Innovative Food Science & Emerging Technologies
·
2025
·
IF 6.8
Yang Wang,Xiang Luo,Man Zhou,Xiaojie Yu,Hafida Wahia,Xiaonan Lu,Cunshan Zhou
The increasing demand for low-calorie natural sweeteners emphasizes the urgent need for highly efficient and cost-effective biosynthesis strategies, particularly for Rebaudioside M (Reb-M). Here, a compatibility-guided glycosyltransferase-sucrose synthase (GT-SuSy) cascade was developed by pairing a structure-guided UGT76G1 variant with Glycine max SuSy. UDP-glucose was effectively regenerated in situ from inexpensive sucrose and UDP, significantly reducing both production costs and environmental impact. Phylogenetic analysis, molecular docking, and enzymatic validation confirmed the optimal compatibility of SuSy with UGT76G1. Through optimization of key parameters and by overcoming substrate solubility and cofactor limitations, Reb-M productivity reached 4621 ± 50 μg/mL/h. Furthermore, an innovative two-step fed-batch strategy enabled, for the first time, complete conversion of high-concentration Reb-D to Reb-M at industrially relevant titers (26,034 ± 90 μg/mL). High-purity Reb-M (98 %) was directly obtained by recrystallization, eliminating the need for costly resin-based concentration and purification. This work demonstrates a green, scalable, and economically viable platform for food-grade Reb-M production, offering a generalizable route for the biosynthesis of high-value steviol glycosides. In addition, it offers a generalizable framework to maximize product titers in multi-enzyme cascades through enzyme compatibility, process optimization, and staged feeding, promoting efficient and sustainable biocatalysis.
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高影响因子
Materials Horizons
·
2025
·
IF 10.7
Menglong Gao,Yao Guo,Shiding Zhang,Yinghui Xue,Jianxin Li,Shuaishuai Hu,Haixiang Song,Kaidi Wu,Miaomiao Li,Huihui Zhao,Zhongyuan Zhou,Qing Shen
We study the interface properties of CsPbBr3/Nb2O5 and CsPbBr3/Ta2O5 heterojunctions for structural, electronic, and optical characteristics. First-principles calculations were performed to analyze interfacial binding energy, electronic local function (ELF), charge density difference, and electrostatic potential. Four interface configurations were constructed based on CsPbBr3 (100) and M2O5 (001) terminations, revealing that the PbBr/TaO interface exhibits the highest binding energy (0.0073 eV Å−2), indicating superior stability. Charge transfer calculations demonstrate electron migration from CsPbBr3 to M2O5, forming an internal electric field that promotes charge separation. ELF and charge density difference maps highlight strong covalent interactions at the interfaces, particularly in the PbBr/TaO interface. Experimental characterization via XRD, SEM, TEM and XPS confirms successful heterojunction formation with preserved crystallinity. These findings provide theoretical and experimental insights into optimizing M2O5-based electron transport layers to enhance PSC efficiency and stability.
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PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Li Wang,Liyuan Li,Penggang Lv,Xin Gao,Yang Gao,Lu Han,Xuedong Zhu,Kake Zhu
A hierarchically structured ZSM-11/ZSM-5 intergrowth zeolite was generated using a polycationic organic structure-directing agent (OSDA), [-N+(CH2CH2CH2CH3)2-(CH2)8-]n[OH–]n, which is conceptually equivalent to bond-linked tetrabutylammonium (TBA), the frequently used OSDA for ZSM-11 synthesis. The produced ellipsoidal crystals have a major axis length of 130–240 nm and a minor axis length of 75–120 nm, made up of aligned nanocrystals of 44 to 83 nm, to construct an auxiliary macro- to mesopore network ranging from 45 to 80 nm. The Si/Al ratio can be manipulated from 50 to ∞, and the intergrowth exhibits acidity comparable to that of ZSM-5, which is distinct from previous reports that formation of hierarchical porosity or intergrowth often compromises the inherent acidity of zeolitic crystals. Such hierarchical architecture also endows the material with enhanced transport properties, as validated by 2-methylhexane adsorption measurements. In the catalytic methylation of meta-xylene with methanol, the hierarchical ZSM-11/ZSM-5 zeolite exhibited superior performance to that of ZSM-5, with enhanced activity and total trimethylbenzene and tetramethylbenzene selectivity, which was elevated from 28% to 39%. These catalytic merits stem from the combined effects of preserved acid strength, optimized pore connectivity, and alleviated diffusion limitations.
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2022
·
IF 5.518
Ning Li,Hong Shao,Haina Qi,Yuqi Sheng,Liu Yang,Yunrui Xie,Dan Li,Wensheng Yu,Qianli Ma,Xiangting Dong
A simple and universal technique of the combination of uniaxial electrospinning with subsequent peculiar dual-crucible fluorination technology is innovatively designed and used to construct metallic fluorides yolk-shell nanofibers (YSNFs) and yolk-shell nanobelts (YSNBs) directly for the first time. As a case study, Yb 3+ /Er 3+ co-doped alkaline earth metal fluoride (BaF 2 , SrF 2 and CaF 2 ) as core layer and SiO 2 as shell layer are applied to construct the yolk-shell one-dimensional nanostructures . Under the optimum calcination temperature (600 °C) and time (5 h), the obtained MF 2 :Yb 3+ , Er 3+ /SiO 2 (M=Ba, Sr, Ca) samples are of pure cubic phase, and display the yolk-shell nanofibers and yolk-shell nanobelts with good size uniformity and green up-converting fluorescence. By HF acid treatment of the samples, it is not only proved that the shell layer is SiO 2 , but also independent core-layer MF 2 :Yb 3+ , Er 3+ (M=Ba, Sr, Ca) nanofibers and nanobelts with good size uniformity and excellent up-conversion luminescence are obtained. Especially, only fluorination process among the halogenation can form such exceptive YSNFs and YSNBs one-dimensional nanostructures , and the formation mechanisms of YSNFs and YSNBs are proposed and verified, and further the novel technique is established. The new technique possesses the merits of simple device and easy operation, large output, well-defined morphology and high preparative success rate of yolk-shell nanofiber and yolk-shell nanobelt, universality to metallic fluorides. The design philosophy and the construction technique for the exceptional yolk-shell one-dimensional nanostructures afford a facile approach for the fabrication of other functional metal fluorides yolk-shell one-dimensional nanostructures.
研究领域:
材料科学
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纳米技术
·
光学
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2017
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IF 3.671
Yuvaraja Gutha,Yaping Zhang,Weijiang Zhang,Xu Jiao
Metal ions cause a serious public health problem. It is a great challenge to find an effective and efficient adsorbent to remove heavy metals from wastewater. Chitosan-based adsorbents are potential and effective for heavy metal ion removal. Hence a novel m-ECCSB was synthesized, characterized and utilized as an adsorbent for the removal of Cu(II) ions from aqueous solution. Various factors affecting the uptake behavior such as pH, adsorbent dosage, contact time, initial concentration of Cu(II) and temperature effect were investigated. Maximum adsorption capability (123.10 mg/g) was obtained at pH = 6, adsorbent dose of = 250 mg, rotational speed = 200 rpm, contact time = 60 min, and temperature of 323 K. The result of the kinetic study shows that the adsorption of Cu(II) could be described by the pseudo-second-order equation. Equilibrium data were analysed with the Langmuir, Freundlich and Dubinin-Radushkevich isotherms and Langmuir model was found to provide the best fit of the experimental data. The thermodynamic parameters showed that the adsorption of Cu(II) onto m-ECCSB was spontaneous (ΔG° = −8.990, −10.00 and −10.593 kJ/mol), endothermic (ΔH° = 15.674, 15.478 and 15.699 kJ/mol) and ΔS° (0.0814 J/mol K) suggests an increased randomness at the solid/solution interface under the studied conditions.
研究领域:
环境科学
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材料科学
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化学工程
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高影响因子
MICROCHIMICA ACTA
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2014
·Vol. 182
·期 3
·479-486
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IF 3.719
Lu Wenbo,Tao Lin,Wang Ying,Ge Juan,Dong Jian,Qian Weiping
An enzymatic glucose biosensor was developed that is making use of microspheres consisting of an m-aminophenol based resin decorated with silver nanoparticles (AgNP/MAPR). It was applied to the detection of H 2 O 2 and, if loaded with glucose oxidase (GOx), to the determination of glucose. The AgNPs were thermally immobilized on the MAPR microspheres. The AgNP/MAPR microspheres were deposited on a glassy carbon electrode (GCE) by surface casting. The resultant electrode exhibits remarkable catalytic performance in terms of H 2 O 2 reduction. The sensor gives an amperometric response to H 2 O 2 within <3 s and has a linear response in the 0.1 mM to 0.18 M concentration range ( r = 0.997). The detection limit is 2.7 μM at an SNR of 3. The glucose biosensor has a linear response in the 2 to 12 mM range and a detection limit of ~0.1 mM. The biosensor was applied to the determination of glucose in human blood serum.
A novel biosensor based on Ag nanoparticle-decorated m-aminophenol based resin (AgNP/MAPR) microsphere is developed for H 2 O 2 and glucose detection. AgNPs/MAPR microspheres not only favor the immobilization of glucose oxidase but also facilitate the electron transfer.
研究领域:
生物化学
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医学检测
·
材料科学
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DOI
高影响因子
Journal of Energy Chemistry
·
2021
·
IF 9.676
Amir Abdul Razzaq,Ganwen Chen,Xiaohui Zhao,Xietao Yuan,Jiapeng Hu,Ziwei Li,Yufeng Chen,Jiabin Xu,Rahim Shah,Jun Zhong,Yang Peng,Zhao Deng
Sulfurized polyacrylonitrile (SPAN) represents a unique class of cathode material for lithium sulfur (Li-S) batteries as it eradicates the polysulfides shuttling issue in carbonate-based electrolyte. However, due to the essential chemical S-linking and organic nature of SPAN, the active mass percentage and rate capability are two bottleneck issues preventing its ultimate deployment outside of laboratories. In the current work, aiming to endow both the charge conductivity and catalytic activity to SPAN for maximizing the redox kinetics of S conversion, a freestanding nanofibrous SPAN cathode embedding conductive CNTs and atomically dispersed Co centers is fabricated via multivariate electrospinning. While the CNTs enable dramatically enhancing the fiber conductivity and generating mesoscopic porosity for facilitating charge and mass transportation, the cross-linking of SPAN by Co-N 4 S motifs creates extra charge conduction pathways and further serves as the catalytic active sites for expediting redox S conversion. As a result, an extraordinary Li-SPAN performance is achieved with a high specific capacity up to 1856 mAh g −1 @0.2 C, a superb rate capability up to 10 C, and an ultra-long battery life up to 1500 cycles@1 C. Consequently, our study here provides insights into the adoption of coordination chemistry to maximize the sulfur utilization by ensuring a more complete redox conversion from SPAN to Li 2 S, and vice versa .
研究领域:
材料科学
·
电化学
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DOI
高影响因子
PHYTOMEDICINE
·
2019
·
IF 4.18
Wensong Yao,Zhen Lin,Gang Wang,Shaoguang Li,Bing Chen,Yuxia Sui,Jianyong Huang,Qicai Liu,Peiying Shi,Xinhua Lin,Qicai Liu,Hong Yao
Background Cervical cancer (CCa) represents the fourth most common cause of cancer-related death in women worldwide. CCa therapy is still a major clinical challenge worldwide. Finding and developing new anti-CCa chemotherapeutic drugs is a very significant issue. Delicaflavone is a rare biflavonoid from Selaginella doederleinii Hieron , which has shown strong anti-cancer activities in our preliminary screening. Purpose The present study aimed to investigate the apoptotic effect and mechanism of delicaflavone against CCa. Methods In this study, the effect and potential mechanism of delicaflavone against CCa were investigated in vitro and in vivo by MTT assay , TEM , flow cytometry, western blot assay, qPCR assay, immunofluorescence assay and the mouse xenograft tumor model. Results It was confirmed that delicaflavone inhibited the proliferation of human CCa HeLa cells, and induced morphological changes, G2/M phase arrest and apoptosis in a dose- and time-dependent manner. HeLa cells treated with delicaflavone showed the loss of mitochondrial membrane potential , release of Cytochrome c , activation of caspases , alteration of Bax/Bcl-2 balance, and the inhibition of MAPK signaling cascades. Furthermore, delicaflavone significantly decreased tumor growth in a dose-dependent manner without apparent side effects in a xenograft tumor model of HeLa cells. Immunohistochemistry analysis confirmed the up-regulation of Caspase-9, Caspase-3, Bax protein and down-regulation of Bcl-2 protein in the xenografts tumors , which was consistent with the results in vitro . Conclusion The results of the current study show that apoptosis is induced by the mitochondrial pathway accompanying with G2/M cycle arrest and inhibition of MAPK signaling cascades in human CCa HeLa cells, which can be used as a promising therapeutic drug for CCa.
研究领域:
肿瘤学
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药理学
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细胞生物学
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分子生物学
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DOI
PubMed
高影响因子
Small
·
2025
·
IF 12.1
Jie Liu,Qiu Ye,Hui Liu,Junliang Chen,Yi Wu,Haoran Wang,Yunan Ye,Lei Zhang,Qipeng Li,Jinjie Qian
Transition metal sulfides (TMSs) have emerged as promising catalysts for the oxygen reduction reaction (ORR), yet achieving activity comparable to Pt-based benchmarks remains challenging. Herein, we present an in situ MOF-carbonization strategy to prepare transition metal-doped ZnS nanoparticles embedded in N, S-codoped carbon nanorods (M─ZnS/NSCNR, M═Fe, Co, Ni). Structural characterization confirms successful dopant integration into ZnS lattices within hierarchical carbon substrates, yielding enhanced defect density and optimal porosity. Furthermore, electrochemical evaluation reveals Fe─ZnS/NSCNR's exceptional ORR performance in 0.1 M KOH, exhibiting a half-wave potential of 0.897 V and limiting current density of 5.20 mA cm −2— surpassing both Pt/C and Co/Ni analogues. In zinc-air batteries, it can achieve a peak power density of 132.1 mW cm −2 , specific capacity of 685.6 mAh g Zn −1 , and minimal voltage gap (0.96 V) during 70 h cycling. DFT calculations show that transition metal doping effectively modulates the ZnS electronic structure by adjusting the position of the d-band center (d ε ). The Fe-doped ZnS model exhibits a well-balanced d ε value (−1.34 eV) and reduced OOH * adsorption barrier (0.62 eV), leading to enhanced ORR activity. This work establishes a scalable route for designing noble metal-free, MOF-derived ORR catalysts with superior activity-durability characteristics for advanced energy technologies.
研究领域:
材料科学
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电化学
·
能量存储与转换
·
纳米材料
·
催化
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DOI
PubMed
高影响因子
JOURNAL OF LUMINESCENCE
·
2026
·
IF 3.8
Xiao Cheng,Hao Zhang,Zixu Chen,Haozhuo Dong,Ting Yu,Ruifang Guan
Room-temperature phosphorescent carbon dots (RTP-CDs) exhibit exceptional biocompatibility and tunable luminescence but are limited by short lifetimes and exciton quenching. Herein, we develop a one-step pyrolysis strategy using m-phenylenediamine and boric acid to fabricate boron-doped RTP-CDs (M-CDs) with ultralong green afterglow (16 s) and extended lifetime (37.03 ms). The rigid polycrystalline boron oxide matrix effectively confines molecular motion, isolates quenchers, and stabilizes triplet excitons, while boron doping reduces the singlet-triplet energy gap (ΔE ST = 0.206 eV) to promote intersystem crossing (ISC). Further heavy-atom doping (Cl/Br) enhances spin-orbit coupling, boosting afterglow to 18 s and lifetime to 41.16 ms, whereas iodine disrupts the matrix. Leveraging tunable afterglow dynamics, we demonstrate dynamic information encryption with visible/UV-switchable patterns. This work provides a cost-effective route to high-performance RTP-CDs and clarifies synergistic regulation mechanisms for advanced optoelectronic applications.
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高影响因子
Advanced Composites and Hybrid Materials
·
2026
·Vol. 9
·期 2
·172
·
IF 15.5
Pan Shijie,Li Shuli,Deng Shuduan,Li Xianghong
Lignin is an ideal precursor for developing efficient, green, and low-cost carbon dot corrosion inhibitors because it is one of the most abundant sustainable resources. Nevertheless, its potential in this field has not yet been fully exploited. In this paper, a novel type of N, S-doped lignin-based carbon dots (N, S-LCDs) with ultra-high inhibition performance was successfully prepared, using lignin as a precursor and 2-thiazoline-2-thiol as both the nitrogen and sulfur source. It was demonstrated that the N, S-LCDs maintained a high corrosion inhibition efficiency of nearly 90% within the temperature range of 20 to 50 °C, with the maximum efficiency of 97.24% observed at 30 °C. Furthermore, a prolonged immersion test over 72 h confirmed the excellent stability of N, S-LCDs. Characterization results indicated that the synergistic co-doping of N and S is the key to N, S-LCDs superior performance. The adsorption of N, S-LCDs on the cold rolled steel (CRS) surface conforms to the Langmuir adsorption isotherm, and a protective film is formed on the CRS surface through physical and chemical adsorption, thereby effectively inhibiting the corrosion process.
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高影响因子
APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Zirui Qin,Jiehao Xie,Xiaofang Wen,Hongcan Lou,Zipin Peng,Xingkun Chen,Yuan Tan,Jisong Zhang
Chlorinated phenols are priority pollutants that require efficient low-temperature removal technologies. Here, we synthesize a series of spinel-type MAl 2 O 4 (M = Co, Mg, Zn, Cu) supports and deposit 1 wt% Pd via incipient-wetness impregnation to evaluate their hydrodechlorination (HDC) performance toward 4-chlorophenol under ambient aqueous conditions (30 °C, 0.2 MPa H 2 ). Catalytic screening shows that the identity of the divalent A-site cation strongly modulates activity: Pd/Co-Al achieves 91.8 % conversion with > 98.3 % selectivity to phenol, outperforming Pd/Ni-Al (84.7 %) and the remaining analogues. Pd/Cu-Al exhibits almost no conversion (<5.0 %), while Pd/Mg-Al and Pd/Zn-Al give moderate conversions (ca.55.4–58.7 %). Detailed characterization by XRD, N 2 -physisorption, H 2 -TPR, XPS and STEM reveals that the superior performance of Pd/Co-Al is rooted in (i) strong metal–support interactions that stabilize a balanced Pd 2+ /Pd 0 surface ensemble, (ii) coherent lattice matching at Pd(1 1 1)/CoAl 2 O 4 (311) interfaces that suppress particle growth, and (iii) high spinel thermostability that mitigates leaching and coking. A 30 h continuous-flow test confirms stable operation without activity loss. This work elucidates how subtle variations in spinel composition dictate Pd electronic structure and interfacial geometry, providing design principles for next-generation HDC catalysts.
研究领域:
环境催化
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材料化学
·
多相催化
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高影响因子
危险品化学品经营许可证（带存储）