JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
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2026
·Vol. 41
·期 3
·828-833
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IF 1.4
Guo Jun,Huang Biwu,Huang Wenbin,Wu Yang
A novel epoxy-based silicon (VECSR) was synthesized from polymethylhydrosiloxane (PMHS) and 1,2-epoxy-4-vinylcyclohexane (VEC) via the hydrosilylation reaction. The structure of VECSR was characterized by FT-IR and 1 H-NMR. A series of UV-curable materials were prepared by blending different ratios of VECSR and alicyclic epoxy resin (2021P) and UV curing with triarylsulfonium hexafluoroantimonate salts solution (UVI-6976) as the photoinitiator, and then were tested for performance. The experimental results showed that when the content of VECSR was 10%, the comprehensive mechanical properties of the UV-curable material were the best, i e , the UV-curable sample with a tensile strength of 48.55 MPa, an elongation at break of 3.2%, the UV-curable film with a flexibility of 3 mm, and an impact strength of 20 kg·cm. Compared to a single 2021P system in the absence of VECSR, the UV-curable materials containing VECSR exhibited better hydrophobicity and thermal stability.
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Nature Communications
·
2026
·
IF 18.1
Sun Lizhi,Jing Yuqian,Liu Ben
Catalytic carbon-nitrogen (C–N) coupling reactions offer a sustainable and environmentally friendly route for the production of high value-added hexamethylenetetramine (HMTA). However, it still suffers from limited chemisorption, low activation kinetics, and unfavorable thermodynamics, resulting in low HMTA Faradaic efficiency (FE HMTA ) and yield rate. Here, by physically constructing hierarchically tip and mesoporous structure, copper mesoporous nanotips (Cu MNTs) realize efficient HMTA synthesis by an electrochemical-chemical cascade catalysis. Unlike traditional catalysts, tip-enhanced site of Cu MNTs electrochemically favors NO 3 − chemisorption and further electroreduction into *NH 3 radicals, while its confined mesoporous nanoreactor ensures cascade chemical C–N coupling and subsequent cyclization to HMTA. With minor byproducts, Cu MNTs deliver a FE HMTA of 94.2% and a yield rate of 0.227 mmol h −1 cm −2 . Moreover, this route enables efficient HMTA synthesis in a flow cell electrolyzer with high economic feasibility and market potential for industrial application. This work thus deepens the physical design strategies of hierarchically structural catalysts that promote electrochemical-chemical cascade C–N coupling reactions for efficient synthesis of various important chemicals and feedstocks.
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BMC MICROBIOLOGY
·
2026
·
IF 5.4
Qing Zhang,Shuteng Huang,Kairu Che,Zhicheng Yin,Xiaohan Wang,Lei Zhang,Yongqiang Lin,Desheng Cai,Jiayu Zhang
Antimicrobial peptides (AMPs), which were conserved constituents of the innate immune system, exhibit antimicrobial properties similar to those of traditional antibiotics and have a low potential for the development of resistance. Thus, they were showing a great capacity for application. This study performed screening of twelve candidate antimicrobial peptides by means of pig skin enzymatic hydrolysis and activity prediction. The synthesis of these peptides was undertaken using Fmoc solid phase synthesis and purified via HPLC than 95%. The Methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus aureus (SA) and Escherichia coli (E. coli) were selected to evaluate antibacterial activity in vitro. The results indicated that peptide P5 exhibited the most significant inhibitory effect on MRSA and SA, with an inhibition rate of 91.83%. Furthermore, its antibacterial activity against MRSA and SA was found to be stronger than that against E. coli, demonstrating a dose-dependent relationship. Growth curve analysis revealed that P5 completely inhibited the growth of MRSA within 16 h at 3 mg/mL. Cytotoxicity was assessed using the CCK-8 assay and live/dead cell staining. The survival rates of both L929 and MDCK cells exceeded 87%, indicating good biocompatibility. Transcriptome sequencing (RNA-seq) and quantitative reverse transcription polymerase chain reaction (qRT-PCR) analyses demonstrated that treatment with the P5 was associated with significant transcriptional changes in MRSA. The differentially expressed genes were enriched in the ABC transporter pathway, as well as pathways related to arginine biosynthesis and metabolism, histidine metabolism, and quorum sensing. These findings suggest a potential link between P5 and these pathways, thereby providing a foundation for future mechanistic studies. In conclusion, the porcine skin-derived antimicrobial peptide P5 exhibited significant antimicrobial activity, low cytotoxicity, and a mechanism of action that was distinct from traditional antibiotics, thereby demonstrating promising potential for clinical translation in the fight against drug-resistant bacterial infections.
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JOURNAL OF ELECTRONIC MATERIALS
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2026
·
IF 2.8
Qin Xueying,Jiang Jia,Yin Shuang,Zhang Yeming,Wan Wei
The development of calcium copper titanate (CaCu 3 Ti 4 O 12 , CCTO) ceramics is often hindered by their high dielectric loss, which limits practical applications. In this work, CCTO powder with tailored micrometer-sized particles, synthesized via a Na 2 SO 4 molten-salt method, was used to fabricate nano-SiO 2 -doped ceramics through an environmentally friendly, water-based gelcasting process with glutinous rice flour as a nontoxic binder. This approach enabled stable slurry processing and effective microstructural control. The incorporation of 3.5 wt.% nano-SiO 2 yielded optimal dielectric performance, achieving a high dielectric constant of 8091 and a significantly reduced loss tangent of 0.08 at 1 kHz; this represents a 71.4% reduction in loss compared to the undoped sample. Microstructural and electrical analyses confirmed that the nano-SiO 2 predominantly segregated at the grain boundaries, forming a continuous amorphous insulating layer. This phase enhanced grain boundary resistivity, optimized the electrical heterogeneity, and substantially improved the frequency and temperature stability of the dielectric properties. This study demonstrates that nontoxic gelcasting combined with nano-SiO 2 doping is an effective and sustainable strategy for tailoring the dielectric properties of CCTO ceramics toward high-performance electronic applications by optimizing the internal barrier layer capacitor structure.
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CHEMICAL PAPERS
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2026
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IF 2.7
Zhou HuiPing,Zhu Wei,Gao YingChun,Zhang YuanGuang
Dopamine (DA) as an important catecholamine neurotransmitter in the human body, plays a crucial role in regulating cognition, emotions, and physical movement. Therefore, quantitative detection of DA is of great significance. Recently, transition metal sulfides such as cobalt sulfide (CoS 2 ) receive widespread attention in the field of DA detection due to their low cost, excellent catalytic performance and structural stability. To achieve the optimal electrochemical response of CoS 2 /Nafion/GCE to DA, we systematically investigate the effects of electrode coating volume, electrolyte solution pH value, and scanning speed on DA detection performance. After optimizing the above parameters, the CoS 2 /Nafion/GCE sensor exhibited excellent peak current responses for the electrochemical detection of DA. It exhibits a linear response range spanning 1.0-300.7 µM, which can be divided into two distinct segments: 1.0-108.8 µM (LOD = 0.13 µM, S/ N = 3) and 108.8-300.7 µM (LOD = 1.3 µM, S/ N = 3). Furthermore, the sensor demonstrates specific electrocatalytic activity toward DA, endowing it with excellent detection selectivity even in the presence of high concentrations of interfering species such as ascorbic acid, uric acid, and glucose. In the detection of real samples of human urine, the recovery rate of DA is 95.47% to 101.78%. This result provides an ideal material platform for developing highly selective and low-cost DA detection sensors.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
·
IF 15
Xia Liu,Hui Li,Ningning Shan,Bingxin Guan,Yang Jiang,Chengyun Zheng,Leisheng Zhang,Dexiao Kong
Aplastic anemia (AA) is a debilitating disorder marked by bone marrow failure, frequently associated with dysregulated T cell activity. The present study explored the therapeutic potential of anti-CD3 antibody-modified calcium silicate nanoparticles loaded with novel 7H-pyrrolo[2,3-d]pyrimidine derivatives (antiCD3-pCaSiNP@NPDP) for AA treatment. Whole-transcriptome sequencing and bioinformatics analysis identified interleukin-2-inducible T-cell kinase (ITK) as a critical regulator of T cell function in AA. In vitro experiments demonstrated that ITK enhances T cell proliferation and promotes differentiation toward inflammatory subsets, thereby contributing to disease progression. The newly developed NPDP derivatives effectively inhibited ITK activity. Targeted delivery of NPDP via antiCD3-pCaSiNP nanoparticles selectively suppressed ITK expression in T cells, resulting in reduced inflammatory T cell proliferation and increased regulatory T cell populations. In an AA mouse model, administration of antiCD3-pCaSiNP@NPDP nanoparticles markedly improved hematopoietic recovery and immune balance. The findings indicate that nanoparticle-mediated ITK inhibition represents a promising therapeutic strategy for restoring immune and bone marrow function in AA.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2026
·Vol. 37
·期 9
·665
·
IF 3.2
Su Xiuyuan,Chen Yuan-Bin,Chen Junyu,Ma Shijie,Lin Haiqiang
In this study, Sr 2+ was employed to substitute Ca 2+ in KCaPr(MoO 3 ) 4 ceramics. Such ion substitution was found to effectively enhance the Q × f value of KCaPr(MoO 3 ) 4 and moderately decrease its sintering temperature. Scanning electron microscopy (SEM) observations and density measurements indicated satisfactory sintering characteristics of this series of ceramics. Meanwhile, X-ray diffraction (XRD) and Raman spectroscopy analyses suggested the formation of a solid solution without obvious secondary phases or impurities, verifying the successful preparation of single-phase molybdate ceramics. On the basis of P–V–L theoretical analysis, it was suggested that K/Ca/Pr–O bonds mainly contribute to the bond ionicity (fᵢ), whereas Mo–O bonds exert considerable influences on the lattice energy (U), bond energy (E), and thermal expansion coefficient (α). Among the as-prepared ceramic samples, KCa 0.98 Sr 0.02 Pr(MoO 3 ) 4 exhibited the most favorable dielectric properties at 700 ℃ with a relative permittivity (εᵣ) of 10.744, a quality factor-frequency product (Q × f ) of 89 349 GHz, and a temperature coefficient of resonant frequency (τ f ) of − 59.947 ppm/ C. Benefiting from the ion substitution strategy, the obtained materials possessed relatively low sintering temperatures and high Q × f values, suggesting promising potential for application in ultra-low-temperature co-fired ceramics (ULTCC).
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JOURNAL OF MATERIALS SCIENCE
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2026
·
IF 4.4
Zhao Jianghui,Cui Huaqiang,Yang Qinqin,Ye Wuyi,Huang Aofeng,Wu Bo,Liu Zhi
Doping has been widely explored as an effective strategy to enhance the photocatalytic performance of TiO 2 under visible light for degrading organic pollutants. However, conventional dopants derived from chemical reagents raise environmental and human safety concerns. In this study, natural down fiber (DF) was innovatively employed as a sustainable and green source of C and N, combined with copper acetate as the copper source, to fabricate C–N–Cu co-doped TiO 2 (C–N–Cu@TiO 2 ) via a facile one-step hydrothermal method. Comprehensive characterization revealed that, compared to pure TiO 2 , the co-doped C–N–Cu@TiO 2 exhibited a narrowed band gap (from 3.11 to 2.83 eV), reduced photoluminescence intensity, and enhanced photocurrent density, indicating improved visible-light absorption and effective suppression of electron–hole recombination. Under simulated one-sun irradiation, C–N–Cu@TiO 2 demonstrated outstanding photocatalytic activity, achieving a high degradation efficiency of 98.20% for methyl orange within 2 h, which is competitive with many reported doped TiO 2 photocatalysts. Trapping experiments identified O 2 − and h + as the primary active species, and a plausible photocatalytic mechanism was proposed accordingly. This work not only confirms the effectiveness of natural DF as an eco-friendly and sustainable doping source, but also encourages further exploration of biomass-derived functional materials for applications in wastewater treatment, photocatalytic hydrogen evolution, carbon dioxide reduction, and related fields.
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Cell Communication and Signaling
·
2026
·
IF 11.6
Deng Weiqian,Yang Xiaoting,Wu Hao,Tang Haojun,Wang Xiaodan,Tu Shuangxi,Yin Kai,Zhu Xiao
Metabolic-associated fatty liver disease (MAFLD), the most prevalent chronic hepatic disorder globally, is pathologically characterized by excessive intrahepatic lipid deposition, oxidative stress, and chronic low-grade inflammation. Apolipoprotein A-I binding protein (AIBP), a critical modulator of lipid metabolism, cellular signaling pathways, inflammatory responses, and metabolic homeostasis, has not been thoroughly investigated in the context of MAFLD pathogenesis. In this study, we identified a significant downregulation of AIBP expression in both high-fat diet (HFD)-induced MAFLD murine models and palmitic acid (PA)-treated HepG2 cells. Systemic AIBP deficiency exacerbated metabolic dysregulation and induced profound perturbations in hepatic architecture and function, culminating in aggravated liver injury. This was evidenced by enhanced steatosis, elevated pro-inflammatory cytokine production, and increased serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. Transcriptomic profiling and molecular characterization of AIBP-deficient HepG2 cells corroborated these pathological alterations. Mechanistic investigations revealed that AIBP silencing potentiates hepatic damage through integrin β3 (ITGβ3)-mediated hyperactivation of the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling cascade. Notably, hepatocyte-specific AIBP overexpression effectively ameliorated these metabolic and inflammatory aberrations. Collectively, our findings establish AIBP as a pivotal hepatoprotective regulator in MAFLD pathogenesis and propose a novel therapeutic paradigm for MAFLD and associated metabolic disorders through targeted AIBP modulation. This study provides compelling evidence for the development of AIBP-centered therapeutic strategies to mitigate MAFLD progression.
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Science China-Materials
·
2026
·
IF 7.7
Zhao Wenhui,Cheng Zhibin,Niu Aohua,Wang Yujing,Wen Rong,Liu Shaoding,Zheng Kaibo,Li Guohui,Cui Yanxia
Solution-processable quasi-2D perovskites are regarded as promising candidates for laser gain media due to their superior exciton binding energy and stability compared to their 3D counterparts. However, quasi-2D perovskites produced through conventional methods often display a distribution of n -value phases, arising from the necessity of multiple precursors to react. The presence of impurity phases may introduce interfacial defects and energetic disorder, which can hinder charge injection into the desired emission centers. In this study, we present the first demonstration of stimulated emission from a phase-pure quasi-2D perovskite achieved through a solvent-sieving method for selective phase removal. This approach enables the dynamic purification of quasi-2D perovskites ( n = 8) and significantly lowers the threshold for amplified spontaneous emission. X-ray diffraction and ultraviolet-visible characterization reveal a nearunity n = 8 phase (99.85%) with no detectable low- n phases in our samples. Additionally, the phase-pure quasi-2D perovskite film exhibits a narrower and more intense 001 peak (full width at half maximum (FWHM) of 0.16 nm, intensity of 16,129) compared to that of the pristine quasi-2D perovskite film (FWHM of 0.22 nm, intensity of 3304), indicating an increased grain size and enhanced crystallinity. This improvement leads to a prolonged charge carrier lifetime of approximately 6.98 ns, suggesting a reduced trap density. Furthermore, the phase-pure perovskite film is nearly pinhole-free and features an exceptionally flat surface with a root mean square roughness of 1.18 nm. Consequently, the phase-pure quasi-2D perovskite demonstrates a lower amplified spontaneous emission threshold of approximately 13.82 µJ cm −2 , representing a 12.5% reduction compared to conventional mixed-phase films. This work offers an efficient method for producing pure-phase quasi-2D perovskite suitable for low-threshold lasers.
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 4
·270
·
IF 5.4
Wang Yuqing,Liu Yutong,Liu Ziqi,Wang Xinyue,Yu Menglu,Gao Guanghui,Zhao Yunli,Hong Jing
A novel MXene nanosheet-supported Fe₃O₄@Ag nanozyme, designed for the dual-mode colorimetric and surface-enhanced Raman scattering (SERS) detection of the pesticide thiram in fruits is presented. The composite ingeniously integrates three key functions: magnetic enrichment, SERS signal amplification, and peroxidase-like nanozyme activity. The resulting nanozyme sensor demonstrates high sensitivity and specificity for thiram detection. The colorimetric method showed a linear range of 0.05 µM to 30 µM with a LOD of 0.016 µM, while the SERS method exhibited a linear range of 10 − 4 M to 10 − 8 M with a LOD of 3.44 × 10 − 9 M. This performance satisfies the demands for agricultural safety monitoring. The present work highlights the significant potential of the developed colorimetric-SERS dual-mode nanozyme platform for on-site pesticide residue determination .
Section
Graphical
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PHARMACEUTICAL RESEARCH
·
2026
·
IF 4.1
Wu Kong,Lin Jinsheng,Liang Xiao,Wang Peipei,Guo Qiaohong,Chen Wenbin,Li Min
Purpose To probe the formation mechanism of N -despropyl ropinirole, an oxidative degradant in ropinirole hydrochloride extended-release tablets. Methods Forced degradation studies were employed to investigate the mechanism by treating ropinirole API with H 2 O 2 and AIBN, respectively, and the samples analyzed by high resolution LC-QTOF-MS. Meanwhile, the samples from the forced degradation of the extended-release tablets were analyzed by GC-QTOF-MS. The proposed mechanism was supported by an H 2 18 O isotope experiment. Lastly, API-excipient compatibility studies were conducted to evaluate the impact of the excipients on the formation of N -despropyl ropinirole. Results The growth trend of N -despropyl ropinirole in the accelerated stability study was similar to that observed in the forced degradation of ropinirole hydrochloride treated with AIBN, but vastly different from that observed in the forced degradation with H 2 O 2 . The forced degradation using isotope labelled H 2 18 O showed that 18 O was incorporated into propionaldehyde, the volatile co-degradant in the formation of N -despropyl ropinirole. The API-excipient compatibility studies indicated that N -despropyl ropinirole was formed gradually in the presence of CMC-Na and HPMC, respectively. Conclusions Degradation of ropinirole in the ropinirole hydrochloride extended-release tablets is most likely to proceed via a free radical-mediated oxidative pathway, rather than a nucleophilic oxidative pathway. The forced degradation experiment using H 2 18 O is consistent with the proposed free radical-mediated degradation mechanism. The source of the free radicals seems to originate from the two excipients, CMC-Na and HPMC. The results obtained in the current study would be quite beneficial for further improvement of the drug product in terms of controlling its major degradation pathway.
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