CARBOHYDRATE POLYMERS
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2024
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IF 10.7
Tanjun Deng,Wenli Lu,Xiaoxian Zhao,Haoyu Wang,Yumeng Zheng,Ao Zheng,Zhengyu Shen
Chronic wounds with bacterial infection present formidable clinical challenges. In this study, a versatile hydrogel dressing with antibacterial and angiogenic activity composite of silk fibroin (SF), chondroitin sulfate (CS), and graphene oxide quantum dots (GOQDs) is fabricated. GOQDs@SF/CS (GSC) hydrogel is rapidly formed through the enzyme catalytic action of horseradish peroxidase. With the incorporation of GOQDs both gelation speed and mechanical properties have been enhanced, and the photothermal characteristics of GOQDs in GSC hydrogel enabling bacterial killing through photothermal treatment (PTT) at ~51 °C. In vitro studies show that the GSC hydrogels demonstrate excellent antibacterial performance and induces type H vessel differentiation of endothelial cells via the activated ERK1/2 signaling pathway and upregulated SLIT3 expression. While in vivo results show that the hydrogel significantly promotes type H vessels formation, which related to the collagen deposition, epithelialization and, ultimately accelerating the regeneration of infected skin defects. Collectively, this multifunctional GSC hydrogel, with dual action of antibacterial efficacy and angiogenesis promotion, emerges as an innovative skin dressing with potential for advancing in infected wound healing.
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高影响因子
MICROCHEMICAL JOURNAL
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2024
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IF 4.9
Xiaohong Tan,Wenzhan Li,Wei He,Tingting Yu,Bingbing Wan,Yong Huang,Jintao Liang,Guiyin Li
Glypican-3 (GPC3), which is a surface heparan sulfate proteoglycan, has been widely known the ideal biomarker for diagnosis and treatment of hepatocellular carcinoma (HCC). Accurate and sensitive detection of serum GPC3 level is an important and challenging task. In this paper, a sandwich electrochemical aptasensor was designed to specifically detect serum GPC3 level through aptamer-target-aptamer recognition. A GPC3 aptamer (GPC3 Apt ) immobilized on the surface of gold nanoparticles@reduced graphene oxide modified screen-printed electrode (Au NPs@rGO/SPCE) was used as the capture probe. Hemin-reduced graphene oxide-carboxymethyl chitosan@platinum nanoparticles (H-rGO-CMC@Pt NPs), with good mimicking peroxidases activity, were labeled with amination GPC3 aptamer, which was employed as the signal probe. Once the target GPC3 was anchored on the surface of GPC3 Apt /Au NPs@rGO/SPCE, the H-rGO-CMC@Pt NPs-GPC3 Apt was further specifically bound to the GPC3, forming the aptamer-target-aptamer sandwich structure, which can catalyze the oxidation of hydroquinone (HQ) to benzoquinone (BQ) and lead the oxidation current of HQ recorded by DPV to changing. The linear relationship between the current signal of oxidation of HQ and GPC3 concentration range of 0.0001–3.0 µg/mL and 3.0–60.0 µg/mL, with a low detection limit (LOD) of 0.0685 ng/mL. Additionally, the electrochemical aptasensor was successfully applied for the detection of GPC3 in human serum samples with the recovery of 99.95–104.06 % and relative standard deviation (RSD) of 1.31–5.22 %. Thus, the sandwich aptasensor could provide a new strategy for detection of serum GPC3 level and improve the early diagnosis rate of HCC.
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Food & Function
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2024
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IF 5.1
Qingqing Lv,Aolin Yang,Ziyu Han,Ruirui Yu,Junying Zhu,Zhan Shi,Chenggang Yang,Shimiao Dai,Mengru Hao,Yuqing Chen,Ji-Chang Zhou
Low selenium levels are closely associated with reduced cognitive performance and lipid dysregulation, yet the mechanism of action remains unclear. The physiological function of selenium is primarily mediated by selenoproteins. Selenoprotein H (SELENOH), as one of the selenium-containing proteins, has an unelucidated role in regulating cognitive status and lipid metabolism. In this study, we established a Selenoh gene knockout (HKO) mouse model to investigate whether Selenoh mediates the impact of selenium on cognitive function. We found that HKO mice showed a significant decline in cognition compared with the wild-type (HWT) littermates, and were not affected by deficient or excessive selenium, while no differences in anxiety and depression behavior were observed. HKO mice showed reduced myelin basic protein expression in hippocampal oligodendrocytes, with decreased glycolipid levels and increased phospholipid and sphingolipid levels in the hippocampus. Furthermore, the high-fat diet (HFD) exerted no effect on cognition and limited impact on the gene profile in the hippocampus of HKO mice. Compared with those of HWT mice, the myelination pathways in the hippocampus of HKO mice were downregulated as revealed by RNA-seq, which was further confirmed by the reduced expression levels of myelin-related proteins. Finally, HKO increased the expression of hippocampal fatty acid transporter (FATP) 4, and HFD increased the FATP4 expression in HWT mice but not in HKO mice. In summary, our study demonstrated that HKO induced cognitive decline by impairing myelination in oligodendrocytes with disrupted hippocampal lipid metabolism, which provided a novel viewpoint on the selenoprotein-mediated neurodegenerative diseases of selenium.
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高影响因子
JOURNAL OF MOLECULAR LIQUIDS
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2024
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IF 5.3
Qihui Ding,Qian Shan,Qi Zhang,Mengda Chen,Ding Cai,Wei Wu
Hexagonal boron nitride (h-BN) with a large specific surface area and unique optoelectronic properties has good application prospects in many fields. The liquid phase exfoliation method is considered the most promising method for achieving controllable preparation of boron nitride nanosheets (BNNSs), but the low-cost, relatively environmentally friendly and efficient liquid phase exfoliation is still difficult to achieve. Choosing a suitable solvent system is the key to achieving efficient exfoliation. Deep eutectic solvents (DESs) have the advantages of simple synthesis, low cost, high thermal and chemical stability and strong biocompatibility and are expected to be green solvents for preparation of BNNSs . In this paper, it was found that the properties of DESs and its interaction with h-BN had a significant impact on the electrochemical exfoliation of h-BN. The intercalation effect of DES and the compatibility between DES and h-BN were the main factors affecting the yield, while the quality of BNNSs mainly depended on the decomposition and expansion effect of DES. This rule also can be applied to prepare highly conductive and hydrophilic two-dimensional material Ti-MXene. This research explores the structure–activity relationship between two-dimensional materials and DESs, and provides a theoretical basis for the environmentally friendly and efficient preparation of two-dimensional materials using DESs as exfoliation solvents.
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ACS Nano
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2024
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IF 15.8
Xu Li,Wenlong Tan,Jinsong Fan,Kun Li
Although the past decade has witnessed a rapid development of oxidoreductase-mimicking nanozymes, the mimicry of cofactors that play key roles in mediating electron and proton transfer remains limited. This study explores how surface Au–H species conjugated to Au nanoparticles (NPs) that imitate formate dehydrogenase (FDH) can serve as cofactors, analogous to NADH in natural enzymes, offering diverse possibilities for FDH-mimicking Au nanozymes to mimic various enzymes. Once O2 is present, Au–H species assist Au NPs to complete the on-demand H2O2 generation for cascade reactions. Alternatively, when oxidizing organic molecules are introduced as substrates, Au–H species confer nitro reductase- and aldehyde reductase-like activities on Au NPs under anaerobic conditions. Furthermore, similar to the dehydrogenase–NADH complex, Au NPs possessing Au–H species are gifted with esterase-like activity for ester hydrolysis. By revealing that Au–H species are prosthetic groups for FDH-mimicking Au nanozymes, this work may inspire explorations into future self-generated cofactor mimics for nanozymes, thereby circumventing the need for exogenous cofactors.
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NEW JOURNAL OF CHEMISTRY
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2025
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IF 2.5
Xiao-Jian Li,Xinli Lu,Yunxia Wang,Zhanquan Zhang,Yongfa Zhang
This study successfully developed a highly sensitive electrochemiluminescence (ECL) sensor based on the ECL resonance energy transfer mechanism for detecting the key biomarker of acute myocardial infarction, heart–type fatty acid binding protein (h–FABP). Through the meticulous design of the Ag/Cu2O/Ti3C2 ternary nanocomposite material, this material demonstrated significant catalase–like catalytic activity, enabling the efficient decomposition of H2O2 to generate more superoxide radicals (O₂•⁻), thereby significantly enhancing the ECL signal of the luminol–H2O2 system. Notably, AgS quantum dots (AgS QDs), due to broad–spectrum ultraviolet absorption overlapping with the ECL emission spectrum of luminol, triggered an efficient energy resonance transfer effect, resulting in the decrease of ECL intensity. NH2–MIL–101(Fe) was utilized to couple with AgS QDs (AgS QDs@NH2–MIL–101(Fe)), which can further enhance the quenching efficiency. Based on this signal–off strategy, an ultrasensitive detection platform for h–FABP was successfully constructed. Experimental results indicated that the immunosensor exhibited an excellent response relationship within a wide linear range from 1.00 fg mL–1 to 100 ng mL–1, and a low detection limit reached 0.36 fg mL–1 (S/N = 3). This study provides an innovative methodological approach for ultra–trace detection of myocardial injury markers and demonstrates significant application potential in early clinical diagnosis.
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Advanced Science
·
2025
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IF 14.1
Jingting Jin,Wenzhi Li,Liqun Wang,Lulu Zhang,Xia Zhang
Direct and efficient methane oxidation to methanol is an appealing route for upgrading abundant methane resources while acquiring building blocks of clean fuels and chemicals. However, owing to its highly symmetrical nature imparted chemical stability and steric hindrance, the design of multi-ångstrom (<3.0 Å) spaced active species capable of activating its first C−H bond remains a fundamental challenge. Herein, Cu−Ni dual-atom Pair is constructed using defect engineering and a stepwise deposition method over indium oxide to precisely modulate the C−H polarization with the Cu atom showing affinity to H end and Ni anchoring the C side. The optimal CuNi/InNT achieves an oxygenates (CH 3 OH and CH 3 OOH) productivity of 106 mmol g cat h −1 , surpassing reported systems. Theoretical calculations validate the dominating role of interatomic distance for methane activation. Specifically, the dual-atom orbital coupling effect in the minimally spaced Cu−Ni pair up-shifts the overall d-band center, significantly enhancing its hybridization with C/O 2p. Further modification through macroscopic reactor design boosts CH 3 OH yield to 36818.84 µmol g cat h −1 with 79.37% selectivity in a 1000 mL semi-industrial prototype. This work provides a comprehensive explanation of the Cu−Ni synergy, bridging atomic-scale catalysis with reactor design, and establishes a common design principle for binary catalysts at the electron and orbital level.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-9
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IF 15.7
Dong Anrui,Lin Gaoxin,Li Zhiheng,Wu Wen,Cao Xing,Li Wenlong,Wang Linqin,Zhao Yilong,Chen Dexin,Sun Licheng
The mechanical stability of the catalytic electrodes used for hydrogen evolution reactions (HER) is crucial for their industrial applications in anion exchange membrane water electrolysis (AEM-WE). This study develops a corrosion strategy to construct a self-supported electrocatalyst (Int-Ni/MoO 2 ) with high mechanical stability by anchoring the Ni/MoO 2 catalytic layer with a dense interlayer of MoO 2 nanoparticles. The Int-Ni/MoO 2 exhibits a strengthened homostructural interface between the interlayer and catalytic layer, preventing the detachment of the catalyst during ultrasonic treatment. The blade-shaped catalytic layer reduces bubble shock and potential fluctuations at high current densities up to −6000 mA cm −2 . As a result, the Int-Ni/MoO 2 electrode exhibits a low overpotential of 73.2 ± 14.2 mV and long-term stability for 6000 h at −1000 mA cm −2 in a 1 M KOH solution. The Int-Ni/MoO 2 assembled AEM-WE device demonstrates long-term stability at 1000 mA cm −2 for 1000 h with a very low degradation rate of 3.96 µV h −1 .
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CHEMICAL ENGINEERING JOURNAL
·
2025
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IF 13.2
Mengting Liu,Fu Yang,Hongyao Zhao,Xiu Zhong,Ruiting Ni,Kwame Nana Opoku,Zhenxiao Wang,Yangping Zhang,Yanyun Wang,Feng Zeng,Yinlong Zhu,Weidong Shi
In electrochemical nitrate reduction reaction (NITRR), the generation of active hydrogen (*H) and its poor utilization in conversion of various nitrate intermediates often cause mismatched kinetics, resulting in low ammonia yield rate (YR NH3 ) and Faraday efficiency (FE NH3 ). Herein, we construct a spatially-confined Cu/Fe 2 O 3 heterointerfaces within porous carbon fiber, featuring oxygen vacancy-rich iron oxide nanoparticles (∼14.7 nm) interface-coupled well-dispersed Cu nanocrystals. The interfacial metallic copper sites with optimized interfacial electron transfer accelerate the consumption of NO 2 – through supplying the most abundant active *H to equilibrate NITRR kinetics. The easy desorption of generated NH 3 from active sites facilitates the accelerated reaction cycles by rapidly exposing the spent active sites. Correspondingly, this catalyst achieves nearly 100 % nitrate conversion, with a YR NH3 of 81.3 mg h −1 mg cat -1 , FE NH3 of 98.11 %, and 100 % NH 3 selectivity without any nitrite accumulation, outperforming most state-to-art catalysts as reported. Impressively, when nitrite acts as reactant, ammonia synthesis through nitrite reduction reaches YR NH3 of 99 mg h −1 mg cat -1 and FE NH3 of 99.44 % outperforming all the same series reported. Moreover, active *H quenching and isotope labeling experiments uncover the generation of the most abundant active *H species and their high utilization among the reported results. Density function theory (DFT) calculations further indicate the interfacial Cu/Fe 2 O 3 regulates the d-band center of the catalyst, optimizing the adsorption of nitrate and further lowering the reaction energy barrier of the decisive step (*NO→*NOH).
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SEPARATION AND PURIFICATION TECHNOLOGY
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2025
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IF 9
Shaohui Xiong,Xingyi Ou,Qingquan Liu,Yiwen Li,Juntao Tang,Guipeng Yu,Chunyue Pan,Shibo Guo,Sitong Li,Menghan Yong
Polymers of intrinsic microporosity (PIM) have attracted considerable attention in the development of mixed matrix membranes (MMMs) for CO 2 separation. A prominent challenge lies in engineering the spacing of the polymer matrix chains while eliminating non-selective interfacial defects. In this study, a CO 2 -philic triazine-based porous polymer, featuring robust hydrogen bond donating groups, was employed to fabricate a series of interfacial defect-free PIM-1 based MMMs (denoted as PIM-1/CSU-1). The interfacial adhesion and compatibility have been greatly improved due to the strengthened hydrogen bond interaction, which was systematically validated through variable-temperature infrared spectroscopy. Additionally, the formation of hydrogen bonds allowed for the regulation of the polymer matrix chain spacing, making the chain distance loose. Remarkably, the resulting membrane exhibited a CO 2 permeability of 13,429 Barrer and CO 2 /N 2 selectivity of 33.1—246.6% and 70.2% higher than pristine PIM-1, respectively, surpassing the latest Jansen/McKeown upper bound established in 2019, but also significantly exceed the performance of previously reported MMMs for CO 2 separation. The strategy of mitigating interfacial defects through the formation of hydrogen bonds between fillers and the polymer matrix emerges as a viable and effective method for fabricating gas separation membranes with exceptional separation capabilities.
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CHEMICAL ENGINEERING JOURNAL
·
2020
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IF 10.652
Kezhu Xu,Jin Wu,Qunling Fang,Linfeng Bai,Jinyu Duan,Jiaxing Li,Huajian Xu,Ailing Hui,Lingyun Hao,Shouhu Xuan
The organic pollutants and heavy metal ions are critical harmful substances in waste water because they destroy the ecological systems and lead diseases to animals and human beings. Unfortunately, the simultaneously remove of them in one system is still a challenge due to their different treating mechanism. Herein, a novel magnetic h-Fe 3 O 4 @Au/Polydopamine (Au/PDA) hybrid hollow nanosphere which can both absorb the potentially toxic U(VI) ions and catalyze the reduction of the 4-nitrophenol is reported. By using a simple in situ redox-oxidizing polymerization method, the h-Fe 3 O 4 hollow nanosphere is well encapsulated by the Au/PDA hybrid shell to form the dual-functional magnetic hollow nanocomposites. Owing to the hollow interior, uniform and functional PDA coating, and high active Au nanocrystals, the final h-Fe 3 O 4 @Au/PDA hollow nanosphere possesses high potential in nanocatalysis, heavy metal ions adsorption, and drug delivery. Because of the PDA protection, the h-Fe 3 O 4 @Au/PDA nanosphere can even keep 90% activity after 7 cycling catalytic reactions on reduction of 4-nitrophenol. Similarly, the h-Fe 3 O 4 @Au/PDA exhibits a good adsorption effect for U(VI) in nuclear waste and its adsorption capability reaches to 82.9 mg·g −1 by 6 successive adsorption–desorption experiments. Due to the facile magnetic separation, the h-Fe 3 O 4 @Au/PDA nanosphere can be easily collected by applying an external magnetic field. In summary, such a multifunctional recyclable h-Fe 3 O 4 @Au/PDA nanosphere with green and facile synthesis, easy manipulation, efficient adsorption performance and good catalytic activity possesses broad application potential in treatment of coexisting toxic water pollution.
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Scientific Reports
·
2022
·Vol. 12
·期 1
·1-12
·
IF 4.996
Zhu Xinhe,Fu Jingguo,Ma Dengqing,Ma Chunsheng,Fu Yunyang,Zhang Zhuokai
A composite ceramic coating containing h-BN particles was prepared on the ZL109 alloy via plasma electrolytic oxidation. The h-BN particles were modified by Polyethylene glycol to improve the dispersibility. The results revealed that the h-BN particles in the electrolyte were inertly incorporated into the coating. Meanwhile, the incorporation of h-BN particles can reduce the porosity and slightly increase the roughness of the composite ceramic coating. Furthermore, the growth rate of the coating and the conversion of γ-Al 2 O 3 and α-Al 2 O 3 were promoted by the incorporation of h-BN particles via the change of the current. In addition, due to the presence of h-BN particles, the composite ceramic coating had a lower friction coefficient and a lower wear rate under dry sliding condition.
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