Journal of Macromolecular Science Part B-Physics
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2017
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IF 0.828
Qiao Zhang,Zhihua Zhou,Cheng Peng,Tianlong Huang,Wenjuan Liu,Qingquan Liu,Hu Zhou,Wei Wang,Hua Yan
Three-dimensional biodegradable porous scaffolds play an important role in tissue engineering. A new polymer based on maleated poly(lactic-co-glycolic acid) (MPLGA) was synthesized using direct melt copolymerization from maleic anhydride (MAH), D, L-lactide, and glycolide monomers. MPLGA porous biodegradable scaffolds were prepared by a solution-casting/salt-leaching method. The effects of content and size of the NaHCO3 porogen on the compressive strength of the MPLGA scaffolds were investigated, and the effect of content of the porogen on the porosity of the MPLGA scaffolds was also studied. The results indicated that MAH was grafted onto PLGA successfully and MPLGA scaffolds with interconnective and open pore structure were obtained. Increasing content of NaHCO3 porogen resulted in an increase of porosity and decrease of the compressive strength of the MPLGA scaffolds with the compressive strength of the scaffolds also decreasing with increasing porogen size.
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高影响因子
OPTICAL MATERIALS
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2017
·
IF 2.238
Guihua Cui,Dehai Zhao,Peng Lv,Zhengguo Gao,Shuiying Chen,Nannan Qiu,Toshifumi Satoh,Toyoji Kakuchi,Qian Duan
A series of novel fluorescent complexes was formed by chelation of the thermosensitive polymers with europium(III) ions. The polymers was synthesized via atom transfer radical polymerization (ATRP), which composed of poly( N -isopropyl acrylamide) (PNIPAM) and 2-amino-2-deoxy- d -glucopyranose( d -glucosamine, GA). The aqueous solutions of the polymers and its Eu(III) complexes exhibited a lower critical solution temperatures (LCSTs), and which were approximately equal to body temperature. The maximum emission intensity of the complexes at 613 nm was enhanced by a factor of approximately 10 relative to that of the corresponding Eu(III) chloride. Cell viability assays suggested that these thermosensitive polymers and Eu(III) complexes showed excellent biocompatibility in vitro.
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高影响因子
TALANTA
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2026
·
IF 6.7
Xueni Yang,Dandan Yang,Wenying Sun,Yinghui Song,Baojun Yang,Peixiang Huang,Jifeng Liu,Xia Gao
An integrated sensor array was developed for simultaneous bacterial identification and AST. • The platform relies on species-specific D-AA metabolic fingerprints with enzyme cascade reaction. • The system enables both precise bacterial differentiation and quantitative detection. • 100% AST concordance with CLSI disk diffusion methods was achieved for clinical isolates. The rapid rise of antimicrobial resistance (AMR) constitutes a global health crisis, demanding diagnostic tools capable of simultaneous bacterial identification and rapid antibiotic susceptibility testing (AST) in a single workflow. Herein, a colorimetric sensor array was developed to address this need by profiling bacterial metabolic fingerprints via a streamlined single-substrate, multi-wavelength strategy. The strategy is built upon the inherent bacteria-specific metabolism of D-amino acids (D-AAs), coupled with the enzymatic selectivity of D-amino acid oxidase (DAAO), which catalyzes the oxidation of D-AAs to generate H 2 O 2 . Differential bacterial consumption of D-Ala directly modulates the substrate available for the subsequent DAAO-coupled cascade reaction, producing varying amounts of H 2 O 2 . Consequently, H 2 O 2 triggers the peroxidase (POD)-like activity of Prussian blue-coated gold nanoparticle (Au@PB NP) nanozyme to produce distinct multi-wavelength optical patterns from TMB oxidation. When coupled with linear discriminant analysis (LDA), this sensing platform enables clear discrimination of bacterial species based on their metabolic fingerprints. Moreover, by assessing the antibiotic-induced inhibition of this metabolic activity, the platform accurately determines bacterial susceptibility profiles, achieving 100% concordance with the standard disk diffusion method for both reference and clinical isolates, and successfully determining minimum inhibitory concentration (MIC) values for reference strains in full agreement with Clinical Laboratory Standards Institute (CLSI) breakpoint interpretation. This work establishes an integrated, rapid, and robust metabolic sensing platform for bacterial phenotyping and AST, offering a promising tool to combat AMR. Bacterial metabolic fingerprints from D-amino acid consumption enable a colorimetric sensor array for rapid identification and antibiotic susceptibility testing with 100% clinical concordance. Download: Download high-res image (346KB) Download: Download full-size image
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INDUSTRIAL CROPS AND PRODUCTS
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2018
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IF 3.849
Shujie Ma,Leilei Fu,Siqi He,Xiaopeng Lu,Yuanyong Wu,Zhiqing Ma,Xing Zhang
The evaluation of herbicidal activity and the isolation of plant allelopathic substances can lead to the discovery of new herbicide. This study has confirmed that the ethanol extract of S. mukorossi leaves was inhibitory to growth of Avena fatua L. and Amaranthus retroflexus L. both in petri dish experiment and pot culture assay, with the fresh weight inhibition varied between 47.60% and 62.05% at a concentration of 40 g/L of the leaf extract, being comparable to that of a commercialized natural product herbicide pelargonic acid at a concentration of 4 g/L. Five herbicidal compounds, oleanolic acid (1) , lupeol (2) , d-pinitol (3) , hexadecanoic acid (4) and octadecanoic acid (5) were isolated from the most active fraction, petroleum ether extract. D-pinitol (3) showed the highest growth inhibitory activity against both the shoot and root of A. fatua , with the half maximal inhibitory concentration (IC 50 ) values of 53.61 and 56.43 μg/mL, respectively. Furthermore, oleanolic acid (1) and d-pinitol (3) also inhibited the growth of A. retroflexus with the IC 50 value of 56.05 and 61.89 μg/mL against shoot growth, and 58.07 and 66.70 μg/mL against root growth, respectively. Thus, oleanolic acid (1) and d-pinitol (3) are the main phytotoxin constituents of S. mukorossi , and these compounds have the potential for further development as a botanical herbicide.
研究领域:
植物生理学
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化感作用
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天然产物化学
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杂草科学
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农药学
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高影响因子
BIOMEDICAL MICRODEVICES
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2025
·Vol. 27
·期 4
·1-12
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IF 3.3
Zhang Jingfei,Nan Xuanxu,Yang Li,Cui Yue
The Lateral flow immunoassay (LFIA) has been widely used in environmental monitoring and disease diagnosis due to its advantages of low cost, simple operation, and convenience. However, its accuracy and sensitivity remain major challenges to be addressed. D-dimer is an important biomarker for thrombotic diseases. In this work, we show for the first time a core–shell Au@Ag nanoparticle (NP) labeled colorimetrically enhanced LFIA for D-dimer detection. The superior performance of Au@Ag LFIA stems from the silver shell's enhancement of plasmon resonance, which boosts optical signals to yield brighter scattering and superior visual contrast. Compared with conventional AuNPs, Au@AgNPs significantly improve sensitivity, leading to more accurate results. The detection limit for D-dimer was improved by approximately tenfold, reaching 1 ng/mL, due to the improved cross-coupling efficiency of Au@AgNPs compared with AuNPs. We anticipate that, with further development and validation, this enhanced LFIA could become a valuable tool in a wide range of clinical diagnostic applications.
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产品关联
DOI
PubMed
高影响因子
Engineering
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2025
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IF 11.6
Chao Sun,Tianzuo Wang,Ruijie Gao,Xiaoyang Liu,Kang Xue,Chengxiang Shi,Xiangwen Zhang,Lun Pan,Ji-Jun Zou
Understanding the intrinsic features of dehydrogenation reactions of liquid organic hydrogen carriers (LOHCs) is a formidable challenge due to the combined impact of electronic and geometric effects. Herein, we constructed a series of Pt/MO x catalysts (CeO 2 , MgO, ZrO 2 , TiO 2 , Al 2 O 3 , or SiO 2 ) with similar sizes of Pt (∼1.7 nm) to investigate the effects of Pt electron structures (tuned by electronic metal‒support interactions) on the catalytic dehydrogenation of LOHCs. The results revealed a volcano-shaped correlation between Pt d electrons on different supports and the turnover frequency of catalytic dehydrogenation. Importantly, the Pt/MgO catalyst exhibited the highest dehydrogenation activity. With decreasing d electron content, Pt/MgO increases the bonding orbital dominance of Pt‒C bonds and leads to stable adsorption of H6-monobenzyltoluene (MBT), which facilitates subsequent C‒H bond scission. This study offers insight for the strategic development of high-efficiency dehydrogenation catalysts via d electron density modulation of Pt sites.
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高影响因子
BIORESOURCE TECHNOLOGY
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2026
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IF 8.2
Jing Zhang,Liqiang Yan,Huihui Su,Xiaoyang Ou,Tao Xiong,Mingyong Xie,Fei Peng
Enzyme–inorganic hybrid nanoflowers (HNFs) are promising immobilization platforms because of their simple fabrication and often enhanced catalytic performance. Here, a robust and highly efficient hybrid nanoflower (β-Gal-SC@ST-LFAI) for d -tagatose biosynthesis was developed using co-immobilizing β-galactosidase (β-Gal) and l -arabinose isomerase (LFAI) by ST/SC–mediated self-assembly and biomineralization. First, the effects of key immobilization conditions on the fabrication of β-Gal-SC@ST-LFAI were investigated. Under optimal conditions, β-Gal-SC@ST-LFAI exhibited higher catalytic activity and activity recovery than a conventional β-Gal@LFAI. Compared with the free enzyme system, β-Gal-SC@ST-LFAI showed enhanced thermal stability, pH tolerance and organic solvent resistance. The structure of β-Gal-SC@ST-LFAI was further characterized by SEM, CLSM, DLS, FTIR, CD and BET technology. The resulting HNFs displayed a typical flower-like architecture with an average diameter of 1.83 μm and specific surface area of 18.57 m 2 ·g −1 . CD spectroscopy showed a decrease in α-helix content and an increase in β-sheet content in β-Gal-SC@ST-LFAI compared to the free cascade enzymes. In addition, β-Gal-SC@ST-LFAI exhibited a lower K m than the free cascade enzymes, indicating enhanced substrate affinity. The HNFs also demonstrated better storage stability than the free enzymes and excellent operational stability, retaining more than 77.99% of their cascade catalytic activity after seven reuse cycles. Finally, β-Gal-SC@ST-LFAI can catalyze the conversion of d -lactose to d -tagatose with a yield of 37.22%. This study provides a practical strategy for constructing multienzyme HNFs with high catalytic efficiency and process robustness.
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PubMed
高影响因子
Science Bulletin
·
2026
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IF 21.1
Chunhui Gao,Zhenjing Jiang,Jie Chen,Kaining Zhang,Huijun Yang,Ruwei Chen,Hang Yang,Qingjin Fu,Zheng Li,Nana Xu,Mengran Wang,Bo Hong,Feixiang Wu,Wei Zhang,Yanqing Lai
Aqueous zinc-ion batteries (AZIBs) are promising for energy storage. However, Zn anode instability—caused by dendrite growth, hydrogen evolution reaction (HER), and by-product formation—limits their practical viability. HER, in particular, accelerates Zn consumption, disrupts electrode integrity, and induces local alkalization, exacerbating passivation. Conventional strategies emphasize electrolyte formulation and surface passivation, yet few address the underlying electronic origin of HER on Zn. Here we report a catalysis-inspired strategy that electronically modulates Zn reactivity via d-band center engineering to intrinsically suppress HER. By introducing oxalic acid (OA) as a molecular additive, we achieve a significant downward shift in the Zn d-band center (from –6.896 to –7.062 eV), weakening hydrogen adsorption and fundamentally reducing HER activity. In parallel, OA disrupts the Zn 2+ solvation structure by displacing coordinated SO2– 4 anions, suppressing interfacial by-product formation. These dual effects yield unprecedented performance: Zn||Zn symmetric cells operate stably for over 3500 h; Zn||Cu cells exhibit 99.41% Coulombic efficiency over 1500 cycles; and Zn||I 2 cell retain 92.8% capacity after 10,000 cycles; the 1.3 Ah Zn||I 2 pouch cell presents good cyclability. This work pioneers a surface electronic tuning paradigm in battery design, extending catalytic d-band theory to electrochemical interfaces for HER suppression and interfacial stabilization in aqueous metal batteries.
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PubMed
高影响因子
ACS Omega
·
2019
·
IF 2.584
Zifeng Zheng,Zhixiang Cui,Junhui Si,Shengrui Yu,Qianting Wang,Wenzhe Chen,Lih-Sheng Turng
Composite tissue engineering scaffolds show good comprehensive properties, but improving their interfacial binding force is still a challenge. In this study, polydopamine (PDA) was used as a glue-like layer to solve the interface problem in three-dimensional (3-D) porous hydroxyapatite (HA)/thermoplastic polyurethane (TPU) composite scaffolds and to improve their comprehensive properties. The morphology, water absorption, porosity, hydrophilicity, mechanical properties, and cell viability of HA/TPU and PDA/HA/TPU scaffolds were systematically studied. The scanning electron microscopy and X-ray photoelectron spectroscopy results showed that a uniform PDA coating layer successfully formed on the surface of 3-D porous HA/TPU composite scaffolds by dopamine self-polymerization. Moreover, the conjugation effect occurred between the PDA and HA/TPU matrix, resulting in an increase in the interfacial binding force of the 3-D PDA/HA/TPU scaffold. The hydrophilicity of the PDA/HA/TPU scaffolds was significantly higher than those of the TPU scaffolds. Both static and dynamic mechanical property tests revealed that the PDA/HA/TPU scaffold possessed excellent comprehensive mechanical properties, such as high strength, high stiffness, and good flexibility, due to the enhancement of the interfacial binding force. Compared with TPU and HA/TPU scaffolds, the addition of a PDA coating could effectively improve the attachment and viability of mouse embryonic osteoblasts cells (MC3T3-E1) incubated on PDA/HA/TPU scaffolds. These results indicate that the PDA/HA/TPU scaffolds possess great potential to be used as tissue engineering scaffolds, and that the PDA coating could be a simple, practical, effective, and universal approach to modify composite scaffolds.
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高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2026
·
IF 6.7
Di Zhang,Kunpeng Yang,Yuting Fan,Ding Jia,Dejun Ma,Yu-Cheng Gu,Han Xu,Zhen Xi
The development of 1-deoxy-d-xylulose-5-phosphate synthase (DXPS) inhibitors still needs an innovative extension with novel chemotypes to avoid herbicide resistance. Herein, a series of 2,4-diphenylquinoline derivatives were designed, synthesized, and structurally optimized from lead compound 24 via stepwise A/B/C-ring modification. Greenhouse assays identified a-3 (3-CF3 A-ring) as the most potent analogue, exhibiting the higher herbicidal activity (71.4% inhibition on DESSO at 375 g a.i./ha) and dosage tolerance than 24. The mechanism of compound a-3 targeting DXPS proteins has been also identified using surface plasmon resonance binding assay, physiological biomarker measurement, substrate accumulation, and molecular docking. The key active motifs between a-3 and DXPS have been further defined based on the structure–activity relationships. This work will further expand the structural diversity of DXPS inhibitors with higher bioactivity.
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PubMed
高影响因子
DIAMOND AND RELATED MATERIALS
·
2026
·
IF 5.2
Lu Sun,Jie Wei,Qing Hu,Xiuquan Xu,Jing Wu,Yaoyao Cao,Yao Zhang,Haoyan Wu
A Fe/V-CN nanozyme with synergistically enhanced POD-like activity was rationally designed. • A sensitive cascade colorimetric platform for detecting gastric cancer-related D-amino acids was successfully constructed. • The assay supports reliable quantification of D-amino acids in complex human saliva matrices. The development of a practical and reliable cascade colorimetric method for detecting D-amino acids (DAAs) provides a promising tool for the prevention and preliminary diagnosis of gastric cancer. Herein, a bimetallic Fe V supported on graphitic carbon nitride (Fe/V-CN) nanozyme was rationally designed and synthesized via a simple annealing strategy. The atomic dispersion of Fe and V species, along with their coexisting multivalent states (Fe 2+ / 3+ , V 4+ / 5+ ) synergistically boosted the intrinsic peroxidase-like (POD) activity to Fe/V-CN, which were characterized by a high substrate affinity ( K m of 0.078 and 0.083 mM for TMB and H 2 O 2 ) and an accelerated catalytic turnover ( V max of 4.94 × 10 −7 and 7.76 × 10 −7 M·s −1 , respectively). Leveraging this improved activity, a cascade colorimetric sensing system was developed by integrating Fe/V-CN with D-amino acid oxidase (DAAO) for the specific detection of DAAs. The platform exhibited favorable analytical performance for D-proline (D-Pro) and D-alanine (D-Ala), offering wide linear ranges of 0–200 μM and 0–160 μM and low detection limits of 0.93 μM and 1.45 μM, respectively, combined with acceptable selectivity against common interferents. For real-sample analysis, the platform was successfully implemented in determine DAAs in human saliva, delivering satisfactory recoveries (95.8–105.7%) and good precision (RSD < 3.5%). This work presented a synergistic Fe/V bimetallic nanozyme and a practical sensing strategy, demonstrating the feasibility of DAAs detection in complex biological matrices. Download: Download high-res image (70KB) Download: Download full-size image
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产品关联
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高影响因子
Biology-Basel
·
2026
·Vol. 15
·期 18
·1652
·
IF 4.3
Haoyu Chai,Jutao Li,Cuiluan Ma,Yu-Cai He
A sequential two-stage chemo-biocatalytic process was investigated for the conversion ofD-xylose to furfuryl alcohol (FOL), an important furan derivative widely used in the manufacture of resins, polymers, fuels, and other value-added products. In the first stage,D-xylose was dehydrated to furfural (FAL) in a ternary Betaine:Formic acid:Malonic acid–water (Bet:FA:MA–H2O) reaction medium. Under the selected conditions, a FAL yield of 65.8% was obtained from 22.5 g/LD-xylose using 15 wt% Bet:FA:MA at 170 °C for 30 min. For the subsequent bioreduction stage, a recombinantEscherichia colistrain co-expressing the aldehyde reductase EutG and glucose dehydrogenase (GDH) was constructed. Using glucose as a co-substrate, EutG–GDH whole cells were able to reduce commercial FAL at concentrations up to 150 mM under the selected conditions of 40 °C and pH 7.5. For the sequential process using theD-xylose-derived dehydration liquor, the acidic reaction mixture was adjusted to pH 7.5 and diluted from 98.7 to 30.0 mM FAL before whole-cell bioreduction. The conditioned 30.0 mM FAL feed was essentially completely converted to FOL within 24 h. These results demonstrate the laboratory-scale feasibility of sequentially combining Bet:FA:MA–H2O-mediatedD-xylose dehydration with EutG–GDH whole-cell FAL reduction after interstage pH adjustment and dilution.
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