Advanced Healthcare Materials
·
2026
·
IF 9.6
Meichan Wu,Puze Li,Xin Xin,Cheng Song,Xiangliang Yang,Qingxia Xu,Yan Liu,Yong Shen,Guoping Wang,Jun Hu
The activation and infiltration of cytotoxic T lymphocytes (CTLs) are the key of tumor immunotherapy. However, the suppressive tumor immune microenvironment usually inhibits the function of CTLs. Tumor-associated macrophages (TAMs) play an important role in remodeling the tumor immune microenvironment. In this work, probiotic Escherichia coli Nissle 1917 (EcN) is used as a bioreactor to achieve intracellular synthesis of copper selenide nanoparticles (Cu 2-x Se NPs), giving Cu 2-x Se@EcN, which effectively repolarize macrophages from pro-tumor M2 phenotype to anti-tumor M1 phenotype mainly through activating MAPK signaling pathway. The synthesized Cu 2-x Se NPs exhibited excellent photothermal performance, inducing hyperthermia-sensitized Fenton-like reaction to catalyze the generation of hydroxyl radical from H 2 O 2 , then resulted in immunogenic death effect of tumor cells and the repolarization of M2 macrophages. Combined with surface-expressed pathogen-associated molecular patterns (PAMPs) of bacteria, Cu 2-x Se@EcN synergistically promoted DCs maturation and TAMs reprogramming, eventually promoting the infiltration and activation of T cells. Therefore, the bacteria-inorganic hybrid nanomaterials showed satisfied effect in inhibiting tumor growth and recurrence.
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高影响因子
Journal of Environmental Chemical Engineering
·
2026
·
IF 7.2
Wenwen Qiu,Chengwei Lin,Wanjie Zhang,Chaolun Zheng,Jianquan Wang
Heavy metals pollution is a problem of concern, and their recycling from waste water is a challenging work. In this study, epichlorohydrin crosslinked TEMPO-oxidized cellulose nanofibers/polyethyleneimine (TOCNFs/PEI, CP) gel was used as a matrix to in-situ plant Zeolitic Imidazolate Framework-67 (ZIF-67), fabricating a nanocomposite gel (CPZ) with abundant active sites to adsorb Cu 2+ ions by mechanism of spontaneous adsorption on heterogeneous surfaces. Then two-step successive calcinations in N 2 and subsequent air were exerted for a Cu 2+ -loading gel (CPZ/Cu) and a virgin CPZ as a control, obtaining corresponding N-doped carbon composites containing metal oxides, i.e., CPZ/Cu-N 2 -Air and CPZ-N 2 -Air; and their application as supercapacitor electrodes was further investigated. The former demonstrates denser porous structure as well as lower surface area and pore volume than the latter owing to the generation of copper oxides, but better electrochemical properties are endowed, reasoned by the enhanced pseudo-capacitance from the synergism of Cu/Co oxides. The sample CPZ/Cu-N 2 -Air demonstrates a promising potential as an energy storage material. This study provides an effective recycling method of Cu 2+ ions from polluted water and develops an efficient solution for further utilization of the used polymer adsorbents containing heavy metals. This strategy achieves a closed-loop recycle from waste resources to advanced energy materials in a “trash to treasure” way, in line with the concept of environmental sustainability.
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LUMINESCENCE
·
2026
·Vol. 41
·期 3
·e70466
·
IF 2.8
Qian Sun,Lu Ren,Shuangbao Li,Zian Wang,Jing Liu,Zhaoyun Yang,Dawei Zhang
A simple Schiff base probe ( E )- N′ -(1-(3-oxo-3 H -benzo[f]chromen-2-yl)ethylidene) picolinohydrazide (CHH) was synthesized and characterized by Fourier transform infrared spectroscopy (FT-IR), 1 H nuclear magnetic resonance spectra ( 1 H NMR), 13 C nuclear magnetic resonance spectra ( 13 C NMR), and high-resolution mass spectrometry (HR-MS). The probe CHH shows high sensitivity and selectivity for the recognition of Cu 2+ in EtOH-H 2 O (1:1, v/v), and exhibits an enhanced fluorescence phenomenon. The binding constant of CHH for Cu 2+ is 2.74 × 10 5 M −1 , and the binding stoichiometry of CHH and Cu 2+ is 1:1. The fluorescence intensity of CHH (10 μM) is well linearized with the Cu 2+ concentration at 0–10 μM, and it has a detection limit of 1.42 nM, which is lower than the detection limits of most similar probes. The reusability of the probe was evaluated by successively adding Cu 2+ and disodium ethylenediaminetetraacetate (Na 2 EDTA) to the CHH solution. The probe CHH was used to quantitatively detect Cu 2+ in actual water samples from different water sources. The recovery rates were within an acceptable range, indicating that the probe CHH can be used for the quantitative detection of Cu 2+ in actual water samples. Furthermore, the probe was applied for fingerprint detection, showing great potential in fingerprint detection and anti-counterfeiting.
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CHEMICAL PAPERS
·
2023
·Vol. 77
·期 8
·4201-4215
·
IF 2.2
Azizi Khereshki Nasibeh,Mohammadi Asadollah,Zavvar Mousavi Hassan,Alizadeh Nina,Evazalipour Mehdi
In this work, a colorimetric chemosensor containing thiazolidinedione as a biologically active molecule (NTCS) was successfully used for the highly selective and ultra-sensitive detection of Pb 2+ and Cu 2+ ions in different water samples as well as in a living cell both visually and optically. The characterization of the probe was confirmed by NMR, FT-IR spectroscopy, and UV–Visible absorption techniques prior to experiments. Probe NTCS exhibits an obvious color change because of a ligand to metal charge transfer (LMCT) complex that transforms it from colorless to yellow in the presence of Cu 2+ and from colorless to peach in complexation with Pb 2+ in aqueous methanol–water solutions that could make it a suitable ‘naked-eye’ indicator for Cu 2+ and Pb 2+ . Based on Job’s plot analysis, the interaction binding mode of probe NTCS with Cu 2+ (NTCS-Cu 2+ ) and Pb 2+ (NTCS-Ni 2+ ) was found to be 1:1 stoichiometry complex. The stability of probe-ligand in different pH ranges (9–11) was concerned with determination of the optimum pH for the detection of Cu 2+ , and Pb 2+ ions, which provides NTCS chemosensor suitable for quantitative analysis of the above-mentioned ions under physiological state. The results illustrated that the low detection limits (LOD) for Cu 2+ and Pb 2+ were calculated as 27.7 nM and 0.79 nM, respectively. In order to quick and convenient “naked-eye” detection of the Cu 2+ and Pb 2+ ions in pure aqueous media, low-cost NTCS-based test paper strips were successfully handed-down. MTT assay and bioimaging results indicated the probe has low toxicity, biocompatibility, and successful cellular absorption; hence, the probe can be used in Cu 2+ and Pb 2+ recognition in living cells with high selectivity and sensitivity compared to other chemosensors being researched in recent years.
Graphical abstract
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MOLECULES
·
2022
·Vol. 27
·期 23
·8383
·
IF 4.927
Yan Li,Yang Yu,Gang Ma
Amyloid fibrillation of α-synuclein is implicated in the pathogenesis of Parkinson’s disease and heavy metal ions such as Fe3+, Zn2+, and Cu2+are known to be involved in the process. In this work, we explored the use of FTIR spectroscopy to look into the modulation effects of Fe3+, Zn2+, and Cu2+on the amyloid fibrillation of α-synuclein. We performed a curve-fitting analysis on the FTIR amide I bands of these α-synuclein fibril systems, namely, the pristine fibril and the fibrils prepared in the presence of Fe3+, Zn2+, and Cu2+. We found that the α-synuclein fibrils under the influences of metal ions all possessed a parallel β-sheet structure, turn structure, and disordered structure, similar to that of pristine α-synuclein fibril. We also observed metal-induced increases in the proportions of the β-sheet secondary structure within the α-synuclein fibrils, with Fe3+being the most effective inducer. We performed second derivative analysis of the side chain carboxylic groups of α-synuclein fibrils and found that the side chain microenvironment of the α-synuclein fibrils was more influenced by Fe3+than Zn2+, and Cu2+. In addition, our atomic force microscopic study revealed that the morphologies of α-synuclein fibrils under the influence of Fe3+was quite different from that of the Zn2+and Cu2+systems. Our FTIR results suggested that the modulation effects of Fe3+, Zn2+, and Cu2+on α-synuclein fibrillation occurred at both secondary and quaternary structural levels. At last, we proposed a mechanistic hypothesis to interpret how metal ions could affect the morphology of α-synuclein amyloid fibril based on the conformational plasticity properties of intrinsically disordered proteins.Keywords:amyloid;FTIR;α-synuclein;fibrillation;metal ion;fibril;secondary structure
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JOURNAL OF LUMINESCENCE
·
2023
·
IF 3.6
Xue Wen,Chengyue Xin,Wenjun Zhang,Cong Ding,Zhongfa Li
Luminescent dye molecules have attracted enormous research interest, whereas, there are inherent drawbacks that limit their utilization across a broad variety of fields. Herein, a novel dual-luminescent carboxylic acid functionalization Eu 3+ /Hoc@UIO-66(H 3 BTC) (Hoc = 7-hydroxycoumarin) was prepared by introducing luminescent dye molecules (Hoc) into the UiO-66-type dual-ligand metal−organic frameworks (MOFs) utilize the encapsulation approach and postsynthetic modification (PSM). UIO-66(H 3 BTC) was constructed using 1,4-dicarboxybenzene (TPA) as the first ligand, which can restrict the aggregation-induced quenching of Hoc dyes and maintains the Hoc dyes stably included after preparation. 1,3,5-benzenetricar boxylic acid (H 3 BTC) was used as a second ligand to sensitize Eu 3+ ions for the antenna effect emission and provide detection sites. Eu 3+ /Hoc@UIO-66(H 3 BTC) material possesses blue luminescence from Hoc molecules as well as red luminescence from Eu 3+ when irradiated by UV lamp, which can be used for ratiometric luminescence detection of Cu 2+ /Fe 3+ through reference to the intensity ratios of two emitting peaks. Eu 3+ /Hoc@MOFs(H 3 BTC) as a luminescence sensor, displays an ultrahigh sensitivity (Cu 2+ :4.58 μM, Fe 3+ :18 μM), strong ant-interference ability, and fast response for detecting analytes. This project demonstrates that the dual-ligand Zr-based MOFs and luminescence dyes offers a novel ratiometric luminescence detection platform for heavy metal ions visible identification.
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高影响因子
DALTON TRANSACTIONS
·
2023
·Vol. 52
·期 30
·10584-10593
·
IF 4
Xue Wen,Wenjun Zhang,Cong Ding,Zhongfa Li,Chengyue Xin
Metal–organic frameworks (MOFs) are a unique class of multifunctional hybrid crystals that have been successfully utilized in diverse ranges of applications. However, since MOFs are prone to aqueous degradation, the development of stable luminescent MOF platforms in aqueous media is still a huge challenge. Here, a novel dual-ligand Eu3+/DUT-52-COOH composite is prepared based on the luminescent DUT-52 prototype structure via a dual-ligand strategy and a post-synthetic modification (PSM) method. The functionalized Eu3+/DUT-52-COOH material exhibits dual emission and good photothermal stability in aqueous media. Thus, Eu3+/DUT-52-COOH is developed as a ratiometric luminescent sensor to achieve highly selective and sensitive detection of Cu2+ and Cr2O72− in aqueous solutions and has a low detection limit of 3.43 μM and 25.7 nM, respectively. This work is one of the few cases of detecting Cu2+ and Cr2O72− in aqueous media based on a DUT-52, and the detection signals can be observed by the bare eye without using sophisticated analytical instruments. The possible sensing mechanism is discussed in detail. The results obtained in this project may provide broad prospects for developing smart sensing systems to accomplish highly efficient, easily operable and quantitative intelligent recognition of Cu2+ and Cr2O72−.
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CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Hui Li,Tiantian Xu,Zhe Zhang,Jiao Chen,Mengyao She,Yali Ji,Boyue Zheng,Zheng Yang,Shengyong Zhang,Jianli Li
The ability to manipulate carbon quantum dots (CQDs) fluorescence with specific substances has been of primary importance for applications in advanced dynamic information encryption. The development of CQDs with specific functionalization, high selectivity and excellent fluorescence stability for information security and sensing remains a challenge. In this paper, we present an N -doped and tryptophan functionalized CQDs that can be applied not only as a fluorescent ink for multiple message encryption but also for fluorescent sensitive and selective recognition of Cu 2+ and cysteine (Cys) by multi-method, including aqueous solutions, filter paper, hydrogels and in human DU-145 Prostate cancer cells. Theoretical calculations and mechanistic studies suggested that this on–off-on mechanism was attributed to the transfer of electrons between Cu 2+ and functionalized groups on the surface of CQDs and stronger coordination capability with Cys. The above results showed that these newly designed CQDs will greatly enrich the fundamental understanding of CQDs by explaining the recognition mechanism between Cu 2+ and Cys, and provide an opportunity for anti-counterfeiting, solid-state fluorescent materials, cellular imaging and environmental.
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WATER RESEARCH
·
2022
·
IF 13.4
Fuwei Sun,Tianhu Chen,Ziyang Chu,Peixun Zhai,Haibo Liu,Qiang Wang,Xuehua Zou,Dong Chen
A system of Cu 2+ /calcite/PDS was constructed to degrade sulfadiazine (SDZ). Different from the traditional Cu-mediated activation, a low concentration of Cu 2+ that met drinking water standards (≤ 1 mg/L) transformed into Cu(Ⅱ) solid in the presence of calcite, and then enhanced the degradation of SDZ via PDS activation over a pH range from 3 to 9. According to scavenger and chemical probe experiments, Cu(Ⅲ), rather than radicals (hydroxyl radicals and sulfate radicals) and singlet oxygen, was the predominant reactive species, which was responsible for the degradation of SDZ. Based on the results of XRD, ATR-FTIR, and CV curves et al., CuCO 3 was the main complex with high reactivity for PDS activation to form Cu(Ⅲ). Moreover, detailed degradation pathways of sulfadiazine were proposed according to the UPLC-ESI-MS/MS and their toxicity was predicted by ECOSAR. Besides, the real water matrix would not seriously affect the degradation of SDZ in the Cu 2+ /calcite/PDS system. In summary, this study reveals a new insight into the synergistic effect of Cu 2+ and calcite on the SDZ degradation, and promotes an understanding of the environmental benefits of natural calcite.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2023
·
IF 5.8
Haiying Xu,Zhongping Su,Hui Zhang,Ying Zhang,Yujun Bao,Huanli Zhang,Xiaodan Wu,Rui Yan,Zhiqiang Wang,Yingxue Jin
Photodynamic therapy (PDT) and chemodynamic therapy (CDT) can activate immunogenicity, so PDT and CDT combined immunotherapy is a promising treatment strategy. However, insufficient hydrogen peroxide activity, hypoxia, and overexpressed glutathione in the tumor microenvironment (TME) significantly impaired the ability to activate immunogenicity. Thus, in this paper, self-reinforcing conjugates Cu 2+ -Pyropheophorbide-a-Cysteine (CuPPaCC), combined synergetic NIR and pH triggered PDT/CDT with glutathione depletion ability was constructed. CuPPaCC was encapsulated in mesoporous silica, and spherical HSCuPPaCC nanoparticles were prepared by Hyaluronic acid (HA) on the silica surface by Schiff base modification. HSCuPPaCC has tumor-specific targeting via HA mediated. In acidic solution, the Schiff base of HSCuPPaCC is destroyed and CuPPaCC is released (>70%), with excellent pH response release function. The results of the MTT analysis showed that the PDT/CDT synergistic anti-tumor effect was significant. HSCuPPaCC was activated in TME, catalyzing the decomposition of hydrogen peroxide to generate hydroxyl radicals and oxygen, alleviating TME hypoxia, replenishing oxygen to PDT, and significantly down regulating hypoxia factor HIF-1α expression. HSCuPPaCC has an excellent dual ROS mechanism and a dual depleting GSH mechanism resulting in a surge in intracellular ROS levels to efficiently kill cancer cells, enhance the ability to induce immunogenicity, and make tumors more sensitive to checkpoint PD-L1 blockade therapy. With the CT26 mouse model, not only the primary tumor was eradicated, but also the distal tumor at the end of treatment was completely suppressed by HSCuPPaCC combined with anti-PD-L1 immune checkpoint blockade therapy.
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RSC Advances
·
2023
·Vol. 13
·期 47
·33276-33287
·
IF 3.9
Yiduo Li,Luyue Wang,Liqiang Wang,Baokun Zhu,Jie Ma
Based on the typical Suzuki coupling reaction and Schiff base reaction, a novel fluorescent molecular PCBW is synthesized and applied as a fluorescence and colorimetric sensor to detect Cu2+ in aqueous solution. The PCBW sensor presents the aggregation-caused quenching (ACQ) effect and at 1 × 10−5 mol L−1 it emits the strongest turquoise fluorescence in the DMSO–H2O system (fw = 40%). The sensor exhibits a ‘turn-off’ fluorescent characteristic by adding Cu2+, and its fluorescent intensity shows a reliable linear relationship with the Cu2+ concentration in the range of 0–6 × 10−6 mol L−1, with a detection limit of 1.19 × 10−8 mol L−1. Meanwhile, the PCBW sensor also exhibits the colorimetric sensing from colorless to light yellow. The sensor has good selectivity and anti-interference and its pH application range can be extended from 5 to 10. The intramolecular charge transfer (ICT) is speculated as the main fluorescence mechanism of PCBW. In addition, the sensor presents good reusability and is practicable to detect Cu2+ in diverse aqueous samples.
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REACTIVE & FUNCTIONAL POLYMERS
·
2023
·
IF 5.1
Liangyun Yu,Xue Chen,Liangju Sun,Qi Zhang,Bairen Yang,Mingquan Huang,Baocai Xu,Qin Xu
It's very exciting to develop an electrochemical sensor for simple, rapid and simultaneous determination of heavy metal ions in Baijiu by applying new nanocomposites. Herein, a novel COF DPTB @gold nanoparticles (AuNPs)@graphene (GR) was obtained via combining COF DPTB synthesized using the Schiff-base condensation between 2, 5-dimethoxyterephthalaldehyde and 1, 3, 5-tris(4-aminophenyl) benzene with AuNPs and GR. Owing to the high porosity and abundant adsorption sites of COF DPTB , the outstanding electrical conductivity of AuNPs and GR, as well as the high specific area and synergy of COF DPTB , AuNPs and GR, the proposed sensor exhibited excellent analysis performance for the detection of Cd 2+ , Pb 2+ and Cu 2+ . Under optimized conditions, the sensor showed good linearity range of 0.5–18 μM for Cd 2+ , and both 0.5–6.0 μM for Pb 2+ and Cu 2+ with the detection limits of 3.025 nM, 5.849 nM and 9.993 nM, respectively. In addition, the recovery measurement suggested the practicality of the prepared sensor.
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