LASERS IN MEDICAL SCIENCE
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2025
·Vol. 40
·期 1
·1-11
·
IF 2.4
Ma Dan,Lu Huixiang,Zhang Hai,Liao Anru,Peng Qianrong,Yang Min
Hypoxia poses a significant challenge to the efficacy of photodynamic therapy (PDT) for cancer treatment. This study aims to design and synthesize PEGylated liposomes encapsulating MnO₂, indocyanine green (ICG), and H-chain ferritin (HFn) to potentially address hypoxia and enhance the therapeutic outcomes of PDT. PEGylated liposomes (ICG/MnO₂-HFn-mPEG-DSPE-Lip) were constructed with a rod-like structure, incorporating MnO₂ as a hypoxia-modulating agent and ICG as a photosensitizer. The drug loading capacity, stability and safety of liposomes were characterized. Singlet oxygen quantum yield (Φ Δ ) was measured under simulated tumor microenvironment conditions. In vitro phototoxicity was evaluated using A549 human lung adenocarcinoma cells. Liposomes have a high drug loading capacity, good biocompatibility and good long-term stability. Under tumor-simulated conditions, Φ Δ was significantly improved, increasing from 0.210 for free ICG to 0.507. The liposomes demonstrated remarkable phototoxic effects on A549 cells (90.5% cell death under combined PDT/PTT vs. 15% for free ICG). This nanoplatform proposes a novel strategy to overcome hypoxia-induced PDT resistance, and the enhanced efficacy may be attributed to the increased oxygen supply mediated by MnO 2 carried by HFn. These findings provide important insights for the development of next-generation therapeutic systems targeting tumor hypoxia.
研究领域:
药学
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肿瘤学
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生物医学工程
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DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Yuefei Zou,Wanlin Wu,Tian Xia,Jiangqi Zhao,Qunhao Wang,Wei Zhang,Canhui Lu
To keep pace with the fast development of portable and wearable electronics, considerable public and scientific attentions have been paid to the flexible energy storage devices with characteristics of light weight, low cost and high electrochemical performance. In this work, we demonstrate a feasible strategy to fabricate novel strand-shaped electrodes from the biomass of Juncus effusus (JE), which can be easily integrated into flexible and rechargeable Zn-MnO 2 batteries with high electrochemical performance. Notably, JE has a very unique three dimensional (3D) triangular-like hollow network microstructure, which greatly favors active material loading, charge transfer and ion diffusion. The obtained aqueous battery presents an excellent specific capacity of 325 mAh g −1 at the current density of 0.3 A g −1 , as well as stunning cycling stability for up to 4000 cycles with 127.53 % retention of the initial capacity. Remarkably, when assembled with a gel electrolyte, the quasi-solid-state battery can work normally under various extreme conditions, including bending, hammering, burning, soaking and puncturing. In addition, due to the high flexibility, the electrodes can be woven in parallel into a textile to form an energy supply unit and successfully power an electronic watch, demonstrating high potential of JE in the fabrication of flexible energy storage devices.
研究领域:
材料科学
·
能源存储
·
可持续发展
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DOI
PubMed
高影响因子
Materials Today Bio
·
2025
·
IF 10.2
Tingting Gong,Xiaohuan Wang,Ziqi Liu,Pengxin Li,Yunqian Lu,Yaoyao Guo,Meihua Han,Xiangtao Wang
A significant obstacle in oncological therapy lies in surmounting the immunosuppressive microenvironment while enhancing the anti-tumor efficacy of chemotherapeutic agents. STING agonists such as Mn 2+ have demonstrated substantial promise in this regard. Squamocin (Squ), a naturally derived compound, exhibits potent anti-tumor activity with minimal drug resistance; however, its application is hampered by poor water solubility (approximately 7.5 μg/mL) and off-target toxicity. In this study, a chemo-immunotherapy approach utilizing MnO 2 nanoparticles combined with squamocin (Squ) has been formulated, with its therapeutic effectiveness further augmented through surface modification with the tumor-targeting IR820 molecule. The intravenously injectable MnO 2 nanoparticles were synthesized from KMnO 4 and anhydrous ethanol, and subsequently modified with Astragalus polysaccharides (APS)-IR820 on their surface to improve stability in physiological media and facilitate tumor targeting and in vivo fluorescence imaging. The resultant MnO 2 @APS-IR820 NPs, measuring 193.4 ± 1.7 nm, generated Mn 2+ in response to the elevated glutathione (GSH) levels within the tumor microenvironment. The generated Mn 2+ notably induced maturation of bone marrow dendritic cells (BMDCs) and promoted the repolarization of tumor-associated macrophages from the pro-tumor M2 phenotype to the anti-tumor M1 phenotype. When combined with Squ@APS-IR820 NPs (220.1 ± 11.2 nm in size), the chemoimmunotherapy significantly stimulated both innate and adaptive immune responses in a 4T1 tumor bearing mouse model and demonstrated a synergistic anti-tumor effect, achieving a tumor inhibition rate of approximately 92%, highlighting its remarkable potential for anti-tumor therapy.
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DOI
PubMed
高影响因子
ChemSusChem
·
2025
·
IF 6.6
Yuchao Chen,Fangfang Wu,Yulong Chen,Dongshu Liu,Junkang Zhang,Pu Wang,Yancong Feng,Wenxian Liu,Tianqi Deng,Wenhui Shi,Xiehong Cao
Aqueous zinc-ion batteries (AZIBs) offer significant promise for large-scale applications due to their low cost,high safety,and sustainability,prompting researchers to address the key issues of zinc dendrite formation,anode side reactions, and cathode dissolution.Despite most current research focusing on optimizing either the anode or the cathode, achieving coordinated improvements in both electrodes is crucial for fully realizing the potential of zinc-ion batteries (ZIBs), and remains a significant challenge due to the complexity involved in balancing the performance of both electrodes. Herein, we propose a sacrificial agent-promoted protective strategy that enhances the performance of both the anode and cathode simultaneously. Specifically, the mercapto-containing sacrificial agent adsorbs on the Zn anode, localizing electrons around the thiol group to trigger an in-situ transformation reaction. This reaction forms a modulation layer that optimizes Zn2+ deposition. Concurrently, the agent promotes the formation of a protective MnO2 nanoparticle shell to reduce cathode dissolution. This strategy significantly enhances the cycling stability of both the Zn||Zn and MnO2||Zn cells, achieving 4.5 and 3 times longer performance,respectively,compared to those in ZnSO4 electrolyte.This work presents a simple and efficient dual-function approach that simultaneously stabilizes the Zn anode and suppresses Mn-based cathode dissolution, offering a promising pathway for the practical development of AZIBs.
研究领域:
材料科学
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电化学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2022
·
IF 16.744
Runlong Hao,Zhen Qian,Xiaojie Yang,Mengchao Luo,Xiaohe Feng,Wanting Qiao,Yi Zhao,Bo Yuan
Developing efficient catalysis-adsorption method for elemental mercury (Hg 0 ) removal with wide temperature window and good sulfur/water resistance is a hot topic. In this study, a novel method of microwave (MW) catalysis of MnO 2 modified molecular sieve (Mn@MOS) composite for Hg 0 removal was developed. Results indicated that Hg 0 removal efficiency of MOS was poor, only 18% at 150 °C, while the efficiency was significantly increased to 97.8% when MW/Mn@MOS was used. Compared with thermo-catalysis way, MW irradiation method achieved better Hg 0 removal efficiency (97.8% vs 86.4%) under a wider temperature window (150–450 °C), and sulfur/water resistance were greatly strengthened under MW irradiation. The dynamical adsorption capacity of Hg 0 was calculated as 1.52 mg/g when the efficiency was below 80%. Kinetic analysis indicated that MW field significantly increased the rate constant and reduced the activation energy. The fate of Hg 0 was unfolded: almost 96% of Hg 0 was chemisorbed as HgO, less than 4% was converted to gaseous Hg 2+ . The mechanism was speculated as followed: (i) excited active site of *MnO 2 was first generated under MW irradiation; (ii) then the oxidizing species including Mn(IV)/Mn(III), O ads , O latt and O* dominated the Hg 0 removal process; (iii) the reactive oxygen species of O ads , O latt and O* were replenished by the interaction between oxygen vacancies and free O 2 . This study first demonstrates the superiority of MW catalysis towards Hg 0 removal, and provides a new thought on the development of the novel Hg 0 removal technologies .
研究领域:
环境科学
·
催化
·
污染控制
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DOI
高影响因子
ADVANCED POWDER TECHNOLOGY
·
2018
·Vol. 30
·期 2
·302-310
·
IF 2.943
Bingbing Liu,Yuanbo Zhang,Jia Wang,Juan Wang,Zijian Su,Guanghui Li,Tao Jiang
Investigations on the MnO 2 -Fe 2 O 3 system roasted in air has been reported in our previous work. This study further investigated the MnO 2 -Fe 2 O 3 system roasted under CO-CO 2 atmosphere. Extensive investigations were concentrated on the reduction of simplex iron oxides or manganese oxides, and little attention were paid on the reduction of MnO 2 -Fe 2 O 3 system regarding to interactive reactions between them. In this work, it was found that spinel-type Mn x Fe 3−x O 4 with high magnetism formed easily under CO-CO 2 atmosphere. The reduction and thermodynamic analyses of pure MnFe 2 O 4 were also researched to better understand the reduction behaviors of MnO 2 -Fe 2 O 3 system. Phase study showed that a series of Mn-Fe composite oxides, including Mn x Fe 3−x O 4 and (MnO) y (FeO) 1−y , generated during the reduction of MnO 2 -Fe 2 O 3 system. Mn x Fe 3−x O 4 was readily generated under CO content of 2.5–25 vol% at 1000 °C. With further increase of CO content, Mn x Fe 3−x O 4 was reduced to (MnO) y (FeO) 1−y and then to MnO and metallic iron. Reduction of manganese oxides, iron oxides and manganese ferrites happened concurrently during the reduction of MnO 2 -Fe 2 O 3 system. And the reduction of MnO 2 , Fe 2 O 3 , Fe 3 O 4 and MnFe 2 O 4 were compared by TG and thermodynamic analyses. In addition, the morphology evolution and magnetism change of the MnO 2 -Fe 2 O 3 system reduced under different CO contents were also studied.
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DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2015
·
IF 2.711
Minghui Zhou,Xiaoli Liu,Baozhi Yu,Jing Cai,Chunyan Liao,Zhenhua Ni,Zhongyue Zhang,Zhaoyu Ren,Jintao Bai,Haiming Fan
Surface-enhanced Raman scattering (SERS) technology has been investigated for long time because of its tremendous potential in chemical and biomolecular detection. One of the challenging works in this field is to fabricate fantastic substrates with high sensitivity, stability, and reproducibility. This work reports a novel SERS substrate based on MnO 2 /Au hybrid nanowall film prepared by simple and cheap hydrothermal method combined with subsequent vacuum thermal evaporation process. Enhanced SERS enhancement factor (EF) with increased thickness of gold layer was observed and a significant increase of EF up to 8 orders of magnitude has been achieved. Finite-difference time-domain (FDTD) simulations have been carried out to elucidate the origin of the enhancement and the distribution of the “hot spots”. Experimental evidences indicate that the as-prepared substrate possesses excellent SERS sensitivity, good stability and high reproducibility. Our results provide a novel MnO 2 /Au hybrid nanowall film as a convenient and robust SERS-active substrate for detecting biomolecules.
研究领域:
材料科学
·
纳米技术
·
分析化学
·
拉曼光谱学
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DOI
高影响因子
Nanoscale
·
2016
·Vol. 8
·期 13
·7309-7317
·
IF 7.76
Ziya Wang,Fengping Wang,Yan Li,Jianlin Hu,Yanzhen Lu,Mei Xu
Structure designing and morphology control can lead to high performance pseudocapacitive materials for supercapacitors. In this work, we have designed interlinked multiphase Fe-doped MnO2 nanostructures (α-MnO2/R-MnO2/ε-MnO2) to enhance the electrochemical properties by a facile method. These hierarchical hollow microspheres assembled by interconnected nanoflakes, and with plenty of porous nanorods radiating from the spherical shells were hydrothermally obtained. The supercapacitor electrode prepared from the unique construction exhibits outstanding specific capacitance of 267.0 F g−1 even under a high mass loading (∼5 mg cm−2). Obviously improved performances compared to pure MnO2 are also demonstrated with a good rate capability, high energy density (1.30 mW h cm−3) and excellent cycling stability of 100% capacitance retention after 2000 cycles at 2 A g−1. The synergistic effects of alternative crystal structures, appropriate crystallinity and optimal morphology are identified to be responsible for the observations. This rational multiphase composite strategy provides a promising idea for materials scientists to design and prepare scalable electrode materials for energy storage devices.
研究领域:
材料科学
·
储能
·
纳米材料
·
电化学
·
超级电容器
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DOI
高影响因子
Journal of Materials Chemistry A
·
2017
·Vol. 5
·期 8
·4058-4066
·
IF 8.867
Jian Zhang,Jie Han,Minggui Wang,Rong Guo
Multifunctional magnetic adsorbents containing MnO2 and polyaniline (PANI) with optimized adsorption properties toward heavy metal ions have been developed. In particular, Fe3O4 spheres were chosen as the magnetic core, followed by PANI and MnO2 coating, realizing the formation of Fe3O4/PANI/MnO2 core–shell hybrids. The as-synthesized Fe3O4/PANI/MnO2 core–shell hybrids showed a hierarchical structure with a large surface area and high magnetic saturation value. In comparison with Fe3O4/PANI and Fe3O4/MnO2 core–shell hybrids, Fe3O4/PANI/MnO2 core–shell hybrids displayed the highest adsorption capacity toward heavy metal ions (including Cd(II), Zn(II), Pb(II) and Cu(II)), thanks to the integrated physical and chemical adsorption behaviors resulting from MnO2 inorganic oxide and the PANI polymer. The developed multifunctional Fe3O4/PANI/MnO2 adsorbents synthesized by a facile and economic route are believed to show high potential in environmental remediation for heavy metal removal.
研究领域:
环境科学
·
材料化学
·
纳米技术
·
水处理
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DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2026
·
IF 4.4
Hou Chaojie,Xu Hang,Zhang Bingbing,Zhao Yuan,Wu Fengmin
A flower-like core–shell MnO 2 @CeO 2 composite was synthesized via hydrothermal method. Characterization by X-ray diffraction, Brunauer–Emmett–Teller, scanning electron microscopy, transmission electron microscopy, and X-ray photoelectron spectroscopy confirmed a micro-spherical morphology with a high specific surface area (266.4 m 2 g −1 ) and well-defined mesoporous structure (average pore size: 7.4 nm), facilitating active site exposure and reactant adsorption. Under optimal conditions (25 mg catalyst, 1.5 mL 25 wt% peroxymonosulfate, 2 mL acetonitrile, 600 ppm initial sulfur, 40℃), the desulfurization efficiency for dibenzothiophene reached 81.26%. It maintained 71% efficiency after 5 cycles, with stable chemical structure and morphology. Quenching experiments confirm that the primary oxidation of dibenzothiophene to dibenzothiophene sulfoxide is predominantly mediated by sulfate radicals (·SO 4 ⁻), while the subsequent oxidation of dibenzothiophene sulfoxide to dibenzothiophene sulfone relies primarily on hydroxyl radicals (·OH). Kinetic analysis showed tandem reaction behavior with rate constants k 1 = 0.213 min⁻ 1 and k 2 = 0.187 min⁻ 1 . This catalyst offers promising potential for industrial production of ultra-low-sulfur fuels. Graphical
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DOI
高影响因子
CERAMICS INTERNATIONAL
·
2020
·
IF 3.83
Qiang Liu,Junjie Yang,Xiaogang Luo,Yifei Miao,Yang Zhang,Wenting Xu,Lijun Yang,Yunxia Liang,Wei Weng,Meifang Zhu
As shining stars of 2-dimensional materials, transition metal carbides (MXene) and transition metal oxides have attracted much interest in various energy fields due to their excellent conductive and electrochemical properties . However, big challenge still remains in the accessibility of high-performance fibrous electrodes for flexible supercapacitors . In this paper, MnO 2 nanorods are loaded on MXene sheets to obtain MnO 2 @MXene composites by a facile hydrothermal method , which are subsequently coated on carbon nanotube fibers (CNTFs). With a fine control on morphology, the resulting MnO 2 @MXene/CNTF electrode exhibits a high specific capacitance of 181.8 F/g at 1 A/g, a capacitance retention of 91% after 5000 charge-discharge cycles, as well as superb flexibility, i.e., neglected capacitance loss at a bending angle of 180°. The as-fabricated flexible composite fiber opens a new door for transition metal carbides and transition metal oxides with great potential in flexible electronics.
研究领域:
材料科学
·
能源科学
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DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Fang Liu,Yang Liu,Dazhi Gao,Shaokai Ma,Shiqing Zhang,Ying Li,Jun Zhang,Yanming Xue,Chengchun Tang
Studying noble-metal-free oxygen reduction reaction (ORR) catalysts is crucial for advancing fuel cells. Manganese dioxide (MnO 2 ) has garnered widespread attention due to its convenient synthesis, low cost, high electrochemical activity, and diverse structures. However, it still faces challenges, such as poor conductivity and relatively lower inherent catalytic activity. In this study, a novel ORR electrocatalyst is introduced by constructing a heterostructure of manganese fluoride (MnF 2 ) and MnO 2 , referred to as MnF 2 /MnO 2 . In a 0.1 M KOH solution, the ORR half-wave potential (E 1/2 ) of MnF 2 /MnO 2 is measured at 0.804 V, surpassing that of the original MnO 2 catalyst (0.69 V). Compared to the MnO 2 electrocatalyst, the MnF 2 /MnO 2 heterostructure exhibits faster ORR reaction kinetics and a larger electrochemically active surface area. Density functional theory (DFT) calculations confirm that the MnF 2 /MnO 2 heterostructure possesses enhanced intrinsic conductivity, facilitating the rapid transfer of ions of and electrons. Therefore, this study provides a promising pathway for enhancing the ORR catalytic activity of noble-metal-free electrocatalysts through rational heterostructure design.
研究领域:
材料科学
·
电化学
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DOI
高影响因子
危险品化学品经营许可证（带存储）