
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Hangzhi Wu,Shuyue Wen,Xiaomin Zhang,Shule Zhang,Xuefeng Guo,Youting Wu
Sterically hindered amines (SHAs), such as 2-amino-2-methyl-1-propanol (AMP), are an important subclass of conventional absorbents with large CO 2 capacity, while ionic liquids (ILs) are novel materials with unique physiochemical properties including negligible vapor pressure and high thermal stability. To combine the characteristics of these two kinds of CO 2 absorbents together, we proposed and successfully synthesized a series of new sterically hindered amino acid ionic liquids (SHAAILs). These SHAAILs (aqueous solutions) were proved to have excellent physiochemical properties, large CO 2 capacity (up to 0.92 mol mol −1 at 313.2 K, 1.0 bar), and fast absorption rate (greater than AMP). Dynamic absorption and thermal regeneration experiments were done to further illustrate the capability of SHAAILs in absorbing and desorbing CO 2 , and [N 1111 ][β-iPrNH-Ala] was found to be an excellent CO 2 absorbent owing to its suitable steric hinderance and also its ionic nature. NMR analysis confirms that the SHAAILs of suitable steric hinderance undergo the carbamate-mediated rapid hydrolysis mechanism in absorbing CO 2 . Due to the comprehensive advantages of SHAAILs, they are believed to have great potentials as efficient CO 2 absorbents in practical applications.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2015
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IF 2.037
Aili Wang,Li Chen,Fan Xu,Zongcheng Yan
Castor oil-based ionic liquid microemulsions are promising alternatives for petroleum-based biolubricant basestocks. This study presents the phase behavior of castor oil-based ionic liquid microemulsions through phase manifestation, and the areas of the single-phase domain (SME) were calculated accordingly to further illustrate the phase-forming capacities of the designed microemulsions. The results indicated that the phase-forming capacities of castor oil-based ionic liquid microemulsions depended largely on the ionic liquid ions, surfactant types, and cosurfactant chain lengths. The SME of different anion-based ionic liquid microemulsions showed the following sequences: [BMIM][Tf2N]-based > [BMIM][PF6]-based > [BMIM][BF4]-based. The longer carbon chain of ionic liquid cations in single surfactant-based systems and the larger percentage of ionic liquid-based surfactant in mixed surfactants-based systems both gave rise to the phase-forming capacities of castor oil-based ionic liquid microemulsions. Given the presence of ionic liquid–castor oil amphiphilic balance in the designed systems, the castor oil–surfactant micelles achieved maximum solubilization capacity for [BMIM][BF4] when the ethoxylated groups’ number of surfactant was about eight in single surfactant microemulsion. In addition, n-hexanol donated a higher phase-forming capacity than n-butanol, while n-octanol brought about a different phase behavior due to the spontaneous curvature effect and oil nature of long-chain alcohols (C ≥ 7) in the castor-oil based ionic liquid microemulsions. Thus, this study presented useful information for formulating optimum castor oil-based ionic liquid microemulsion biolubricants based on different ionic liquids, surfactants, and cosurfactants, which were not evaluated in previous research.
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JOURNAL OF MOLECULAR LIQUIDS
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2016
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IF 2.74
Zhen Song,Qian Zeng,Jinwei Zhang,Hongye Cheng,Lifang Chen,Zhiwen Qi
When applying ionic liquids (ILs) in extractive and oxidative desulfurization of fuel oils, the potential solubility of IL in fuel phase is an important concern whereas research particularly on this issue is still scarce. In this work, COSMO-RS was first employed to predict the solubilities of 220 imidazolium-based ILs (11 cations and 20 anions) in 7 model fuel hydrocarbons (namely, n -hexane, n -heptane, n -octane, i -octane, cyclohexane , benzene and toluene), which cover different characters of ILs and hydrocarbons. To understand the effect of IL and hydrocarbon on the IL-in-hydrocarbon solubility, different types of molecular interactions between IL and hydrocarbon were further analyzed from COSMO-RS point of view. Finally, the solubilities of 5 representative ILs in the studied hydrocarbons were experimentally determined by nitrogen analyzer, demonstrating the good qualitative and acceptable quantitative ability of COSMO-RS for predicting IL-in-hydrocarbon solubilities.
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CHEMICAL ENGINEERING RESEARCH & DESIGN
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2017
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IF 2.538
Yunchang Fan,Xiaojing Li,Lufei Song,Jing Li,Lei Zhang
In this work, a series of hydrophobic ionic liquids (ILs) with ClO 4 − , BF 4 − , PF 6 − , CF 3 SO 3 − and bis(trifluoromethanesulphonyl)imide (NTf 2 − ) as anions were synthesized. Their extraction ability for the two alkaloids, quinine and gramine was studied. The experimental results suggested that the extraction ability of ILs had no clear relationship with the alkyl chain length on the IL cation but depended on the hydrophobicity and hydrogen-bonding strength of the IL anion. The CF 3 SO 3 − -based ILs were stable against hydrolysis and exhibited better extraction ability for the two alkaloids. Thermodynamic analysis suggested that the extraction of the two alkaloids was an entropy-driven process. These results indicate that CF 3 SO 3 − -based ILs are ideal solvents for recovering alkaloids from the water phase.
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JOURNAL OF MOLECULAR LIQUIDS
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2016
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IF 2.74
Runping Wang,Yuena Chang,Zhijian Tan,Fenfang Li
Phase diagrams of a series of ionic liquid-based aqueous biphasic systems (ILABS) composed of novel choline amino acid ionic liquids and inorganic salts were measured experimentally at T = (288.15, 298.15 and 308.15) K. Ionic liquids, salts, and temperature influenced the phase separation ability of the studied ILABS. Several parameters of the Merchuk equation were estimated by fitting the binodal curve data. Liquid-liquid equilibria of the investigated ILABS were determined by a gravimetrical method, including the tie-line lengths and slope of the tie-lines. Critical points of the corresponding ILABS were obtained by a mathematical calculation different from the conventional extrapolation. In the case of the phenylalanine + K 3 PO 4 + H 2 O system at 298.15 K, the gravimetrical method and the mathematical calculation were validated by the tie-lines determined experimentally and the critical point derived from the extrapolation.
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ACS Applied Materials & Interfaces
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2016
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IF 7.145
Nannan Guo,Min Li,Yong Wang,Xingkai Sun,Feng Wang,Ru Yang
Soybeans are extensively cultivated worldwide as human food. However, large quantities of soybean roots (SRs), which possess an abundant three-dimensional (3D) structure, remain unused and produce enormous pressure on the environment. Here, 3D hierarchical porous carbon was prepared by the facile carbonization of SRs followed by chemical activation. The as-prepared material, possessing large specific surface area (2143 m2 g–1), good electrical conductivity, and unique 3D hierarchical porosity, shows outstanding electrochemical performance as an electrode material for supercapacitors, such as a high capacitance (276 F g–1 at 0.5 A g–1), superior cycle stability (98% capacitance retention after 10,000 cycles at 5 A g–1), and good rate capability in a symmetric two-electrode supercapacitor in 6 M KOH. Furthermore, the maximum energy density of as-assembled symmetric supercapacitor can reach 100.5 Wh kg–1 in neat EMIM BF4. Moreover, a value of 40.7 Wh kg–1 is maintained at ultrahigh power density (63000 W kg–1). These results show that the as-assembled supercapacitor can simultaneously deliver superior energy and power density.
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CHINESE JOURNAL OF POLYMER SCIENCE
·
2016
·Vol. 35
·期 1
·54-65
·
IF 1.811
Chen Qi-jing,An Ze-sheng
A series of well-defined core cross-linked star (CCS) polymeric ionic liquids (PILs) were synthesized via a three-step approach. First, the styrenic imidazole-based CCS polymer (S-PVBnIm) was prepared by the RAFT-mediated heterogeneous polymerization in a water/ethanol solution, followed by the quaternization of S-PVBnIm with bromoalkanes and anion exchange. The CCS polymers were characterized by gel permeation chromatography (GPC), nuclear magnetic resonance (NMR) spectroscopy, Fourier transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA), and differential scanning calorimetry (DSC). The obtained CCS polymers were used as the effective emulsifiers for oil-in-water high internal phase emulsions (HIPEs). Multiple oils with different polarity including n -dodecane, undecanol, toluene and octanol were emulsified using 0.5 wt% S-PVBnIm aqueous solution under the acidic condition to form HIPEs with long-term stabilities. The excellent emulsification properties of CCS PILs were demonstrated by HIPE formation for a variety of oils. The properties of HIPEs in terms of emulsion type and oil droplet size were characterized by the confocal laser scanning microscopy (CLSM). The intriguing capability of CCS PILs to stabilize HIPEs of various oils holds great potentials for the practical applications.
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TRIBOLOGY INTERNATIONAL
·
2016
·
IF 2.259
Lili Zhu,Gaiqing Zhao,Xiaobo Wang
In this study, three oil-soluble phosphonium-based ionic liquids (ILs) were synthesized and then investigated them as potential lubricating additives. The friction-reduction and antiwear performances of the ILs as lubricant additives in pentaerythritol oleate (PETO) and trimethylolpropane trioleate (TMPTO) were evaluated on an Optimol SRV-IV oscillating reciprocating friction and wear tester. The results indicated that tetradecyltrihexylphosphonium O,O′-diethyldithiophosphate (IL3=TTP−DDP) exhibited considerably better lubrication properties than commercially available tricresyl phosphate (TCP) by performing very well at 200 °C. SEM and XPS were performed to analyze the worn surfaces and revealed the fabrication of tribofilm composed of Fe(OH)O, Fe 3 O 4 , FePO 4 and FeSO 4 , which played a crucial role in the excellent lubricating behaviours of the ILs-additived lubricants.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2016
·
IF 3.299
Chenglong Shi,Yan Jing,Jiang Xiao,Xingquan Wang,Ying Yao,Yongzhong Jia
Two non-fluorinated ionic liquids (ILs), namely tetrabutylammonium bis(2-ethylhexyl)-phosphate, [N 4444 ][DEHP], and tetraoctylammonium bis(2-ethylhexyl)-phosphate, [N 8888 ][DEHP], were synthesized and fully characterized by 1 H and 13 C NMR spectroscopy. These functionalized ILs were subsequently evaluated in terms of their ability to extract lithium ions from aqueous solution. The extraction efficiencies of these functionalized ILs for lithium ions were measured as a function of various extraction parameters, including aqueous acidity, temperature and extractant concentration. The extracted species were determined using a slope analysis method, which indicated that the ILs formed a 1:1 (metal:ligand) complex. Fourier transform infrared spectroscopy studies were conducted to better understand the nature of the extracted species. We also investigated the stripping of the lithium ions from the organic phase and the re-use of the ionic liquid in a subsequent extraction step.
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ENERGY CONVERSION AND MANAGEMENT
·
2017
·
IF 5.589
Heng Zhang,Hu Li,Hu Pan,Anping Wang,Chunbao (Charles) Xu,Song Yang
Biodiesel, typically derived from non-edible vegetable oils via heterogeneous catalysts, is being deemed as a promising alternative to fossil fuels. Herein, basic polymeric ionic liquids (PILs) immobilized on magnetic mesoporous carrier (Fe 3 O 4 @SiO 2 @SBA-15), FnmS-PILs, were synthesized through the facile radical polymerization and anion exchange methods, and were further utilized to catalyze transesterification of non-food feedstock-crude Firmiana platanifolia L.f. oil (CFPO, acid value of 1.20 mg KOH/g) into biodiesel directly. The characterization results demonstrated that FnmS-PILs with uniform core–shell structure, moderate surface area (153.2 m 2 /g), pore size (4.1 nm), strong magnetism (13.6 emu/g) and relative higher basicity (2.3 mmol/g) exhibited high catalytic performance, giving a high biodiesel yield of 92.8 wt% under mild reaction conditions (9/1 methanol/oil molar ratio, 4 wt% catalyst dosage at 85 °C for 5 h). Furthermore, kinetic study was also investigated accordingly, wherein the activation energy was found to be 51.6 kJ/mol along with a determined pseudo first order model. More importantly, the catalyst could be recovered easily by means of magnetic force and remained sufficiently active in five consecutive cycles.
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危险品化学品经营许可证（带存储）