INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
·
2025
·
IF 4.6
Yi Lu,Xiaoying Yu,Yandi Pan,Hang Yin,Qingqing Yang,Xin Shen,Xuefeng Cao,Zhiwei Li,Lianci Peng,Rendong Fang
With the increased bacterial resistance to conventional antibiotics, there is an urgent need for the development of novel antimicrobial agents. Cathelicidins belonging to the family of cationic host defense peptides (HDPs) are a critical component of the innate immune system with antimicrobial and immunomodulatory activities. Our previous study has shown that CATH-1 exhibits potent bactericidal activity against Streptococcus suis ( S. suis ), but the underlying mechanism is still unclear. In this study, we investigated the effect of CATH-1 on the resistance development and antibacterial mechanisms against S. suis strain SC19. Our results revealed that CATH-1 did not induce bacterial drug-resistance. Proteomics and metabolomics analyses revealed that CATH-1 exerts its antibacterial effects by modulating multiple pathways, including the cell membrane, bacterial virulence, and energy metabolism pathway. Mechanistically, CATH-1 exerts dual antimicrobial effects by disrupting bacterial membrane integrity and targeting the serine/threonine kinase (STK) to inhibit capsular polysaccharide (CPS) synthesis. The interaction between STK and CATH-1 was evident by molecular docking, GST affinity-isolation assay, cellular thermal shift assay (CETSA) and drug affinity responsive target stability (DARTS). Furthermore, stk deficiency abrogated the anti- S. suis efficacy of CATH-1 both in vitro bactericidal assay and in vivo infection model, indicating that STK is the potential target of CATH-1. Our study reveals a novel antibacterial target of CATH-1, providing new insights into the development of antimicrobial peptides as anti-infective agents.
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DOI
PubMed
高影响因子
Materials Today Bio
·
2025
·
IF 10.2
Chunyi Li,Kongcheng Wang,Jie Shao,Junmeng Zhu,Yaohua Ke,Baorui Liu,Lanqi Cen
Peptide vaccines have potential for tumour immunotherapy but face challenges in clinical trials, such as human leukocyte antigen limitations, potential cytotoxic T lymphocyte tolerance, short T-cell response duration, weak immune response, and other issues. Optimizing the antigens of peptide vaccines and selecting an effective delivery system are crucial for enhancing their antitumour effects. 3 multiepitope long peptides (NLP) targeting the NY-ESO-1 antigen were screened using bioinformatics methods. An engineered Lactococcus lactis strain (FOLactis) expressing FMS-like tyrosine kinase 3 ligand and the costimulator OX40 ligand was previously developed to activate immune cells. In this study, FOLactis was utilized as a biological carrier for NLP via Mg 2+ -based metal-organic frameworks to stimulate innate and adaptive immunity. The FOL-M@NLP were characterized, and various tumour models were established to assess the antitumour efficacy of the biovaccine. The preliminary mechanism of the immune effect induced by FOL-M@NLP was studied both in vivo and in vitro . The biovaccine FOL-M@NLP was effectively taken up by antigen-presenting cells (APCs). APCs were activated, activating the T-cell response. When FOL-M@NLP was administered subcutaneously in vivo , their antitumour activity was superior to that of NLP and FOLactis alone. The biovaccine improved the immune infiltrating state of the tumour microenvironment and metastasis niche, inhibited tumor progression and prevented recurrence. It is demonstrated that FOL-M@NLP serves as a potent and safe antitumour platform that enhances antigen peptide delivery and facilitates the advancement of therapeutic biological vaccine platforms.
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PubMed
高影响因子
FIBERS AND POLYMERS
·
2016
·Vol. 17
·期 11
·1741-1748
·
IF 1.022
Xu Bin,Li Qiaoping,Zhuang Linghua,Wang Qiang,Li Chao,Wang Guowei,Xie Fengwei,Halley Peter J.
3-methyl-1-(ethylacetyl)imidazolium chloride ([EtMIM]Cl), was synthesized for chitosan dissolution, and the dissolution and regeneration behaviors of chitosan in [EtMIM]Cl were thoroughly investigated. The solubility of chitosan in [EtMIM]Cl was measured at temperatures ranging from 40 °C to 110 °C, based on which the thermodynamic parameters of chitosan in [EtMIM]Cl were calculated. The polarizability and hydrogen bond accepting ability was determined by solvatochromic UV/vis spectroscopy. The regenerated chitosan from [EtMIM]Cl by adding methanol was characterized by thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and scanning electron microscopy (SEM). Density functional theory (DFT) computations were performed to study the interactions between [EtMIM]Cl and chitobiose. Five kinds of hydrogen bonds, C-H/O, O-H/O, O-H/Cl, C-H/Cl, N-H/Cl were found, suggesting strong interactions between [EtMIM]Cl and chitobiose. In particular, the oxygen atom and the active methylene group of carboxylic ester in [EtMIM] + , formed strong hydrogen bonding with chitobiose. The molecular simulation results indicated that both the Cl − anions and [EtMIM] + cation played important roles in the chitosan dissolution process, by the disruption of native hydrogen bonds of chitosan.
研究领域:
生物化学
·
材料科学
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高影响因子
FOOD MICROBIOLOGY
·
2026
·
IF 5.4
Wei-Tao Zhai,Han Zhao,Li-Juan Chai,Wei Zhang,Xiao-Juan Zhang,Zhen-Ming Lu,Chuan-Qiang Gao,Guan-Ru Si,Wen-Qing Zhang,Song-Tao Wang,Cai-Hong Shen,Zheng-Hong Xu
1-Propanol is a crucial flavor compound in Jiang-flavor Baijiu, yet the key microbial pathways and environmental factors controlling its synthesis have not been systematically investigated. Using an integrated approach of metagenomics and culture-dependent techniques, this study identified the key microbes, pathways, and factors controlling 1-propanol synthesis. The highest 1-propanol level was detected in first-round base Baijiu, with rapid accumulation during early pit fermentation. Metagenomics revealed the propanoate pathway as the dominant route, primarily contributed by Limosilactobacillus , while Pichia and Saccharomyces were key providers of pyruvate decarboxylase in the citramalate and threonine pathways. Pure-culture validation confirmed that L. panis MR32 predominantly utilizes 1,2-propanediol as the precursor, while yeasts such as P. kudriavzevii 2J2 and S. cerevisiae LB7A prefer the 2-ketobutyrate pathway. Environmental tests revealed optimal 1-propanol production by L. panis MR32 at pH 5.5 and increasing yields with temperature (25–45 °C). In contrast, most yeasts produced the most 1-propanol at 30 °C, beyond which yields declined, with only P. kudriavzevii 2J2 and I. orientalis IO tolerating high lactic acid. Our findings clarify the microbial division of labor and environmental drivers of 1-propanol formation, enabling targeted fermentation control.
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PubMed
高影响因子
Frontiers in Chemical Engineering
·
2026
·
IF 2.6
Gideon Abaidoo Ocran,Bosong Zhang,Yi Zuo,Huali Tan,Gudan Li,Hong Yang,Chunshan Song,Xinwen Guo
The epoxidation of allyl alcohol with H2O2 over titanium silicalite-1 (TS-1) is an environmentally friendly route for producing glycidol. However, the catalytic activity and stability of TS-1 is not satisfactory. In this study, strip-shaped TS-1 was hydrothermally treated by TPAOH solution, change theTi coordination states and diffusion property, thereby enhancing its catalytic performance. The influences of TPAOH concentration and treating time on the physical chemical property and catalytic performance were studied systematically. It was found that the SiO2 agglomerant was dissolved and crystallized during the treatment, resulting in an increased Si content on the external surface. The tetrahedrally coordinated Ti was transformed to pentahedrally and octahedrally coordinated Ti, which possess higher catalytic activity for selective oxidation. The treatment also leads to the formation of cavities in the TS-1 crystals, which can shorten the diffusion pathway of substates and improve the diffusion property. Both the chemical property and microstructure enhance the catalytic activity for allyl alcohol epoxidation.
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高影响因子
MATERIALS RESEARCH BULLETIN
·
2024
·
IF 5.3
He Cui,Chen Li,Raz Muhammad,Yuanyuan Wang,Zhihua Qian,Kaixin Song
In this study, (1- x )Ni 0.5 Zn 0.5 Fe 2 O 4 - x K 2 MoO 4 ((1- x )NZO- x KMO) composite ceramics were prepared through a cold sintering process. The research aimed to investigate the effect of different cold sintering conditions on the densification, phase, and magnetic/dielectric properties of the composites. The 0.6NZO-0.4KMO composite, prepared at 180 °C for 30 min under an applied pressure of 500 MPa, and utilizing 10 wt.% deionized water as a solvent, exhibited a high dielectric constant and permeability. SEM analysis revealed that the two phases were uniformly mixed, and the microstructure was dense. The cold sintering mechanism proposed for (1- x )NZO- x KMO composites suggests that the 'dissolution-precipitation' mechanism plays a key role in driving the densification of the ceramics.
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高影响因子
MATERIALS LETTERS
·
2014
·
IF 2.269
Shanshan Ji,Peixia Yang,Jinqiu Zhang,Ye Lian,Jie Zhang,Maozhong An
BMIm-OTF (1-Butyl-3-methylimidazolium trifluoromethanesulfonate) ionic liquid was used for the first time to prepare Cu 1.00 In 0.83 Ga 0.23 Se 1.64 thin films . The standard CIGS sample was calibrated using its inductively coupled plasma optical emission. The morphological properties were detected using scanning electron microscopy . The band gap of the CIGS thin film was approximately 1.55 eV, as measured using UV–visible absorption spectra . The carrier concentration and average Hall coefficient of the CIGS thin films were 2.741×10 20 cm −3 and 2.277×10 −2 cm 3 /C, respectively.
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2015
·
IF 3.368
Xiang Shen,Bing Yan
A series of luminescent Ln 3+ @bio-MOF-1 (Ln = Eu, Tb, bio-MOF-1 = Zn 8 (ad) 4 (BPDC) 6 O⋅2Me 2 NH 2 (ad = adeninate, BPDC = biphenyldicarboxylate)) are synthesized via postsynthetic cation exchange by encapsulating lanthanide ions into an anionic metal–organic framework (MOF), and their photophysical properties are studied. After loading 2-thenoyltrifluroacetone (TTA) as sensitized ligand by a gas diffusion (“ship-in-bottle”) method, it is found that the luminescent intensity of Eu 3+ is enhanced. Especially, when loading two different lanthanide cations into bio-MOF-1, the luminescent color can be tuned to close white (light pink) light output. Additionally, bio-MOF-1 and Eu 3+ @bio-MOF-1 are selected as representative samples for sensing metal ions . When bio-MOF-1 is immersed in the aqueous solutions of different metal ions , it shows highly sensitive sensing for Fe 3+ as well as Eu 3+ @bio-MOF-1 immersed in the DMF solutions of different metal ion. The results are benefit for the further application of functionalized bio-MOFs in practical fields.
研究领域:
无机化学
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材料科学
·
分析化学
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纳米生物技术
·
光物理学
·
配位化学
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高影响因子
LANGMUIR
·
2018
·
IF 3.789
Xiangyu Ge,Jinjin Li,Chenhui Zhang,Zhongnan Wang,Jianbin Luo
The robust liquid superlubricity of a room-temperature ionic liquid induced by tribochemical reactions is explored in this study. Here, 1-ethyl-3-methylimidazolium trifluoromethanesulfonate ([EMIM]TFS) could realize stable superlubricity (μ < 0.01) with water at the interfaces of Si3N4/SiO2. A superlow and steady friction coefficient of 0.002–0.004 could be achieved under neutral conditions (pH of 6.9 ± 0.1) after 600 s of running-in process. Various factors that could affect superlubricity were explored, including concentration of [EMIM]TFS, sliding speed, applied load, and volume of the lubricant. The results reveal that superlubricity can be achieved with [EMIM]TFS aqueous solution under a broad scope of conditions. The results of surface analysis show that a steady composite tribochemical layer comprising [EMIM]TFS, silica, ammonia-containing compounds, and sulfides was formed by tribochemical reactions between [EMIM]TFS and Si3N4 during the running-in period. The film thickness calculation reveals that the achieved superlubricity is in a mixed lubrication regime that comprises boundary lubrication and thin film lubrication. The superlubricity state is governed by a firm composite tribochemical layer, a molecular adsorption layer (electric double layer of [EMIM]TFS), and a fluid layer. The liquid superlubricity achieved by the ionic liquid is helpful for the development of new ionic liquids with superlubricity characteristics and is of great significance for scientific understanding as well as engineering applications.
研究领域:
摩擦学
·
材料科学
·
表面化学
·
润滑工程
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高影响因子
JOURNAL OF ORGANOMETALLIC CHEMISTRY
·
2021
·
IF 2.369
Ji Wu,Ke Cao,Cai-Yan Zhang,Xin-Yu Wen,Bo Li,Junxiao Yang
A FeCl 3 catalyzed tandem condensation/cyclization/aerobic oxidation process for synthesis of 1-benzoxazolyl- o -carboranes has been developed. The degradation of o -carborane in the presence of aza-/oxa-nucleophiles was completely suppressed, and a series of 1-benzoxazolyl- o -carboranes, 1-benzothiazolyl- o -carborane and 1-benzimidazolyl- o -carborane have been synthesized with good to excellent yields. This work offers a general protocol for synthesis of 1-benzoxazolyl- o -carboranes, which has important reference for synthesis of aromatic heterocycle-carborane derivatives and promote its applications in miscellaneous areas.
研究领域:
有机化学
·
硼化学
·
催化化学
·
杂环化学
·
材料化学
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高影响因子
INORGANIC CHEMISTRY
·
2019
·
IF 4.85
Ming-Ming Yao,Chen-Hui Jiang,Ji-Song Yao,Kun-Hua Wang,Chen Chen,Yi-Chen Yin,Bai-Sheng Zhu,Tao Chen,Hong-Bin Yao
Lead halide perovskite nanocrystals (NCs) exhibit great application potential in optoelectronic devices because of their tunable band gaps and facile colloidal synthesis, but they suffer from serious lead toxicity and instability. It is highly desirable to substitute lead with other elements to acquire nontoxic and environmentally friendly lead-free perovskite NCs for optoelectronic devices. Here, we report a general method for the colloidal synthesis of a series of bismuth/antimony-based halide perovskite NCs with various constituents and optical band gaps from 1.97 to 3.15 eV. In our proposed synthetic system, 1-dodecanol is adopted as the solvent instead of the conventionally used 1-octadecene to realize size controllability of bismuth/antimony-based metal halide perovskite NCs. It is found that 1-dodecanol can act as a surfactant to tightly adsorb on the surface of bismuth/antimony-based halide perovskite NCs, enabling their small sizes (∼2 nm) and high dispersibility. Simultaneously, the band gaps of bismuth/antimony-based halide (A3B2X9, where A = CH3NH3, Cs, or Rb, B = Bi or Sb, and X = Cl, Br, or I) perovskite NCs can be systematically tuned by the atomic substitution of A, B, or X lattice sites. Moreover, to show the optoelectronic application potential of these lead-free halide perovskite NCs, a solar cell based on colloidal Cs3Bi2I9 perovskite NCs is demonstrated. The developed colloidal synthesis of bismuth/antimony-based halide NCs in 1-dodecanol will offer an alternative route to fabricating lead-free halide perovskite optoelectronic devices.
研究领域:
材料科学
·
纳米技术
·
光电子学
·
无机化学
·
能源材料
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DOI
高影响因子
NANOTECHNOLOGY
·
2021
·Vol. 32
·期 47
·475708
·
IF 3.874
Qiu-Ping He,Yun Zou,Peng-Fei Wang,Xiao-ming Dou
Silicalite-1 zeolitic membranes have been successfully fabricated on the porous α-Al2O3 support by templated and template-free protocol, respectively, for vapor permeation separation of dichlorobenzene (DCB) isomers. After proving the high quality of the membranes by single gas permeation (He and SF6) performance, the vapor-permeation of DCB isomers over two types of the silicalite-1 membrane was then investigated. The separation results clearly indicated that under the lower partial pressure and higher temperature, the effect of DCB isomer adsorption on the permeance could be kept at a sufficiently low level and sharp selectivity become more important. Thus, high p-DCB selectivity could be achieved. Comparatively, the template-free silicalite-1 zeolite has a much higher p-DCB selectivity due to the relatively fewer inter-crystalline gaps. Under certain separation conditions, the highest selectivity of p-DCB for p-/m-DCB and p-/o-DCB binary systems could reach 165 and 113, respectively.
研究领域:
材料科学
·
化学工程
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DOI
高影响因子
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