Chemical Science
·
2021
·Vol. 12
·期 37
·12437-12444
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IF 9.825
Xiaopei Li,Dongdong Wang,Yongjie Zhang,Wenqi Lu,Songqiu Yang,Guangjin Hou,Zhenchao Zhao,Haijuan Qin,Yahui Zhang,Minmin Li,Guangyan Qing
Aggregation-induced enhanced emission (AIEE) molecules have significant applications in optoelectronics, biomedical probes and chemical sensors, and large amounts of AIEE molecules have been reported since the concept of AIEE was proposed. Most aromatic AIEE molecules have complex structures consisting of multiple aromatic rings and/or polycyclic skeletons. In this study, we find that 2-aminophenylboronic acid (2-APBA) with a simple structure is highly emissive in the solid state. Further studies reveal that 2-APBA exists in a dimeric form, and the 2-APBA dimer is a novel AIEE molecule. The underlying AIEE mechanism is that the 2-APBA dimeric units aggregate through intermolecular interactions to produce highly ordered molecular packing without the presence of π–π stacking interactions that would lead to aggregation-caused quenching. Furthermore, the 2-APBA dimer aggregates could reversibly transform into its non-fluorescent monomer form driven by new kinds of dynamic covalent B–N and B–O bonds, illustrating its good potential in molecular recognition, nanogating, chemo/bio-sensing and controlled drug release.
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NANO LETTERS
·
2021
·
IF 11.189
Hua Kang,Xuejun Wang,Mingquan Guo,Changhao Dai,Renzhong Chen,Lei Yang,Yanling Wu,Tianlei Ying,Zhaoqin Zhu,Dapeng Wei,Yunqi Liu,Dacheng Wei
The fast spread of SARS-CoV-2 has severely threatened the public health. Establishing a sensitive method for SARS-CoV-2 detection is of great significance to contain the worldwide pandemic. Here, we develop a graphene field-effect transistor (g-FET) biosensor and realize ultrasensitive SARS-CoV-2 antibody detection with a limit of detection (LoD) down to 10–18 M (equivalent to 10–16 g mL–1) level. The g-FETs are modified with spike S1 proteins, and the SARS-CoV-2 antibody biorecognition events occur in the vicinity of the graphene surface, yielding an LoD of ∼150 antibodies in 100 μL full serum, which is the lowest LoD value of antibody detection. The diagnoses time is down to 2 min for detecting clinical serum samples. As such, the g-FETs leverage rapid and precise SARS-CoV-2 screening and also hold great promise in prevention and control of other epidemic outbreaks in the future.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2021
·
IF 7.312
Jia Deng,Xiang Zhan,Feng Wu,Shuxian Gao,Li-Zhi Huang
Trichloroethylene (TCE), one of the most frequently detected chlorinated organic pollutants (COPs) in groundwater, has potential risks to human health. The bimetallic system consisting of zero-valent iron (ZVI) and a second catalytic metal has been widely investigated for reductive dechlorination of COPs. However, the passivation layer of ZVI inhibits the electron transfer causing a low dechlorination efficiency. In this work, we designed a novel bimetallic system using Fe(OH) 2 and Ni for fast dechlorination of TCE. The reduction efficiency of TCE reaches 94.8 % after 5 h of reaction in the Fe(OH) 2 /Ni system. TCE was completely dechlorinated to nontoxic gas products including ethylene and ethane, which was attributed to the generation of active hydrogen species (H*) in the system. The Ni 2+ cations undergo the process of hydroxylation and olation. Subsequently, electrons of Fe(OH) 2 were transferred to Ni(II) causing the formation of Ni(0). The catalytic Ni(0) sites generate H* for TCE dechlorination via catalytic reduction of H 2 O/H + . A part of Fe(II) in the Fe hydroxide layer of Fe(OH) 2 was oxidized to Fe(III) leading to the formation of green rust with a hexagonal structure. Our work demonstrates Fe(OH) 2 /Ni is a promising composite material for the remediation of TCE-contaminated groundwater.
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ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Zhong Wei Jiang,Ting Ting Zhao,Chun Mei Li,Yuan Fang Li,Cheng Zhi Huang
A reliable and sensitive detection approach for SARS-CoV 2 is essential for timely infection diagnosis and transmission prevention. Here, a two-dimensional (2D) metal–organic framework (MOF)-based photoelectrochemical (PEC) aptasensor with high sensitivity and stability for SARS-CoV 2 spike glycoprotein (S protein) detection was developed. The PEC aptasensor was constructed by a plasmon-enhanced photoactive material (namely, Au NPs/Yb-TCPP) with a specific DNA aptamer against S protein. The Au NPs/Yb-TCPP fabricated by in situ growth of Au NPs on the surface of 2D Yb-TCPP nanosheets showed a high electron–hole (e–h) separation efficiency due to the enhancement effect of plasmon, resulting in excellent photoelectric performance. The modified DNA aptamer on the surface of Au NPs/Yb-TCPP can bind with S protein with high selectivity, thus decreasing the photocurrent of the system due to the high steric hindrance and low conductivity of the S protein. The established PEC aptasensor demonstrated a highly sensitive detection for S protein with a linear response range of 0.5–8 μg/mL with a detection limit of 72 ng/mL. This work presented a promising way for the detection of SARS-CoV 2, which may conduce to the impetus of clinic diagnostics.
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ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Yiwei Han,Yichen Zhang,Shuai Wu,Mohammed Jalalah,Saeed A. Alsareii,Yongmei Yin,Farid A. Harraz,Genxi Li
The structures assembled by peptides have attracted great attention due to their unique physicochemical properties. Moreover, the co-assembly of peptides with additional components can endow the structures with extended functions. In this work, we have explored the co-assembly of peptides and carbon nanodots (CNDs) by taking advantage of their non-covalent binding; thus, the obtained structure may show both the recognition capability of peptides and the catalytic activity of CNDs. Therefore, we have further used the assembled structure for the sensitive analysis of transglutaminase 2 with a low detection limit of 0.25 pg/mL. By simply replacing the peptide sequences or the nanomaterials, the strategy proposed in this work can be developed as a universal model to build the co-assemblies of peptides and nanomaterials, thus leading to their broader applications in biological and biomedical research.
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FUEL
·
2021
·
IF 6.609
Bo Wang,Ya-Feng Huang,Peng-Fei Wang,Xiao-Jie Liu,Chang Yu,Wei-Guang Li,Xiao-Feng Wang,Xiong-Min Liu
The thermal oxidation reaction of 2,5-dimethylfuran (DMF) was investigated using a custom-designed mini closed pressure vessel test (MCPVT) and traced by 1 H nuclear magnetic resonance( 1 H NMR). The oxidation behavior was monitored by-via temperature–time (T-t) and pressure–time (p-t) plots of MCPVT recording. Oxidation products were determined via gas chromatography-mass spectrometry (GC–MS), and the generated peroxide was examined by iodimetry and thin-layer chromatography (TLC), with the thermal decomposition hazard evaluation by differential scanning calorimeter (DSC) and MCPVT. Results show that the DMF oxidation reaction proceeded through initial oxygen absorption at 39.3 °C, followed by an exothermic self-accelerating oxidation at 84.5 °C. DMF could form high level peroxide in auto-oxidation; the decomposition of peroxides would lead to the radical oxidation that the generated ·OH radical mainly attacks on the position 2/5 of DMF with subsequent addition of O 2 initiating ring-opening reaction, in which DMF was firstly converted to cis -3-hexene-2,5-dione, and then produced the trans -3-hexene-2,5-dione with strong photoisomerism. DMF oxidation showed a high level of residue formation, and those solid products contained considerable amount of peroxides with a high thermal hazard; its exothermic onset temperature (T 0 ) and decomposition heat (Q DSC ) of 58.8 °C and 1982.3 J∙g −1 , and the decomposition maximum temperature rising rate (dT/dt) max and maximum of pressure rising rate (dp/dt) max was 9.98 °C∙s −1 and 291 kPa∙s −1 , respectively. Thermal decomposition of those peroxide products could give rise to thermal runaway of DMF oxidation, and further transformed into a detonation possibly.
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2021
·
IF 3.981
Xiuting He,Zhongcheng Cao,Nuannuan Li,Liuxiang Chu,Jiazhen Wang,Chunyan Zhang,Xiaoyan He,Xiaoyan Lu,Kaoxiang Sun,Qingguo Meng
7-Ethyl-10-hydroxycamptothecin (SN-38)-loaded polyethylene glycol-GPLGVRG-poly β-benzyl- l -aspartic acid (PEG-GPLGVRG-PBLA) self-assemblies were successfully prepared using a classical nanoprecipitation method to give an enzyme-responsive nano-drug delivery system. The PEG-GPLGVRG-PBLA/SN-38 self-assemblies were characterized by transmission electron microscopy , dynamic light scattering , and high-performance liquid chromatography. The encapsulation efficiency was 91.7 ± 1.21% and the drug loading was 16.6 ± 0.93%. The 12 h in vitro release of SN-38 from PEG-GPLGVRG-PBLA/SN-38 treated with MMP-2 was 73.2 ± 2.05%, which was significantly higher than that for the group without MMP-2, demonstrating the enzyme-responsiveness of the nano-drug delivery system. In addition, the cellular uptake and tumor accumulation of PEG-GPLGVRG-PBLA were better than those of PEG-PBLA, and the blank PEG-GPLGVRG-PBLA showed high biocompatibility . These findings indicate that the enzyme-responsive nano SN-38 delivery system could provide new opportunities in tumor therapy.
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BIOSENSORS & BIOELECTRONICS
·
2021
·
IF 10.618
Ying Peng,Yanhong Pan,Zhaowei Sun,Jinlong Li,Yongxiang Yi,Jie Yang,Genxi Li
The pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is continuously worsening globally, herein we have proposed an electrochemical biosensor for the sensitive monitoring of SARS-CoV-2 RNA. The presence of target RNA firstly triggers the catalytic hairpin assembly circuit and then initiates terminal deoxynucleotidyl transferase-mediated DNA polymerization. Consequently, a large number of long single-stranded DNA products can be produced, and these negatively charged DNA products will bind a massive of positively charged electroactive molecular of Ru(NH 3 ) 6 3+ due to the electrostatic adsorption. Therefore, significantly amplified electrochemical signals can be generated for sensitive analysis of SARS-CoV-2 RNA in the range of 0.1–1000 pM with the detection limit as low as 26 fM. Besides the excellent distinguishing ability for SARS-CoV-2 RNA against single-base mismatched RNA, the proposed biosensor can also be successfully applied to complex matrices, as well as clinical patient samples with high stability, which shows great prospects of clinical application.
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Molecular Catalysis
·
2021
·
IF 5.062
Yue Zhang,Zhiyong Pan,Nan Wang,Li Wang
Silica SBA-15 without removal of template P123 was calcined in an inert atmosphere and the carbon-modified SBA-15 thus obtained was used as the support of Pd catalyst for the hydrogenation of 2-ethylanthraquinone (EAQ). The effects of extraction times of P123 in SBA-15 with water prior to inert calcination and calcination temperature on the structure and catalytic performance of Pd catalyst were studied. The results of elemental analysis, X-ray diffraction, X-ray photoelectron spectroscopy, inductively coupled plasma, Fourier transform infrared spectroscopy, Raman spectra, water contact angle measurement, N 2 adsorption-desorption, transmission electron microscopy and energy dispersive X-ray mapping showed that carbon content of catalysts varied in the range of 3.4 % and 1.1 % with increasing extraction times from 0 to 6 due to the decrease in the residual amount of P123 in uncalcined SBA-15. With rising calcination temperature, the occurrence state of carbon in catalysts was converted from amorphism into graphite. The Pd catalyst supported on SBA-15 extracted for 3 times and calcined at 650 °C had 2.0 % carbon, and exhibited the highest activity (0.37 molH 2 ·gPd −1 ·min −1 ) and selectivity (98.9 %). This is due to the presence of appropriate amount of carbon, which provided a relatively high hydrophobicity without significantly reducing the specific surface area and pore size of SBA-15 support. The high hydrophobicity benefits the adsorption of EAQ from the working solution to the surface of catalyst.
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ELECTROCHIMICA ACTA
·
2021
·
IF 6.901
Xiaofei Miao,Xiangxin Zhang,Sujing Chen,Yongchuan Liu,Yuanqiang Chen,Junhong Lin,Qi Chen,Yining Zhang
For improving the energy density of carbon-based supercapacitors, the highly reversible redox mediators with giant pseudocapacitance have been studied extensively. In this work, the dual-redox combination of sodium anthraquinone-2-sulfonate (AQS) and potassium bromide (KBr) is introduced into the carbon-based supercapacitors to enhance the electrochemical performances. In the dual-redox enhanced supercapacitors (DRESc), the performances of negative and positive electrodes are improved by AQS and KBr, respectively. In order to use AQS and KBr rationally and effectively, two different approaches are studied: (I) redox mediators are adsorbed in the electrodes; (II) redox mediators are added into the electrolyte. The experimental results demonstrate that the combination of adsorbing AQS onto the negative electrode (the approach I) and adding KBr in the electrolyte (the approach II) is the best approach. Furthermore, electrochemical results prove that it is an optimal choice to adsorb 3 mg AQS for the negative electrode in this work. Meanwhile, to match the AQS-enhanced negative electrode, synchronous potential measurements indicate that the optimal choice for the positive electrode is adding 1.5 M KBr in the 1 M H 2 SO 4 electrolyte. Finally, the DRESc achieved a maximum gravimetric energy density (E G ) of 32.05 Wh kg −1 at 0.5 A g −1 and a maximum gravimetric power density (P G ) of 2200 W kg −1 at 8 A g −1 , implying that the AQS-Br dual-redox system is a promising candidate for energy storage and conversion.
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MINERALS ENGINEERING
·
2020
·
IF 3.795
Xiaoxiao Qiao,An Liu,Zhihong Li,Jinchuan Fan,Canjin Luo,Panpan Fan,Yizhou Liu,Minqiang Fan
A novel combined reagent dodecylamine (DDA)–2-octanol–kerosene was employed to overcome the problems associated with DDA, that is, DDA has a high freezing point and needs to be acidified with hydrochloric or acetic acid when it is used for flotation. The analysis of the basic physical properties of the agent showed that DDA–2-octanol–kerosene had significant advantages in freezing point and dispersibility and its freezing point can be reduced to below 0 °C. From the flotation results of magnetite, it can be seen that DDA–2-octanol–kerosene has a better selectivity. Response Surface Methodology based on a three-level, three-variable Box–Behnken design (BBD) was employed to define the quadratic relationship between the recovery of quartz and the composition of the mixed agent. The results indicated that the recovery of quartz increased with the increase of DDA or 2-octanol dosage, however, kerosene had a marginal positive effect on the recovery of quartz when the amount of kerosene was less than 0.76 times that of DDA and otherwise a negative effect. This study provides a new method and technical support for its industrial application for the reverse flotation of iron ore for the combination of agents in the field of iron ore flotation. And allows for a deeper macro-level understanding of the interaction between the DDA–2-octanol–kerosene ternary mixed agents.
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2020
·Vol. 326
·期 1
·185-192
·
IF 1.137
Hu Ke,Liu Zhirong,Xiu Taoyuan,Zhou Limin,Wang Yun
The Cu 3 (BTC) 2 (BTC = 1,3,5-benzenetricarboxylic acid) was synthesized by water/solvent heat method. The Cu 3 (BTC) 2 was characterized by SEM/EDS, Zeta potential and XRD. Batch static adsorption experiments investigated the various factors affecting the adsorption of Th(IV) in aqueous solution such as pH, solid–liquid ratio, contact time, initial concentration and temperature, and the adsorption mechanism is also discussed. The adsorption process was in line with the pseudo-second-order kinetic model and the Langmuir isotherm model. At the same time, compared with other adsorbents. The results showed that Cu 3 (BTC) 2 had good adsorption for Th(IV) with a maximum adsorption of 757.58 mg g −1 .
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