ANALYTICAL CHEMISTRY
·
2026
·
IF 6.7
Xiang Chen,Chunxiang Mao,Yuanji Gao,Chaoting Shi,Yu Wang,Zhuolin Jin,Bing Xia,Yan Zhou
Direct quantitative analysis of low-abundance protein biomarkers by electrospray ionization mass spectrometry (ESI-MS) remains challenging due to poor ionization efficiency and matrix interferences. Herein, we report an ultrasensitive analytical platform, termed CRISPR/Cas12a-mediated liposomal amplification coupled with electrospray ionization mass spectrometry (CMLA-MS), that overcomes this limitation by integrating CRISPR/Cas12a-mediated dual-cascade signal amplification with an ESI-MS readout. The strategy converts the detection of poorly ionizable protein molecules into the quantification of numerous, highly ionizable small-molecule reporters: proteins trigger Cas12a trans-cleavage (first amplification), which subsequently cleaves single-stranded DNA (ssDNA) probes anchored to signal-loaded liposomes, causing the burst release of thousands of MS-detectable reporters (second, physical amplification). This dual-amplification strategy enabled an exceptionally low limit of detection (LOD) of 10.8 fg/mL, and the method successfully quantified cardiac troponin I (cTnI) in clinical serum samples with high recoveries (90.3–101.6%).
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2020
·Vol. 8
·期 27
·13610-13618
·
IF 11.301
Qian Zhang,Xuqiang Liu,Nana Li,Bihan Wang,Quan Huang,Lin Wang,Dongzhou Zhang,Yonggang Wang,Wenge Yang
Sillen compounds with the general formula of PbBiO2X (X = Cl, Br, I) are frequently studied as photocatalysts, and have attracted widespread attention due to their degradation of organic contaminants and water oxidation under visible light irradiation. Among many photoelectric materials, the band gap has been reduced approaching to the optimum value by pressure (1.34 eV for photovoltaic materials according to the Shockley–Queisser limit), which is favorable to their photo-responsive applications. However, such enhanced properties are usually restored after the pressure is released. Here, by combining the pressure and chemical engineering tools, we discovered that the optimized structure and optical band gap of PbBiO2Br could be locked after compression–decompression treatment cycling by selecting appropriate elemental species. The pressure-induced strain retention in PbBiO2Br could be the cause of the structural and optical irreversible behavior. Moreover, the compression behavior and optical band gap under high pressure in the PbBiO2X system were studied systematically by in situ high pressure synchrotron X-ray diffraction, UV-vis absorption spectroscopy and resistivity experiments. Along with the enhanced photocurrent under compression, the PbBiO2X compounds under external pressure exhibited great potential for photocatalytic applications under solar light irradiation. In a suitable element category, the pressure-driven structural lock-in preserves its optical performance, opening up a new window for manipulating and filtrating better multifunctional materials.
研究领域:
材料科学
·
凝聚态物理
·
无机化学
·
光催化
·
功能材料
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DOI
高影响因子
Materials Today Energy
·
2024
·
IF 9
Songyu Li,Penghui Ren,Di Zhao,Dan Liu,Jianqiao Wang,Hang Zhou,Wei Liu,Yuheng Zeng,Xuegong Yu,Can Cui,Peng Wang
Recently, p-type inorganic copper-based compounds have attracted increasing interest as hole-selective layers for crystalline silicon (c-Si) heterojunction solar cells. Among them, copper(I) thiocyanate (CuSCN) has a small valence band offset with c-Si and high stability, however, it has not been explored in c-Si solar cell applications. Herein, we successfully demonstrate that solution-processed CuSCN film acts as an effective hole-selective contact layer for p-Si solar cells. Nevertheless, the p-Si/CuSCN heterostructure suffers from an unsatisfactory surface passivation and a relatively high contact resistivity originated from the uncontrollable vacancy defects in the film. The I − doping of CuSCN film (CuSCN:I − ) not only suppresses the generation of SCN vacancies, but also increases the Cu vacancies, significantly improving the hole selectivity . Moreover, a better energy band alignment is formed based on CuSCN:I − /MoO 3 bilayer for hole selective contact of p-Si substrate, achieving a remarkably high photoelectric conversion efficiency (PCE) of 19.42 %. The PCEs of unencapsulated p-Si/CuSCN heterojunction solar cells maintain over 92 % of the initial values under storing in air atmosphere for 1200 h or after annealing at 350 °C. This work highlights that CuSCN is a very promising hole selective layer with superior stability for c-Si solar cell applications.
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DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2020
·Vol. 44
·期 33
·14103-14107
·
IF 3.288
Chanchan Xu,Le Lv,Dawei Luo,Wei Liu
By using pyrazine derivatives, three different types of copper(I) iodide based inorganic–organic hybrid structures, 1D-CuI(2-mo-pz) (1, 2-mo-pz = 2-methoxy-pyrazine), 2D-CuI(2,3-dm-pz)0.5 (2, 2,3-dm-pz = 2,3-dimethyl-pyrazine), and 2D-Cu2I2(2,5-dm-pz)2 (3, 2,5-dm-pz = 2,5-dimethyl-pyrazine), have been obtained by using a slow-diffusion method. Single crystal and powder X-ray diffraction analyses reveal that these hybrid structures are a one-dimensional (1D) staircase chain based structure, two-dimensional (2D) staircase-chain based structure, and 2D rhomboid dimer based structure, respectively. All of the three compounds show photoluminescence, with the internal quantum yield (IQY) as high as 88.2% for 1. This work provides evidence that for this type of hybrid materials, the structure of the inorganic module could be determined by the selection of the organic ligands and that the substituted group on the organic ligands can influence the luminescence efficiency of the hybrid structures.
研究领域:
无机化学
·
材料化学
·
配位化学
·
光物理
·
功能材料
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DOI
高影响因子
ACS Nano
·
2015
·
IF 12.881
Feng Zhang,Haizheng Zhong,Cheng Chen,Xian-gang Wu,Xiangmin Hu,Hailong Huang,Junbo Han,Bingsuo Zou,Yuping Dong
Organometal halide perovskites are inexpensive materials with desirable characteristics of color-tunable and narrow-band emissions for lighting and display technology, but they suffer from low photoluminescence quantum yields at low excitation fluencies. Here we developed a ligand-assisted reprecipitation strategy to fabricate brightly luminescent and color-tunable colloidal CH3NH3PbX3 (X = Br, I, Cl) quantum dots with absolute quantum yield up to 70% at room temperature and low excitation fluencies. To illustrate the photoluminescence enhancements in these quantum dots, we conducted comprehensive composition and surface characterizations and determined the time- and temperature-dependent photoluminescence spectra. Comparisons between small-sized CH3NH3PbBr3 quantum dots (average diameter 3.3 nm) and corresponding micrometer-sized bulk particles (2–8 μm) suggest that the intense increased photoluminescence quantum yield originates from the increase of exciton binding energy due to size reduction as well as proper chemical passivations of the Br-rich surface. We further demonstrated wide-color gamut white-light-emitting diodes using green emissive CH3NH3PbBr3 quantum dots and red emissive K2SiF6:Mn4+ as color converters, providing enhanced color quality for display technology. Moreover, colloidal CH3NH3PbX3 quantum dots are expected to exhibit interesting nanoscale excitonic properties and also have other potential applications in lasers, electroluminescence devices, and optical sensors.
研究领域:
材料科学
·
纳米技术
·
光电子学
·
显示技术
·
光子学
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DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2018
·Vol. 42
·期 17
·14332-14339
·
IF 3.201
Nan Zhou,Xingwei Zhang,Yanping Shi,Zeliang Li,Zhibiao Feng
Nitrogen-doped carbon quantum dots (CDs) were synthesized in ethanol media by using citric acid (CA) as the carbon source and ethanediamine (EDA) as the nitrogen source. The obtained CDs were characterized by multiple analytical techniques including high resolution transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FTIR). The prepared CDs can be constructed as a fluorescent probe for the detection of Hg2+ with good sensitivity and selectivity. Upon addition of I−, the fluorescence can be restored due to the strong interaction between Hg2+ and I−. The fluorescence can also be restored with the addition of Br− by changing the buffer solution. The linear ranges and the limits of detection were 0–20 μM and 65 nM for I−, and 0–28 μM and 98 nM for Br−, respectively. In addition, the UV-vis spectrum of this sensing system was studied to validate the detection mechanism of Hg2+, I− and Br−.
研究领域:
分析化学
·
纳米材料
·
环境监测
·
传感器与生物传感器
·
荧光光谱学
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DOI
高影响因子
Journal of Materials Chemistry C
·
2024
·Vol. 12
·期 9
·3175-3184
·
IF 5.7
H. Chang,F. Q. He,E. H. Song,Q. Y. Zhang
Broadband near-infrared (NIR) phosphors are crucial for fabrication of next-generation smart light sources; however, the development of a broadband NIR II emission phosphor with the full width at half maximum (FWHM) above 200 nm remains challenging. Herein, a Cr3+ doped fluoride phosphor LiInF4:Cr3+ with tunable emission from the NIR I to the NIR II spectral region is achieved using a site-occupancy control strategy. By changing the volume ratio of HF to H2O in the synthesized solution, nearly pure NIR I emission at ∼818 nm to NIR II emission centered at ∼1000 nm with a FWHM of 220 nm is realized. The density functional theory (DFT) calculations and experimental analysis reveal that the NIR I and NIR II emissions originated from the Cr3+ ions at In3+ and Li+ sites in this fluoride, which are coordinated with six and seven F− ions, respectively. The relatively low local symmetry environment is the main factor for the NIR II emission of Cr3+. A phosphor converted light-emitting diode with broadband NIR II emission is fabricated by combining the phosphor LiInF4:Cr3+ and a commercial 460 nm blue InGaN chip, showing good potential for non-destructive detection, vein imaging, etc. This work also provides insights into the luminescence tuning of Cr3+ ions.
研究领域:
材料科学
·
光学材料
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光子学
·
固态化学
·
发光
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DOI
高影响因子
Desalination and Water Treatment
·
2024
·
IF 1
Song Deng,Jingrong Huang,Meng Guo,Xueni Sun,Xiuxiu Ren,Jing Zhong,Rong Xu
Novel p-phenylenediamine-bridged organosilica (PPDA-BOS-T) materials were synthesized via the co-condensation reaction assisted by tetraethyl orthosilicate (TEOS). These amino-functionalized organosilicas were characterized by Fourier transform infrared spectrometer, N 2 sorption, scanning electron microscopy, and transmission electron microscopy. The addition of TEOS played a positive role in the construction of the porous network structure of the bridged organosilicas. The saturation adsorption capacity for Ag(I) of the PPDA-BOS-T could reach 82.88 mg g –1 . The conformity to the Freundlich model indicated multilayer adsorption with active sites. Furthermore, the adsorption was followed well by the pseudo-second-order model, and the intraparticle diffusion was proved to be the rate-limiting step during the adsorption of Ag(I). Finally, the thermodynamic parameters including the change of free energy (ΔG), enthalpy (ΔH), and entropy (ΔS) of adsorption were calculated.
研究领域:
环境科学
·
材料科学
·
化学工程
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DOI
高影响因子
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2023
·Vol. 39
·期 4
·654-659
·
IF 3.1
Zhu Xia,An Jiakun,Chen Gaoyu,Xing Chenyu,Bao Jianchun,Xu Xiangxing
Perovskite single crystals are prominent semiconductor materials due to their high carrier mobility, long carrier diffusion length, and large absorption coefficient. They can be used as optoelectronic functional materials for narrowband or broadband photodetectors. In this report, the photodetection band tunability was achieved by doping MAPbX 3 (MA=methylammonium, X=Cl/Br/I) perovskite single crystals with sub-nano carbon dots (MAPbX 3 -C). The sub-nano size and good dispersibility of the carbon dots ensured controllable doping. The absorption of the sub-nano carbon dots and trap states in the MAPbX 3 -C single crystals resulted in the special responsivity spectrum features.
研究领域:
材料科学
·
光电子学
·
半导体物理
·
纳米技术
·
光子学
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DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2022
·
IF 3.119
Li Chen,Lingbin Shen,Yuhang Chen,Zhengyang Luo,Zexin Ren,Rongrong Li,Cunbin Du
The solubility data of nimesulide (form I) in different mono- and mixed solvents over the temperature range from 273.15 to 318.15 K are determined. In this work, it is further studied to improve the solubility data of nimesulide (form I) and analyze the intermolecular force. The solubility profiles in mono- and mixed solvents are correlated by some thermodynamic models. The results of statistical analysis show that all selected models could provide a good correlation of the dissolution profile for nimesulide in selected solvents at all investigated temperatures. At 318.15 K, the largest solubility in mole fraction is obtained in acetone (7.812 × 10–2), followed by 2-butanone (6.334 × 10–2), cyclohexanone (4.977 × 10–2), ethyl acetate (3.803 × 10–2), tetrahydrofuran (3.651 × 10–2), acetonitrile (2.975 × 10–2), ethanol (2.169 × 10–3), toluene (1.788 × 10–3), isobutanol (1.348 × 10–3), isopropanol (1.201 × 10–3), and propylene glycol (PG, 6.764 × 10–4). However, in mixtures of (ethyl acetate + isopropanol), the solubility data increase with the increase of the mass fraction of ethyl acetate at a given temperature. The effect of solute–solvent interactions on the solid–liquid phase equilibrium of the solute is discussed with the solvent properties. The calculation of preferential solvation parameters shows that solute molecules are preferentially solvated by isopropanol in isopropanol-rich regions and as the mass fraction of ethyl acetate increases, nimesulide is preferentially solvated by ethyl acetate. Studying the dissolution process of nimesulide is of great practical significance for its purification.
研究领域:
药学
·
物理化学
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DOI
高影响因子
CANCER LETTERS
·
2026
·
IF 11.8
Hui Wang,Yu Zhang,Dinghua Liu,Chang Liu,Shuang Wu,Zhuoyao Wu,Tianming Cui,Gongyao Yu,Yan Xu,Weitao Yang,Bingbo Zhang
The Warburg effect drives cancer cells to rely preferentially on glycolysis, resulting in diminished mitochondrial oxidative phosphorylation (OXPHOS). This metabolic phenotype limits the ability of excess copper (Cu) ions to trigger cuproptosis in dysfunctional mitochondria, leading to suboptimal therapeutic outcomes. Therefore, remodeling tumor energy metabolism to counteract the Warburg effect represents a pivotal strategy to enhance cuproptosis efficacy. Herein, we developed a Cu(I)-stabilized metal-organic framework nanoplatform (CuTz-1) encapsulated by Azurin (CuTz-1@Azurin) as a cuproptosis sensitizer. Mechanistically, Azurin increases p53 protein levels by intercepting MDM2-mediated ubiquitin-proteasome degradation. Elevated p53 subsequently inhibits pyruvate kinase M2 (PKM2) activity, suppressing glycolysis, while simultaneously promoting mitochondrial OXPHOS—collectively shifting cellular metabolism from glycolysis toward mitochondrial respiration and sensitizing tumor cells to Cu-induced proteotoxic stress. In addition, CuTz-1@Azurin triggers oxidative stress via reactive oxygen species (ROS) generation and glutathione (GSH) depletion, which act together with p53-mediated apoptosis to suppress tumor growth. Meanwhile, the oxidation of Cu(I) to paramagnetic Cu(II) enables real-time monitoring of the therapeutic process by magnetic resonance imaging (MRI). Both in vitro and in vivo results demonstrate good antitumor performance of CuTz-1@Azurin. This study highlights the potential of Azurin-mediated metabolic regulation as a promising strategy to potentiate cuproptosis for combined cancer therapy.
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DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2026
·
IF 2.4
Lihong Jia,Zixiang He,Hanchang Huang,Xing Fan,Yuan Sui,Yongping Han
The solubility of meglumine Form I was systematically determined in 12 pure solvents (methanol, ethanol, n-propanol, isopropanol, n-butanol, ethyl formate, methyl acetate, ethyl acetate, tetrahydrofuran, 1,4-dioxane, N,N-dimethylformamide (DMF), and acetonitrile) using a gravimetric method over the temperature range of 288.15 to 328.15 K. Solubility increased with temperature in all systems, with DMF exhibiting the highest solubility and acetonitrile the lowest. Three thermodynamic models (the modified Apelblat, λh, and van’t Hoff) were employed to correlate the solubility data, among which the modified Apelblat model provided the best fit. The solubility behavior of meglumine Form I was further analyzed using Hirshfeld surface analysis, the Kamlet–Abboud–Taft linear solvation energy relationship (KAT-LSER) model. The results demonstrate that the solvent’s hydrogen-bond acceptor capability is the key determinant of solubility, as it generates sufficiently strong solute–solvent interactions to overcome the robust hydrogen-bond network within the crystal lattice. These findings provide essential thermodynamic data and mechanistic insights for the optimization of meglumine crystallization and formulation processes.
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DOI
高影响因子
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