International Journal of Nanomedicine
·
2024
·
IF 6.6
Chen Lin,Xinyi Bai,Linkun Zhang
Purpose MicroRNA-34c-5p (miR-34c-5p) plays a pivotal role in bone remodeling, yet its therapeutic potential is hindered by challenges such as instability, limited cellular internalization, and immune responses. This study was aimed at developing innovative scaffolds capable of efficiently delivering microRNAs (miRNAs), specifically miR-34c-5p.Methods Chitosan (CS)/sodium tripolyphosphate (STPP)/sodium alginate (SA) scaffolds, referred to as CTS scaffolds, were synthesized at a specific ratio and characterized using dynamic light scattering and scanning electron microscopy (SEM). Cytotoxicity assessments were conducted through cell activity staining. The loading capacity and releasing performance of miRNAs were quantified using spectrophotometry. Subsequently, the in vivo efficacy of miR-34c-5p Agomir/Antagomir in regulating bone repair was evaluated in the rabbit cranial bone defect model, with micro-CT scanning and histological analysis conducted at 4, 8, and 12 weeks.Results CTS scaffolds with a composition ratio of 1:0.2:0.1 were successfully synthesized, exhibiting a mean particle size of 360.1 nm. SEM revealed scaffolds had the porous spongy structure. Cell activity staining confirmed the excellent biocompatibility of the CTS scaffolds. Spectrophotometry demonstrated miR-34c-5p Antagomir were continually released, reaching 91.41% within 30 days. Differential new bone formation was observed between the miR-34c-5p Agomir and Antagomir groups. Micro-CT imaging and histological staining revealed varying degrees of bone regeneration, with notable improvements in the miR-34c-5p Antagomir group.Conclusion CTS scaffolds with a composition ratio of 1:0.2:0.1 demonstrate favorable biocompatibility and enable efficient loading and sustained release of miR-34c-5p Antagomir. The study suggests potential applications of miR-34c-5p Antagomir in promoting bone repair and highlights the promise of innovative scaffolds for therapeutic miRNAs administration in bone regeneration.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Yao Liu,Dongshu Chen,Panpan Gu,Yue Liu,Bai Wang,Xiaoxu Xu,Jianshe Hu
With the rapid development of wearable electronic devices and smart sensors, flexible sensors have received much attention due to their excellent mechanical properties and good adaptability. However, developing a simple method to produce conductive hydrogels with excellent electrical conductivity , mechanical properties, environmental stability, and durability is still a major challenge. In this study, a novel dual-network composite flexible sensor was developed, which was mainly composed of xanthan gum (XG), sodium alginate (SA), polyacrylamide (PAAm), and gallium‑indium alloy (Ga-In). The sensor combined the good biocompatibility and thickening properties of natural polysaccharides , the flexibility of polymers, and the excellent electrical conductivity of conductive metal alloys. The sensors exhibited good mechanical properties (stress ≈ 400 KPa, strain ≈ 540 %), high fatigue resistance , recoverability and excellent environmental adaptability. In addition, the addition of liquid metal could increase the conductivity (1.83 S m −1 ) of the hydrogel while maintaining high transparency, and the flexible sensor device constructed from it had high sensitivity to strain (GF = 2.75). Therefore, the hydrogel as a flexible sensor showed promising applications in detecting human movement, which could monitor the movement of human joints, micro-expressions, and handwriting. This will provide new ideas for scientific management of sports and health monitoring.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yunzhong Tu,Lang Qiu,Xinyi Li,Jingwen Zhu,Junli Chen,Hongling Liu
Recently, flexible wearable electronic devices have attracted extensive attention as an alternative to traditional rigid metallic conductors in the fields of personal health monitoring, human motion tracking, and biomimetic skin, due to their unique properties. However, most current wearable sensing devices are generally limited by poor sensitivity, limited detection range, and the inability to integrate well with clothing. In this paper, a hydrogen-bonded crosslinked network based on sodium alginate (SA) and wool keratin (WK) non-covalently modified carbon nanotubes (CNTs) was rationally designed and fabricated into a flexible pressure sensor named as SA&WK/CNT sensor. The resulting sensor is capable of accurately detecting the motion of various joints, with a fast response time of 0.15 s, a high sensitivity of 4.32 kPa −1 , and an excellent strength of 17.57 MPa. Moreover, the SA1WK2/CNT15@fabric flexible sensor, prepared by combining plain weave fabric with SA1WK2/CNT15 composite, exhibits enhanced sensitivity of 13.33 kPa −1 . Notably, the flexible sensor demonstrates outstanding performance in practical applications, including handwriting recognition and precise motion detection. This work not only reveals the inherent piezoresistive excellence of protein-based flexible films but also establishes a novel paradigm for developing high-performance fabric sensors through synergistic integration with textile substrates, paving the way for wool keratin-based materials in next-generation wearable technologies and smart health monitoring systems.
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JOURNAL OF ENVIRONMENTAL MANAGEMENT
·
2025
·
IF 8.4
Yiming Liu,Weixuan Pan,Hui Zhang,Ningxin Geng,Liangxu Jiang,Jiaan Bao,Huiwen Wu,Qi Liu
In this study, a composite aerogel was synthesized through the in situ integration of ZIF-8 within a sodium alginate (SA) framework, followed by cross-linking and freeze-drying. SA@ZIF-8 demonstrated enhanced adsorption capacity and reusability. The introduction of ZIF-8 improved the aerogel’s surface properties and generated abundant porous adsorption sites. At 298 K, the composite exhibited a maximum theoretical adsorption capacity of 200.4 mg g −1 for tetracycline (TC). The adsorption process of SA@ZIF-8 for tetracycline followed the pseudo-second-order kinetic model and the Langmuir isotherm model. The adsorption mechanisms include synergistic effects, hydrogen bonding, coordination bonding, electrostatic attractions, and π–π interactions. In addition, following ten adsorption-desorption cycles, the material consistently demonstrated a removal efficiency surpassing 65.7 %. On the whole, this study demonstrates an efficient biomass adsorbent for the removal of tetracycline from drain water. The prepared composite aerogel exhibits excellent reusability for efficient tetracycline removal from wastewater, demonstrating strong potential for practical water treatment applications.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·Vol. 30
·期 44
·99842-99854
·
IF 5.8
Xie Yaping,Du Guoxing,Pang Jiaju,Kong Linghan,Lu Linguo
To resourcefully utilize algal biomass and effectively remove bisphenol A (BPA) from water, sodium alginate (SA) was prepared as the nitrogen-doped magnetic porous carbon material (SAC/N/Fe) with well-developed pore structure according to a one-step method using K 2 CO 3 , melamine, Fe(NO 3 ) 3 ·9H 2 O as the activator, nitrogen dopant, and magnetic precursor, respectively, in this study. The best product, SAC/N/Fe-0.2, was obtained by adjusting the mass ratio of raw materials, and its specific surface area and pore volume were 2240.65 m 2 g −1 and 1.44 cm 3 g −1 , respectively, with a maximum adsorption capacity of 1248.23 mg g −1 for BPA at 308 K. SEM, XRD, XPS, VSM, and FT-IR characterization confirmed that the iron was successfully doped, giving the porous carbon a magnetic separation function. The adsorption process of BPA was more consistent with the Langmuir model and the proposed secondary kinetics, and the adsorption effect was stable and efficient in a wide pH range and under the interference of different metal ions. At the same time, the porous carbon was easy to separate and recover with good regeneration performance.
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JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
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2025
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IF 2.8
Zhikun Li,Yuanyuan Li,Yulong Ma,Wenxin Ji,Yonggang Sun
The purification of biomacromolecules, particularly proteins, plays an increasingly vital role in the fields of medicine, biopharmaceuticals, and emerging technologies. Adsorbents with excellent adsorption capacity, superior cycling performance, and environmental compatibility are crucial for protein separation and adsorption. A temperature- and pH dual-stimulus responsive hydrogel material for the adsorption and separation of protein was successfully prepared by copolymerizing sodium alginate (SA) as the matrix with N-isopropylacrylamide (NIPAM), acrylic acid (AAC), and simultaneously introducing zirconium-based metal-organic frameworks (Zr-MOF). This hydrogel material exhibits excellent adsorption and controlled release properties for protein including bovine hemoglobin (BHB) and bovine serum albumin (BSA) with maximum adsorption capacities of 617.45 mg/g and 527.06 mg/g at 45 °C, respectively. Experimental results demonstrate that the adsorption and release behavior of the hydrogel toward proteins can be effectively regulated by adjusting environmental temperature or pH value in an aqueous medium without any acidic, alkaline, high-salt, or organic solvent. Additionally, the material exhibits good cyclic stability, maintaining more than 85 % of its initial protein adsorption capacity after five adsorption-desorption cycles. This study provides new insights into the development of smart responsive biomolecular adsorption materials and has significant application potential in the fields such as drug controlled release and biological separation.
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CARBOHYDRATE POLYMERS
·
2026
·
IF 13.2
Xin Wang,Xiaowen Cui,Xiao Sun,Yicheng Wang,Ting Wang,Tinghui Wu,Haoyue Wu,Wenhan Wang,Junyi Tao,Yongqi Yang,Mengzhu Liu,Yongpeng Wang,Zhe Chen,Tao Jia
Solar-driven interfacial evaporation is promising for sustainable freshwater production but faces challenges like salt accumulation and energy loss. Inspired by the crack networks in chameleon skin, we developed a three-dimensional Janus foam evaporator (3D-JRSMP) with engineered micro-cracks. It is constructed by anchoring recycled carbon fibers in a melamine foam scaffold integrated with a sodium alginate (SA) hydrogel. The Ca 2+ crosslinked SA forms a hierarchical crack network for enhanced water transport and light harvesting. A top polydimethylsiloxane coating creates a superhydrophobic/superhydrophilic Janus interface for efficient heat localization and salt rejection. Crucially, the SA hydrogel facilitates the formation of “intermediate water”, substantially reducing evaporation enthalpy. The evaporator achieves an evaporation rate of 4.98 ± 0.12 kg m −2 h −1 and a solar-to-vapor efficiency of 97.29 ± 0.03% under 1 sun irradiation. It maintains stable performance in 20 wt% brine over 20 cycles and effectively purifies water containing heavy metals, dyes, and antibiotics. By leveraging the evaporation-induced temperature gradient, an integrated thermoelectric system delivers 305.1 ± 4.6 mW m −2 . Outdoor desalination yielded 29.8 ± 0.4 kg m −2 of freshwater in 10 h. This work presents a scalable platform combining bioinspired design, upcycled materials, and polysaccharide-enabled low-enthalpy evaporation for integrated water and energy harvesting.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.5
Amatjan Sawut,Yurou Feng,Rena Simayi,Manfang Pan
Heavy metal ion pollution in wastewater, particularly Cu 2+ contamination, threatens ecology and human health, demanding efficient adsorption materials in environmental remediation. However, conventional adsorbents suffer from insufficient capacity, poor mechanical stability, weak selectivity, and low reusability, restricting their practical application. Herein, a semi-interpenetrating network composite hydrogel (ZIF-8-AVA) was fabricated via in situ self-assembly, integrating ZIF-8 nanocrystals into a poly(acrylamide- co -vinylimidazole)/sodium alginate (AVA) matrix. Vinylimidazole units served as nucleation anchors, firmly immobilizing ZIF-8 on the polymer backbone via metal-ligand coordination to form a stable system. ZIF-8 significantly enhanced AVA's mechanical properties and Cu 2+ adsorption performance: the composite followed the Langmuir monolayer adsorption model with a maximum adsorption capacity of 355.9 mg/g, achieving 93.81% Cu 2+ removal efficiency at an initial concentration of 50 mg/L. Furthermore, the ZIF-8-AVA hydrogel exhibited excellent selectivity for Cu 2+ in multi-competing-ion systems and maintained high adsorption efficiency after 5 consecutive adsorption-desorption cycles. The key innovation lies in the in situ self-assembly strategy that realizes the intimate integration of ZIF-8 with the hydrogel matrix via coordination-driven anchoring, overcoming the common issue of MOF particle leaching and synergistically enhancing adsorption capacity, selectivity, and mechanical stability. This work offers a novel approach for tunable MOF hydrogels, with great potential in heavy metal wastewater treatment.
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FOOD CHEMISTRY
·
2026
·
IF 9.8
Hui Shen,Jingsong Zhu,Yinxue Jiao,Yajing Qi,Teng Li,Wenhui Qi,Ying Shu,Kaixuan Zhao,Fengyang Wu,Chi Ren,Zhisheng Zhang
This study systematically explored the effects of sodium alginate (SA) on the structural and interfacial properties of donkey myofibrillar protein (DMP), and the curcumin stability and delivery performance in the DMP-based Pickering emulsion. The results showed that SA interacted with DMP via hydrogen bonding and van der Waals forces, increased surface hydrophobicity, and electrostatic repulsion. These interactions promoted the formation of the three-dimensional network within the emulsion continuous phase, significantly improving its rheological properties and storage stability. Molecular docking showed that SA enhanced the binding affinity between curcumin and DMP. Consequently, SA addition (optimal at 0.4%) significantly increased the curcumin embedding efficiency and stability ( P < 0.05). In vitro digestion studies demonstrated that SA inhibited the rate of curcumin release during gastric digestion and improved its bioaccessibility by approximately 10%. This study provides a protein-polysaccharide-based strategy for developing stable Pickering emulsion systems for the effective delivery of hydrophobic bioactive substances.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2017
·
IF 3.671
Xinyu Zhao,Jiacheng Li,Yuhong Feng,Gaobo Yu,Qingfeng Zhou,Furui He,Dunchao Xiao,Kai Chen,Lei Zhang
In this study, cholesteryl-grafted sodium alginate derivatives (CSAD) with different molecular weights were synthesized by esterification. The structure of CSAD was confirmed by FT-IR and 1 H NMR spectrometers. The effects of pH and CSAD polymer concentration on the self-assembled behavior and particle size of CSAD were investigated by fluorescence measurement (FM) and dynamic light scattering (DLS). In the presence of Ca 2+ , the cholesteryl-grafted sodium alginate derivative was used for fabricating self-assembled nanoparticles that can effectively encapsulate the drug acetamiprid . The drug-loaded nanoparticles were characterized by transmission electron microscopy (TEM). The encapsulation efficiency ( EE ) and acetamiprid drug release behavior from the nanoparticles were also studied. The results reveal that CSAD self-assembled nanoparticles had a diameter of 100 nm and were nonaggregated in aqueous media; Moreover, the encapsulation efficiency and the release behavior of nanoparticles were influenced by the MW of CSAD. The mechanism of acetamiprid release was found to vary from non-Fickian (anomalous) to Fickian transport with a decrease in the molecular weight of CSAD.
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LANGMUIR
·
2026
·
IF 3.9
Muhammad Yawar Younis,Muhammad Yasir Younis,Safdar Abbas,Yun Wei
Advanced phosphate removal is crucial for mitigating eutrophication. Adsorption stands out for phosphate removal, yet, a weak affinity and slow mass transfer at low concentrations often hinder it. Herein, hierarchical CuCo-LDH@SA-10 hydrogel beads prepared by ZIF-67 conversion and alginate immobilization were fabricated with freeze-drying, which yielded a nanosheet-coated mesoporous architecture accelerating transport. The adsorbent removed phosphate from 50 to 0.05 mg L–1 in real wastewater within three cycles, achieving an adsorption capacity of 140.65 mg g–1 under batch conditions. Equilibrium data followed the Langmuir isotherm, while the pseudo-second-order model provided the best description of uptake kinetics. High removal persisted over a pH range of 3–6, with good tolerance to coexisting anions (chloride being the most suppressive). Beyond phosphate, the material effectively removed chromate, achieving an uptake of 86.75 mg g–1. The beads were regenerable, retaining ≥90% capacity over three cycles and 87% after five cycles. Overall, the integration of hierarchical porosity, strong performance at low concentrations, and demonstrated dual-pollutant removal underscores CuCo-LDH@SA-10 as a promising adsorbent for advanced phosphate and chromate polishing in wastewater.
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ACS Nano
·
2026
·
IF 17.3
Wang Lin,Wei Jingjiang,Wu Xiaoqian,Wang Zheng,Liu Yin,Tang Jiexin,Jiang Yanna,Xie Hao,Wang Weimin,Wang Hao,Ping Hang,Fu Zhengyi
The continuous miniaturization and increasing power density
of
modern electronic devices have led to severe localized heat accumulation,
posing significant challenges to device performance, reliability,
and lifespan. Passive radiative cooling offers a promising, energy-free
solution for thermal management. However, most reported radiative
cooling materials are mechanically fragile films, lacking the structural
stability required for long-term integration with electronic devices.
Inspired by the brick-and-mortar architecture of natural nacre structures,
we report a nacre-mimetic bulk boron nitride (BN) composite that combines
efficient radiative cooling with high mechanical strength. The composite
is fabricated via a pressure-driven, water-molecule-assisted orientation
and interfacial coupling strategy, in which sodium alginate (SA)-assisted
BN dispersion and Ca 2+ ionic cross-linking enable highly
ordered BN nanosheet alignment and strong interfacial bonding during
laminated hot pressing, resulting in a nacre-like hierarchical structure.
The resulting BN–SA composite exhibits a flexural strength
of 78.3 MPa and fracture toughness of 2.48 MPa·m 1/2 , alongside outstanding optical properties including high solar reflectance
( R = 89.7%) and mid-infrared emissivity (84.5%).
Consequently, net radiative cooling power reached 140.1 W·m –2 at night, lowering outdoor temperatures by 12.5 ° C.
This work provides a bio-inspired strategy for constructing mechanically
robust radiative cooling materials, offering a viable solution for
thermal management in high-heat-flux electronic devices.
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