查找使用阿拉丁产品的科研文献

A novel polyurethane microcapsule coated with polyacrylamide using D-sorbitol as chain extender for enhanced oil recovery

Wu Yaowei,Jiang Zuming,Wang Yuhao,Jiang Xiancai,Hou Jian,Wei Bei

Polyacrylamide (PAM) serves as an effective thickening agent for oil recovery. However, its viscosity loss during underground transport significantly reduces oil recovery efficiency in reservoir applications. To solve this problem, polyurethane was selected for microencapsulation of PAM through a simple emulsion polymerization method in this work. It is worth mentioning that non-toxic and renewable D-sorbitol was used as a chain extender in the synthesis of polyurethane microcapsules instead of the commonly used diols or diamines obtained from non-renewable petroleum resources, which has not been reported in previous reports. Mechanical stirring was used to simulate the state of polymer subjected to shear during stratigraphic transport. The releasing performance of the microcapsules was characterized by measuring the change of viscosity with time. Meanwhile, we optimized the ratio of D-sorbitol to achieve the longest release time. Experiments showed that D-sorbitol was feasible as a chain extender for the preparation of microcapsules of polyurethane, and the microcapsules prepared at a concentration of 8% D-sorbitol solution had the longest slow-release time of 75 h at 25 °C and 500 rpm. We also prepared samples with BDO as a chain extender for comparison, and the experiments showed that SO8 has a longer slow-release time and can better meet the demand. The prepared microcapsules SO8 exhibited excellent shear resistance and heat resistance, which was attributed to the rigidity and high cross-linking density brought about by D-sorbitol as a hard chain segment of polyurethane. These PAM-containing microcapsules had a promising application in enhancing oil recovery.

Engineering Brønsted Acidity in Metal-Organic Gels via d⁰-Electron Configuration for Wide-Temperature Anhydrous Proton Conduction

Cuiwen Lu,Wenli Wu,Lingfei Li,Feng Zhang,Jiyu Tang,Siyu Sun,Xiaoqin Zou

The development of solid-state proton conductors that operate efficiently across a wide temperature range, from sub-zero to elevated temperatures, remains a significant challenge, hindered by the inherent limitations of water-dependent materials. Herein, we introduce heterometallic sulfates into a bimetallic metal-organic gel (M/Zr-FA-xerogel) via a one-pot synthesis, resulting in the formation of a hierarchical proton conduction network. This innovative strategy concurrently addresses the quantity, quality, and connectivity of proton carriers. In this network, structural defects enhance carrier concentration, while sulfate groups establish extensive hydrogen-bonding pathways. Importantly, we demonstrate that the intrinsic Brønsted acidity of defect sites can be rationally tuned by manipulating the electronic structure of the dopant.Specifically, the d 0 electronic configuration of Ti 4+ serves as an effective electron sink, significantly reducing the proton dissociation barrier, which is critical for cryogenic transport. This integrated design culminates in an adaptive conduction mechanism that transitions from being dominated by acid strength at low temperatures to being limited by carrier concentration at high temperatures. As a result, the optimized Ti/Zr-FA-xerogel exhibits an exceptional anhydrous conductivity of 1.9 × 10 -3 S cm -1 at 233 K, surpassing its counterpart by 3 orders of magnitude, and 5.0 × 10 -2 S cm -1 at 433 K. This research not only develops a novel design strategy for proton conductors operable across a wide temperature range, but also elucidates the intricate interplay between electronic structure, defect chemistry, and proton dynamics in amorphous coordination polymers.

Synthesis and antibacterial activity of C2 or C5 modified and D ring rejiggered canthin-6-one analogues

Jiangkun Dai,Wenjia Dan,Nian Li,Ruixue Wang,Yao Zhang,Nannan Li,Ruizhi Wang,Junru Wang

Thirty-one canthin-6-one analogues, mainly including C 2 or C 5 or D ring modified canthin-6-ones, were designed and synthesized in order to study their antibacterial activity and structure-activity relationships. The analogue 28 with the highest bioactivity had a peak minimum inhibitory concentration of 4 μg/ml and showed low cytotoxicity against L02 cells and good “drug-like” properties. The antibacterial effect of 28 was characterized further by scanning electron microscopy, cytoplasmic β -galactosidase leakage assay, molecular docking evaluation, UV–visible analysis and isothermal titration calorimetry (ITC) measurement. The results showed that 28 may exert its bactericidal effect by damaging bacterial cell membranes and disrupting the function of DNA topoisomerases, both of which could lead to rapid cell death.

Self-assembled micelles based on Chondroitin sulfate/poly (d,l-lactideco-glycolide) block copolymers for doxorubicin delivery

Hui Zhang,Jiangkang Xu,Liang Xing,Jianbo Ji,Aihua Yu,Guangxi Zhai

Doxorubicin (DOX) is one of the most common chemotherapeutic agents for the treatment of various cancers, but its clinical usage is limited by dose-dependent cardiotoxicity. We have recently synthesized a series of Chondroitin sulfate/poly ( d , l -lactideco-glycolide) block copolymers (Chs- b -PLGA) with different length of hydrophobic block by an end-to-end coupling strategy. The structure of the amphiphilic block copolymers with low critical micelle concentration (∼28   mg/L) were confirmed by 1 H NMR. The copolymers could self-assemble into stable micelles in aqueous environment with homogeneous size distribution and negative zeta potential . The hemolytic study indicated their excellent blood compatibility and potential application for intravenous administration. DOX can be efficiently encapsulated by the Chs- b -PLGA micelles. The DOX-loaded micelles showed a sustained and pH dependent drug release behavior. The cytotoxicity assay showed no associated toxicity with blank micelles while concentration-related cell inhibition with DOX-loaded micelles. Moreover, fast cellular uptake of DOX-loaded micelles was observed by fluorescent microscope. In vivo pharmacokinetics study showed that the Chs- b -PLGA micelles could significantly prolong the blood circulation time of DOX. The maximum tolerated dose (MTD) of DOX-loaded micelles in Kunming mice was about 2-fold higher of the MTD of free DOX, indicating a high tolerance of the DOX-loaded micelles. In conclusion, the Chs- b -PLGA micelles would be a potentially useful drug delivery system for cancer therapy.

Electronegativity-driven d-band center shifts in Ru–Ni alloys for low methane hydrogenolysis of polyolefin plastics

Qianfeng Zhou,Huijie Li,Shengdong Zhang,Changhu Leng,Chuanya Li,Yongchao Wang,Chenyang Ma,Wanglei Wang,Xiaogang Fu,Lei Zhu,Tengshijie Gao,Cheng Wang,Li-Zhu Wu,Zhi-Jun Li

Ruthenium (Ru) catalysts are highly efficient in the hydrogenolysis of polyolefin waste, converting the waste into valuable alkanes. However, excessive C–C bond cleavage of strongly adsorbed olefin intermediates often leads to low-value byproducts, primarily methane (CH4). In this study, we developed a Ru–Ni bimetallic catalyst supported on silica (RuxNiy/SiO2) that directly modulates olefin intermediate adsorption to suppress CH4 formation during polyolefin hydrogenolysis. By alloying low-electronegativity Ni with high-electronegativity Ru, we shift the Ru d-band center through electron transfer from Ni, weakening the adsorption of olefin intermediates. This modification facilitates hydrogenation and desorption pathways while suppressing excessive C–C bond cleavage. The resulting catalyst achieved complete polyethylene (PE) conversion at 250 °C, with 96.9 wt% liquid product yield and only 2 wt% CH4 production. Gasoline- and diesel-range alkanes (C5–C22) accounted for 77.1 wt% of the products. Additionally, the catalyst demonstrated excellent performance with real-world single-use polyolefin products. This work provides a new approach for controlling intermediate adsorption in polyolefin recycling, offering a promising path to enhance the efficiency and selectivity of plastic recycling technologies.

Rhodotorula mucilaginosa JAASSRY Alleviated Oxidative Damage in D-Galactose-Induced Aging Mice by Modulating the Gut Microbiota

Fenghao An,Yanchun Feng,Da Li,Mei Hua,Xiuquan Wang,Xifei Xu,Yuguang He,Xinyu Miao,Mubai Sun,Honghong Niu

As one of the few carotenoid-producing microorganisms,Rhodotorula mucilaginosaremains underexplored for its antioxidant activity. This study investigated the effects ofR. mucilaginosaJAASSRY on D-galactose-induced aging mice. The high-dose JAASSRY (HR) significantly increased body weight by 9.89% compared to the model group (AM), while reducing organ indices of the spleen, liver, kidneys, and brain (p< 0.01). Compared with the AM group, the HR group exhibited increased serum activities of SOD (20.26%), GSH-Px (9.03%), and CAT (133.01%), with a 24.87% decrease in MDA level. In brain tissue, SOD, GSH-Px, and CAT activities increased by 79.49%, 8.45%, and 60.23%, respectively, while MDA decreased by 8.29%.R. mucilaginosaJAASSRY also dose-dependently alleviated structural damage in the hippocampus and spleen and improved motor strength and learning-memory capacity. Furthermore,R. mucilaginosaJAASSRY increased the abundance ofLactobacillusand reducedProteobacteria,Helicobacter, andOscillospira, while enhancing antioxidant capacity by modulating nucleotide, lipid, and carbohydrate metabolism.LactobacillusandPediococcuswere positively correlated with memory latency and CAT/SOD activities (p< 0.05), whereasActinormycesandDehalobacteriumshowed negative correlations. Notably, HR performed comparably or superiorly to β-carotene in improving cerebral oxidative stress and beneficial microbiota, suggesting its potential in neuroprotection and gut–brain axis regulation. In conclusion,R. mucilaginosaJAASSRY mitigates aging-related oxidative damage and behavioral deficits by modulating gut microbiota structure and function, demonstrating its promise as a β-carotene alternative in animal husbandry and functional foods.

Preparation and Properties of Novel Maleated Poly (D, L-lactide-co-glycolide) Porous Scaffolds for Tissue Engineering

Qiao Zhang,Zhihua Zhou,Cheng Peng,Tianlong Huang,Wenjuan Liu,Qingquan Liu,Hu Zhou,Wei Wang,Hua Yan

Three-dimensional biodegradable porous scaffolds play an important role in tissue engineering. A new polymer based on maleated poly(lactic-co-glycolic acid) (MPLGA) was synthesized using direct melt copolymerization from maleic anhydride (MAH), D, L-lactide, and glycolide monomers. MPLGA porous biodegradable scaffolds were prepared by a solution-casting/salt-leaching method. The effects of content and size of the NaHCO3 porogen on the compressive strength of the MPLGA scaffolds were investigated, and the effect of content of the porogen on the porosity of the MPLGA scaffolds was also studied. The results indicated that MAH was grafted onto PLGA successfully and MPLGA scaffolds with interconnective and open pore structure were obtained. Increasing content of NaHCO3 porogen resulted in an increase of porosity and decrease of the compressive strength of the MPLGA scaffolds with the compressive strength of the scaffolds also decreasing with increasing porogen size.

A Common Indoor Pollutant, 1,4-Dichlorobenzene, Induces Colonic Inflammation via Vitamin D Receptor-Reg3γ-Gut Microbiota Axis

Chaoyu Tong,Yang Song,Daniel Schlenk,Jing Liu

1,4-Dichlorobenzene (1,4-DCB), a widely used household insect repellent and fungicide, has been epidemiologically linked to ulcerative colitis, yet its potential mechanisms remain poorly understood. In this study, juvenile male mice developed colonic inflammation following exposure to 1,4-DCB at doses of 0.03–3 mg/kg/day, a range corresponding to the human estimated daily intake (EDI) and relevant internal exposure levels in adolescents. This was evidenced by increased fecal moisture (by 12.22%–18.21%) and colon weight (17.57%–38.33%), shortened colon length (13.51%–24.88%), crypt expansion, and connective tissue hyperplasia. 1,4-DCB exposure upregulated the colonic expression of regenerating family member 3 gamma (Reg3γ), a key antimicrobial peptide that targets Gram-positive bacteria. This upregulation was accompanied by gut microbiota dysbiosis, elevated colonic levels of lipopolysaccharide (LPS) and pro-inflammatory cytokines, as well as decreased levels of tight junction proteins. Microbiota depletion alleviated these colitis symptoms induced by 1,4-DCB. In human colonic cells, we further validated LPS-induced inflammation and impaired permeability as well as identified vitamin D receptor (VDR) as a potential primary molecular target for 1,4-DCB. Overall, this study provides the first evidence that environmentally relevant levels of 1,4-DCB induce colonic inflammation through the VDR-Reg3γ-gut microbiota axis. These findings highlight the potential colonic health risk posed by this prevalent indoor pollutant.

Stable isotope labeling LC–MS for profiling the amine submetabolome in a D-lactate treated cell model

Yue-qiang Chen,Xiao-xia Dong,Li Liu,Xiu-ping Chen,Chen-guo Feng,Li-xing Zhan,Yue Su,Fang Zhang,Yin-long Guo

Background Alterations in the amine submetabolome are closely associated with cellular metabolic status and are important for understanding metabolic regulation under intervention conditions. In this study, a stable isotope labeling derivatization combined with liquid chromatography–mass spectrometry (LC–MS) was employed to characterize alterations in the cellular amine submetabolome. Optimization of chromatographic separation and cellular metabolic quenching procedures improved the separation performance of amine metabolites while enabling more accurate preservation of the metabolic state at the time of sampling. Results The established method was applied to a D-lactate–treated BEAS-2B cell model to evaluate amine submetabolome alterations under different compound intervention conditions. The results demonstrated that selenomethionine (SeMet) and berberine alleviated D-lactate induced abnormalities in the amine submetabolome and showed metabolic regulatory effects consistent with tumor-suppressive trends observed under in vivo experiments. Significance Overall, this analytical strategy enables characterization of the amine submetabolome in complex biological samples and provides a reliable methodological reference for metabolome-based investigations of cellular metabolic alterations.

Assessment of p-Xylene Migration Behaviour in Unsaturated Soil Systems: A 3-D Sand Flow Chamber Study

The influence of soil water content and contaminant injection pressure on the migration behaviour of p-Xylene (one of the organic pollutants in Benzene Toluene Ethylbenzene & Xylene) is investigated in the unsaturated zone using the controlled laboratory sandbox experiments. The results show that, at equivalent migration distances, higher soil water content leads to longer migration durations and reduces transport velocities, whereas greater injection pressure promotes faster contaminant movement. These findings highlight the governing role of water saturation in the water–oil–gas three-phase system, in which increased water content decreases the relative permeability of the oil phase and retards capillary-driven BTEX transport. Unlike many previous studies in which contaminants commonly migrate downward toward the groundwater table, the BTEX in this study did not reach the water table and exhibited partial upward migration. Overall, the results provide experimental-scale insight into key mechanisms governing BTEX transport in unsaturated sandy media and serve as a reference for improving predictions of contaminant fate and migration pathways in field settings.

Shape-Induced d-Band Center Optimization of PdBiNi Nanocubes for Exclusive Oxidation of Glycerol into C3 Products

Zeng Qing,Tamtaji Mohsen,Zhou Rui,Zhou Tao,Guo Zhengxiao,Chen GuanHua,Tse Edmund C. M.

Electrocatalytic oxidation of glycerol toward high-value C3 products on Pd-based catalysts presents a promising strategy for upgrading and converting glycerol. However, C3 intermediates often adsorb too tightly on Pd-based catalyst surfaces during glycerol oxidation, leading to C–C bond cleavage. Herein, cubic-shaped PdBi nanoparticles with tunable Ni doping levels are successfully synthesized through a one-step solvothermal method. Owing to the downshift of d-band center originating from the introduction of Bi and Ni as well as the cubic shape, the PdBiNi ternary nanocubes (NCs) exhibit excellent electrocatalytic performance for the glycerol oxidation reaction (GOR). Specifically, Pd 83 Bi 12 Ni 5 NCs with the lowest d-band center exhibit a specific activity of 61.12 mA cm geo –2 and a mass activity of 5.34 A mg Pd –1 . Notably, the Faradaic efficiency (FE) toward C3 products exceeds 97%. In situ Fourier transform infrared spectroscopy and density functional theory calculations show that key C3 intermediates are easily desorbed from the catalyst surface, thereby suppressing C–C bond cleavage and thus preventing overoxidation into low-value products. In addition, Pd 83 Bi 12 Ni 5 NCs possess long-term durability over the course of 16 cycles (1 h/cycle) with an FE for C3 products between 92.5% and 97.6% upon scale-up deployment in a flow electrolyzer, validating its feasibility in practical operations.

Synthesis and characterization of Eu(III)-based coordination complexes of modified d-glucosamine and poly(N-isopropylacrylamide)

Guihua Cui,Dehai Zhao,Peng Lv,Zhengguo Gao,Shuiying Chen,Nannan Qiu,Toshifumi Satoh,Toyoji Kakuchi,Qian Duan

A series of novel fluorescent complexes was formed by chelation of the thermosensitive polymers with europium(III) ions. The polymers was synthesized via atom transfer radical polymerization (ATRP), which composed of poly( N -isopropyl acrylamide) (PNIPAM) and 2-amino-2-deoxy- d -glucopyranose( d -glucosamine, GA). The aqueous solutions of the polymers and its Eu(III) complexes exhibited a lower critical solution temperatures (LCSTs), and which were approximately equal to body temperature. The maximum emission intensity of the complexes at 613 nm was enhanced by a factor of approximately 10 relative to that of the corresponding Eu(III) chloride. Cell viability assays suggested that these thermosensitive polymers and Eu(III) complexes showed excellent biocompatibility in vitro.