CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Chao Liu,Yanqiao Ren,Can Hong,Xuyu Li,Mengqing Guo,Le Zhao,Yan Liu,Chuansheng Zheng,Xiangliang Yang,Yanbing Zhao
Transarterial chemoembolization (TACE) is a first-line clinical therapy on hepatocellular carcinoma (HCC). However, the presence of TACE resistance leads to less than satisfactory treatment outcomes and prognosis. By genomic analysis on the 147 HCC patients in the Gene Expression Omnibus (GEO) database, in the present work, the key role of glycolysis on hypoxia and immunosuppressive tumor microenvironment (TME) was well verified, contributing to the development of TACE resistance. Aiming to the issue, radiofrequency (RF)-responsive liposome hydrogels (3BP-TSLIP) was successfully prepared by thin-film hydration of temperature sensitive polymers (DSPE- p NIPAM), cationic lipid, the glycolytic inhibitor 3-bromopyruvate (3BP) and other phospholipids. 3BP-TSLIP showed temperature sensitive sol-gel phase transition at nearby body temperature, allowing to a sufficient embolization by intubating super-selectively into tumor-feeding arteries. By synergizing with RF irradiation, 3BP-TSLIP inhibited tumor glycolysis, reduced lactic acid (LA) efflux, and alleviated hypoxia. It was attributed to the protection of TSLIP to 3BP from hydrolysis and its unique RF-heating effect, facilitating to glycolysis suppression of 3BP by RF-thermo-sensitization. In the VX2 tumor-bearing rabbit model, 3BP-TSLIP showed favorable embolization to tumor-feeding arteries, and the enhanced antitumor efficacy by co-treating with RF irradiation. 3BP-TSLIP can serve as RF responsive embolic agent for opening a new avenue to overcome TACE resistance.
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产品关联
DOI
高影响因子
CHEMBIOCHEM
·
2026
·Vol. 27
·期 1
·e202500945
·
IF 2.8
Min Huang,Jiayi Han,Hao Li,Junhao Lin,Qingbo Jiao,Zexing Cao,Qunfang Lei,Wenjun Fang,Gerui Ren,Zhijun Song,Ying Zheng,Ruibo Wu,Hujun Xie
Growing interest in sustainable nutrition has improved the importance of understanding the interactions between (-)-Epigallocatechin-3-gallate (EGCG), a polyphenol in green tea, and proteins for functional food development. In this study, we investigated the regulatory effects of EGCG on the aggregation behavior of zein, ovalbumin, and their complexes. The addition of EGCG at 100 μg mL −1 led to significant changes in particle sizes of zein, ovalbumin, and zein-ovalbumin complexes, increasing them from 215.6, 3485.3, and 2081.0 nm to 4822.3, 7857.0, and 5895.7 nm, respectively. The zeta potentials of these samples decreased from 8.4, −2.6, and 5.0 mV to −5.3, −0.66, and 2.13 mV, respectively, indicating a reduction in net surface charges and promotion of protein aggregation. UV–vis absorption spectroscopy revealed hyperchromic effects and blue shifts upon EGCG addition, suggesting conformational changes. Molecular dynamics simulations further revealed that EGCG contributed to the structural stabilization of both individual proteins and their complexes by reinforcing hydrophobic and electrostatic contacts at the molecular interface. These findings provide molecular-level insights into the regulatory role of EGCG in protein assembly and offer guidance for the rational design of plant-animal protein complexes with tailored functional properties for food applications. Graphical EGCG plays a significant regulatory role in protein aggregation behavior. EGCG interacts with protein molecules, promoting conformational changes and aggregation, particularly in systems involving zein and ovalbumin. This study highlights the potential application of EGCG in the development of functional foods.
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DOI
PubMed
高影响因子
Advanced Composites and Hybrid Materials
·
2021
·Vol. 4
·期 3
·629-638
·
IF 5.693
Song Haixiang,Zhang Qiqi,Zhang Yanwei,Wang Yanfei,Zhou Zhongyuan,Zhang Ping,Yuan Bingnan
To study the influences of 3-amino-polyhedral oligomeric silsesquioxane (NH 2 -POSS) on the properties of waterborne polyurethanes (WPU), a series of NH 2 -POSS modified WPUs were synthesized by using polypropylene glycol (PPG-2000, PPG-310), 2,2-dimethylolpropionic acid (DMPA), isophorone diisocyanate (IPDI), and NH 2 -POSS via a one-pot reaction and a high shear emulsification method. The results showed that when the NH 2 -POSS amount in the WPU/NH 2 -POSS nanoemulsion was 5.73 wt% (WPU2, based on the weight of WPU resin), its viscosity was 2.496 MPa · s and its Zeta potential was 63.7 mV(pH = 6.1), showing lower viscosity and better dispersion stability. The particle size of WPU2 is smaller than that of WPU0, and the polydispersion index (PDI) of WPU2 was decreased from 5.520 to 3.837 indicating a higher crosslinking density. In addition, the thermal stability of WPU/NH 2 -POSS nanoemulsion was increased with the content of NH2-POSS from 0.00 to 13.19%. The water contact angle values for the WPU2 (84.5°) were higher than that of WPU0 (80.2°), showing an improvement of the hydrophobic properties. This WPU/NH2-POSS nanocomposites can be used for making coating adhesive for textile and hosting matrix for making multifunctional nanocomposites. Graphical abstract
研究领域:
材料科学
·
化学工程
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DOI
高影响因子
DALTON TRANSACTIONS
·
2023
·Vol. 53
·期 3
·996-1003
·
IF 4
Qiang Zhang,Xin Ding,Bin Liu,Yuhua Wang
The development of novel phosphors with excellent luminescence properties for white light-emitting diodes (WLEDs) is always a formidable task. Compared with the traditional laborious and aimless “trial and error” experiments, a mineral-inspired prototype strategy can provide an efficient and accurate method. Herein, for the first time, a novel yellow-emitting phosphor NaBaY2(PO4)3:Eu2+ was discovered using the mineral-inspired prototype strategy and cation substitution method. The phosphor was prepared via the high-temperature solid-state reaction method, and its crystal structure, luminescence properties and potential application for WLEDs were systematically investigated. The NaBaY2(PO4)3 phase was derived from the K2Mg2(SO4)3-type mineral structure and a photoluminescence study revealed that the phosphor can emit bright yellow light with a maximum at 545 nm upon excitation at 351 nm. A WLED lamp was fabricated by the use of a blend of commercial blue-emitting BaMgAl10O17:Eu2+, yellow-emitting NaBaY2(PO4)3:Eu2+ and red-emitting (Ca, Sr)AlSiN3:Eu2+ phosphors with a 380 nm LED chip. The CIE, CCT, Ra and efficiency of the as-fabricated LEDs were measured to be equal to (0.366, 0.365), 4327 K, 91.2 and 40.8 lm W−1, respectively. These results suggest that NaBaY2(PO4)3:Eu2+ could be a promising candidate for n-UV WLEDs.
研究领域:
材料科学
·
无机化学
·
光电子学
·
半导体照明
·
发光材料
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DOI
高影响因子
MATERIALS LETTERS
·
2014
·
IF 2.269
Shanshan Ji,Peixia Yang,Jinqiu Zhang,Ye Lian,Jie Zhang,Maozhong An
BMIm-OTF (1-Butyl-3-methylimidazolium trifluoromethanesulfonate) ionic liquid was used for the first time to prepare Cu 1.00 In 0.83 Ga 0.23 Se 1.64 thin films . The standard CIGS sample was calibrated using its inductively coupled plasma optical emission. The morphological properties were detected using scanning electron microscopy . The band gap of the CIGS thin film was approximately 1.55 eV, as measured using UV–visible absorption spectra . The carrier concentration and average Hall coefficient of the CIGS thin films were 2.741×10 20 cm −3 and 2.277×10 −2 cm 3 /C, respectively.
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DOI
高影响因子
PHOTOCHEMISTRY AND PHOTOBIOLOGY
·
2012
·Vol. 88
·期 4
·840-843
·
IF 2.413
Zhan Zhou,Qianming Wang,Jintai Lin,Yanna Chen,Chuqin Yang
Herein, a novel fluorescent indicator for the real-time monitoring of amines is described. This probe contains a complex of europium-(thenoyltrifluoroacetone) 3 (Eu(TTA) 3 ) that efficiently reacts with primary and secondary amines. The electron-withdrawing trifluoroacetyl undergoes a nucleophilic addition with amines, and the complex was used to selectively detect BuNH 2 and Et 2 NH (quenching concentration for BuNH 2 : 10 −4 m , for Et 2 NH: 1.2 × 10 −3 m ) by monitoring emission; no changes were observed in the emission spectrum of Eu(TTA) 3 in the presence of Et 3 N, [Bu 4 N]Cl, or PhNH 2 in aqueous solution (THF/H 2 O = 1:1). The ratio of emission intensity to amine concentration was linear by the least-squares fitting method.
研究领域:
分析化学
·
生物传感
·
分子探针
·
稀土化学
·
有机合成
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DOI
高影响因子
LANGMUIR
·
2018
·
IF 3.789
Xiangyu Ge,Jinjin Li,Chenhui Zhang,Zhongnan Wang,Jianbin Luo
The robust liquid superlubricity of a room-temperature ionic liquid induced by tribochemical reactions is explored in this study. Here, 1-ethyl-3-methylimidazolium trifluoromethanesulfonate ([EMIM]TFS) could realize stable superlubricity (μ < 0.01) with water at the interfaces of Si3N4/SiO2. A superlow and steady friction coefficient of 0.002–0.004 could be achieved under neutral conditions (pH of 6.9 ± 0.1) after 600 s of running-in process. Various factors that could affect superlubricity were explored, including concentration of [EMIM]TFS, sliding speed, applied load, and volume of the lubricant. The results reveal that superlubricity can be achieved with [EMIM]TFS aqueous solution under a broad scope of conditions. The results of surface analysis show that a steady composite tribochemical layer comprising [EMIM]TFS, silica, ammonia-containing compounds, and sulfides was formed by tribochemical reactions between [EMIM]TFS and Si3N4 during the running-in period. The film thickness calculation reveals that the achieved superlubricity is in a mixed lubrication regime that comprises boundary lubrication and thin film lubrication. The superlubricity state is governed by a firm composite tribochemical layer, a molecular adsorption layer (electric double layer of [EMIM]TFS), and a fluid layer. The liquid superlubricity achieved by the ionic liquid is helpful for the development of new ionic liquids with superlubricity characteristics and is of great significance for scientific understanding as well as engineering applications.
研究领域:
摩擦学
·
材料科学
·
表面化学
·
润滑工程
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DOI
高影响因子
MATERIALS TECHNOLOGY
·
2018
·
IF 1.232
Binggong Yan,Lei Kang,Masashi Kotobuki,Fei Wang,Xiaodi Huang,Xuan Song,Kaiyong Jiang
NASICON-structured Li1.5Al0.5Ge1.5(PO4)3 (LAGP) has been a promising solid-state glass-ceramic electrolyte for all-solid-state lithium ion batteries. However, the non-ideal ionic conductivity, non-uniformity of chemical composition, distortion and micro-cracks, etc., have limited its practical application. Considering these issues, in this work, we first of all introduce partial substitution of Al3+ by Ga3+. To avoid segregation of secondary phase, microwave sintering technology to prepare LAGP was used. With the help of microwave irradiation, sintering could be finished in just 30 min, and the size of crystals was homogeneous across the cross-section. No distortion and micro-cracks could be identified. Characterisations such as DTA, XRD, SEM and EIS were used to evaluate the material and electrochemical properties of the Li1.5Al0.5-xGaxGe1.5(PO4)3 (x = 0.1 ~ 0.5) samples. A high bulk conductivity of 6.67 × 10−4 S/cm at room temperature has been achieved when x = 0.1 and the activation energy was about 0.66 eV.
研究领域:
材料科学
·
电化学
·
储能技术
·
陶瓷学
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DOI
高影响因子
IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING
·
2025
·
IF 8.6
Lilong Zou,Xuan Feng,Hai Liu,Amir M. Alani,Cai Liu
Forests are vital components of the ecosystem of the Earth, regulating climate, conserving soil and water, and fostering biodiversity. Sustainable forest management offers crucial long-term benefits, but challenges such as disease threaten tree health. Disease-infected trees in both forests and urban areas pose risks to safety, property, and culture, leading to economic losses. Traditional inspection methods, such as resistance drilling, are invasive and laborious, while nondestructive techniques such as ground penetrating radar (GPR), offer promising alternatives. Although GPR shows potential, complexities such as tree structure and electromagnetic properties hinder accurate disease detection. In order to address these challenges, a new approach integrates structure-from-motion (SfM) photogrammetry with GPR measurement, and a novel holographic radar tomography processing approach has been proposed in this article. These methodologies accurately reconstruct tree trunks in 3-D, enabling precise GPR positioning and the obtaining of trunk permittivity. An arc-shaped Kirchhoff migration algorithm, moreover, helps mitigate irregular trunk shapes, enhancing data accuracy. The proposed framework demonstrates efficacy in real-tree measurement, offering high-precision disease monitoring. This innovation not only aids in preserving biodiversity but also enhances ecosystem services by promoting sustainable forest management. Effective disease monitoring ensures timely intervention, safeguarding valuable old trees and ecosystems while minimizing economic and cultural losses.
研究领域:
林业
·
遥感
·
无损检测
·
环境监测
·
地球物理学
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DOI
高影响因子
JOURNAL OF ELECTRONIC MATERIALS
·
2019
·Vol. 48
·期 11
·7068-7075
·
IF 1.676
Li Shuhui,Zhou Ying,Cui Lijun,Ge Zhenhua,Feng Jing
In 2 O 3 (ZnO) k superlattice ceramics are promising oxide thermoelectric materials, as superlattice interfaces are effective in scattering phonons and filtering low-energy electrons to decrease thermal conductivity and improve the figure of merit ( ZT ) value. In this work, homologous compounds were prepared by solid-state reaction method using ZnO and In 2 O 3 as raw materials. Phase purity and crystal structure were characterized by x-ray diffraction, revealing that In 2 O 3 (ZnO) k crystallizes in an R3 m space group for odd k values and P6 3 /mmc for even k values. The study of thermoelectric (TE) properties showed that as k increased, the thickness of InO(ZnO)
+ 3
also increased, while the electrical conductivity, thermal conductivity, Seebeck coefficient, power factor and ZT value were all decreased. In 2 O 3 (ZnO) 3 samples obtained a maximum power factor of 651 μ W m −1 K −2 at 973 K, and also achieved a maximum ZT value of 0.24 at 973 K.
研究领域:
材料科学
·
凝聚态物理
·
能源转换技术
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DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2021
·
IF 5.316
Yalin Qin,Peikun Yan,Fuxuan Han,Yongcheng Zhang,Zonglin Lv,Chunming Zhou
The enhancement of both transparency and piezoelectric properties in transparent ferroelectric ceramics is a challenge. In this work, we prepared transparent 0.75Pb(Mg 1/3 Nb 2/3 )O 3 -0.25PbTiO 3 : x Pr 3+ ceramics by oxygen atmosphere sintering together with hot pressing sintering. When x = 1.5 mol%, a transparency of 68% @ 900 nm (close to the theoretical value ~71%) was achieved, and the piezoelectric properties increased to twice as much as those in undoped ceramics ( x = 0). The small average domain size (below 200 nm) that far below the visible light wavelength was believed to benefit light transmittance. Meanwhile, the minute amount of tetragonal component induced by Pr 3+ irons, was supposed to be responsible for the improved piezoelectric properties. These merits make Pr 3+ -doped 0.75PMN-0.25PT transparent ceramics promising functional materials for transparent piezoelectric devices.
研究领域:
材料科学
·
物理学
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DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2019
·
IF 6.361
Jiadong Liu,Yijia Wang,Lei Wang
A polyvinylidene fluoride (PVDF) organic conductive membrane with photoelectric activity was successfully developed via printing of oxidant (FeCl 3 ·6H 2 O) layer by layer and then chemical vapor deposition (CVD) of Poly (3, 4-ethylenedioxythiophene) (PEDOT). Four kinds of membranes were prepared by changing the number of oxidant coatings layers. The structure and photoelectric properties of four membranes were well characterized. The photocurrent density of 3.7 × 10 −4 A indicated that the four-oxidant coating layers membrane achieved the best performance in photo-electricity activity. A comprehensive study of degradation efficiency under different photoelectric conditions was carried out. Results showed that the photoelectrocatalytic removal of tetracycline hydrochloride was 1.6 and 7.9 times higher than that of photocatalysis and photolysis, respectively, under a voltage of 3 V assisted with visible light irradiation. The anti-interference and stability tests in continuous filtration process demonstrated that the dissolved organic matters (DOMs) can result in a 30% fluctuation on removal rate. The streaming potential tests of DOMs adsorption on membrane surface indicated that the more obvious the adsorption phenomenon was, the degradation of tetracycline hydrochloride was weaker. The degradation intermediates were identified and pathways were proposed in this work. The photoelectrocatalysis of PEDOT modified PVDF membrane provided a new potential for water purification .
研究领域:
环境科学
·
材料科学
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DOI
高影响因子
危险品化学品经营许可证（带存储）