FOOD HYDROCOLLOIDS
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2024
·
IF 11
Runliang Feng,Mingzhu Wang,Zhimei Song,Yunjing Jia,Yuli Li,Qingmin Liu,Fuyou Wang,Guangxi Zhai
A liquid formulation with suitable consistency and sustained release characteristics can improve compliance in users with dysphagia. In the study, we prepared curcumin-loaded lipid nanocapsules (Cur-LNCs) and incorporated it in a mixture of sodium alginate, dextrin, calcium chloride and sodium citrate to form a pH-responsive pre-hydrogel solution (SA-DEX:Cur-LNCs). The SA-DEX:Cur-LNCs exhibited a pH-responsive solution-gel conversion: solubilized at near neutral (pH = 7) and rapidly gelatinized to a strong elastic gel at stomach acid (pH = 2.5). The SA-DEX:Cur-LNCs could effectively improve the thermal and pH stability of Cur, and maintain its antioxidant effect. Interestingly, the bioaccessibility of SA-DEX:Cur-LNCs in gastrointestinal was significantly increased to 37.00% when compared with free Cur. The SA-DEX:Cur-LNCs also significantly improved the small intestinal absorption of Cur, being 16 times higher than that of free Cur. Therefore, incorporating lipid nanocapsule in pH-responsive pre-hydrogel provided a new oral administration platform of hydrophobic bioactive compounds for compliance improvement of users with dysphagia.
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高影响因子
JOURNAL OF CONTROLLED RELEASE
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2024
·
IF 10.5
Fan Cao,Kun Liang,Wei-Wei Tang,Qin-Yu Ni,Zhi-Yu Ji,Chen-Kai Zha,Ya-Kun Wang,Zheng-Xuan Jiang,Shengping Hou,Li-Ming Tao,Xianwen Wang
Uveitis comprises a cluster of intraocular inflammatory disorders characterized by uncontrolled autoimmune responses and excessive oxidative stress leading to vision loss worldwide. In the present study, curcumin (CUR) was conjugated with polyvinylpyrrolidone (PVP) to form PVP-CUR nanoparticles with significantly elevated solubility and outstanding multiple radical scavenging abilities. In vitro studies revealed that PVP-CUR nanoparticles markedly mitigated oxidative stress and reduced apoptosis in a H 2 O 2 -induced human retinal pigment epithelial cell line (ARPE-19) and promoted phenotypic polarization from M1 to M2 in an LPS-induced human microglial cell line (HMC3). Further in vivo studies demonstrated the prominent therapeutic effects of PVP-CUR nanoparticles on experimental autoimmune uveitis (EAU), which relieved clinical and pathological progression, improved perfusion and tomographic manifestations of retinal vessels, and reduced blood–retinal barrier (BRB) leakage; these effects may be mediated by mitigating oxidative stress and attenuating macrophage/microglia-elicited inflammation. Notably, treatment with PVP-CUR nanoparticles was shown to regulate metabolite alterations in EAU rats, providing novel insights into the underlying mechanisms involved. Additionally, the PVP-CUR nanoparticles showed great biocompatibility in vivo . In summary, our study revealed that PVP-CUR nanoparticles may serve as effective and safe nanodrugs for treating uveitis and other oxidative stress- and inflammation-related diseases.
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Li Wang,Jianlu Qu,Zixuan Yan,Cunhao Li,Xingchu Gong,Wenlong Li
Curcumin (CUR) exhibits broad pharmacological activities, including anti-inflammatory, antibacterial, and antioxidant effects, and shows promising therapeutic potential in diseases such as diabetes and liver injury. However, its poor water solubility and low stability significantly limit clinical application. Conventional nanoemulsion solidification techniques, such as spray-drying and lyophilization, often involve high energy input, drug degradation, and poor redispersibility, making it challenging to achieve both stability and performance. In this study, we developed a novel strategy combining design-of-experiments (DoE) optimized curcumin nanoemulsions (CUR-NE) with fluidized bed coating to systematically enhance solubility and stability. Plackett-Burman design was used to screen key variables, and Box-Behnken design further optimized these factors, revealing that formulation parameters exert a more pronounced effect on particle size and polydispersity index (PDI) than process variables. The optimized CUR-NE exhibited an extremely small droplet size (Z-Ave = 13.48 ± 0.20 nanometers) and uniform distribution (PDI = 0.064 ± 0.013), and maintained a low redispersibility index (109.95 ± 1.18 percent) when coated onto pellets (CUR-Ps). Structural characterization using FT-IR and XRD confirmed negligible drug and excipient interactions and partial amorphization of CUR. Unlike conventional solidification methods, fluidized bed coating significantly improved the storage stability of the nanoemulsion while preserving its excellent solubility. This approach not only provides a new technical pathway for the development of curcumin delivery systems but also offers an innovative reference for the industrial production and application of poorly soluble drugs.
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Biomaterials Science
·
2018
·Vol. 7
·期 3
·1011-1027
·
IF 5.831
Xiaoqun Shi,Yang Wang,Haiyan Sun,Yujuan Chen,Xingzhen Zhang,Jiangkang Xu,Guangxi Zhai
Graphene-based nanomaterials (GBNMs) have great potential in drug delivery and photothermal therapy owing to their unique physicochemical properties. However, inferior water solubility and biocompatibility related issues greatly restricted their further applications. Herein, to rectify the obstructive problems, we prepared uniform and smaller sized graphene oxide (GO) nanosheets (∼85 nm) via a modified Hummers’ method, which exhibited significantly improved hemocompatibility compared to random large sized GO nanosheets prepared by a common method. Then, we grafted unfractionated heparin (UFH) onto reduced graphene oxide (rGO) covalently using adipic acid dihydrazide (ADH) as a linker to fabricate biocompatible nanocomposites for the cellular delivery of curcumin (Cur). The novel nanocomposites showed quite a small size of 42 nm in average lateral dimension and exhibited a significantly stronger photothermal effect than GO nanosheets. Besides, in vitro cell experiments verified that the potential anticancer efficacy of Cur-loaded vehicles and cytotoxicity of rGO-UFH/Cur against MCF-7 and A549 cells could be further enhanced under 808 nm irradiation, suggesting the possibility of combinational chemotherapy and photothermal therapy. Moreover, consistent with the in vitro sustained drug release performance, an in vivo pharmacokinetics study also indicated that the retention time of Cur could be significantly prolonged when loaded on rGO-UFH nanocomposites than in free Cur solution. Notably, we firstly discussed the interaction between rGO and Cur, and demonstrated the meliorative biocompatibility of uniform rGO compared to GRO via a molecular dynamics simulation (MD) study. Thus, the in vitro, in vivo and computational study demonstrated that the small sized rGO-UFH nanocomposites had wide application prospects as drug delivery vehicles.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Qian Han,Yuqing Zhou,Fangfang Liu,Yang Guo,Xing Zhang,Jinda Peng,Chenzhuo Wei,Nanfeng Zhu,Juqing Cui
Functional nanofiber films were successfully fabricated through an electrospinning process by incorporating curcumin and tannic acid as active components. • The resulting PBAT/CA@Cur/TA films exhibited remarkable and sustained antioxidant and antibacterial performance. • These PBAT/CA films effectively protected strawberries from postharvest quality deterioration, thereby significantly extending their shelf life. Poly(butylene adipate- co -terephthalate) (PBAT) is a biodegradable polyester that has attracted considerable attention in food packaging applications due to its favorable mechanical performance and processability. However, PBAT films are not ideal for the loading and controlled release of active compounds, and their relatively high cost further limits their practical application. This study reports the fabrication of PBAT/cellulose acetate (CA) films by electrospinning, with the incorporation of curcumin (Cur) and tannic acid (TA) as natural bioactive agents to confer antimicrobial and antioxidant functionalities. The incorporation of Cur improved the mechanical performance of PBAT/CA films and imparted approximately 90% DPPH radical scavenging activity, while TA contributed antibacterial properties. Strawberry preservation experiments demonstrated that PBAT/CA@Cur/TA films, particularly those containing 12% Cur and TA, effectively prolonged fruit shelf life. At 4% and 8%, the scavenging efficiency reached approximately 91%. This preservation effect is attributed to the antioxidant action of Cur and the antimicrobial properties of TA. Based on the obtained results, the PBAT/CA films can be considered potential candidates for multifunctional active packaging. Download: Download high-res image (103KB) Download: Download full-size image
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LWT-FOOD SCIENCE AND TECHNOLOGY
·
2026
·
IF 7.1
Mingyue Wang,Yana Liu,Shaolin Deng,Xinyi Li,Siming Lu,Xia Wang,Yun Bai,Xinglian Xu,Minyi Han
Chicken head gelatin enabled high-value utilization of poultry by-products. • Curcumin improved multiple properties of gelatin-based composite films. • Curcumin exerted antibacterial activity via release and contact dual mechanisms. • The optimized film inhibited quality deterioration of refrigerated chicken breast. • Selected films prolonged shelf life from 4 days to 6 and 8 days versus the control. To address the spoilage susceptibility of poultry products during refrigerated storage, as well as the environmental limitations of conventional non-degradable packaging films and the single functionality of existing gelatin films with insufficient antioxidant and antibacterial activities, this study utilized chicken heads, a by-product of poultry processing, for gelatin extraction. Curcumin was incorporated as a natural active ingredient to develop an active packaging film for extending the shelf life of refrigerated chicken breast. The effects of different curcumin loadings (0, 5, 10, 15, and 20 g/kg) on the packaging and functional properties of gelatin-based composite films were investigated to determine the optimal concentration. The results indicated that films with 20 g/kg curcumin loading exhibited optimal performance, with significantly enhanced antioxidant (DPPH and ABTS radical scavenging rates were 87.95% and 95.21%, respectively) and antibacterial activities (bactericidal rates against Escherichia coli and Staphylococcus aureus were 74.43% and 75.35%, respectively). Under storage at 4 °C, films at this concentration effectively inhibited microbial growth, delayed protein decomposition and lipid oxidation, and extended the shelf life from 4 to 8 d. This study achieves high-value utilization of poultry processing by-products and provides a novel, green and efficient packaging solution for the refrigerated preservation of chicken breast.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2026
·Vol. 27
·期 4
·1642
·
IF 5.6
Shuang Wang,Keyi Wu,Meiqi Sun,Xinrui Wang,Jingying Li,Guorong Zhang,Zhidong Qiu
Tendinopathy is a common musculoskeletal disorder that increases the risk of tendon rupture if not properly treated. Current local injection therapies require frequent administration, and no fully effective drug is yet available. Curcumin (Cur) exhibits excellent anti-inflammatory and antioxidant effects, but its poor water solubility and low stability limit its clinical application. To overcome these challenges, this study encapsulated Cur into pluronic F127-based nanomicelles (Cur-F127) to improve its aqueous solubility and stability. Subsequently, the micelles were incorporated into a hydrogel network (Cur-F127&gel) formed by oxidized hyaluronic acid (oxi-HA) and adipic acid dihydrazide (ADH) to achieve sustained release. The resulting Cur-F127 micelles had a particle size of 20.14 ± 0.287 nm, an encapsulation efficiency (EE%) of 89.95 ± 0.60%, and a drug loading (DL%) of 5.57 ± 0.05%. The composite hydrogel possessed a loose, porous three-dimensional network, excellent biocompatibility, and favorable degradation behavior. The system enabled sustained release of Cur for over 20 days without an initial burst. In a rat model of tendinopathy, Cur-F127&gel significantly promoted tendon repair, as evidenced by reduced inflammatory cell infiltration, improved collagen fiber alignment, restored expression of key mitochondrial-related proteins (Ndufs3, Uqcrq, Uqcr10, Atp5mc3), and alleviated oxidative stress damage demonstrated by increased SOD activity and decreased MDA content in tendon tissue, thereby suppressing disease progression. This injectable sustained-release hydrogel system for poorly soluble drugs provides an effective approach for the local, long-acting delivery of Cur and long-term repair of tendinopathy, highlighting its potential value for clinical application.
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PubMed
高影响因子
FOOD CONTROL
·
2026
·
IF 7
Ning Zhang,Lina Yang,Fuming Zhang,Huaying Pan,He Liu
Intelligent packaging materials offer innovative solutions for the freshness monitoring and quality maintenance of high-protein foods during their preservation and distribution. However, most existing intelligent packaging films rely on single natural pigments or synthetic indicators, which suffer from narrow color-changing ranges or safety controversies, while their biodegradability is largely overlooked. To this end, the present study prepared composite films comprising soy hull nanocellulose, polyvinyl alcohol, and pullulan, into which purple cabbage anthocyanin (PCA), curcumin (CU), and their blends at different ratios (PCA:CU = 8:2, 5:5, and 2:8 v/v) were incorporated. Results indicated that PCA and CU formed a hydrogen bond network with the film matrix via phenolic hydroxyl groups, significantly enhancing the mechanical properties of the composite films (P < 0.05). The incorporation of PCA and CU also improved thermal stability and hydrophobicity while reducing water vapor permeability. Among the formulations, PCA/CU-3 (8:2 v/v) exhibited optimal overall performance, showing the most distinct color response across pH 4–12, an antibacterial rate of 93.87% against Pseudomonas fragi , and effective delay of microbial growth and total volatile basic nitrogen (TVB-N) accumulation in dried tofu, extending its shelf life to 12 days. The film color gradually changed from deep red to deep purple during spoilage, enabling visual monitoring. Additionally, PCA/CU-3 degraded noticeably within 25 days under soil-burial conditions. Overall, this study demonstrates a novel degradable food-packaging material integrating antibacterial preservation and real-time spoilage monitoring functions.
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LWT-FOOD SCIENCE AND TECHNOLOGY
·
2026
·
IF 7.1
Biao Liang,Xinying Guo,Yuanyuan Wang,Shumin Yi,Jianrong Li,Beibei Ye,Yanwei Liu,Jinxiang Wang,Cikun Liu,Xuepeng Li
At 9000 s, G i ′ increased by approximately six orders of magnitude relative to C1. • The 0.5% pectin emulsion showed a dense interfacial layer and a 3D network. • At 0.5% pectin, the emulsified phase volume fraction remained at 100% over 180 d. • C1–P0.5 resisted freeze–thaw, thermal, pH, and salt stresses. • Curcumin loading efficiency peaked at 0.3% pectin, while retention peaked at 0.5%. Designing highly stable Pickering emulsions with common biopolymers and expanding their applications to the effective loading of lipophilic bioactives remain formidable challenges. In this study, we successfully fabricated a series of Pickering emulsions stabilized by gelatin–pectin complexes containing gelatin (1.0%, w/w) and pectin (0.1%, 0.3%, and 0.5%, w/w). Pectin incorporation significantly reduced the mean droplet size and increased the zeta-potential magnitude, with C1–P0.5 reaching < 6 μm and > 35 mV, respectively. Interfacial and bulk rheological measurements, together with cryo-SEM and LF-NMR, indicated that pectin incorporation strengthened both the interfacial layer and the continuous-phase structure, forming a multiscale reinforcing architecture. This architecture comprised a dense, viscoelastic interfacial layer and an interconnected 3D honeycomb-like scaffold, which collectively provided robust electrosteric stabilization and geometric confinement. Consequently, the high-pectin group (C1–P0.5) achieved high stability across a broad range of environmental stressors, including 180-day room temperature storage, freeze–thaw cycles, thermal treatment (60–100 °C), and wide fluctuations in pH and ionic strength (NaCl/MgCl 2 ). Furthermore, the C1–P0.3 formulation achieved a curcumin loading efficiency of > 95%, and pectin incorporation enhanced curcumin retention under UV exposure and thermal treatment. These findings provide a mechanistic basis for using simple biocomposites to develop highly stable Pickering systems for the loading and protection of sensitive lipophilic bioactives.
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Advanced Healthcare Materials
·
2026
·
IF 11
Min Wang,Guoqiang Wang,Sihua Li,Jiachen Wang,Jing Tian,Yanzi Zhao,Hao Yang
Hydrogel dressings that can simultaneously curb infection and dampen inflammation are particularly attractive for accelerating multidrug-resistant bacteria-infected wound healing. However, clinical translation of many reported hydrogels is often constrained by multi-component formulations, complicated preparation procedures, and insufficient sprayability, which limit conformal coverage on irregular wound beds. Polyitaconate possesses intrinsic antibacterial and anti-inflammatory activities, yet its weak antioxidative properties and lack of thermogelling properties limit its utility in infected wound healing. In this study, we develop a curcumin-modified polyitaconate-based hydrogel (FPIC) that integrates antibacterial, anti-inflammatory, and antioxidant properties. FPIC hydrogel exhibits thermoresponsive gelation, injectability, sprayability, and shear-thinning properties, allowing convenient close contact with complex wound geometries. FPIC hydrogel inhibits bacterial growth, moderates excessive inflammatory responses, and eliminates reactive oxygen species while promoting angiogenesis, thereby facilitating the shift from the inflammatory phase to the proliferative phase of healing. Moreover, FPIC hydrogel enhances collagen deposition, speeds re-epithelialization, and supports balanced tissue remodeling, enabling improved skin regeneration with a lower propensity for fibrosis. These findings establish FPIC hydrogel as a multifunctional and highly bioactive polyitaconate-based hydrogel dressing with strong promise for treating infection- and inflammation-associated wounds and advancing toward clinical use.
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高影响因子
MATERIALS & DESIGN
·
2026
·
IF 8.2
Yue Peng,Cuiman Tang,Mingcong Niu,Tianyi Xu,QingYu Meng,Xinran Li,Rongheng Ma,Huimin Yu
A traditional medicine-inspired strategy provides a logical framework for constructing carrier-free hybrids. • Precise structural modifications successfully circumvent the inherent bioaccessibility limitations of natural products. • The covalent integration of diverse functional modules enables synergistic therapeutic efficacy against arthritis. • The therapeutic action is closely associated with the modulation of protein kinase B and hypoxia-inducible factor signaling. Curcumin (Cur) possesses potent anti-inflammatory activity but faces clinical challenges due to poor aqueous dispersibility, insufficient membrane affinity, and low bioavailability. Borneol (Bor), a classic “envoy” component in Traditional Chinese Medicine (TCM), exhibits prominent membrane-penetrating properties. Inspired by the “monarch-envoy” compatibility theory, we rationally designed carrier-free hybrids by covalently conjugating Cur (“monarch”) with Bor (“envoy”). Systematic characterization confirmed the successful synthesis and controllable optimization of key properties, including enhanced dispersibility, improved cellular uptake, and favorable biocompatibility. Using rheumatoid arthritis (RA) as a disease model, we identified SCBMS as the optimal formulation owing to its superior dispersibility and uptake, which directly translated into the most potent anti-RA efficacy. The hybrids exerted synergistic multifunctional effects—including robust anti-inflammatory and antioxidant activities—effectively reducing the arthritis index and ameliorating synovial hyperplasia and joint destruction in vivo . Mechanistically, our results indicate a close correlation between the therapeutic effects and the downregulation of the AKT/mTOR/HIF-1α signaling pathway, supporting the involvement of this pathway in the observed anti-RA activity. This study provides a generalizable framework for developing functional hybrids guided by TCM principles and validates their translational potential. Download: Download high-res image (152KB) Download: Download full-size image
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Rui Tie,Xueqing Chai,Xingzhuo Zhang,Zhaocan Li,Zhiyan Wang,Shuyi Zhou,Simin Wu,Yao Zhang,Yujuan Jin,Huafeng Tian,Yan Jia
The synergistic optimization of antibacterial activity and mechanical properties has emerged as a priority in the development of medical dressings for chronic wounds. In this study, curcumin (Cur)-loaded polylactic acid/microcrystalline cellulose (PLA/MCC) nanofiber membranes were fabricated via electrospinning technology. It was found that the incorporation of 3% Cur significantly enhanced the mechanical properties of the electrospun nanofiber membrane compared with neat PLA. Its tensile strength and elongation at break increased by 240.2% and 181.2%, respectively, which meets the mechanical property requirements for clinical applications (1–40 MPa). The antibacterial activity is a core indicator that directly determines the practical application value of wound dressings. 3% Cur-loaded PLA/MCC nanofiber membranes show excellent antibacterial and antioxidant properties. Compared with PLA/MCC, the inhibition rate was increased by 20.1% against Escherichia coli and 72.2% against Staphylococcus aureus , with antioxidant activity exceeding 68.0%. In addition, cytotoxicity and hemocompatibility tests verified that all nanofiber membranes complied with the safety standards of biomedical materials. In conclusion, the PLA/MCC/Cur nanofiber membranes hold great promise as a novel, efficient, and safe dressing candidate for the clinical management of chronic wounds. Download: Download high-res image (185KB) Download: Download full-size image
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危险品化学品经营许可证（带存储）