Cell Host & Microbe
·
2024
·
IF 20.6
Dongping Li,Meijuan Wan,Lanfeng Xue,Zhelin Zhang,Yifeng Qiu,Fengyi Mei,Niexing Tang,Chunxiao Yu,Yao Yu,Tianqi Chen,Xing Ding,Qin Yang,Qiuyan Liu,Peng Gu,Wei Jia,Yu Chen,Peng Chen
Cholestatic liver disease (CLD) is a common liver disorder with limited treatment options. Here, we demonstrate that zinc (Zn) supplementation can alter the gut microbiome to mitigate cholestatic liver injury. Oral Zn altered the microbiota of mice and humans (this study was registered at clinicaltrials.gov [NCT05597137]), increasing the abundance of Blautia producta ( B. producta ) and promoting the generation of p-coumaric acid. Additionally, p-coumaric acid concentrations were negatively correlated with liver injury parameters in CLD patients. In mice, the protective effects of Zn were partially mediated by p-coumaric acid, which directly bound to nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (NOX2) and suppressed the production of reactive oxygen species (ROS) in hepatocytes, thus preventing hepatocyte cell death and liver damage. Additionally, knocking out the histidine ammonia-lyase, which catalyzes the conversion of tyrosine to p-coumaric acid in B. producta , blunted the protective effects of Zn. These findings highlight a host-microbiota interaction that is stimulated by Zn supplementation, providing potential benefits for CLD.
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PubMed
高影响因子
Advanced Composites and Hybrid Materials
·
2024
·Vol. 7
·期 4
·1-13
·
IF 23.2
Li Mufang,Chen Huijun,Zhao Jiale,Xia Ming,Qing Xing,Wang Wen,Liu Qiongzhen,Lu Ying,Luo Mengying,Zhu Xiufang,Wang Dong
The increased human demand for an intelligent life puts forward a great requirement for lightweight, stretchable, and comfort sensing and energy harvesting devices. Stretchable thermoelectric fiber becomes very attractive due to it can directly convert human body waste heat into electricity and enables stress, strain, and temperature sensing by designing the structure of the materials. However, the preparation of stretchable poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) fibers with enhanced performances and continuous p-n alternating structure remains a challenge. In this study, the stretchable continuous p-n alternating thermoelectric fibers were prepared by a simple and controllable microfluidic wet-spinning process, in which the single-walled carbon nanotubes (SWCNT)/PEDOT:PSS/polyurethane (PU) and polyethyleneimine (PEI) doped SWCNT/PEDOT:PSS/PU were used as p- and n-type segments, respectively. To optimize the performances, the effect of SWCNT and PEI concentration on the morphology, thermoelectric, and mechanical properties of p- and n-type fibers were analyzed. The power factor of the p- and n-type fibers were 2.67 and 3.48 µW m −1 K −2 , respectively, with a stress of 16 ~ 19 MPa and strain of 70%. Then, the strain and temperature sensors were constructed by the stretchable TE fibers and used for respiration and motion monitoring, showing excellent sensitivity and stability. All the results demonstrate the multifunctions of the stretchable TE fibers used as flexible wearable electronics.
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ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Yiming Shen,Jiyizhe Zhang,Xiao Liang,Kai Wang
Electrochemical synthesis, with its mild conditions and high atom economy, offers a sustainable alternative for creating high-value products. However, for electrochemical reactions, commonly involving a larger parameter space than traditional chemical reactions, it is challenging to efficiently identify optimal reaction conditions or investigate the underlying principles. In this article, a two-step framework of AI-guided exploration is proposed for investigating the Co(II)-mediated electro-oxidation of p-xylene. A multiobjective diversity-driven Bayesian optimization approach is applied for the first step to search the space of operation, identifying Pareto-optimal solutions that balance maximizing reaction yield and minimizing Faradaic contribution. These solutions are then analyzed by employing SHAP (SHapley Additive Explanations) and additional experiments in the second step to investigate the reaction mechanisms. The optimized conditions achieved higher yields and lower energy consumption compared to reported studies in the literature while avoiding the use of toxic solvents. The framework demonstrates the advantage of AI-guided optimization to accelerate the research of electrochemical reactions by significantly reducing the cost of experiments and reducing reagent consumption as well as waste generation, presenting a new path for exploring sustainable chemical processes.
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Nano-Micro Letters
·
2023
·Vol. 16
·期 1
·1-18
·
IF 26.6
Li Xudong,Qiang Zhuomin,Han Guokang,Guan Shuyun,Zhao Yang,Lou Shuaifeng,Zhu Yongming
High-entropy catalysts featuring exceptional properties are, in no doubt, playing an increasingly significant role in aprotic lithium-oxygen batteries. Despite extensive effort devoted to tracing the origin of their unparalleled performance, the relationships between multiple active sites and reaction intermediates are still obscure. Here, enlightened by theoretical screening, we tailor a high-entropy perovskite fluoride (KCoMnNiMgZnF 3 -HEC) with various active sites to overcome the limitations of conventional catalysts in redox process. The entropy effect modulates the d -band center and d orbital occupancy of active centers, which optimizes the d – p hybridization between catalytic sites and key intermediates, enabling a moderate adsorption of LiO 2 and thus reinforcing the reaction kinetics. As a result, the Li–O 2 battery with KCoMnNiMgZnF 3 -HEC catalyst delivers a minimal discharge/charge polarization and long-term cycle stability, preceding majority of traditional catalysts reported. These encouraging results provide inspiring insights into the electron manipulation and d orbital structure optimization for advanced electrocatalyst.
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CHEMOSPHERE
·
2024
·
IF 8.1
Kai Wang,Lu He,Xiaoyu Liu,Mengfei Wu
Sodium p -perfluorous nonenoxybenzene sulfonate (OBS)—one of the main alternatives to perfluorooctane sulfonate—has been increasingly detected in both aquatic environments and human bodies. Therefore, the pathogenic risks of OBS exposure warrant attention, especially its central nervous system toxicity mechanism under long-term exposure. In this study, the effects and mechanisms of OBS on the zebrafish brain at 40 days post exposure were examined. The results demonstrated that at 3.2 μg/L, OBS had no significant effect on the zebrafish brain, but 32 μg/L OBS caused depression or poor social behavior in zebrafish and reduced both their memory and survival ability. These changes were accompanied by histological damage and cell apoptosis. Furthermore, OBS caused the accumulation of excessive reactive oxygen species in the fish brain, leading to oxidative stress and subsequently cell apoptosis. Moreover, an imbalance of both inflammatory factors (IL-6, IL-1β, IL-10, TNF-α, and NF-κB) and neurotransmitters (GABA and Glu) led to neuroinflammation . Additionally, 32 μg/L OBS induced decreases in mitochondrial membrane potential and Na + -K + -ATPase activity, leading to both mitochondrial structural damage and the emergence of mitochondrial autophagosomes , partly explaining the neurotoxicity of OBS. These results help to analyze the target sites and molecular mechanisms of OBS neurotoxicity and provide a basis for the scientific evaluation of its health risks to humans.
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高影响因子
ACS Applied Nano Materials
·
2025
·
IF 5.5
Yue Guo,Chengyan Liu,Geng Cheng,Huimin Zhou,Ke Zhang,Guodong Yang,Yan Li,Jianhua Zhou,Lei Miao,Dong Hu
Lithium−oxygen batteries (LOBs) are considered promising candidates for next-generation energy storage systems due to their ultrahigh theoretical energy density. However, their practical application is challenged by sluggish reaction kinetics and unstable discharge product formation. Herein, we report the rational nanoscale engineering of a Bi2Se3/Bi2O3 heterostructured cathode via a controlled hydrothermal synthesis, addressing these limitations. The type-I band alignment in nanocomposite Bi2Se3/Bi2O3 generates a built-in electric field at the heterointerface, facilitating electron and ion transport and lowering the energy barriers for oxygen reduction (ORR) and evolution (OER) processes. Consequently, the Bi2Se3/Bi2O3 heterointerface catalyst exhibits exceptional specific capacity (19433.6 mAh g−1) and cycle stability (201 cycles at 200 mA g−1; 98 cycles at 1000 mA g−1), surpassing pristine Bi2Se3 by 320% in cycle life. This study establishes heterointerface engineering as a universal strategy for developing high-performance LOB catalysts.
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高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2025
·
IF 6.2
Liying Zhang,Hanchen Wang,Zhenghan Cai,Feng Zhu,Biao Huang,Qi-Lin Lu
The construction of hierarchically porous carbon with a rational pore distribution using environmentally benign activators, while simultaneously incorporating heteroatom doping, is crucial for the preparation of electrode materials for supercapacitors. Here, a green one-step method has been developed that utilizes a biomass derivative, chitosan, as the matrix to construct a nitrogen-doped carbon framework, with polyethyleneimine (PEI) for synergistic nitrogen doping and hydrogen bonding interactions to optimize the carbon framework. Phytic acid (PA) is employed as a phosphorus source, activator, and crosslinker to build hierarchical porous carbon containing phosphorus doping, while carboxylated nanocellulose (CNC) is introduced to regulate the uniformity of the pore structure. The resulting HPC exhibits a specific surface area of 939.87 m²/g, a total pore volume of 0.45 cm³ /g, and a high specific capacitance of 350 F/g at a current density of 1 A/g. Furthermore, the HPC supercapacitor assembled at this current density demonstrates an energy density of 18.3 Wh/kg at a power density of 450 W/kg, with a capacitance retention rate of 86 % and a coulombic efficiency of 97 % after 10,000 cycles. Therefore, the approach in this study, which involves the use of PA to activate carbon precursors while incorporating heteroatom doping and adding CNC to promote uniform heteroatom doping, provides valuable insights for the facile, efficient, and green synthesis of biomass-based porous carbon materials, and contributes to energy storage applications.
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Advanced Composites and Hybrid Materials
·
2021
·Vol. 4
·期 3
·469-477
·
IF 5.693
Wang Ziman,Gao Yin,Ma Yu,Xie Xixi,Yang Ming,Zhang Hang
This paper investigates the electrocaloric effect (ECE) in polymer nanocomposite films containing ferroelectric poly (vinylidene fluoride-trifluoroethylene-chlorofluoroethylene) [P(VDF-TrFE-CFE)] terpolymer matrix and lead-free nanopowders. The nanopowders include pure BaTiO 3 and rare-earth substituted Ba 0.94 R 0.04 TiO 3 , where R = La, Nd, Sm, prepared by a modified sol-hydrothermal method. The substitution influences the lattice parameters, but all samples exhibit a perovskite-type tetragonal phase. The dopant enhances the relaxation behavior of the matrix and decreases the current. Using the Maxwell equations, the ECE performance is systematically studied for all samples. As the rare-earth ionic radius decreases, the Curie temperature of the nanocomposite increases and the dielectric constant decreases. The isothermal entropy changes (Δ S ), adiabatic temperature changes (Δ T ), cooling energy densities ( Q ), and electrocaloric strengths versus temperature exhibit different dependences on electric field ( E ). The results demonstrate that rare-earth doping can effectively modify the ECE. Our composites achieve large EC strength values (|Δ T |/|Δ E |) of 7 to 21 μK m kV −1 over a wide temperature range of 25 to 60 °C and electric field range of 750 to 1250 kV cm −1 and provide typical examples of polymer ECE materials containing rare-earth doped nanopowders. Graphical abstract The preparation of the polymer nanocomposites and the adiabatic temperature changes and the corresponding electrocaloric strengths of the samples.
研究领域:
材料科学
·
物理学
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高影响因子
WORLD JOURNAL OF GASTROENTEROLOGY
·
2015
·
IF 2.369
Gui-Li Huang,Dong-Yan Shen,Cheng-Fu Cai,Qiu-Yan Zhang,Hong-Yue Ren,Qing-Xi Chen
AIM: To develop a safe and effective agent for cholangiocarcinoma (CCA) chemotherapy. METHODS: A drug combination experiment was conducted to determine the effects of β-escin in combination with chemotherapy on CCA cells. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay was performed to determine the effects of β-escin and common chemotherapeutics on the proliferation of human CCA cells (QBC939, Sk-ChA-1, and MZ-ChA-1). Immunocytochemistry was used to detect the expression of P-glycoprotein (P-gp) protein. Luciferase reporter assay was used to detect the activation of the Wnt/β-catenin pathway. The protein levels of P-gp, pS9-GSK3β, pT216-GSK3β, GSK3β, β-catenin, and p-β-catenin were further confirmed by western blotting. RESULTS: The drug sensitivity of QBC939 and QBC939/5-fluorouracil (5-FU) cells to 5-FU, vincristine sulfate (VCR), or mitomycin C was significantly enhanced by β-escin compared with either agent alone ( P < 0.05). In addition, the combination of β-escin (20 μmol/L) with 5-FU and VCR was synergic with a combination index < 1. Further investigation found that the mRNA and protein expression of P-gp was down-regulated by β-escin. Moreover, β-escin induced GSK3β phosphorylation at Tyr-216 and dephosphorylation at Ser-9, resulting in phosphorylation and degradation of β-catenin. Interestingly, activation of the GSK3β/β-catenin pathway induced by Wnt3a resulted in up-regulation of P-gp, which was effectively abolished by β-escin, indicating that β-escin down-regulated P-gp expression in a GSK3β-dependent manner. CONCLUSION: β-escin was a potent reverser of P-gp-dependent multidrug resistance, with said effect likely being achieved via inhibition of the GSK3β/β-catenin pathway and thus suggesting a promising strategy of developing combination drugs for CCA.
研究领域:
肿瘤学
·
分子生物学
·
药理学
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高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2017
·
IF 3.615
Hong Jiang,Songlin Xue,Yefei Liu,Weihong Xing,Rizhi Chen
The Pd@ZIF-L catalysts with uniform crosshair-star shape and a size of about 20 μm were synthesized by an assembly method, in which a two-dimensional layered zeolitic imidazolate framework-L (ZIF-L) was used as the support to immobilize Pd nanoparticles . Their catalytic activities were evaluated by the catalytic reduction of p -nitrophenol to p -aminophenol. The results highlight that the physical-chemical and catalytic properties of the Pd@ZIF-L catalysts are greatly affected by the synthesis temperature. The temperature variation can make the catalysts transform from two-dimensional flakes to zero-dimensional spheres. High temperature is beneficial for increasing Pd loading and encapsulating Pd nanoparticles within the ZIF-L matrix. However, under the temperature larger than 30 °C, the dense dia(Zn) structures are formed. Increasing Pd loading in the Pd@ZIF-L catalysts leads to a significantly higher p -nitrophenol conversion. The relative dense structure of the as-synthesized catalysts makes p -nitrophenol access the active centers difficultly and a lower catalytic activity is observed. These findings would aid the development of high-performance Pd@ZIF-L catalysts.
研究领域:
材料科学
·
催化化学
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高影响因子
Green Chemical Engineering
·
2022
·
IF 0
Ying Zhang,Xue Cao,Yufeng Yang,Sumin Guan,Xiaotian Wang,Heyu Li,Xiaobing Zheng,Liya Zhou,Yanjun Jiang,Jing Gao
The worldwide application of organophosphorus pesticides (OPs) has promoted agricultural development, but their gradual accumulation in soil and water can seriously affect the central nervous system of humans and other mammals. Organophosphorus hydrolase (OPH) is an effective enzyme that can catalyze the degradation of the residual OPs. However, the degradation products such as p -nitrophenol ( p -NP) is still toxic. Thus, it is of great significance to develop a multi-functional support that can be simultaneously used for the immobilization of OPH and the further degradation of p -NP. Herein, a visible light assisted enzyme-photocatalytic integrated catalyst was constructed by immobilizing OPH on hollow structured Au-TiO 2 (named OPH@H-Au-TiO 2 ) for the degradation of OPs. The obtained OPH@H-Au-TiO 2 can degrade methyl parathion to p -NP by OPH and then degrade p -NP to hydroquinone with low toxicity by using H-Au-TiO 2 under visible light. OPH molecules were immobilized on H-Au-TiO 2 through adsorption method to prepare OPH@H-Au-TiO 2 . After 2.5 h of reaction, methyl parathion is completely degraded, and about 82.64% of the generated p -NP is further degraded into hydroquinone. After reused for 4 times, the OPH@H-Au-TiO 2 retains more than 80% of the initial degradation activity. This research presents a new insight in designing and constructing multi-functional biocatalyst, which greatly expands the application scenarios and industrial value of enzyme catalysis.
研究领域:
环境科学
·
生物化学
·
材料科学
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2021
·
IF 5.816
Shuyi Fu,Wenrui Feng,Ying Jia,Tielong Deng,Wenzhong Wang,Guling Zhang,Junli Fu
ZnO/Cu 2 S nanotube arrays are fabricated firstly by a facile and capping-agent-free method, and the photo-electrochemical performance has been studied systematically. The results show that ZnO/Cu 2 S nanotube arrays achieve enhanced photo-electrochemical water splitting performance and the photocurrent densities of ZnO/Cu 2 S are 7.9 times than that of ZnO at 0 V versus Ag/AgCl. The performance of the ZnO/Cu 2 S nanotube arrays can be adjusted by changing the amount of Cu 2 S microcrystals. The results confirm that the enhanced photo-electrochemical performance of ZnO/Cu 2 S is due to the significantly improved visible light absorption, effective separation of photo-induced carriers due to the well band energy match and the formed p-n junction between ZnO and Cu 2 S.
研究领域:
材料科学
·
能源科学
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高影响因子
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