JOURNAL OF APPLIED POLYMER SCIENCE
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2019
·Vol. 136
·期 23
·47630
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IF 2.188
Liang Wang,Wei Wu,Dietmar Drummer,Renbo Ma,Zhaowen Liu,Wanting Shen
To develop thermally conductive PA6 composites with the aim of decreasing filler content, structure-complexed fillers were fabricated. This research presented an effective approach by noncovalent functionalization of poly(dopamine) (PDA) followed by silver nanoparticles decoration to fabricate 3-dimensional (3-D) structured boron nitride hybrids (BN@PDA@AgNPs). BN hybrids were then introduced into PA6 to prepare thermally conductive PA6 composites. The results demonstrated that PA6/BN hybrids (PMB) composites exhibited higher thermal conducivity compared with PA6/BN composites, which revealed more effective construction of thermal conductive network in the composites with the addition of 3-D structured fillers. The effects of BN hybrids with different loadings on thermal stability, mechanical property, as well as electrical resistance of the composites were also analyzed. Overall, the prepared PMB composites exhibited outstanding performance in thermal conductivity, thermal stability, mechanical property, while retaining good electrical insulating property, which showed a potential application in electronic packaging fields. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136 , 47630.
研究领域:
材料科学
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高分子化学
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Biomaterials Advances
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2026
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IF 6.7
Shuqi Li,Mengyuan Liu,Linglin Zhu,Jingxian Zhang,Min Ji,Huasong Gao,Yumin Yang,Luzhong Zhang
Indole-3-propionic acid loaded hydrogels were synthesized for spinal cord injury. • The synthesized hydrogels possessed good biocompatibility and alleviated oxidative stress. • The hydrogels significantly enhanced recovery of both motor and sensory functions. • The hydrogels provided a novel therapeutic strategy for SCI treatment. Spinal cord injury (SCI) is a devastating neurological condition with an exceptionally high disability rate. The clinical management of SCI remains suboptimal primarily owing to both the inhibitory characteristics of the post-injury microenvironment and inherently limited regenerative ability. In this study, we report an indole-3-propionic acid (IPA) loaded polyethylene glycol dimethacrylate (PEGDA)/lysine hydrogel for repairing spinal cord injury. Compressive Young's moduli of hydrogels can be precisely tuned by adjusting the compositional ratios. The IPA loaded hydrogels exhibits not only excellent biocompatibility but also possesses a remarkable ability to alleviate oxidative stress. In an established spinal cord injury model, 3.4 kPa IPA loaded hydrogels significantly enhanced functional recovery, promoted axonal regeneration, and supported the growth of newborn neurons. These findings indicate that the IPA loaded hydrogel offers a promising new therapeutic avenue for SCI treament.
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JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
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2026
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IF 2.7
Zhe Dong,Wei Xue,Jianhua Lv,Daolai Sun
BACKGROUND 3-Hydroxybutanal (3-HBA) is an important chemical product with a wide range of applications. This study investigated the liquid-phase condensation of acetaldehyde to produce 3-HBA over MgO-based catalysts, such as MgO–Y 2 O 3 , MgO–La 2 O 3 , and MgO–Al 2 O 3 . The influence of the Mg/Y ratio on the catalyst performance was thoroughly investigated, and the effects of the reaction conditions on the formation of 3-HBA were also studied. Furthermore, the relationship between the catalyst properties and the catalytic activity was investigated. RESULTS The MgO–Y 2 O 3 catalyst showed a high catalytic performance for the production of 3-HBA, and the optimal Mg/Y molar ratio was 1:1. The MgO–Y 2 O 3 catalyst with a molar ratio of 1:1 exhibited both weak acidic and weak basic properties, and its acid and base amounts were lower than those of MgO. Reaction temperature significantly affected the reaction, and increasing the temperature was detrimental to the formation of 3-HBA. In the reaction conducted using the MgO–Y 2 O 3 catalyst at 45 °C for 2.5 h, the conversion of acetaldehyde achieved was 52.5% with a 3-HBA selectivity of 82.4%. CONCLUSION The MgO–Y 2 O 3 catalyst with appropriate acid–base properties effectively promotes the formation of 3-HBA. An insufficient or excessive number of acidic or basic active sites is detrimental to 3-HBA yield. It is proposed that the acidic sites activate the CO bond via an electron-withdrawing effect, while the basic sites facilitate α -H elimination to generate a delocalized reactive intermediate. This intermediate subsequently undergoes nucleophilic addition to form 3-HBA. © 2026 Society of Chemical Industry (SCI).
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JOURNAL OF MEMBRANE SCIENCE
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2026
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IF 8.8
Wenyuan Qiu,Xiaoke Wei,Tao Wang,Hao-yan Yin,Haibing Wei
Anion exchange membranes (AEMs) are central to clean-energy electrochemical technologies, yet achieving high hydroxide conductivity together with dimensional and alkaline stability remains challenging. Here we implement a straightforward branching strategy in poly(arylene 3-piperidinium)s by incorporating two trifunctional units, i.e., triptycene and 1,3,5-triphenylbenzene, into the polymer backbone. This architecture suppresses water uptake and swelling without compromising the membrane's ion-transport efficiency and chemical durability. Compared to linear membranes, the branched membranes exhibit a 34−36% reduction in water absorption. Triptycene-based branched AEMs achieved superior performance, including suppressed swelling (<18% at 80 °C), high conductivity up to 191 mS cm −1 at 80 °C, and improved alkaline stability, remaining intact in 1 M NaOH for at least 2000 h. Importantly, a water electrolyzer based on B-PT3Pip-3%Trip demonstrated a current density of 6.9 A cm −2 at 2.0 V and 80 °C, and can operate stably under 1 A cm −2 at 60 °C for 1000 h with a voltage decay of only 81 μV h −1 . The synthetic simplicity of the branching strategy, together with the combination of suppressed swelling, high conductivity, and long-term durability, makes branched poly(arylene 3-piperidinium) AEMs highly promising for AEM water electrolysis applications.
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Nanoscale
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2026
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IF 5.2
Le Luo,Xiaoming Mo,Yusheng Song,Zhentao Du,Sheng Cao,Jinju Zheng,Bingsuo Zou,Jialong Zhao
Quantum-confined CsPbBr3 nanoplatelets (NPLs) are appealing candidates for ultraviolet (UV)/blue photodetectors due to their strong excitonic binding energy and large absorption coefficient. However, the inherent soft lattice and surface defects of CsPbBr3 NPLs lead to poor operational stability, limiting their practical applications. Here, we report an A-site alloying strategy that enhances the structural rigidity and defect formation energy of CsPbBr3 NPLs. The strategy synergistically employs short-chain tetrolic acid (TLA) ligands to passivate uncoordinated Pb2+ ions and formamidinium (FA+) cations to compensate for Cs+ vacancies. This dual repair strategy enhanced both the conductivity and UV irradiation stability of CsPbBr3-based NPLs. As a result, the self-powered UV photodetectors based on Cs0.73FA0.27PbBr3-TLA NPLs exhibited a responsivity of 89 mA W-1, a specific detectivity of 3.99 × 1012 Jones, and an on/off ratio approaching 106 at 0 V bias. Even after 30 days of ambient storage, the device maintained excellent photoresponse and a high specific detectivity of 1.73 × 1012 Jones. Clear images obtained with a custom-built 2D imaging system corroborate the fast response and excellent stability of the device. These results underscore the efficacy of the combined lattice and surface engineering approach for realizing high-performance, durable perovskite NPL-based UV photodetectors.
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INORGANIC CHEMISTRY
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2026
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IF 4.6
Bailin Chen,Yansheng Jiang,Hangwei Jia,Shuai An,Xueling Hou,Shilie Pan
Birefringent crystals, as core materials for polarization modulation, hold significant importance for the advancement of laser polarizing technology, high-precision instruments, and other optical communication fields today. However, balancing the deep ultraviolet (DUV) cutoff edge and birefringence remains a demanding challenge. Borophosphates have emerged as a promising research direction for optoelectronic functional materials, but the small birefringence of most borophosphates limits their applications. Here, a novel mixed-coordinated hydroxyborophosphate, NH4B3PO6(OH)3, has been successfully designed and obtained. This compound belongs to the triclinic space group P1 (No. 2), exhibiting pronounced birefringence (the experimental refractive index difference value is 0.057 at 546 nm) and a short DUV cutoff edge below 200 nm. These properties indicate that NH4B3PO6(OH)3 exhibits excellent potential as a DUV birefringent material.
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Science China-Life Sciences
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2025
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IF 9.5
Feng Yue,Lin Zishen,Wang Haoran,Men Zhaoyue,Shen Jiakun,Ma Xi
Deoxynivalenol (DON) is a prevalent mycotoxin in animal feed that particularly impacts weaned piglets, causing liver damage, growth retardation, and posing significant public health risks. However, the precise mechanisms underlying DON-induced liver damage and optimal treatment approaches remain unclear. The pregnane X receptor (PXR) holds a pivotal position in hepatic xenobiotic elimination and drug metabolism. This research aimed to explore the involvement of PXR in DON-induced liver injury and evaluate the potential of the PXR agonist, 3-indolepropionic acid (IPA), to alleviate liver damage and associated diarrhea in weaned piglets under practical farming conditions. The results demonstrated that DON initiates p53-mediated hepatocyte apoptosis in weaned piglets. RNA-seq and hepatocyte-specific PXR knockout (PXR-HKO) mice revealed PXR’s regulatory role in DON-induced hepatocyte apoptosis. IPA reduces DON-induced hepatocyte apoptosis in piglets, mice, and hepatocyte cell lines by enhancing PXR expression and facilitating nuclear translocation. Furthermore, AlphaFold3 predictions and Co-IP assays demonstrate that DON diminishes PXR-p53 binding, thereby amplifying p53-mediated apoptotic transactivation. In conclusion, this study elucidates a novel mechanism by which PXR decreases its binding to p53 upon DON exposure, thereby promoting hepatocyte apoptosis. Additionally, it validates the positive impact of IPA in mitigating liver damage and diarrhea caused by DON in weaned piglets.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2024
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IF 5.7
Zhongyin Chen,Hui Cai,Xiao Zhang,Meng Zhang,Ge-Fei Hao,Zhichao Jin,Shichao Ren,Yonggui Robin Chi
To discover protoporphyrinogen oxidase (PPO) inhibitors with robust herbicidal activity and crop safety, three types of substituted 3-(pyridin-2-yl)phenylamino derivatives bearing amide, urea, or thiourea as side chain were designed via structure splicing strategy. Postemergence herbicidal activity assessment of 33 newly prepared compounds revealed that many of our compounds such as 6a, 7b, and 8d exhibited superior herbicidal activities against broadleaf and monocotyledon weeds to commercial acifluorfen. In particular, compound 8d exhibited excellent herbicidal activities and high crop safety at a dosage range of 37.5–150 g ai/ha. PPO inhibitory studies supported our compounds as typical PPO inhibitors. Molecular docking studies revealed that compound 8d provided effective interactions with Nicotiana tabacum PPO (NtPPO) via diverse interaction models, such as π–π stacking and hydrogen bonds. Molecular dynamics (MD) simulation studies and degradation studies were also conducted to gain insight into the inhibitory mechanism. Our study indicates that compound 8d may be a candidate molecule for the development of novel herbicides.
研究领域:
植物科学
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农药化学
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生物化学
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Applied Sciences-Basel
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2025
·Vol. 15
·期 13
·7318
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IF 2.5
Jiawei Cui,Yan Li,Ming Yan
D-allulose is a rare sugar with promising applications in food and health industries, owing to its low caloric value and multiple health benefits. In this study, we systematically investigated a thermostable D-allulose 3-epimerase (TcDAEase) fromThermogemmatispora carboxidivoransfor food-compatible continuous production. The enzyme exhibited remarkable thermostability, with over 70% activity retained at 80 °C, and showed broad pH tolerance across the range of 8.0 to 13.0. Notably, TcDAEase exhibited high catalytic activity toward D-allulose and D-fructose even without the addition of metal ions. Moreover, food-grade Mg2+was identified as enhancing enzyme activity by 14.3%, thus ensuring compliance with Generally Recognized as Safe (GRAS) standards for food applications. To improve industrial applicability, the enzyme was immobilized using a chitosan-diatomaceous earth (DE) matrix via three-step adsorption–crosslinking–embedding strategy. The immobilized TcDAEase achieved 48.7% ± 2.4% activity recovery and retained 90.3% ± 1.5% activity over seven reaction cycles. Furthermore, continuous production of D-allulose was realized in a packed-bed reactor, operating stably at 60 °C, pH 8.0 and 5 mM Mg2+for 150 days, producing 756 kg of D-allulose with a conversion yield exceeding 89.7% of the theoretical maximum. Overall, this study provides a feasible strategy for the continuous and efficient production of high-value-added D-allulose in the food industry.
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JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
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2025
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IF 6
Weiwei Lu,Xiantao Liang,Jianmin Liu,Fangfen Jing,Mingzhu Jin,Xinyang He,Tao Wang,Rongtai Yu
Heavy metal pollution in water poses severe threats to ecosystems and human health, demanding urgent development of efficient and sustainable adsorbents. Herein, we report a novel amino-functionalized phenolic resin (APF) synthesized via a facile self-assembly strategy using 3-aminophenol and formaldehyde. This approach eliminates the need for toxic crosslinkers or complex post-modification steps, offering a green and scalable route for nanoscale polymer fabrication. The APF particles were engineered with controlled amino group density and hierarchical porosity through optimizing monomer ratios, achieving abundant active sites for multi-metal interactions. The APF adsorbent exhibits exceptional adsorption capacities for both cationic and anionic heavy metals, notably achieving 297.75 mg·g −1 for Cd 2+ – surpassing conventional clay composites and rivaling advanced MOFs. Its multifunctional groups (–NH 2 , –OH) enable synergistic mechanisms: (1) electrostatic attraction for Cr 6+ oxyanions at low pH, (2) chelation-dominated Cd 2+ capture via amino coordination, and (3) ion exchange for Pb 2+ /As 3+ . This work advances the design of cost-effective, multi-mechanistic adsorbents for comprehensive heavy metal remediation.
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Journal of Advanced Research
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2021
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IF 10.479
Min Mu,Haifeng Chen,Rangrang Fan,Yuelong Wang,Xin Tang,Lan Mei,Na Zhao,Bingwen Zou,Aiping Tong,Jianguo Xu,Bo Han,Gang Guo
Introduction Numerous options for treatment of glioblastoma have been explored; however, single-drug therapies and poor targeting have failed to provide effective drugs. Chemotherapy has significant antitumor effect, but the efficacy of single-drug therapies in the clinic is limited over a long period of time. Thus, novel therapeutic approaches are necessary to address these critical issues. Objectives The present study, we investigated a tumor-specific metal-tea polyphenol-based cascade nanoreactor for chemodynamic therapy-enhanced chemotherapy. Methods HA-EGCG was synthesized for the first time by introducing epigallocatechin-3-gallate (EGCG) into the skeleton of hyaluronic acid (HA) with reducible disulfide bonds. A rapid and green method was developed to fabricate the metal-tea polyphenol networks (MTP) with an HA-EGCG coating ( [email protected] /HA-EGCG) based on Fe 3+ and EGCG for targeted delivery of doxorubicin hydrochloride (DOX). GL261 cells were used to evaluate the antitumor efficacy of the [email protected] /HA-EGCG nanoreactor in vitro and in vivo . Results [email protected] /HA-EGCG nanoreactors were able to disassemble, resulting in escape of their components from lysosomes and precise release of DOX, Fe 3+ , and EGCG in the tumor cells. HA-EGCG depleted glutathione to amplify oxidative stress and enhance chemodynamic therapy. The results of in vivo experiments suggested that [email protected] /HA-EGCG specifically accumulates at the CD44-overexpressing GL261 tumor sites and that sustained release of DOX and Fe 3+ induced a distinct therapeutic outcome. Conclusions The findings suggested the developed nanoreactor has promising potential as a future GL261 glioblastoma therapy.
研究领域:
肿瘤学
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药剂学
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纳米医学
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SENSORS AND ACTUATORS A-PHYSICAL
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2021
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IF 3.407
Xiaoying Pan,Jun Hu,Jialiang Li,Yufei Zhai,Song Li,Min Wang,Takashiro Tsukamoto,Shuji Tanaka
The temperature dependent photoluminescence of temperature sensitive paint (TSP) makes it an attractive candidate for infrared (IR) thermal imaging, but its low luminescence intensity and poor photostability hinder its extensive use in infrared detectors . Herein, a novel complex luminophore of AgNPs/[Ru(phen) 3 ]Cl 2 /PVDF was designed to fabricate a thermal imaging device with improved sensitivity and signal-to-noise ratio. It is found that the localized surface plasmon resonance (LSPR) of silver nanoparticles (AgNPs) could enhance the local intensity of the excitation light , consequently an increase in the luminescence intensity of neighboring luminophore can be achieved. Thus, not only the fluorescence intensity of the obtained sensor array is enhanced, but the temperature sensitivity is also improved to − 4.5%/K at 20 °C, which increased by 25% compared to that of the blank film without AgNPs addition. Furthermore, the detector array is used for IR thermal imaging, which can successfully obtain the thermal images of observation object at room temperature . The minimal detectable temperature is as small as about 313 K.
研究领域:
材料科学
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光学
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热工程
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纳米技术
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危险品化学品经营许可证（带存储）