INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
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2025
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IF 4.6
Yi Lu,Xiaoying Yu,Yandi Pan,Hang Yin,Qingqing Yang,Xin Shen,Xuefeng Cao,Zhiwei Li,Lianci Peng,Rendong Fang
With the increased bacterial resistance to conventional antibiotics, there is an urgent need for the development of novel antimicrobial agents. Cathelicidins belonging to the family of cationic host defense peptides (HDPs) are a critical component of the innate immune system with antimicrobial and immunomodulatory activities. Our previous study has shown that CATH-1 exhibits potent bactericidal activity against Streptococcus suis ( S. suis ), but the underlying mechanism is still unclear. In this study, we investigated the effect of CATH-1 on the resistance development and antibacterial mechanisms against S. suis strain SC19. Our results revealed that CATH-1 did not induce bacterial drug-resistance. Proteomics and metabolomics analyses revealed that CATH-1 exerts its antibacterial effects by modulating multiple pathways, including the cell membrane, bacterial virulence, and energy metabolism pathway. Mechanistically, CATH-1 exerts dual antimicrobial effects by disrupting bacterial membrane integrity and targeting the serine/threonine kinase (STK) to inhibit capsular polysaccharide (CPS) synthesis. The interaction between STK and CATH-1 was evident by molecular docking, GST affinity-isolation assay, cellular thermal shift assay (CETSA) and drug affinity responsive target stability (DARTS). Furthermore, stk deficiency abrogated the anti- S. suis efficacy of CATH-1 both in vitro bactericidal assay and in vivo infection model, indicating that STK is the potential target of CATH-1. Our study reveals a novel antibacterial target of CATH-1, providing new insights into the development of antimicrobial peptides as anti-infective agents.
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DOI
PubMed
高影响因子
Materials Today Bio
·
2025
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IF 10.2
Chunyi Li,Kongcheng Wang,Jie Shao,Junmeng Zhu,Yaohua Ke,Baorui Liu,Lanqi Cen
Peptide vaccines have potential for tumour immunotherapy but face challenges in clinical trials, such as human leukocyte antigen limitations, potential cytotoxic T lymphocyte tolerance, short T-cell response duration, weak immune response, and other issues. Optimizing the antigens of peptide vaccines and selecting an effective delivery system are crucial for enhancing their antitumour effects. 3 multiepitope long peptides (NLP) targeting the NY-ESO-1 antigen were screened using bioinformatics methods. An engineered Lactococcus lactis strain (FOLactis) expressing FMS-like tyrosine kinase 3 ligand and the costimulator OX40 ligand was previously developed to activate immune cells. In this study, FOLactis was utilized as a biological carrier for NLP via Mg 2+ -based metal-organic frameworks to stimulate innate and adaptive immunity. The FOL-M@NLP were characterized, and various tumour models were established to assess the antitumour efficacy of the biovaccine. The preliminary mechanism of the immune effect induced by FOL-M@NLP was studied both in vivo and in vitro . The biovaccine FOL-M@NLP was effectively taken up by antigen-presenting cells (APCs). APCs were activated, activating the T-cell response. When FOL-M@NLP was administered subcutaneously in vivo , their antitumour activity was superior to that of NLP and FOLactis alone. The biovaccine improved the immune infiltrating state of the tumour microenvironment and metastasis niche, inhibited tumor progression and prevented recurrence. It is demonstrated that FOL-M@NLP serves as a potent and safe antitumour platform that enhances antigen peptide delivery and facilitates the advancement of therapeutic biological vaccine platforms.
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PubMed
高影响因子
APPLIED CATALYSIS A-GENERAL
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2025
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IF 4.8
Jin Guo,Xueying Bai,Xianquan Li,Jifeng Pang,Lele Feng,Yujia Zhao,Yang Su,Shimin Liu,Chaoqian Liu,Mingyuan Zheng
Copper(Cu)-based catalysts are highly promising candidates for ethanol dehydrogenation owing to their exceptional activity in cleaving O-H and C-H bonds. Nevertheless, their widespread application is hindered by challenges such as rapid deactivation and complex preparation procedures. Herein, inspired by the deactivation mechanism of Cu/MFI (silicalite-1) catalysts, two strategies, i.e., using mixed solvents for impregnation and enriching silanol nests of MFI to anchor Cu particles, were used to synthesize Cu/MFI-R catalysts with high stability and activity. The mixed solvent approach reduces the surface tension of solvents, enhancing the uniform dispersion of Cu over the hydrophobic surface of MFI. Subsequently, a MFI-R support with abundant silanol nests was synthesized via optimizing hydrothermal conditions, as confirmed by reaction results and characterizations of FT-IR, UV-Vis and solid NMR. By combining these strategies, Cu/MFI-R catalysts were synthesized for ethanol dehydrogenation, achieving > 90 % ethanol conversion and 95 % acetaldehyde selectivity over the 600 h time on stream test. This work provides a very promising scalable approach for the design of stable Cu-based catalysts in hydrogen-related reactions.
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高影响因子
MATERIALS RESEARCH BULLETIN
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2024
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IF 5.3
He Cui,Chen Li,Raz Muhammad,Yuanyuan Wang,Zhihua Qian,Kaixin Song
In this study, (1- x )Ni 0.5 Zn 0.5 Fe 2 O 4 - x K 2 MoO 4 ((1- x )NZO- x KMO) composite ceramics were prepared through a cold sintering process. The research aimed to investigate the effect of different cold sintering conditions on the densification, phase, and magnetic/dielectric properties of the composites. The 0.6NZO-0.4KMO composite, prepared at 180 °C for 30 min under an applied pressure of 500 MPa, and utilizing 10 wt.% deionized water as a solvent, exhibited a high dielectric constant and permeability. SEM analysis revealed that the two phases were uniformly mixed, and the microstructure was dense. The cold sintering mechanism proposed for (1- x )NZO- x KMO composites suggests that the 'dissolution-precipitation' mechanism plays a key role in driving the densification of the ceramics.
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高影响因子
MATERIALS LETTERS
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2014
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IF 2.269
Shanshan Ji,Peixia Yang,Jinqiu Zhang,Ye Lian,Jie Zhang,Maozhong An
BMIm-OTF (1-Butyl-3-methylimidazolium trifluoromethanesulfonate) ionic liquid was used for the first time to prepare Cu 1.00 In 0.83 Ga 0.23 Se 1.64 thin films . The standard CIGS sample was calibrated using its inductively coupled plasma optical emission. The morphological properties were detected using scanning electron microscopy . The band gap of the CIGS thin film was approximately 1.55 eV, as measured using UV–visible absorption spectra . The carrier concentration and average Hall coefficient of the CIGS thin films were 2.741×10 20 cm −3 and 2.277×10 −2 cm 3 /C, respectively.
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高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
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2023
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IF 5.2
Lei Wu,Mengmeng Zhao,Qiuyan Ye,Xian Xin,Kun Zhang,Yongnan Chen,Ziwei Wang
Electrochemical synthesis of polymer/MOF composite membranes holds great potential for practical applications, yet the preparation of flexible and dense MOF layers remains a challenge, which is crucial for achieving practicality. Herein, a novel ultra-flexible polyethersulfone (PES)/Cu-based metal–organic framework (HKUST-1) composite membrane has been fabricated via an electrochemical synthesis method. Various reaction conditions, including voltage, stirring speed, and reaction time, were systematically investigated to elucidate their influence on crystal growth and the resulting membrane uniformity. The characterization results showed that high voltage and moderate stirring as well as are conducive to obtaining uniform fine crystals. Additionally, a relatively extended reaction time is advantageous for achieving a more continuous and denser MOFs membrane with outstanding flexibility. The optimized membrane possesses an excellent separation flux (2.81 × 10 3 ±32 L m −2 h −1 ·bar −1 ) and efficiency (99.7 ± 0.3%) for n -hexane/water mixtures, as well as excellent photodegradation efficiency (>99%) for methylene blue (MB). Remarkably, the optimized membrane exhibits remarkable scalability and stability, maintaining superior separation performance even after being rolled up 10 times with a curvature of 200 m −1 . This suggests that it has great potential for practical applications in complex environments.
研究领域:
材料科学
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环境工程
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膜技术
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电化学
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纳米材料
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高影响因子
LANGMUIR
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2018
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IF 3.789
Xiangyu Ge,Jinjin Li,Chenhui Zhang,Zhongnan Wang,Jianbin Luo
The robust liquid superlubricity of a room-temperature ionic liquid induced by tribochemical reactions is explored in this study. Here, 1-ethyl-3-methylimidazolium trifluoromethanesulfonate ([EMIM]TFS) could realize stable superlubricity (μ < 0.01) with water at the interfaces of Si3N4/SiO2. A superlow and steady friction coefficient of 0.002–0.004 could be achieved under neutral conditions (pH of 6.9 ± 0.1) after 600 s of running-in process. Various factors that could affect superlubricity were explored, including concentration of [EMIM]TFS, sliding speed, applied load, and volume of the lubricant. The results reveal that superlubricity can be achieved with [EMIM]TFS aqueous solution under a broad scope of conditions. The results of surface analysis show that a steady composite tribochemical layer comprising [EMIM]TFS, silica, ammonia-containing compounds, and sulfides was formed by tribochemical reactions between [EMIM]TFS and Si3N4 during the running-in period. The film thickness calculation reveals that the achieved superlubricity is in a mixed lubrication regime that comprises boundary lubrication and thin film lubrication. The superlubricity state is governed by a firm composite tribochemical layer, a molecular adsorption layer (electric double layer of [EMIM]TFS), and a fluid layer. The liquid superlubricity achieved by the ionic liquid is helpful for the development of new ionic liquids with superlubricity characteristics and is of great significance for scientific understanding as well as engineering applications.
研究领域:
摩擦学
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材料科学
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表面化学
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润滑工程
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高影响因子
JOURNAL OF ORGANOMETALLIC CHEMISTRY
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2021
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IF 2.369
Ji Wu,Ke Cao,Cai-Yan Zhang,Xin-Yu Wen,Bo Li,Junxiao Yang
A FeCl 3 catalyzed tandem condensation/cyclization/aerobic oxidation process for synthesis of 1-benzoxazolyl- o -carboranes has been developed. The degradation of o -carborane in the presence of aza-/oxa-nucleophiles was completely suppressed, and a series of 1-benzoxazolyl- o -carboranes, 1-benzothiazolyl- o -carborane and 1-benzimidazolyl- o -carborane have been synthesized with good to excellent yields. This work offers a general protocol for synthesis of 1-benzoxazolyl- o -carboranes, which has important reference for synthesis of aromatic heterocycle-carborane derivatives and promote its applications in miscellaneous areas.
研究领域:
有机化学
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硼化学
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催化化学
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杂环化学
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材料化学
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高影响因子
INORGANIC CHEMISTRY
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2019
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IF 4.85
Ming-Ming Yao,Chen-Hui Jiang,Ji-Song Yao,Kun-Hua Wang,Chen Chen,Yi-Chen Yin,Bai-Sheng Zhu,Tao Chen,Hong-Bin Yao
Lead halide perovskite nanocrystals (NCs) exhibit great application potential in optoelectronic devices because of their tunable band gaps and facile colloidal synthesis, but they suffer from serious lead toxicity and instability. It is highly desirable to substitute lead with other elements to acquire nontoxic and environmentally friendly lead-free perovskite NCs for optoelectronic devices. Here, we report a general method for the colloidal synthesis of a series of bismuth/antimony-based halide perovskite NCs with various constituents and optical band gaps from 1.97 to 3.15 eV. In our proposed synthetic system, 1-dodecanol is adopted as the solvent instead of the conventionally used 1-octadecene to realize size controllability of bismuth/antimony-based metal halide perovskite NCs. It is found that 1-dodecanol can act as a surfactant to tightly adsorb on the surface of bismuth/antimony-based halide perovskite NCs, enabling their small sizes (∼2 nm) and high dispersibility. Simultaneously, the band gaps of bismuth/antimony-based halide (A3B2X9, where A = CH3NH3, Cs, or Rb, B = Bi or Sb, and X = Cl, Br, or I) perovskite NCs can be systematically tuned by the atomic substitution of A, B, or X lattice sites. Moreover, to show the optoelectronic application potential of these lead-free halide perovskite NCs, a solar cell based on colloidal Cs3Bi2I9 perovskite NCs is demonstrated. The developed colloidal synthesis of bismuth/antimony-based halide NCs in 1-dodecanol will offer an alternative route to fabricating lead-free halide perovskite optoelectronic devices.
研究领域:
材料科学
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纳米技术
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光电子学
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无机化学
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能源材料
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DOI
高影响因子
Frontiers in Chemical Engineering
·
2026
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IF 2.6
Gideon Abaidoo Ocran,Bosong Zhang,Yi Zuo,Huali Tan,Gudan Li,Hong Yang,Chunshan Song,Xinwen Guo
The epoxidation of allyl alcohol with H2O2 over titanium silicalite-1 (TS-1) is an environmentally friendly route for producing glycidol. However, the catalytic activity and stability of TS-1 is not satisfactory. In this study, strip-shaped TS-1 was hydrothermally treated by TPAOH solution, change theTi coordination states and diffusion property, thereby enhancing its catalytic performance. The influences of TPAOH concentration and treating time on the physical chemical property and catalytic performance were studied systematically. It was found that the SiO2 agglomerant was dissolved and crystallized during the treatment, resulting in an increased Si content on the external surface. The tetrahedrally coordinated Ti was transformed to pentahedrally and octahedrally coordinated Ti, which possess higher catalytic activity for selective oxidation. The treatment also leads to the formation of cavities in the TS-1 crystals, which can shorten the diffusion pathway of substates and improve the diffusion property. Both the chemical property and microstructure enhance the catalytic activity for allyl alcohol epoxidation.
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Advanced Science
·
2026
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IF 14.1
Honggang Su,Huimin Pan,Yaqiang Liu,Wei Wang,Yang Jiao,Yumo Hang,Xiahe Huang,Yong E. Zhang,Yuhang Chen,Mei Ding,Xun Huang
Lipid droplets (LDs) are central to cellular energy homeostasis and lipid metabolism. While LD-associated proteins are known to regulate LD dynamics and function, their roles in LD transport and their broader cellular significance remain poorly understood. In this study, we identify lipid droplet-localized spindle apparatus coiled-coil protein 1 (SPDL1-L) as a key regulator of intracellular LD transport. SPDL1-L localizes to LDs through the synergistic action of its hydrophobic region and nearby basic residues. SPDL1-L expression promotes LD clustering at the microtubule-organizing center (MTOC) and the formation of donut-shaped (toroidal) nuclei during cell division. SPDL1-L-mediated LD clustering is likely through dynein-mediated minus end transport. LD clustering activity is diminished when the LD targeting or dynein binding function of SPDL1-L is impaired. Together, our findings provide new insights into the mechanisms governing LD dynamics and their impact on cellular organization.
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PubMed
高影响因子
JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
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2026
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IF 6.2
Yinzhi Wang,Yunqing Zhou,Zhenzhen Wu,Hualiang Li,Chuanqi Shi,Siyi Bao,Jianhua Yan,Hao Zhang
The pyrolysis mechanism of polyethylene (PE) remains elusive owing to its inherent complexity and the difficulty in identifying reactive intermediates. In this work, 1-hexadecene was employed as a model compound and pyrolyzed in a custom low-pressure flow tube reactor. The pyrolysis intermediates and products were detected via in-situ electron ionization molecular beam mass spectrometry (EI-MBMS) across 300–980 °C. A total of up to 59 species were identified, including primary pyrolysis intermediates (PPIs), primary pyrolysis products (PPPs), secondary reaction intermediates (SRIs), and secondary reaction products (SRPs), with 16 key species quantified. Three distinct pyrolysis stages were revealed: at the initial stage (320–680°C), 1-hexadecene underwent limited decomposition, dominated by β -scission near the double bond, producing mainly unsaturated hydrocarbons, while hydrogen transfer reactions exhibited pronounced olefin selectivity. At the stage with increasing temperature (680–880°C), the radical concentration increased sharply, promoting extensive β -scission and the onset of secondary reactions. Aromatic precursors such as cyclopentadiene emerged, accompanied by intensified dehydrogenation. At the final stage (880–980°C), the reactant was nearly depleted, and olefins underwent deep cracking. Both Diels–Alder reactions and the chain reaction hydrocarbon aggregation (CHRCR) mechanism jointly drove aromatization, with the propargyl radical (C 3 H 3 ) serving as a key intermediate for the first aromatic ring formation. This study systematically elucidates the pyrolysis pathway of 1-hexadecene from radical initiation to aromatic and small-molecule formation, highlighting the temperature-dependent transition from primary bond scission to extensive dehydrogenation and aromatization. The findings offer fundamental insights for accurate modeling and optimization of polyethylene pyrolysis in chemical recycling.
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高影响因子
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