EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
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2017
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IF 3.756
Yue Yang,Xiaoyu Lu,Qi Liu,Yu Dai,Xiaojie Zhu,Yanli Wen,Jiaqiu Xu,Yang Lu,Di Zhao,Xijing Chen,Ning Li
Combination therapy with two drugs and nanoparticle-based drug delivery systems are widely applied to reduce the adverse effects of traditional treatment by chemotherapeutic drugs. Palmitoyl ascorbate (PA) as a lipophilic derivative of ascorbic acid shows the advantages in cancer treatment. The aim of the study was to prepare a doxorubicin (DOX) and PA co-loaded liposome to synergistically treat tumor and effectively alleviate the toxicity caused by DOX. The effects were evaluated by in vitro and in vivo studies. The liposomes (weight ratio of DOX to PA = 1:20, DOX 1 /PA 20 -LPs) exhibited the strongest synergistic effects, combination index was 0.38, 0.56, and 0.05 in MCF-7, HepG2, and A549 cells, respectively. In vitro cellular uptake study, the intercellular concentration of DOX in DOX 1 /PA 20 -LPs was 2.5-fold greater than DOX loaded liposome, and DOX 1 /PA 20 -LPs was taken in not only by macropinocytosis, but also by clathrin-mediated endocytosis. Intracellular distribution experiment showed that DOX 1 /PA 20 -LPs efficiently concentrated in the nucleus. In vivo studies indicated that co-encapsulated liposome not only showed the strongest antitumor ability by tumor growth suppression, but also significantly enhanced the safety by the change of body weight and reduced damages to other tissues (evidenced by histopathology study). These results indicated that DOX and PA co-delivery liposome successfully enhanced the anticancer efficacy and mitigated the toxicities of DOX, which displayed potential for clinical application with enhanced safety and efficacy.
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ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
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2025
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IF 6.1
Weishou Shen,Yang Wu,Futao Li,Shirui Zhang,Hongmei Jin,Bei Gao
Microplastics, as emerging contaminants, can absorb antibiotics, and their coexistence in soil ecosystems poses serious threats to soil health. While previous studies have primarily focused on the individual effects of microplastics or antibiotics, the interactions between these pollutants in soil environments remain poorly understood. In this study, we investigated the combined effects of sulfonamide antibiotics and microplastics—both non-degradable low-density polyethylene and degradable polylactic acid—on soil microbiota and physicochemical properties. Our findings revealed significant changes in soil properties under co-exposure conditions. Dissolved organic carbon emerged as the most influential factor affecting bacterial and fungal diversity. Co-exposure altered the composition of bacterial and fungal communities at both the phylum and genus levels, with soil bacteria showing stronger responses than fungi. Importantly, co-exposure exacerbated the ecological risks associated with individual contaminants. We also observed differences in how non-degradable and degradable microplastics impacted the stability and complexity of microbial community networks. Notably, co-exposure to degradable microplastics and sulfonamides led to a significant increase in the expression of antibiotic resistance genes ( sul1 and int1 ). These findings enhance our understanding of the combined effects of microplastics and antibiotics on soil ecosystems and underscore the need for further research into their ecological risks.
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ChemistrySelect
·
2024
·Vol. 9
·期 44
·e202403927
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IF 1.9
Hui Han,He Cui,Jiabo Wang,Kai Ge,Yongfang Yang
Graphical In this paper, 2D MOF-Co, 2D MOF-Co/Cu, and 2D MOF-Co/Cu/Fe are designed and prepared using 1,4-benzendicarboxylic acid (1,4-BDC) as organic ligands. Their charge transfer, separation efficiency, and effects on photocatalytic CO 2 reduction are studied. The results show that 2D multimetallic MOF-Co/Cu/Fe has better photocatalytic CO 2 reduction activity, so it has higher research value and development prospect in the field of photocatalytic CO 2 reduction. In this study, 2D multimetallic MOFs combined with the advantages of 2D nanosheets, with the synergetic effect of multimetallic nodes, exhibited good photocatalytic activity for reduction of CO 2 . Herein, a 2D MOF-Co/Cu/Fe were successfully prepared via one-pot stirring of the solutions of multimetal salts and organic ligands at room temperature. Introduction of the second and third metal (Cu and Fe) into MOF-Co does not change the 2D morphology of MOFs, although it improved the photocatalytic CO 2 reduction performance by broadening the light absorption range of 2D MOF-Co, accelerating the separation efficiency and transfer rate of photogenerated carriers. Upon irradiation with full-spectrum light, the average CO yield of 2D MOF-Co/Cu/Fe achieved 17.06 µmol·g −1 ·h −1 , being about 1.8 and 1.2 times that of 2D MOF-Co and 2D MOF-Co/Cu. This work provides an insight into 2D multimetallic MOFs-based photocatalysts in catalytic CO 2 reduction.
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CERAMICS INTERNATIONAL
·
2024
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IF 5.1
Yushi Qi,Jiangfan Xu,Yanhan Fei,Lanjun Du,Yan Ren,Wenbo Han,Gang Chen,Zhiming Du
This study investigated the preparation of SiC porous ceramics using an organic foam impregnation-high temperature sintering process. To address the poor wettability of SiC ceramics when used as the reinforcement phase, the surface of SiC porous ceramics was modified with Al 2 O 3 . SiC-Al 2 O 3 /2A50 co-continuous composites were then fabricated by infiltrating 2A50 aluminum alloy into the SiC-Al 2 O 3 porous ceramics under pressure. Microstructural observations, along with friction, wear performance, and thermal stability test, demonstrated that Al 2 O 3 surface modification significantly enhances the friction and wear performance as well as the thermal stability of the co-continuous composites. The prepared SiC-Al 2 O 3 /2A50 co-continuous composite exhibited excellent wear resistance, good thermal stability and stable bonding at heterogeneous interfaces. Compared to 38CrSi steel, the SiC-Al 2 O 3 /2A50 co-continuous composite not only offers the advantage of reduced weight but also shows a significantly lower wear rate of 9.3 × 10 −5 mm 3 /N·min under a 50 N load. These findings suggest that the SiC-Al 2 O 3 /2A50 co-continuous composite has the potential to replace 38CrSi steel as a wear-resistant material.
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WATER ENVIRONMENT RESEARCH
·
2024
·Vol. 96
·期 10
·e11146
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IF 2.5
Wenquan Sun,Yiming Xie,Ming Zhang,Jun Zhou,Yongjun Sun
In this work, a Co–Ce@RM ozone catalyst was developed using red mud (RM), a by-product of alumina production, as a support material, and its preparation process, catalytic efficiency, and tetracycline (TCN) degradation mechanism were investigated. A comprehensive assessment was carried out using the 3E (environmental, economic, and energy) model. The optimal production conditions for Co–Ce@RM were as follows: The doping ratio of Co and Ce was 1:3, the calcination temperature was 400°C, and the calcination time was 5 h, achieving a maximum removal rate of 87.91% of TCN. The catalyst was characterized using different analytical techniques. Under the conditions of 0.4 L/min ozone aeration rate, with 9% catalyst loading and solution pH 9, the optimal removal rates and chemical oxygen demand by the Co–Ce catalytic ozonation at RM were 94.17% and 75.27%, respectively. Moreover, free radical quenching experiments showed that superoxide radicals (O 2 − ) and singlet oxygen (1O 2 ) were the main active groups responsible for the degradation of TCN. When characterizing the water quality, it was assumed that TCN undergoes degradation pathways such as demethylation, dehydroxylation, double bond cleavage, and ring-opening reactions under the influence of various active substances. Finally, the 3E evaluation model was deployed to evaluate the Co–Ce@RM catalytic ozonation experiment of TCN wastewater. Practitioner Points The preparation of Co–Ce@RM provides new ideas for resource utilization of red mud. Catalytic ozonation by Co–Ce@RM can produce 1 O 2 active oxygen groups. The Co–Ce@RM catalyst can maintain a high catalytic activity after 20 cycles. The degradation pathway of the catalytic ozonation of tetracycline was fully analyzed. Catalytic ozone oxidation processes were evaluated by the “3E” (environmental, economic, and energy) model.
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Materials Today Communications
·
2024
·
IF 3.7
Jia Mi,Yingchun Li,Wensheng Wang,Zhimao Li,Tong Liu,Guang Nie,Zheyu Zhang
Bio-based copolyesters have garnered significant attention in the domains of packaging and agriculture due to their exceptional degradability and mechanical properties. Building upon existing research, this study further modifies bio-based copolyesters with the objective of enhancing their comprehensive mechanical properties and broadening their application scope. High-performance aromatic copolyesters were synthesized through a two-step esterification and polycondensation process, utilizing terephthalic acid, adipic acid, 1,4-butanediol, and erythritol as raw materials. The structures of the synthesized copolyesters were characterized using FTIR, 1 H NMR, 13 C NMR. Compared to PBAT, the tensile strength and elongation at break of the copolyesters demonstrated improvements of 22.14 % and 80.14 %, respectively. Moreover, the tear strength and puncture resistance of the copolyesters were enhanced by 25.10 % and 54.13 %, respectively. TG indicated that the copolyesters exhibit high thermal stability. Notably, these copolyesters maintained good degradability after 35 days at ambient temperature. In conclusion, the enhancement of both mechanical and degradation properties of copolyesters was imperative for the advancement and promotion of degradable foams, films, and elastomers.
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APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Hongyue Li,Jun Yao,Zhiqiang Peng,Mengyun Yang,Taotao Zhao,Peng Wang,Yupei Zhao
As is well known that, transition metal sulfides often face challenges such as excessive intermediate adsorption and poor electrical conductivity, which greatly limits their use in large-scale water electrolysis. Herein, we prepare a Fe-Co bimetallic synergistic catalyst based on solvothermal method. This catalyst ((FeCo) 9 S 8 /C-1) exhibits excellent oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) performance due to multiple synergistic effects. For instance, low overpotentials of 284.7 mV for OER and 310 mV for HER at 10 mA·cm −2 could be reached in 1 M KOH, while the electrochemical active surface area reaches 40.25 m 2 ·g −1 , which is twofold compared to bare Co 9 S 8 . Density Functional Theory (DFT) calculations further reveal the strong charge transfer between Fe and Co would reduce the energy barriers for the rate-determining steps, enhancing the desorption of *OOH and *H intermediates, as well as improving the electrocatalytic efficiency. This study opens new avenue for designing other dual-transition metal sulfides for water splitting with high-performance.
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Materials Today Communications
·
2024
·
IF 3.7
Haitao Yin,Can Wei,Yuwei Ye,Zhixiang Wang,Shengguo Zhou
Carbon dots have significantly contributed to corrosion resistance due to their varied physical and chemical properties, excellent biocompatibility, and high surface activity. Therefore, designing and developing high-performance carbon dot inhibitors is of great significance. The study successfully synthesized lanthanum and nitrogen co-modified carbon dots (La/N-CDs), which function as a green and effective corrosion inhibitor. It was found that the La/N-CDs inhibitor presented a nanostructure with size of 3–9 nm. Electrochemical experiments, such as Tafel plots and EIS, showed that the presence of La/N-CDs effectively suppressed metal corrosion in a chloride-containing corrosion solution. In a 3 wt% NaCl solution, 400 mg/L La 15 % /N-CDs exhibited the best corrosion inhibition performance, with an impedance modulus of 2165.33 Ω cm² and an inhibition efficiency reaching as high as 93.07 %, while the surface roughness of the steel and the corrosion rate was also minimized. This might be explained by the formation of an adsorption layer by La/N-CDs on the metal surface, a phenomenon confirmed by Langmuir isotherm and XPS investigations. These findings confirmed that La/N-CDs could form a protective film on the metal surface, significantly improving its corrosion resistance and extending its service life in corrosion environment. The study’s findings offered insights and a conceptual structure for enhancing corrosion inhibitors using carbon dots that were augmented with rare earth elements.
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JOURNAL OF LUMINESCENCE
·
2025
·
IF 3.6
Yutian Zhang,Lianjie Li,Junyu Chen,Hai Guo
Fluorescent thermometers based on lanthanide-doped phosphors have broad application prospect because of their quickly response, highly sensitivity, non-contact mode and widely application scenarios. However, their relative sensitivity is limited by fixed thermal coupling energy level. Herein, Ca 2 GdNbO 6 :Dy 3+ ,Eu 3+ samples possessing dual-emission centers were fabricated as fluorescence thermometers based non-thermal coupling energy level. When excited by 393.5 nm, the characteristic emissions from Dy 3+ and Eu 3+ in CGNO:Dy 3+ ,Eu 3+ can be simultaneously detected. Furthermore, CGNO:Dy 3+ ,Eu 3+ phosphors exhibit excellent temperature sensing performance in fluorescence intensity (FI) relied on Eu 3+ and fluorescence intensity ratio (FIR) relied on dual-emission centers. The maximum relative sensitivities ( S Rmax ) reach 1.61 %K −1 at 426 K for FI at 703 nm, 1.01 %K −1 at 391 K for FIR of FI at 616 nm and FI at 576 nm, and 2.18 %K −1 at 501 K for FIR of FI at 703 nm and FI at 576 nm, respectively. These findings demonstrate that Ca 2 GdNbO 6 :Dy 3+ ,Eu 3+ samples are prime candidates for fluorescent thermometers.
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Molecular Catalysis
·
2024
·
IF 3.9
Xing Gao,Ying Ma,Yingying Ruan,Wenna Zhang,Shihao Zhang,Wenxue Xiong,Dong Tian,Shiliu Yang,Pei Fan,Yanhui Yang,Yihu Dai
Non-noble metal-catalyzed selective C O hydrogenation of α,β-unsaturated aldehydes to corresponding alcohols is chemically atom economic and practically feasible. This work reports hydrotalcite-derived Co-based catalysts for catalyzing aqueous phase selective hydrogenation reaction of cinnamaldehyde to cinnamyl alcohol. The structure characterizations demonstrate the phase transition from hydrotalcite to co-existed CoO x and metallic Co 0 in the optimal Co 2 Al-H 2 -400 catalyst. It exhibits superior catalytic activity and selectivity relative to other as-obtained Co catalysts, because of the synergy effect of Co 2+ sites to promote the adsorptive activation of C O group and small-size Co 0 sites to facilitate the activating dissociation of hydrogen. Furthermore, the catalytic role of water has also been explored. Adopting water as pure solvent and partially adding water into organic solvent can both effectively enhance the activity and selectivity. Such reaction environment may induce creation of more intermolecular hydrogen bonds for promoting the hydrogen transfer and thus boosting the hydrogenation reaction.
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Materials Today Chemistry
·
2025
·
IF 6.7
Yuansen Xiao,Huimin Li,Zheng Wang,Zhihan Liu,Chenyang Li,Bin Wu,Longfei Yan,Huidong Zheng,Fuweng Zhang
Borneol synthesis faces challenges from co-generated impurities (isoborneol/camphor) and competing dehydration/dehydrogenation during isomerization. Here, Co/TiO 2 is demonstrated as a selective catalyst for isoborneol-to-borneol isomerization, effectively suppressing structural degradation. Controlled acidity and cobalt dispersion are identified as critical factors: TiO 2 's moderate acidity promotes isomerization, while strongly acidic supports (e.g., Mordenite) favor dehydration to camphene. Reduced cobalt particle size enhances active-site accessibility, lowering activation energy and boosting borneol yield. A one-pot two-step process achieves >62 % borneol content with <0.5 % camphor, meeting ChPC purity standards. This strategy bypasses traditional purification bottlenecks, offering a scalable route for high-purity borneol synthesis. The mechanistic insights into acid strength and metal dispersion provide a framework for rational catalyst design in industrial isomerization applications.
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Bioactive Materials
·
2025
·
IF 20.3
Zaiyan Wang,Jianxiang Zhu,Bobin Mi,Ming Ni,Yuming Xue,Yiling Deng,Lu Chen,Xiangyang Xu,Xiaoyan Li,Guohui Liu,Tao Yu
The high invasiveness and metastatic potential of breast cancer increase the risk of postoperative recurrence. To address this issue, a composite hydrogel drug delivery system based on sodium alginate (SA) has been developed for the in situ release of carbon monoxide (CO) at the tumor resection site. This system aims to enhance the effectiveness of chemotherapy and improve the clearance of residual tumor cells after surgery, thereby preventing tumor recurrence and metastasis. A gold nanoparticle-modified g-C 3 N 4 nanophotocatalyst (C 3 N 4 /Au) has been designed to convert CO 2 within the tumor into CO under visible light irradiation. The C 3 N 4 /Au is loaded into an SA hydrogel and applied to the postoperative incision in a spray form. The rapid crosslinking reaction between SA and Ca 2+ forms a network structure, enabling precise drug delivery. CO is generated in situ in the postoperative tumor tissue under light stimulation and is combined with folic acid (FA) modified doxorubicin (DOX) micelles (FA@DM) to achieve effective synergy between CO therapy and chemotherapy. The composite hydrogel drug delivery system not only increases the concentration of CO within the tumor and reduces systemic toxicity but also enhances the effectiveness of chemotherapy by increasing oxidative stress within tumor cells. It provides a new and safe strategy for efficient and precise postoperative tumor treatment, reducing the risk of tumor recurrence and metastasis.
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