BIOMATERIALS
·
2020
·
IF 10.317
Yuanlin Wang,Zhenglin Li,Ying Hu,Jing Liu,Mengyu Guo,Hengxiang Wei,Shanliang Zheng,Tingting Jiang,Xiang Sun,Zhuo Ma,Ye Sun,Flemming Besenbacher,Chunying Chen,Miao Yu
In vivo chemical reactions activated by the tumor microenvironment (TME) are particularly promising for antitumor treatments. Herein, employing Cu 2-x Se-Au Janus nanoparticles (NPs), photothermal conversion-coordinated Fenton-like and photocatalytic reactions are demonstrated in vitro/vivo . The amorphous form of Cu 2-x Se and the catalytic effect of Au benefit the OH generation, and the photo-induced electron‒hole separation of the Janus NPs produces additional OH. The plasmonic electrons of Au facilitate the conversion from Cu 2+ to Cu + . Both Cu 2-x Se and Au contributes to the efficient photothermal conversion, further promoting the reactions. As a result, the H 2 O 2 utilization rate is largely increased, and remarkable generation of reactive oxygen species is achieved by cell endogenous H 2 O 2 in vitro/vivo . A competent tumor inhibition effect is afforded, with high-contrast multimodal imaging. This work opens up the route synergistically integrating photothermal therapy with chemodynamic therapy and photocatalytic therapy into tri-combination antitumor therapy, simply by heterojunction of semiconductor and noble metal.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Haitao Ren,Yuqing Chen,Abdelkader Labidi,Ke Zhao,Xiaoqian Xu,Sarah I. Othman,Ahmed A. Allam,Hassan Ahmad Rudayni,Chuanyi Wang
Developing carbon quantum dots (CQDs) from bio-waste lignin for effectively detecting Cu 2+ is of great significance for promoting the value-added utilization of lignin resources. However, the limited amount of surface-active groups and low quantum yield of lignin-based CQDs hinder their application in this regard. Herein, bio-waste lignin was converted into value-added amine functionalized CQDs using a facile two-step hydrothermal approach. The as-synthesized CQDs modified with amino groups exhibit bright green fluorescence, abundant surface functional groups, high water solubility and uniform particle size (3.9 nm). Systematic analysis demonstrates that the rich NH 2 groups (~12.3 %) on the CQDs backbone improve their fluorescence properties (quantum yield increased from 3.4 % to 21.1 %) and specific detection ability for Cu 2+ . The developed NH 2 -CQDs serve as an efficient fluorescent probe , displaying high sensitivity and selectivity towards Cu 2+ in aqueous system, with a detection limit of 2.42 μmol/L, which is lower than the maximum permitted amount of Cu 2+ in drinking water (20 μmol/L). The detection mechanism of NH 2 -CQDs for Cu 2+ is attributed to the synergy of static quenching and photo-induced electron transfer . This study provides a valuable reference for the synthesis of high-quality fluorescent CQDs from lignin resources and the effective detection of trace Cu 2+ in aquatic environments.
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PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Keting Feng,Kangqi Wu,Kai Li,Weijun Wang,Shihui Gao,Jun Fan,Tao Sun,Enzhou Liu
Localized surface plasmon resonance (LSPR) effect plays a crucial role in the field of solar energy utilization. In this work, we successfully prepared a Cu 2-x Se/ZnSe S-scheme heterojunction with a broad-spectrum response using the hot-injection and low-temperature water bath method. Importantly, we demonstrated that the photothermal effect induced by the LSPR of nonstoichiometric Cu 2-x Se can significantly improve the slow kinetics of water splitting, resulting in an apparent activation energy reduction from 50.1 to 28.7 kJ·mol −1 . This improvement is responsible for achieving the highest photocatalytic H 2 evolution rate of 63.6 mmol·g −1 ·h −1 over 2.7 % Cu 2-x Se/ZnSe under the wavelength ranged from 200 to 2500 nm, which is 3.4 and 5.6 times higher than that of ZnSe and Cu 2-x Se, respectively. Furthermore, the composite exhibits a remarkable H 2 production rate of 0.108 mmol·g −1 ·h −1 under near-infrared spectroscopy (800<λ<2500 nm), while ZnSe shows limited capability in H 2 releasing. Additionally, Cu 2-x Se/ZnSe demonstrates distinct photocurrent response when λ > 800 nm. The enhanced performance in H 2 evolution can be attributed to the synergistic effect of LSPR-induced light absorption and S-scheme heterojunction, which not only expands the light absorption range to the near-infrared region but also facilitates hot electron injection, charge carrier separation and transfer, leading to a faster surface reaction kinetics. This study provides an effective approach for designing a broad-spectrum light responsive non-precious metal-based photothermal-assisted photocatalytic system.
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PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Min Hu,Yu Zhang,Yan Zhang,Meng Wang,Shanying Zhang,Jin Zhang,Congying Xu,Xiaoyu Liang
Pesticides are essential for controlling plant diseases and pests in modern agriculture, yet traditional formulations often suffer from poor adhesion, rapid UV degradation, and loss due to rainwater runoff. This study introduces Pro@TA-Cu 2+ -Pal, a novel pH-responsive release system designed to enhance the performance of prochloraz, a widely used fungicide. By integrating tannic acid and copper ions onto palygorskite, this nanocarrier with metal–phenolic networks improves prochloraz wettability and adhesion on leaf surfaces while significantly enhancing UV stability and rainfastness. Under UV exposure, Pro@TA-Cu 2+ -Pal showed a 3.9-fold lower degradation rate than the commercial emulsion-in-water formulation (Pro EW). In simulated rain tests, Pro@TA-Cu 2+ -Pal exhibited superior rain-fastness, retaining >80 % of the applied fungicide on leaf surfaces, whereas Pro EW showed a marked reduction in retention. Pot trials showed that Pro@TA-Cu 2+ -Pal provided excellent control against wheat powdery mildew, outperforming Pro EW in both protective and curative treatments, with more effective and sustained disease control. Importantly, Pro@TA-Cu 2+ -Pal proved safe with no phytotoxicity observed in the crop. These findings highlight the potential of Pro@TA-Cu 2+ -Pal as an economical, eco-friendly, and sustainable solution for improving pesticide efficiency, reducing environmental impact, and supporting long-term crop protection.
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高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2025
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IF 4.1
Yu Rao,Penghua Liang,Chenxiao Guo,Xize Chen,Minglei Cao,Chuankun Zhang,Rui Tong,Kongjun Zhu
Metal sulfide is a promising anode material for lithium-ion batteries due to their unique layered structure and high theoretical specific capacity. However, the challenge lies in enhancing electronic conductivity and cycling stability. An effective method to enhance the rate capability and cycle performance of metal sulfide materials is to construct the hybrid structure. In this paper, the interfacial engineering of multiple sulfides is explored to develop ideal lithium-ion storage anode materials. Hence, the one-step mixed hydrothermal method was used to synthesize the Cu 2-x S/ZnS hybrid structure. The synthesized Cu 2-x S/ZnS hybrid structure exhibits better lithium storage performance and higher electronic conductivity compared with the single Cu 2-x S, which has resulted from the existence of the phase interface generating the built-in electric field and boosting Li + storage properties at the phase interfaces. In comparison with the single Cu 2-x S, the results display that the Cu 2-x S/ZnS hybrid structure shows enhanced rate capability and prominent long-term cycling performance (416.9 mAh g −1 at 1 A g −1 after 1300 cycles). This strategy demonstrates that the construction of hybrid structure can improve the electronic conductivity and structure stability for other advanced anode materials.
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高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Faisal Ahmad,Yelan Xiao,Tong Shu,Guangyao Zhang,Xueji Zhang
Electrochemiluminescence (ECL) is rapidly emerging as an excellent electrochemical analytical technique for the specific and sensitive detection of various biomarkers and hazardous trace metals. Among ECL emitters, gold nanoclusters (AuNCs) have proven to be excellent luminophores due to their remarkable luminescent properties, stability, and biocompatibility. However, the low ECL efficiency of AuNCs precludes their application in ultrasensitive biosensing. One of the key reasons for the low ECL efficiency of AuNCs is the nonradiative energy transitions arising from intramolecular vibrations and rotations of the ligands on the surface of AuNCs. Herein, we explore the ECL of Zn2+/Au22(SG)18/PDA nanoclusters (NCs), where Zn2+ and 2,6-pyridinedicarboxaldehyde (PDA) activate the restriction of intramolecular motion (RIM) through aggregation-induced emission (AIE) to aggregation-induced enhanced emission (AIEE). This effect is achieved via cross-linking of Zn2+ and PDA with glutathione on the surface of Au22(SG)18, resulting in a significant enhancement of ECL emission compared to Au22(SG)18 NCs alone. A sensitive ECL sensing system was devised with Zn2+/Au22(SG)18/PDA as the ECL emitter, with triethylamine (TEA) as the coreactant, for the detection of Cu2+ and histidine in the linear ranges of 0.1 to 40 μM and 1 to 85 μM, respectively, with detection limits of 0.705 and 1.928 μM, respectively.
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PubMed
高影响因子
ChemistrySelect
·
2025
·Vol. 10
·期 36
·e03645
·
IF 2
Miaomiao Tian,Qingwen Zheng,Yuanyuan Pang,Fangjun Wang,Gang Liu
In this study, we developed a novel and facile fluorescent turn-on sensing method for the selective detection of Cu 2+ ions based on the specific oxidative reaction between Cu 2+ ions and 3-carboxyphenylboronic acid (3-CPBA). In this reaction, 3-CPBA was oxidized by Cu 2+ to form 3-hydroxybenzoic acid, which emitted strong fluorescence emission at 412 nm. The resulting product was characterized using comprehensive spectroscopic analyses, including proton nuclear magnetic resonance ( 1 H NMR), carbon-13 nuclear magnetic resonance ( 13 C NMR), and electrospray ionization mass spectrometry (ESI-MS). These analyses confirmed the formation of 3-hydroxybenzoic acid as the primary product. Under optimal conditions, the proposed method could detect Cu 2+ in the range of 0.1–3 µM with a detection limit of 10.2 nM. The developed method exhibited high sensitivity, ease of operation, practicality, and good selectivity toward Cu 2+ over other metal ions. Furthermore, the practical applicability of the method was validated by successfully detecting Cu 2+ in real water samples, with good recoveries of 94.0–105.0%. Graphical A fluorescence turn-on method for Copper ions (Cu 2+ ) detection via oxidative hydroxylation of 3-carboxyphenylboronic acid (3-CPBA) was developed. Under alkaline conditions, Cu 2+ converted non-fluorescent 3-CPBA into highly fluorescent 3-hydroxybenzoic acid (λ ex/e m = 315/412 nm). The method achieved a 10.2 nM detection limit with linear response (0.1–3 µM), superior selectivity over competing metal ions, and validated performance in environmental waters.
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高影响因子
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Pengyun Liu,Xiaoqing Yang,Yonghui Chen,Huimin Xiang,Wei Wang,Ran Ran,Wei Zhou,Zongping Shao
Although organic–inorganic halide perovskite solar cells (PSCs) have shown dramatically enhanced power conversion efficiencies (PCEs) in the last decade, their long-term stability is still a critical challenge for commercialization. To address this issue, tremendous research efforts have been devoted to exploring all-inorganic PSCs because of their intrinsically high structural stability. Among them, CsPbIBr2-based all-inorganic PSCs have drawn increasing attention owing to their suitable band gap and favorable stability. However, the PCEs of CsPbIBr2-based PSCs are still far from those of their organic–inorganic counterparts, thus inhibiting their practical applications. Herein, we demonstrate that by simply doping an appropriate amount of Cu2+ into a CsPbIBr2 perovskite lattice (0.5 at. % to Pb2+), the perovskite crystallinity and grain size are increased, the perovskite film morphology is improved, the energy level alignment is optimized, and the trap density and charge recombination are reduced. As a consequence, a decent PCE improvement from 7.81 to 10.4% is achieved along with an enhancement ratio of 33% with a CsPbIBr2-based PSC. Furthermore, the long-term stability of CsPbIBr2-based PSCs against moisture and heat also remarkably improved by Cu2+ doping. This work provides a facile and effective route to improve the PCE and long-term stability of CsPbIBr2-based all-inorganic PSCs.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Fei Liu,Chang Chen,Yanxin Chen,Shaowu Jiu,Yan Liu
Hierarchical brush-like calcium sulfate dihydrate micro-assemblies (H-B-CSDM) were synthesized as a high-efficiency adsorbent via a synergistic additive-mediated aqueous precipitation method. Their adsorption performance toward Cd 2+ , Pb 2+ , and Cu 2+ was systematically evaluated, and the distinct mechanisms were elucidated through multi-scale characterization and density functional theory (DFT) calculations. Under optimized conditions (pH 6.0, an adsorbent dosage of 2 g·L −1 ), H-B-CSDM achieves adsorption equilibrium for all three heavy metal ions within 60 min. Pb 2+ exhibits the highest adsorption capacity and pronounced selectivity, with an uptake of 49.0 mg·g −1 in the ternary system, which is 1.16 and 1.26 times those of Cd 2+ and Cu 2+ , respectively. The adsorption of Cd 2+ and Pb 2+ followed pseudo-second-order kinetics and the Freundlich isotherm model, indicating chemisorption-dominated heterogeneous multilayer adsorption, whereas Cu 2+ displayed multi-mechanism coupling behavior. XRD, FTIR, XPS, and SEM analyses collectively demonstrate three distinct immobilization pathways: ion-exchange-induced surface precipitation (PbSO 4 formation) for Pb 2+ , electrostatic attraction with reversible outer-sphere complexation for Cd 2+ , and surface complexation with partial lattice substitution for Cu 2+ . Density functional theory (DFT) calculations corroborate these findings: Pb 2+ exhibits the most negative adsorption energy (−0.988 eV) at surface sites, making it thermodynamically most prone to surface deposition; whereas Cu 2+ and Cd 2+ exhibit adsorption energies of −0.385 eV and − 0.211 eV, respectively, indicating a decreasing order of chemical adsorption strength, with Cd 2+ primarily undergoing weak electrostatic outer-sphere complexation. H-B-CSDM maintained high adsorption efficiency over five regeneration cycles, demonstrating the best regeneration capacity for Pb 2+ . This study provides a theoretical basis and design paradigm for upgrading gypsum-based minerals from low-cost carriers to highly efficient active adsorption platforms for treating complex wastewater.
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高影响因子
RARE METALS
·
2026
·Vol. 45
·期 6
·e70345
·
IF 12.1
Zhizhong Sun,Yifei Wang,Yi Zheng,Minying Li,Longbao Feng,Ziwei Jiang,Hengrui Liu,Rui Guo,Weipeng Sun
en This link goes to a English section zh This link goes to a Chinese section Bone restoration is often hindered by the spatiotemporal dysregulation of immune and regenerative signals. Conventional bio-inert implants, providing only passive support, fail to modulate this microenvironment, leading to infections and poor healing. To achieve proactive regulation of the osteo-immune niche alongside robust antimicrobial defense, we developed a novel 3D-printed, high-strength hydrogel composed of methacrylated silk fibroin (SFMA), copper-epigallocatechin gallate (Cu-EGCG), and silver nanoparticles (AgNPs), characterized by dual-ion release kinetics. A sophisticated staged-release strategy was engineered wherein the rapid initial burst of Cu 2+ establishes an immediate antimicrobial barrier and initiates early immunomodulation, whereas the sustained, long-term release of Ag + ensures continuous pathogen suppression. This “fast-and-slow” synergistic release profile effectively bridges the gap between acute-phase infection control and the requirement for a stable environment during chronic tissue maturation. In vitro studies confirmed that the hydrogel possesses superior mechanical integrity, biocompatibility, and potent antibacterial activity, significantly promoting the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). In vivo results demonstrated robust new bone formation, with near-complete anatomical restoration of critical-size bone defects achieved within 4 weeks in the experimental group. Transcriptomic analysis further elucidated the underlying mechanism, revealing that the SFMA/Cu-EGCG/AgNPs hydrogel significantly reshaped gene expression profiles associated with immunity and osteogenesis. By activating immune-regulatory pathways—specifically IL-17 and TGF-β—the hydrogel successfully orchestrated a pro-regenerative immune microenvironment. Simultaneously, the significant enrichment of Wnt signaling and ossification-related pathways confirmed its dual-functional role in accelerating bone regeneration at the molecular level. In summary, this hydrogel facilitates a synergistic “infection control-immunomodulation-osteogenesis” tripartite repair strategy, offering a highly promising biomimetic approach for the clinical management of complex bone defects. 摘要 en This link goes to a English section zh This link goes to a Chinese section 骨缺损修复过程常受到免疫反应与再生信号时空失调的显著制约。传统生物惰性植入材料仅提供被动结构支撑,难以有效调控局部微环境,易导致感染发生及组织修复不良。针对上述问题,该研究构建了一种新型3D打印高强度水凝胶体系,由甲基丙烯酰化丝素蛋白(SFMA)、铜-表没食子儿茶素没食子酸酯复合物(Cu-EGCG)及银纳米颗粒(AgNPs)组成,具有双离子协同释放特性。通过构建分阶段释放策略,实现了Cu 2+ 与Ag + 的“快-慢协同”调控:初期快速释放的Cu 2+ 可迅速建立抗菌屏障并启动早期免疫调节,而Ag + 的持续释放则维持长期抗菌效应,从而有效衔接急性感染控制与后期组织稳定再生过程。体外实验表明,该水凝胶具有优异的力学性能与生物相容性,并表现出显著的抗菌活性,同时能够促进骨髓间充质干细胞(BMSCs)的增殖与成骨分化。体内实验结果显示,实验组在4周内实现了临界尺寸骨缺损的近完全结构修复。转录组分析进一步揭示其作用机制:SFMA/Cu-EGCG/AgNPs水凝胶显著重塑了与免疫调控及成骨相关的基因表达谱,通过激活IL-17与TGF-β信号通路,构建促再生免疫微环境; 同时,Wnt信号通路及骨形成相关通路的显著富集,证实其在分子水平上具有促进骨再生的双重功能。综上,该水凝胶通过构建“抗感染—免疫调控—成骨再生”协同修复策略,为复杂骨缺损的临床治疗提供了一种具有重要应用前景的仿生材料新方案。
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高影响因子
ChemistrySelect
·
2026
·Vol. 11
·期 3
·e04564
·
IF 2
Han-yu Dong,Jin-feng Deng,Ying-jie Qiu,Ai-ping Chang,Hu Zhu
Metal ions are extensively employed in the design of polysaccharide-based dressings owing to their reversible non-covalent interactions and bioactivity. This study reports an injectable, self-healing, and antibacterial wound dressing using a bimetallic Ca 2 + /Cu 2 + cross-linking strategy in sphingan WL gum. The target hydrogel, designated WL-Ca-Cu, was fabricated using a facile soaking–adsorption method. Fourier-transform infrared spectroscopy confirmed the presence of ion-polymer coordination bonds. These bonds, along with electrostatic interactions, synergistically reinforce the inherent hydrogen-bonding network of WL to drive physical cross-linking. The resulting WL-Ca-Cu hydrogel demonstrated excellent water retention (> 80%), injectability, and self-healing capability. It exhibited sustained ion release (following first-order kinetics), potent antibacterial efficacy of Cu 2 + against Escherichia coli and Staphylococcus aureus , and good biocompatibility in hemolysis and L929 cytotoxicity assays. The promising performance in cell scratch assays further supports its pro-healing potential. Collectively, these findings underscore the significant therapeutic potential of WL-Ca-Cu as a multifunctional wound dressing material. Graphical A multifunctional hydrogel is fabricated via a facile soaking-adsorption method by cross-linking sphingan WL gum with Ca 2+ /Cu 2+ ions. The material integrates injectability, self-healing, sustained antibacterial activity, biocompatibility, and pro-migration function, demonstrating its potential as a versatile wound dressing.
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高影响因子
CARBOHYDRATE POLYMERS
·
2019
·
IF 6.044
Shile Zhou,Hui He,Wei Guo,Hongxiang Zhu,Fei Xue,Meixiao Cheng,Jiehan Lin,Lei Wang,Shuangfei Wang
A novel biomass cellulose-based colorimetric sensor (DAC-PDH) was prepared by a Schiff base reaction between the aldehyde groups of dialdehyde cellulose (DAC) and the amino groups of 2,6-pyridine dihydrazide (PDH). The as-prepared sensor (DAC-PDH) showed selective recognition of Cu 2+ and a visual colour change from white to green. The visual limit of detection for Cu 2+ was 10 −7 mol/L. Furthermore, DAC-PDH responded to Cu 2+ within 30 s by the method of dynamic condition. The sensor possessed the properties of a high density of functional groups ( C O, NH , NH 2 ), a large external surface area, a short transit distance and flexibility; thus, Cu 2+ can be rapidly absorbed and enriched on the DAC-PDH through multi-dentate ligand chelation between Cu 2+ and the carbonyl groups ( C O) and the amino groups ( NH , NH 2 ) of DAC-PDH. The as-prepared DAC-PDH colorimetric sensor exhibits promising prospects for in situ identification of Cu 2+ .
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高影响因子
危险品化学品经营许可证（带存储）