CELLULOSE
·
2026
·
IF 4.6
Zhang Xinyan,Zhou Jingqiu,Han Xue,Xing Xu,Yang Kun,Wu Tao,Li Hao,Hao Xujia,Du Qiang,Liu Xinwei,Gong Tianxing,Leng Hongrui,Wei Shibo
Carboxymethyl cellulose (CMC) exhibits excellent biocompatibility and water retention, yet its high hydrophilicity often leads to excessive swelling and poor mechanical stability in physiological environments, limiting its utility in topical skin therapies. In this study, we developed a robust, chemically crosslinked CMC-based hydrogel loaded with curcumin (Cur@CL) using natural lysine as a non-toxic crosslinker. This green crosslinking strategy significantly reinforced the hydrogel network, achieving a swelling ratio of 3074 ± 226% and a compressive stress of 20.06 ± 1.0 kPa. The Cur@CL hydrogel demonstrated a sustained curcumin release profile of 83.98 ± 5.68% over 144 h, ensuring prolonged local bioavailability. In vitro, Cur@CL exhibited excellent cytocompatibility with L929 fibroblasts, accelerated fibroblast-associated wound closure, and reduced intracellular reactive oxygen species (ROS) levels by 62.97%. Furthermore, in a 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) mouse model, topical application of Cur@CL significantly alleviated clinical symptoms, reducing epidermal thickening by 71.5% compared with the DNCB-challenged model group, with no detectable systemic toxicity. This study presents a simple, tunable, and eco-friendly cellulose-based hydrogel platform for the effective, non-steroidal management of AD.
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DOI
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2026
·
IF 7.1
Biao Liang,Xinying Guo,Yuanyuan Wang,Shumin Yi,Jianrong Li,Beibei Ye,Yanwei Liu,Jinxiang Wang,Cikun Liu,Xuepeng Li
At 9000 s, G i ′ increased by approximately six orders of magnitude relative to C1. • The 0.5% pectin emulsion showed a dense interfacial layer and a 3D network. • At 0.5% pectin, the emulsified phase volume fraction remained at 100% over 180 d. • C1–P0.5 resisted freeze–thaw, thermal, pH, and salt stresses. • Curcumin loading efficiency peaked at 0.3% pectin, while retention peaked at 0.5%. Designing highly stable Pickering emulsions with common biopolymers and expanding their applications to the effective loading of lipophilic bioactives remain formidable challenges. In this study, we successfully fabricated a series of Pickering emulsions stabilized by gelatin–pectin complexes containing gelatin (1.0%, w/w) and pectin (0.1%, 0.3%, and 0.5%, w/w). Pectin incorporation significantly reduced the mean droplet size and increased the zeta-potential magnitude, with C1–P0.5 reaching < 6 μm and > 35 mV, respectively. Interfacial and bulk rheological measurements, together with cryo-SEM and LF-NMR, indicated that pectin incorporation strengthened both the interfacial layer and the continuous-phase structure, forming a multiscale reinforcing architecture. This architecture comprised a dense, viscoelastic interfacial layer and an interconnected 3D honeycomb-like scaffold, which collectively provided robust electrosteric stabilization and geometric confinement. Consequently, the high-pectin group (C1–P0.5) achieved high stability across a broad range of environmental stressors, including 180-day room temperature storage, freeze–thaw cycles, thermal treatment (60–100 °C), and wide fluctuations in pH and ionic strength (NaCl/MgCl 2 ). Furthermore, the C1–P0.3 formulation achieved a curcumin loading efficiency of > 95%, and pectin incorporation enhanced curcumin retention under UV exposure and thermal treatment. These findings provide a mechanistic basis for using simple biocomposites to develop highly stable Pickering systems for the loading and protection of sensitive lipophilic bioactives.
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DOI
高影响因子
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2025
·Vol. 105
·期 7
·3593-3605
·
IF 3.5
Zhi-feng Tan,Guan-hua Zhao,Da-yong Zhou,Zhen-wen Shao,Liang Song
Background Traditional methods for fabricating protein-polyphenol conjugates have not preserved the structural and functional integrity essential for the food industry effectively. This research introduces an advanced encapsulation methodology designed to overcome these limitations, with the potential to enhance the stability of edible oil matrices significantly, leading to improved preservation techniques and extended shelf life. Results Glycated pea protein isolate-curcumin conjugates ( g PPI-CUR) were developed, demonstrating a marked improvement in the oxidative stability of walnut oil (WO), a proxy for edible oil matrices. Characterized by a Z-average diameter of 158.37 nm and an encapsulation efficiency of 80.94%, these conjugates demonstrated exceptional performance in reducing lipid oxidation and aldehyde formation. Molecular docking analysis confirmed the formation of robust bonds with curcumin, thereby amplifying antioxidant activity. The uniform distribution of g PPI-CUR throughout the walnut oil matrix, as validated by confocal microscopy, ensured sustained bioactivity and mitigated the risk of localized oxidation. Electron spin resonance spectroscopy corroborated the superior antioxidant properties of the conjugates, which translated into a substantial 19-day increase in the shelf-life of the oil. Conclusion The g PPI-CUR conjugates enhanced the oxidative stability of walnut oil significantly, as demonstrated by the increased shelf life and reduced lipid oxidation. This study introduced an effective encapsulation method that improved the stability and extended the shelf life of edible oils, aligning with consumer demands for high-nutrition food products. The results indicate that the g PPI-CUR conjugates could serve as a promising antioxidant strategy for food preservation, offering a practical approach to enhance food quality and safety. © 2025 Society of Chemical Industry.
研究领域:
食品科学
·
生物化学
·
营养学
·
材料科学
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产品关联
DOI
PubMed
高影响因子
Biomolecules
·
2022
·Vol. 12
·期 8
·1057
·
IF 6.064
Yubo Liu,Xiaohong Chen,Yuhang Gao,Yuyang Liu,Dengguang Yu,Ping Liu
The inefficient use of water-insoluble drugs is a major challenge in drug delivery systems. Core–sheath fibers with various shell thicknesses based on cellulose acetate (CA) were prepared by the modified triaxial electrospinning for the controlled and sustained release of the water-insoluble Chinese herbal active ingredient curcumin. The superficial morphology and internal structure of core–sheath fibers were optimized by increasing the flow rate of the middle working fluid. Although the prepared fibers were hydrophobic initially, the core–sheath structure endowed fibers with better water retention property than monolithic fibers. Core–sheath fibers had flatter sustained-release profiles than monolithic fibers, especially for thick shell layers, which had almost zero-order release for almost 60 h. The shell thickness and sustained release of drugs brought about a good antibacterial effect to materials. The control of flow rate during fiber preparation is directly related to the shell thickness of core–sheath fibers, and the shell thickness directly affects the controlled release of drugs. The fiber preparation strategy for the precise control of core–sheath structure in this work has remarkable potential for modifying water-insoluble drug release and improving its antibacterial performance.
研究领域:
材料科学
·
药学
·
生物医学工程
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DOI
高影响因子
International Journal of Nanomedicine
·
2022
·
IF 7.033
Yumeng Wei,Mingtang Zeng,Chao Pi,Hongping Shen,Jiyuan Yuan,Ying Zuo,Jie Wen,Pu Guo,Wenmei Zhao,Ke Li,Zhilian Su,Xinjie Song,Shaozhi Fu,Robert J Lee,Ling Zhao
Purpose Paclitaxel (PTX) has been widely utilized for the treatment of breast cancer. However, drawbacks, such as poor aqueous solubility, rapid blood clearance and severe toxicity, greatly reduce its efficacy and safety. Herein, a novel self-developed curcumin derivative (CUD) was chosen as the carrier to develop a long-acting PTX nano-delivery system (PTX-Sln@CUD) in order to improve its pharmacokinetic behavior, anti-breast cancer efficacy and safety. Methods PTX-Sln@CUD was prepared using solid dispersion and ultrasonic technology. Relevant physical and chemical properties, including stability and release behavior, were characterized. The clearance of PTX-Sln@CUD in vivo was studied by pharmacokinetic experiments. The anti-tumor activity of PTX-Sln@CUD was investigated in vitro and in vivo. Hemolysis experiments, acute toxicity and cumulative toxicity studies were performed in mice to determine the safety of PTX-Sln@CUD. Results The average particle size, PDI, Zeta potential, encapsulation efficiency and loading efficiency of the PTX-Sln@CUD were 238.5 ± 4.79 nm, 0.225 ± 0.011, −33.8 ± 1.26 mV, 94.20 ± 0.49% and 10.98 ± 0.31%, respectively. PTX-Sln@CUD was found to be stable at room temperature for half a year. The cumulative release rates of PTX-Sln@CUD at 24, 96 and 168 h were 17.98 ± 2.60, 57.09 ± 2.32 and 72.66 ± 4.16%, respectively, which were adherent to zero-order kinetics. T 1/2 , MRT (0-t) and AUC (0-t) of the PTX-Sln@CUD group were 4.03-fold (44.293 h), 7.78-fold (38.444 h) and 6.18-fold (14.716 mg/L*h) of the PTX group, respectively. PTX-Sln@CUD group demonstrated stronger anti-breast cancer activity than the PTX group. Importantly, the PTX-Sln@CUD group was safer compared to the PTX group both in vitro and in vivo. Conclusion PTX-Sln@CUD was verified as promising therapeutic nanoparticles for breast cancer and provided a novel strategy to solve the problem of low efficacy and poor safety of clinical chemotherapy drugs.
研究领域:
药理学
·
肿瘤学
·
纳米医学
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DOI
PubMed
高影响因子
Biomolecules
·
2025
·Vol. 15
·期 8
·1070
·
IF 4.8
Man Wang,Hongying Liu,Wei Zhao,Huafen Wang,Yuwei Zhuang,Jie Yang,Zhaohui Liu,Jing Zhu,Sichong Chen,Jinghui Cheng
In the context of critical challenges in curcumin-modified polyurethane synthesis—including limited curcumin bioavailability and suboptimal biodegradability/biocompatibility—a novel polyurethane material (Cur-PU) with good mechanical, shape memory, pH-responsive, and biocompatibility was synthesized via a one-pot, two-step synthetic protocol in which HO-PCL-OH served as the soft segment and curcumin was employed as the chain extender. The experimental results demonstrate that with the increase in Cur units, the crystallinity of the Cur-PU material decreases from 32.6% to 5.3% and that the intensities of the diffraction peaks at 2θ = 21.36°, 21.97°, and 23.72° in the XRD pattern gradually diminish. Concomitantly, tensile strength decreased from 35.5 MPa to 19.3 MPa, and Shore A hardness declined from 88 HA to 65 HA. These observations indicate that the sterically hindered benzene ring structure of Cur imposes restrictions on HO-PCL-OH crystallization, leading to lower crystallinity and retarded crystallization kinetics in Cur-PU. As a consequence, the material’s tensile strength and hardness are diminished. Except for the Cur-PU-3 sample, all other variants exhibited exceptional shape-memory functionality, with Rfand Rrexceeding 95%, as determined by three-point bending method. Analogous to pure curcumin solutions, Cur-PU solutions demonstrated pH-responsive chromatic transitions: upon addition of hydroxide ion (OH−) solutions at increasing concentrations, the solutions shifted from yellow-green to dark green and finally to orange-yellow, enabling sensitive pH detection across alkaline gradients. Hydrolytic degradation studies conducted over 15 weeks in air, UPW, and pH 6.0/8.0 phosphate buffer solutions revealed mass loss <2% for Cur-PU films. Surface morphological analysis showed progressive etching with the formation of micro-to-nano-scale pores, indicative of a surface-erosion degradation mechanism consistent with pure PCL. Biocompatibility assessments via L929 mouse fibroblast co-culture experiments demonstrated ≥90% cell viability after 72 h, while relative red blood cell hemolysis rates remained below 5%. Collectively, these findings establish Cur-PU as a biocompatible material with tunable mechanical properties, and pH responsiveness, underscoring its translational potential for biomedical applications such as drug delivery systems and tissue engineering scaffolds.
研究领域:
材料科学
·
高分子化学
·
生物医学工程
·
药剂学
·
纳米技术
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产品关联
DOI
PubMed
高影响因子
Materials Today Bio
·
2025
·
IF 10.2
Gang Li,Pengqi Zhu,Caifang Gao,Ye Cai,Ru Feng,Jinghua Sun,Ruiping Zhang
Vitiligo is a depigmenting autoimmune disease driven by oxidative stress and immune-mediated melanocyte destruction. Current therapies are limited by poor drug permeability, systemic side effects, and insufficient efficacy. Herein, we developed a novel carbomer-based hydroxypropyl-β-cyclodextrin-encapsulated crisaborole/curcumin hydrogel (Cri/Cur@CD-Gel) for combinational transdermal intervention of vitiligo via dual antioxidant and anti-inflammatory pathways. Hydroxypropyl-β-cyclodextrin (HP-β-CD) inclusion complexation overcame the inherent hydrophobicity of crisaborole (Cri) and curcumin (Cur), significantly enhancing their aqueous solubility, stability, and transdermal permeability. Leveraging its skin-adhesive properties, the carbomer hydrogel matrix enhanced drug retention and enabled sustained release at lesion sites, thereby improving drug bioavailability. In vitro , Cri/Cur@CD, leveraging the solubilizing power of HP-β-CD, restored melanocyte viability under oxidative stress, scavenged ROS, normalized mitochondrial membrane potential, and elevated cAMP levels to enhance melanogenesis and tyrosinase activity. In vivo , Cri/Cur@CD-Gel achieved significant repigmentation in monobenzone-induced vitiligo mice, markedly reducing epidermal ROS, CD8+ T-cell infiltration, and inflammatory cytokines (TNF-α, IL-1β, and IL-6). This study demonstrates that the combination of HP-β-CD-based encapsulation and carbomer hydrogel delivery serves as a potential topical administration platform for co-delivering hydrophobic crisaborole and curcumin, and establishes a promising strategy to alleviate vitiligo, that concurrently addresses oxidative damage, inflammatory responses, and melanocyte regeneration.
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Mingli Yue,Bixian Wang,Jianbo Zhao,Liangzhong Lv,Ying Fu,Fei Ye
Cancer, the world’s second leading killer, has increasing crude incidence rates and faces multiple prevention/control challenges. Curcumin (Cur) has anticancer activity but low bioavailability, restricting its use in cancer therapy. A nanomaterial (Fe₃O₄/PDA@Cur) for targeted curcumin delivery is developed in this work, which has a magnetic Fe 3 O 4 core made by solvothermal synthesis and a polydopamine (PDA) shell made by one-pot synthesis. Results show that drug loading rate reached 40.3 % when the mass ratio of Fe₃O₄/PDA: Cur was 1:3. The hemolysis rate was measured to be 1.24 % in the hemocompatibility test. The complex exhibited good antibacterial efficacy against both Staphylococcus aureus ( S. aureus , MIC 250.0 μg/mL and MBC 500.0 μg/mL), Escherichia coli ( E. coli , MIC 625.0 μg/mL and MBC 1250.0 μg/mL), which was attributed to the properties of the incorporated PDA. The material has good blood compatibility and antibacterial effects, and it effectively prevents secondary infection at the tumor site and red-blood-cell lysis. Notably, at pH 5.0, drug release reached 75.5 % via pH-responsive mechanisms which tumor microenvironment (pH 5.0–6.5), drug release is accelerated in these regions, enabling targeted therapy that minimizes toxicity to normal cells and systemic side effects, thereby enhancing treatment safety. This complex, which possesses both drug delivery and antibacterial properties, holds significant clinical importance for preventing opportunistic infections during tumor treatment.
研究领域:
纳米医学
·
药物递送
·
癌症治疗
·
生物医学材料
·
抗菌剂
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2026
·Vol. 27
·期 4
·1642
·
IF 5.6
Shuang Wang,Keyi Wu,Meiqi Sun,Xinrui Wang,Jingying Li,Guorong Zhang,Zhidong Qiu
Tendinopathy is a common musculoskeletal disorder that increases the risk of tendon rupture if not properly treated. Current local injection therapies require frequent administration, and no fully effective drug is yet available. Curcumin (Cur) exhibits excellent anti-inflammatory and antioxidant effects, but its poor water solubility and low stability limit its clinical application. To overcome these challenges, this study encapsulated Cur into pluronic F127-based nanomicelles (Cur-F127) to improve its aqueous solubility and stability. Subsequently, the micelles were incorporated into a hydrogel network (Cur-F127&gel) formed by oxidized hyaluronic acid (oxi-HA) and adipic acid dihydrazide (ADH) to achieve sustained release. The resulting Cur-F127 micelles had a particle size of 20.14 ± 0.287 nm, an encapsulation efficiency (EE%) of 89.95 ± 0.60%, and a drug loading (DL%) of 5.57 ± 0.05%. The composite hydrogel possessed a loose, porous three-dimensional network, excellent biocompatibility, and favorable degradation behavior. The system enabled sustained release of Cur for over 20 days without an initial burst. In a rat model of tendinopathy, Cur-F127&gel significantly promoted tendon repair, as evidenced by reduced inflammatory cell infiltration, improved collagen fiber alignment, restored expression of key mitochondrial-related proteins (Ndufs3, Uqcrq, Uqcr10, Atp5mc3), and alleviated oxidative stress damage demonstrated by increased SOD activity and decreased MDA content in tendon tissue, thereby suppressing disease progression. This injectable sustained-release hydrogel system for poorly soluble drugs provides an effective approach for the local, long-acting delivery of Cur and long-term repair of tendinopathy, highlighting its potential value for clinical application.
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产品关联
DOI
PubMed
高影响因子
Frontiers in Pharmacology
·
2024
·
IF 4.4
Jie Wen,Lingmao Zhao,Zhuohan Li,Chao Pi,Xianhu Feng,Peng Shi,Hongru Yang,Ligang Chen,Xiaodong Wang,Furong Liu,Yumeng Wei,Ling Zhao
Chemotherapy remains the first choice of treatment for colon cancer despite the inevitable adverse effects. Curcumin (CU) possesses antitumor activity but has poor aqueous solubility, low bioavailability, and weak activity. To address this, nine novel monocarbonyl CU analogues were designed, synthesized, and evaluated in the present study. Among them, CA8 exhibited the highest water solubility, which was approximately 2.37 × 106 times that of CU. In addition, compared with CU, its cytotoxicity on Caco-2 cells (19.2 times/48 h) was stronger. Of note, CA8 arrestedthe cell cycle of Caco-2 cells at the G2/M phase and induced apoptosis. Meanwhile, acute toxicity experiments indicated that KM mice tolerated CA8 for up to 300 mg/kg CA8 (oral administration) and 50 mg/kg CA8 (intraperitoneal injection). The oral administration of CA8 to Sprague Dawley rats exhibited higher AUC (0-t) (6.23-fold) and longer MRT (0-t) (3.35-fold) than that of CU. CA8 also inhibited the proliferation and angiogenesis of tumor cells more than CU and tegafur. Finally, CA8 may exert anti-tumor effects through the activation of JNK pathway and inhibition of AKT pathway. These results suggest that CA8 is a safe and highly effective new drug for colon cancer treatment.
研究领域:
肿瘤学
·
药理学
·
生物化学
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DOI
PubMed
高影响因子
TISSUE & CELL
·
2022
·
IF 2.586
Taiding Wu,Xin Li,Shiwei Tu,Wenbo Tan,Longju Chen
Demyelination disease as diabetes mellitus (DM) complication is characterized by apoptosis of Schwann cells (SCs) and several reports have demonstrated that high glucose content can induce an inflammation response and lead to the apoptosis of SCs. For NF-κB plays a pivotal role in the inflammatory response, hence we hypothesized that high glucose content can induce inflammation though the NF-κB pathway. First we verified that 150 mM high glucose can increase the expression of cleaved caspase 3 , interleukin (IL)− 1β, Cyto-C and NF-κB with time through Western blot and increase the apoptosis of RSC96s through Flow Cytometry. Then we found that high glucose can increase the nuclear translocation NF-κB through confocal system which can promote the expression of inflammation genes such as IL-1β. Curcumin has been reported to possess anti-inflammation activities to protect cells. In this study, we found that application with 25 μM curcumin could alleviate the inflammation response and protect the cells from apoptosis. We revealed that the expression of NF-κB and p-NF-κB was decreased and the translocation was also inhibited after curcumin application. Accordingly, the secretion of IL-1β and the apoptosis of RSC96s induce by high glucose was suppressed. Our cumulative findings suggest that curcumin can protect SCs from apoptosis through the inhibition of the inflammatory response though the NF-κB pathway.
研究领域:
神经科学
·
药理学
·
糖尿病研究
·
细胞生物学
✓ 已验证
DOI
PubMed
高影响因子
CHEMICO-BIOLOGICAL INTERACTIONS
·
2019
·
IF 3.407
Jialin Xu,Leilei Zhou,Qi Weng,Linxia Xiao,Qingyong Li
Beta-amyloid (Aβ) has pivotal functions in the pathogenesis of Alzheimer's Disease (AD). In the present study, we adopted an vitro model that involved Aβ 25-35 -induced oxidative damage in PC12 cells. Aβ 25-35 (10 μΜ) treatment for 24 h induced significant cell death and oxidative stress in PC12 cells, as evidenced by cell viability reduction, LDH release, ROS accumulation and increased production MDA . (1E,4E)-1, 5-bis(4-hydroxy-3-methoxyphenyl) penta-1, 4-dien-3-one (CB) and (1E, 4E)-1-(3, 4-dimethoxyphenyl)-5-(4-hydroxy-3, 5-dime-thoxyphenyl) Penta-1, 4-dien-3-one (FE), two Curcumin (Cur) analogues displayed neuroprotective effects against Aβ 25-35 -induced oxidative damage and cellular apoptosis in PC12 cells. Here, we investigated three different treatment ways of CB and FE. It was interesting that post-treatment of CB and FE (restoring way) showed similar effect to the preventive way, while attenuating way did not show any protective effect. We found that low dose CB and FE increased transcriptional factor NF-E2-related factor 2 (Nrf2)/hemo oxygenase 1 (HO-1) protein expression and decreased Kelch-like ECH-associated protein 1 (Keap1) in PC 12 cells. In addition, CB and FE promoted the translation of Nrf2 into nuclear and enhanced the activity of superoxide dismutase (SOD)/catalase, which confirmed cytoprotection against Aβ 25-35 -induced oxidative damage. Moreover, CB and FE could increase Bcl-2 expression level, decrease the level of Bax and Cyt-c in Aβ 25-35 -treated PC12 cells. Ultimately, the neuroprotective effect of CB and FE provides a pharmacological basis for its clinical use in prevention and treatment of AD.
研究领域:
神经科学
·
药理学
·
细胞生物学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
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