CHINESE JOURNAL OF CHEMISTRY
·
2012
·Vol. 30
·期 4
·815-821
·
IF 0.755
Baolei Wang,Yi Ma,Lixia Xiong,Zhengming Li
A series of novel N -pyridylpyrazole carbonyl thioureas were designed and synthesized. Their structures were characterized by melting points, 1 H NMR, IR and elemental analysis or HRMS. The bioassay tests indicated that some of these compounds exhibited moderate insecticidal activity against Mythimna separata Walker and Culex pipiens pallens . Among 17 compounds, 5n and 5p showed 100% larvicidal activity against Mythimna separata Walker at the test concentration of 100 mg/L.
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Asia-Pacific Journal of Chemical Engineering
·
2024
·
IF 1.4
Bo Wang,Pei-ya Li,Shu-han Lu,Bin Wang,Fusheng Yang,Tao Fang
Liquid organic hydrogen carrier (LOHC) technology has unique advantages in hydrogen storage and transportation. However, the lack of research on the continuous dehydrogenation process of LOHCs has hindered the design and application of industrial dehydrogenation processes. In this work, a highly active dehydrogenation catalyst 1.5 wt% Pd/activated carbon (Pd/C) and a commercial catalyst 5 wt% Pd/Al 2 O 3 were used for the continuous dehydrogenation of dodecahydro-N-ethylcarbazole (12H-NEC). Based on a tubular reactor and lab-scale apparatus, 1.5 wt% Pd/C catalyst achieved a maximum dehydrogenation conversion of 98.3% and a maximum NEC selectivity of 95.3%, while dehydrogenation conversion and NEC selectivity with 5 wt% Pd/Al 2 O 3 were 98.3% and 97.6%, respectively. It showed the equally excellent performance between Pd/C and Pd/Al 2 O 3 , and the former has less Pd loading than the latter, with the potential of reducing the production cost of the dehydrogenation catalyst. The dehydrogenation results also indicated the difference in catalytic performance between the two kinds of catalysts. The obtained kinetics data were analyzed, and the dynamics of continuous dehydrogenation were studied to provide fundamental information for dehydrogenation scale-up.
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ADVANCED MATERIALS
·
2024
·
IF 27.4
Zhengbo Cui,Wen Li,Bo Feng,Yunfei Li,Xuemin Guo,Haobo Yuan,Qiang Weng,Tengyi You,Wenxiao Zhang,Xiaodong Li,Junfeng Fang
The p- or n-type property of semiconductor materials directly determine the final performance of photoelectronic devices. Generally, perovskite deposited on p-type substrate tends to be p-type, while perovskite deposited on n-type substrate tends to be n-type. Motived by this, a substrate-induced re-growth strategy is reported to induce p- to n-transition of perovskite surface in inverted perovskite solar cells (PSCs). p-type perovskite film is obtained and crystallized on p-type substrate first. Then an n-type ITO/SnO 2 substrate with saturated perovskite solution is pressed onto the perovskite film and annealed to induce the secondary re-growth of perovskite surface region. As a result, p- to n-type transition happens and induces an extra junction at perovskite surface region, thus enhancing the built-in potential and promoting carrier extraction in PSCs. Resulting inverted PSCs exhibit high efficiency of over 25% with good operational stability, retaining 90% of initial efficiency after maximum power point (MPP) tracking for 800 h at 65 °C with ISOS-L-2 protocol.
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METALLURGICAL AND MATERIALS TRANSACTIONS B-PROCESS METALLURGY AND MATERIALS PROCESSING SCIENCE
·
2024
·
IF 2.4
Chen Mao,Chen Buxin,Jiang Yang,Zheng Kui,Hu Meilong,Qiu Shuxing
Ti(C,N) is commonly observed in vanadium titanomagnetite blast furnaces and greatly affects the stable and smooth operation of the smelting processes. To get fundamental insight into Ti(C, N) formation, systematic experiments were conducted to investigate the effects of the composition of slags, temperatures, reaction time and reaction atmosphere on the formation of Ti(C,N) from TiO 2 -containing slags. The results show that TiN and TiC contents increase with TiO 2 content increases. When TiO 2 is larger than 30 wt pct, TiN contents increase dramatically. Control of basicity, MgO and Al 2 O 3 concentrations in the slag could help to reduce Ti(C,N) contents in slags. TiN and Ti(C,N) contents increase dramatically with the extension of time. TiN is more easily formed at high temperatures, and TiN contents increase with the increase of temperature. With the increase of N 2 contents, TiC contents are relatively stable, and TiN and Ti(C,N) contents increase almost linearly. H 2 would greatly promote the formation of TiC. This paper can provide a theoretical basis for minimizing the formation of Ti(C,N) in different blast furnace conditions.
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PHYSIOLOGICAL RESEARCH
·
2025
·
IF 2
D Shao,L Bai,Q Chen,Y Chen,Z Qiu,Y Liu,S Jin,Y Wu,J Dai
Trimethylamine N-oxide (TMAO) is involved in the development of kidney disease. However, the specific mechanism by which it leads to kidney injury is unclear. This study explored the role of regulated cell death in TMAO-induced kidney injury. We constructed a TMAO-induced chronic kidney injury model by intraperitoneal injection of TMAO (100 micromol/kg/day for three months). Plasma creatinine (Cre) and urea nitrogen (BUN) levels were measured to evaluate kidney function. Masson staining was used to evaluate kidney pathological changes. The expression levels of regulated cell death-related proteins were measured using western blotting. Plasma Cre and BUN, the area of kidney fibrosis in the TMAO group significantly increased. The western blotting results showed cleaved-Caspase-8, Caspase-8, Caspase-1, NOD-like receptor protein 3 (NLRP3), interleukin-1beta (IL-1beta), cleaved-gasdermin D (cleaved-GSDMD), Z-DNA binding protein 1 (ZBP1), phosphorylation of receptor-interacting protein kinase 3 (RIP3) and mixed-lineage kinase domain-like pseudokinase (MLKL) significantly elevated in the TMAO group. The transferrin receptor 1 (TFR1), ferritin heavy chain (FTH), ferroportin (FPN), nuclear factor erythroid 2-related factor 2 (NRF2), and glutathione peroxidase 4 (GPX4) protein expression in kidney tissue of the TMAO group significantly up-regulated. However, there was no change in iron and MDA levels. The results suggested that PANoptosis, including pyroptosis, apoptosis, and necroptosis components, might be involved in TMAO-induced chronic kidney injury.
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PROTEIN EXPRESSION AND PURIFICATION
·
2022
·
IF 2.025
Zhiting Lao,Shuanqi Li,Jinhui Liang,Jingyi Su,Xin Gong,Xiping Cui,Suqing Zhao
Glypican-3 (GPC3) has a promise to be the diagnostic biomarker as well as therapeutic target for hepatocellular carcinoma (HCC). Nanobody have the great potential in clinical diagnosis and treatment for their characteristics of small size, high solubility, stability, manipulability, binding advantages, and ease of production. In this study, the recombinant glypican-3-N terminal (GPC3-N) protein was expressed as inclusion body in E. coli BL21(DE3)pLysS cells and then purified, which is then used as the immunogen to construct nanobody phage library. The positive clone (named MF15) was obtained by four rounds of bio-panning, and then transformed into the E. coil TOP10F’ cells to express nanobody protein, with the molecular weight of 19 kDa. Both Western blot and immunofluorescence analysis revealed that bacterially expressed GPC3-N protein is biologically active, and MF15 could specifically recognized native GPC3 expressed in HepG2 cells. The results in this study would provide the technical support for the development of diagnostic kits and antibody drugs targeting GPC3.
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Materials Reports: Energy
·
2025
·
IF 13.8
Wei Fang,Zeping Ou,Yifan Wang,Xiaoxue Lin,Hao Yang,Yujie Zheng,Jing Li,Lei Wang,Lijun Hu,Chen Li,Jianyong Ouyang,Kuan Sun
Thermocells are attracting growing interest as a promising thermoelectric technology for low-grade heat harvesting. However, the scarcity of high-performance redox couples featuring intrinsically high thermopower ( S e ) and fast redox kinetics hinders thermocells rapid development. Identifying potential intrinsically high-performance redox couples remains a significant challenge. This work introduces a novel n-type copper (Ⅰ/Ⅱ) chloride (CuCl/CuCl 2 ) redox couple with intrinsically high performance. Through tailored electrolyte design, long-term stability was significantly improved by reducing proton concentration to suppress cuprous ion photo-oxidation, while ammonium chloride solvation enhanced cuprous ion solubility. The resulting system achieves a S e value closely aligned with theoretical predictions and exhibits rapid redox kinetics. Consequently, the optimized CuCl/CuCl 2 intrinsic system demonstrated a high S e of 1.52 mV K ‒1 and a record-high normalized power density P max (Δ T ) ‒2 of 0.399 mW m ‒2 K ‒2 , surpassing previously reported intrinsic n-type thermocells and rivaling the performance of p-type pristine 0.4 M ferri/ferrocyanide systems. A prototype module comprising 30 p-n units successfully powered a line of light-emitting diodes or a thermohygrometer. This work introduces a valuable redox couple for further advancing high-performance thermocells and demonstrates a viable strategy for developing novel redox systems.
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ChemistrySelect
·
2025
·Vol. 10
·期 43
·e05445
·
IF 2
Hui Li
Direct methanol fuel cells (DMFCs) face significant challenges due to sluggish methanol oxidation reaction (MOR) kinetics and catalyst poisoning by carbon intermediates (e.g., CO ads ). To address this, we rationally designed nitrogen-doped carbon (NC) carriers with tailored N-configurations (pyridinic-N, pyrrolic-N, and graphitic-N) via controlled pyrolysis temperatures (700–1000 °C) and anchored Pt nanoparticles (NPs) to enhance metal-support interaction (MSI). The NC-900 carrier achieved optimal N-configuration distribution (56.7% pyridinic-N, 25.2% pyrrolic-N, 18.1% graphitic-N) and the highest defect density ( I D /I G = 1.12), enabling ultra-dispersed Pt NPs (1.69 nm) and strong electron donation to Pt. XPS confirmed a 61.2% Pt° content in Pt/NPC-900, facilitating efficient methanol adsorption/activation. In alkaline media, Pt/NPC-900 delivered a record mass activity of 4687.5 mA mg −1 Pt - 4.36 × higher than Pt/PC—along with exceptional stability (79.6 % current retention after 500 cycles). In situ Raman spectroscopy revealed a non-CO pathway, circumventing poisoning intermediates. This work establishes a precise N-configuration engineering strategy to optimize MSI for next-generation DMFC catalysts. Graphical Schematic diagram for the preparation of N-doped carbon-supported Pt nanoparticles catalysts by chemical reduction method.By adjusting the roasting temperature, it is possible to control the proportion of different N-configuration distributions. This enables effective control of the dispersion degree and electronic properties of the active metal Pt, thereby enhancing the activity and stability of the catalyst during the alkaline methanol oxidation reaction.
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PHYSIOLOGICAL RESEARCH
·
2025
·Vol. 74
·期 3
·613
·
IF 2
Decui SHAO,Lu BAI,Qian CHEN,Yuhong CHEN,Zhaoxu QIU,Yinuo LIU,Sheng JIN,Yuming WU,Jing DAI
Trimethylamine N-oxide (TMAO) is involved in the development of kidney disease. However, the specific mechanism by which it leads to kidney injury is unclear. This study explored the role of regulated cell death in TMAO-induced kidney injury. We constructed a TMAO-induced chronic kidney injury model by intraperitoneal injection of TMAO (100 μmol/kg/day for three months). Plasma creatinine (Cre) and urea nitrogen (BUN) levels were measured to evaluate kidney function. Masson staining was used to evaluate kidney pathological changes. The expression levels of regulated cell death-related proteins were measured using western blotting. Plasma Cre and BUN, the area of kidney fibrosis in the TMAO group significantly increased. The western blotting results showed cleaved-Caspase-8, Caspase-8, Caspase-1, NOD-like receptor protein 3 (NLRP3), interleukin-1β (IL-1β), cleaved-gasdermin D (cleaved-GSDMD), Z-DNA binding protein 1 (ZBP1), phosphorylation of receptor-interacting protein kinase 3 (RIP3) and mixed-lineage kinase domain-like pseudokinase (MLKL) significantly elevated in the TMAO group. The transferrin receptor 1 (TFR1), ferritin heavy chain (FTH), ferroportin (FPN), nuclear factor erythroid 2-related factor 2 (NRF2), and glutathione peroxidase 4 (GPX4) protein expression in kidney tissue of the TMAO group significantly up-regulated. However, there was no change in iron and MDA levels. The results suggested that PANoptosis, including pyroptosis, apoptosis, and necroptosis components, might be involved in TMAO-induced chronic kidney injury.
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Nature Communications
·
2025
·
IF 15.7
Jiaxin Du,Yunshuo Wu,Siyu Fang,Daliang Xu,Min Liu,Heng Liang,Zhongbiao Wu,Gaoqing Max Lu,Xuanhao Wu
The electrochemical co-reduction of CO 2 and nitrate provides a sustainable route for urea synthesis via C–N coupling, yet kinetic limitations and poor intermediate interactions hinder urea yields. Here, we engineer a nano-confined CuRu bimetallic catalyst within mesoporous carbon hollow spheres (MCHS) to overcome these barriers. By spatially confining reactants and intermediates, the catalyst achieves a urea yield of 12.51 g h –1 g cat –1 at 250 mA cm –2 , with 125-hour stability. In situ spectroscopy and computational analyses reveal that nano-confinement switches the C–N coupling pathway from the thermodynamically favored *COOH–*NH 2 to kinetically driven *OCO–*NO intermediates, bypassing energy barriers. Precise pore-size engineering (4–11 nm) demonstrates that optimal confinement simultaneously enhances reactant transport and intermediate retention, boosting selectivity. This work establishes nano-confinement as a versatile approach for controlling multi-step electrocatalytic processes, enabling sustainable chemical synthesis. This study introduces a nano-confined CuRu catalyst that leverages confinement effects to enhance CO 2 –nitrate C–N coupling by improving reactant transport and strengthening the stabilization of key reaction intermediates, thereby achieving high urea yield and long-term operational stability.
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PLANT PHYSIOLOGY AND BIOCHEMISTRY
·
2018
·
IF 2.718
Chen Geng,Tengfei Zhao,Chunxian Yang,Qiaozhuo Zhang,Feng Bai,Junlan Zeng,Fangyuan Zhang,Xiaoqiang Liu,Xiaozhong Lan,Min Chen,Zhihua Liao
N -methylputrescine is the precursor of nicotine and pharmaceutical tropane alkaloids such as hyoscyamine . Putrescine N -methyltransferase (PMT) catalyzes the N -methylation of putrescine to form N -methylputrescine. While the role of PMT in nicotine biosynthesis is clear, knowledge of PMT in the biosynthesis of tropane alkaloids (TAs) and the regulation of polyamines remains limited. We characterized a PMT gene from Hyoscyamus niger , designated HnPMT that was specifically expressed in roots, especially in the secondary roots and dramatically induced by methyl jasmonate (MeJA). The GUS gene was specifically expressed in Arabidopsis roots or in the vascular tissues , including pericycles and endodermis , of the H. niger hairy root cultures , when it was driven by the 5′-flanking promoter region of HnPMT . The recombinant HnPMT was purified for enzymatic assays. HnPMT converted putrescine to form N -methylputrescine, as confirmed by LC-MS. The kinetics analysis revealed that HnPMT had high affinity with putrescine but low catalytic activity, suggesting that it was a rate-limiting enzyme . When HnPMT was suppressed in the H. niger plants by using the VIGS approach, the contents of N -methylputrescine and hyoscyamine were markedly decreased, but the contents of putrescine, spermidine and a mixture of spermine and thermospermine were significantly increased; this suggested that HnPMT was involved in the biosynthesis of tropane alkaloids and played a competent role in regulating the biosynthesis of polyamines . Functional identification of HnPMT facilitated the understanding of TA biosynthesis and thus implied that the HnPMT-catalyzed step might be a target for metabolic engineering of the TA production in H. niger .
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2013
·Vol. 131
·期 7
·
IF 1.395
Bojian Hu,Xiaoqin Chen,Yan Zuo,Zuliang Liu,Xiaodong Xing
Bi-functional antibacterial material was prepared by co-grafting N -halamine and quaternary ammonium salt monomers from cellulose fiber. The grafted fiber was characterized by Fourier transform infrared spectra, and X-ray photoelectron spectra. The N -halamine derived from the precursor 4-[(acryloxy)methyl]-4-ethyl-2-oxazolidinone via chlorination treatment and the oxidative chlorine (Cl + ) leaching behavior were investigated. The antibacterial activities of singly (only QAs-functionalized or only Cl + -releasing) and dual (QAs-functionalized and Cl + -releasing) functional cellulose fibers were tested against Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus . Compared to singly functionalized formulations, the bi-functional cellulose fiber exhibited excellent and rapid bactericidal performance against both E. coli and S. aureus . © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 40070.
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