COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Heying Li,Jingming Zhai,Qingnan Zhang,Jinghua Li
Infections resulting from bacteria resistant to antibiotics represent a significant risk to human health. Therefore, exploring novel and effective antibacterial treatment strategies as substitutes for traditional antibiotics is essential. Here, we developed heterogeneous bimetallic Pd@Pt Cubes with a core-shell structure for near-infrared light-enhanced bacterial infection treatment. Heterogeneous core-shell bimetallic Pd@Pt nanocubes demonstrated remarkable photothermal properties along with peroxidase-mimic activity, promoting the combined interaction between photothermal antibacterial therapy (PTT) and chemodynamic therapy (CDT). As demonstrated in vitro antibacterial tests, Pd@Pt Cubes can effectively eliminate both E. coli and S. aureus , and enhance drug penetration in biofilm by disrupting the biofilm. Furthermore, in vivo antibacterial tests indicated that Pd@Pt Cubes can significantly enhance the repair of tissues in bacterial infection sites. Overall, this study constructed an efficient and multifunctional antibacterial nanoplatform through a rational combination and design, and achieved PTT/CDT bimodal bacterial infection treatment through multiple enhancement strategies.
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FUEL PROCESSING TECHNOLOGY
·
2024
·
IF 7.2
Xiequan Chen,Qi Zhang,Song Li,Haiyong Wang,Xinghua Zhang,Lungang Chen,Longlong Ma,Jianguo Liu
Acidic promoters are significant in the hydrodeoxygenation (HDO) of bioderived furans into alkanes over metal-acid bifunctional catalysts. Here, a supported Pd/HPW-SiO 2 catalyst was prepared to investigate the promotion effect of phosphotungstic acid (HPW) on the HDO of HMF-acetone adduct (H-Ac). Characterizations suggested that an intimate contact between Pd and HPW was established in Pd/HPW-SiO 2 . HPW promoters significantly reduced the reduction temperature of Pd oxides with enhanced hydrogenation and HDO capability. Particularly, in-situ DRIFTS confirmed that Pd-HPW sites significantly weakened the π CO η 2 adsorption mode (ν 3 (C=O)) of C=O group on Pd surfaces. Thereby, the HDO efficiency was synergistically improved through releasing more Pd metal sites to activate hydrogen for hydrogenation and HDO with HPW promoters. Eventually, >90% yield of nonane was efficiently achieved at 160 °C. This work is applicable to explore the structure-activity relationship of bifunctional catalysts in the efficient HDO of complicated oxygenated bioderived furans.
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Advanced Optical Materials
·
2025
·Vol. 13
·期 10
·2402968
·
IF 7.2
Lei Yao,Yunjia Wei,Xing Zhao,Xiangnan Zhu,Dexiang Chen,Xiao Tang,Xingce Fan,Teng Qiu,Qi Hao
Plasmonic catalysis employs nanomaterials to mediate the conversion of photon energy into localized electromagnetic fields, hot carriers, and thermal energy, facilitating molecular transformations under mild conditions. Understanding the mechanisms governing plasmonic effects is crucial for optimizing the yield and selectivity in plasmonic catalysis. However, challenges persist in elucidating the role of plasmonic field effects due to the complex interactions among various contributing mechanisms. This study introduces Au@Al 2 O 3 -Pd-Au@Al 2 O 3 trimer arrays to decouple plasmonic field effects from other influences. The alumina coating on the Au particles prevents charge transfer between gold and reactants, enabling focused examination of the field effects on Pd catalysts. Employing real-time monitoring with liquid-state surface-enhanced Raman scattering (SERS), this work investigates the catalytic efficiency and kinetics of the C─C coupling reactions on palladium by tuning the near-field strengths. Polarization-dependent studies reveal that strong near-field intensity around the trimer structures is amplified by ≈60-fold under optimized conditions. The findings offer insights for optimizing catalytic reaction conditions and designing more effective composite plasmonic catalysts.
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Acta Pharmaceutica Sinica B
·
2025
·
IF 14.6
Changyong Guo,Shipeng He,Huaxing Shen,Wei Cong,Jinqiu Li,Yajing Ji,Wenjing Huang,Fei Gao,Honggang Hu
Checkpoint blockade immunotherapy has emerged as a transformative approach in cancer treatment by activating tumor-infiltrating T cells. However, the efficacy of PD-L1 blockade is restricted in “cold” tumors, which are characterized by low immunogenicity, presenting a challenge to immunotherapy. This study introduces an innovative strategy, utilizing cathepsin-cleavable N -(2-hydroxypropyl) methacrylamide (HPMA) polymer-assisted combined photodynamic therapy (PDT) and PD-L1 degradation for the first time, effectively treating T cell-deficient tumors. The degradable main-chain polymer, conjugated with photosensitizer porphyrin, facilitates the accumulation of reactive oxygen species (ROS), triggering immunogenic cell death (ICD) and promoting cytotoxic T lymphocytes (CTLs) infiltration into tumors. Multivalent peptide antagonists of PD-L1 promote PD-L1 degradation in lysosomes through receptor crosslinking, overcoming the adaptive cycling of PD-L1 to the tumor cell surface. These findings demonstrate that polymer-assisted PDT and PD-L1 crosslinking degradation represent a potential novel strategy for anti-tumor immunotherapy, providing valuable tools for expanding immunotherapy applications in immunosuppressive cancers.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Xinyue Zhang,Yuan Yao,Yingying Cao,Xin Tan,Xiaomin Fang,Yanqiang Zhang
The high strain energy of the three-membered ring can increase the combustion calorific value of space fuels. At present, the cyclopropanation of alkenes is the bottleneck to obtain highly-energy three-member-ring fuels. In this article, Pd single-site catalysts (SSCs) were prepared to catalyze the cyclopropanation of norbornene. Pd2+ on the SSCs enhanced the adsorption of CH2N2 through electrostatic interaction, efficiently forming metal carbene. The conversion and selectivity of norbornene cyclopropanation reached 99.9% and 96.9%, which are much higher than those of commercial Pd/C (conversion 42.3%, selectivity 80.8%). In addition, the obtained tricyclooctane shows excellent properties (density 0.93 g/cm3, calorific value 42.75 MJ/kg) to be a promising high-performance rocket fuel. This work provides an efficient method for the synthesis of cyclopropane-based space fuels from alkenes.
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Scientific Reports
·
2021
·Vol. 11
·期 1
·1-9
·
IF 4.38
Yue Song,Sun Kexin,Li Siyuan,Liu Yi,Zhu Qihao,Chen Yiyu,Yuan Dong,Wen Tao,Ge Mingjian,Yu Qiubo
In this paper, we first synthesis three-dimensional jasmine-like Cu@L-aspartic acid(L-ASP) inorganic–organic hybrid nanoflowers to load palladium-platinum nanoparticles (Pd–Pt NPs) as the signal enhancer in order to quantify intracellular speckle-type POZ domain protein. Scanning electron microscope, fourier transform infrared, energy dispersive spectrometer, X-ray photoelectron spectroscopy analysis was used to characterize the newly synthesized materials. The newly formed Cu@L-Asp/Pd-PtNPs can catalyze the decomposition of hydrogen peroxide and exhibit excellent catalytic performance. When different concentration of speckle-type POZ domain protein is captured by speckle-type POZ domain protein antibody linked to the surface of Cu@L-Asp/Pd–Pt NPs, the current signal decreases with the increase concentration of speckle-type POZ domain protein. After optimization, the speckle-type POZ domain protein immunosensor exhibited a good linear response over a concentration range from 0.1–1 ng mL −1 with a low detection limit of 19 fg mL −1 . The proposed sensor demonstrates good stability within 28 days, acceptable reproducibility (RSD = 0.52%) and selectivity to the speckle-type POZ domain protein in the presence of possible interfering substances and has potential application for detecting other intracellular macromolecular substances.
研究领域:
分析化学
·
生物化学
·
纳米技术
·
生物传感器
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RSC Advances
·
2025
·Vol. 15
·期 47
·40056-40066
·
IF 4.6
Huimin Jia,Ya Wang,Yiting Yang,Chuang Liu,Weiwei He
Constructing a multi-interface synergistic catalytic system represents an effective strategy for developing highly efficient photocatalysts; however, the challenge lies in fabricating ideal heterojunctions that can fully harness the multiple synergistic effects of the components. In this study, a series of TiO2/Pd/Ti3C2 nanocomposite photocatalysts with 2D/0D/2D heterojunctions were successfully fabricated through a combination of photoreduction and electrostatic self-assembly techniques by varying the mass ratios. Under irradiation from a 300 W xenon lamp, the as-constructed TiO2/3% Pd/1% Ti3C2 heterojunction photocatalyst exhibited a significantly enhanced H2 evolution rate of 21.60 mmol h−1 g−1, which was approximately 135-fold and 25.4-fold higher than those of pristine TiO2 nanosheets (NSs) and TiO2/1% Ti3C2, respectively. Electrochemical impedance spectroscopy, photoluminescence spectroscopy, and electron spin resonance analysis collectively revealed that the enhanced photocatalytic performance can be attributed to the formation of a synergistic catalytic interface among the TiO2 NSs, highly active Pd NPs, and monolayer Ti3C2 nanosheets. This interface facilitated efficient charge separation, shortened the charge transfer pathways, and enhanced the generation of reactive oxygen species. This study presents a promising strategy for improving catalytic performance through multi-interface synergy and offers a preliminary investigation into the underlying synergistic mechanisms using multiple characterization techniques.
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CRYSTENGCOMM
·
2025
·
IF 2.6
hanchi Ma,Hao Wang,Xiya Yan,Bin Liu,Jianhui Yang
Au@Pd@Pt core-shell nanoparticles (CSNs) with mesoporous structures and nanocavities were synthesized through a seed-mediated growth method. The process involved the initial formation of Au@Pd CSNs via the reduction of PdCl₄²⁻ by ascorbic acid (VC), followed by a reduction of PtCl62- by VC and a galvanic replacement reaction between the Pd shell and PtCl₆²⁻. The galvanic replacement reaction is a critical step in the formation of Au@Pd@Pt CSNs featuring distinctive void in the mesoporous structures. The electrocatalytic performance of the as-synthesized Au@Pd@Pt CSNs for the ethanol oxidation reaction (EOR) was systematically evaluated. Due to the unique hierarchical structure featuring both mesoporosity and internal nanocavities, the Au@Pd@Pt CSNs exhibited significantly enhanced electrocatalytic activity compared to Au@Pd CSNs, Au@Pt CSNs, and commercial Pd/C catalysts. This work presents a facile strategy for constructing hierarchical core-shell nanostructures, demonstrating considerable potential for application in electrocatalytic ethanol oxidation.
研究领域:
纳米材料
·
电催化
·
能量转换
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燃料电池
·
纳米技术
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Chemistry-An Asian Journal
·
2021
·Vol. 16
·期 15
·2113-2117
·
IF 4.568
Da Yang,Guang-Zhao Zhou,Long-Li Zhang,Huan Liu
Graphical The hydroamidocarbonylation of alkynes with amides was accomplished over a bifunctional ligand based Pd catalyst. The hydroamidocarbonylation of alkynes with amides allows for the synthesis of α,β-unsaturated imides with the advantage of 100% atomic economy. Herein, the bifunctional ligand ( L1 ) containing a sulfonic acid group (-SO 3 H) and phosphino-fragment enable the Pd catalyst to accomplish the hydroamidocarbonylation of alkynes with amides. It was found that, due to an intramolecular synergetic effect, the L1 -based Pd-catalyst exhibited much higher activity than the individual mechanical mixtures of Xantphos-based Pd-complex and MeSO 3 H. The formation and stability of Pd-H species were promoted by the presence of L1 , which was verified by in situ high-pressure FT-IR analysis. Under the optimized conditions, the target products of the branched imides were obtained with yields in the range of 46–87% over the L1 -based Pd-catalyst. Advantageously, as an ionic ligand, the L1 -based Pd-catalyst could be recycled for 4 runs in the ionic liquid of [Bmim]NTf 2 without any obvious activity loss and detectable metal leaching.
研究领域:
有机化学
·
催化化学
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EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
·
2022
·Vol. 2022
·期 33
·e202200316
·
IF 3.261
Yong Wang,Hui Wang,Qifan Yang,Shihua Xie,Hongjun Zhu
Graphical Herein, palladium(II)-catalyzed halogenation of 2-phenylquinazolines using N -halosuccinimides as halogen sources was described via C−H activation under mild reaction conditions. A series of halogen-substituted 2-arylquinazolines were synthesized through C−H functionalization. An efficient quinazoline-assisted ortho -halogenation of 2-arylquinazolines has been developed using N -halosuccinimides as halogen sources with Pd(II)-catalyzed C−H bond activation. No additional ligand and oxidant are required. This protocol is highly regioselective and applicable to a broad range of quinazoline substrates bearing different functional groups, giving yields of up to 98 %. The mechanism of the quinazoline ortho -halogenation was investigated by comprehensive experimentation.
研究领域:
有机化学
·
合成化学
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JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2016
·Vol. 16
·期 3
·3014-3020
·
IF 1.338
Liu Xing-Quan,Chen Xue-Song,Wu Jian,Yao Lei
Three-dimensional (3D) Pd–Pt alloy with coral-like nanostructures were synthesized via bubble dynamic templated electrodeposition method at room temperature. The morphology of the asprepared nanostructures was characterized using scanning electron microscopy (SEM), EDS, high-resolution
transmission electron microscopy (HRTEM), respectively. Cyclic voltammetry method was adopted to evaluate the electrocatalytic activities of the synthesized electrodes toward oxygen reduction in KCl solution. The electrochemical results indicated that the Pd–Pt alloy with coral-like
nanostructures hold the high performance for oxygen reduction.
研究领域:
材料科学
·
电化学
·
纳米技术
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Frontiers of Chemical Science and Engineering
·
2017
·Vol. 12
·期 1
·24-31
·
IF 1.712
Han Dongxu,Zhang Zhiguo,Bao Zongbi,Xing Huabin,Ren Qilong
We have successfully prepared a series of Pd-Ni/TiO 2 catalysts by a one-step impregnation-reduction method. Among these catalysts with different compositions of Ni and Pd, the one with the Ni:Pd ratio of 2.95 showed the best activity. Small monodispersed Pd-Ni bimetallic nanoparticles were loaded on the surface of titanium oxide nanopowder as confirmed with TEM and EDS mapping. The XPS analysis demonstrated that Pd exists as 31% Pd(II) species and 69% Pd(0) species and all nickel is Ni(II). The prepared Pd-Ni/TiO 2 exhibited enhanced catalytic activity compared to an equal amount of Pd/TiO 2 for Suzuki-Miyaura reactions together with excellent applicability and reusability.
研究领域:
化学
·
材料科学
·
催化反应
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