Scientific Reports
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2026
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IF 4.9
Zu Kaiyang,Xue Jionghao,Wang Yicong,Li Zhonghan,Gao Jianping,Chen Yu,Luo Xi,Ju Lili,Wang Hao
The study aimed to characterize the regional histological architecture, collagen type I/III composition, and biomechanical properties of human dura mater to provide insights for the biomimetic design of dural repair substitutes. Dura from nine formalin-fixed cadavers were harvested from four anatomical regions: the cranial calvaria, skull base, cervical enlargement, and lumbosacral enlargement. Histological architecture and collagen type I/III composition were assessed using H&E and picrosirius red staining; elastic fibers were visualized with aldehyde fuchsin staining. Collagen type I/III contents were quantified by LC–MS/MS. Mechanical properties, including thickness, ultimate tensile strength, elastic modulus, elongation at break, and toughness, were determined by uniaxial tensile testing. Prototype patches were fabricated using a collagen type I/III blend and mechanically compared against those made from type I collagen alone using uniaxial tensile testing. Cranial dura exhibited four to five interwoven collagen lamellae, whereas spinal dura comprised three predominantly longitudinal layers. Low levels of collagen III were detected in both cranial and spinal dura. Cranial samples were dominated by collagen I with lower collagen III/I ratio, whereas spinal dura showed a relatively higher collagen III/I ratio, mainly attributable to lower collagen I content rather than an increase in absolute collagen III content. Elastic fibers were sparse in cranial dura, least abundant at the skull base, and most abundant in the lumbosacral region. Tensile tests showed that spinal dura had higher elastic modulus than the calvaria. The lumbosacral region exhibited greater tensile strength, elongation at break, and toughness than the calvaria, and higher tensile strength than the skull base. Correlation analyses suggested regional collagen subtype ratio and elastic fiber abundance were associated with elastic modulus. In the preliminary proof-of-concept tensile comparison, patches incorporating 20% type III collagen exhibited increased elongation at break and higher ultimate tensile strength than type I collagen-only control patches. Human dura mater displays pronounced site-dependent structure-composition-mechanics relationships. Regional variations in architecture, collagen type I/III ratio and elastin abundance help explain the distinct mechanical characteristics in cranial and spinal dura. The findings provide a basis for the design of biomimetic dural graft to improve repair outcomes.
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高影响因子
JOURNAL OF FLUORESCENCE
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2026
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IF 3.4
Liu Xiujin,Lai Gengneng,Shu Zongcheng,Li Wei,Ke Fang
Thyroid-associated ophthalmopathy (TAO) is a complex autoimmune inflammatory disease. There is an urgent clinical need for highly sensitive and minimally invasive biomarkers to enable early diagnosis and dynamic disease monitoring. Among them, miR-320a has been confirmed to be closely associated with oxidative stress regulation, fibroblast activation, and fibrosis progression. However, current detection methods, especially those based on real-time quantitative polymerase chain reaction (RT-qPCR), still suffer from cumbersome procedures, high instrumentation costs, and limited adaptability for rapid point-of-care diagnostics. To address this, we developed a nanozyme-assisted colorimetric biosensing platform integrating target-triggered probe hybridization with Co-g-C 3 N 4 , which exhibits enhanced peroxidase-like activity and stability. The method involves Co-g-C 3 N 4 synthesis, probe-nanozyme interface construction, catalytic optimization, and colorimetric detection via TMB oxidation, validated in spiked serum and with smartphone readout. The platform achieves sensitive miR-320a detection down to picomole levels with excellent linearity and specificity. In spiked human serum analysis, it reliably quantifies endogenous miR-320a with strong recovery rates (94.6-108.9%). However, we acknowledge that direct clinical validation using confirmed TAO patient samples is required for full diagnostic implementation, and this represents a limitation of the current study. Generally speaking, this work provides a portable, cost-effective, amplification-free colorimetric nanozyme platform for miRNA detection, requiring only basic laboratory equipment, and holding significant promise for point-of-care precision diagnostics in autoimmune and fibrotic diseases.
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CHEMICAL ENGINEERING JOURNAL
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2026
·
IF 12.5
Enxiu Liu,Jing Zhao,Shixuan Wang,Yanzhuo Zhang,Xueting Song,Jinghua Lv,Xiaozhuan Zhang,Jianbiao Peng,Alexandr V. Bildyukevich
N/NS co-doping boosts PAA activation, removing 97.5% sulfonamides in 30 min. • EPR and electrochemistry verify dual-channel degradation dominated by 1 O 2 . • DFT confirms 1 O 2 -induced N-S scission and ring opening mitigate toxicity. • DOM-antibiotic complexation negligibly impacts degradation efficiency. Element-doped biochar has emerged as an effective catalyst for activating peracetic acid (PAA) toward antibiotic degradation. However, the electron transfer processes occurring at the biochar interface remain insufficiently understood. In this study, N-doped biochar (NBC) and N/S co-doped biochar (NSBC) are employed to efficiently degrade sulfonamide antibiotics through PAA activation. Active sites, including pyridinic N, thiophene S, and graphitic defects, synergistically promote PAA activation, preferentially generating singlet oxygen ( 1 O 2 ) accompanied by •OH and O 2 •− . Radical and non-radical pathways operate simultaneously, resulting in an average removal efficiency of 97.45% for the target sulfonamides within 30 min. Quenching experiments, electron paramagnetic resonance, and electrochemical analyses collectively confirm the dual-pathway activation mechanism. Liquid chromatography-mass spectrometry combined with density functional theory calculations reveals that the main transformation pathways involve S N bond cleavage, aromatic ring opening, and hydroxylation reactions. Toxicity prediction and plant growth assays further demonstrate a significant reduction in the overall toxicity of the degradation intermediates. In addition, dissolved organic matter released during the biochar reaction process forms complexes with sulfonamide antibiotics, although these interactions are insufficient to substantially affect antibiotic degradation efficiency. Overall, this study not only elucidates the multi-channel activation mechanism of the NBC/NSBC-PAA system but also provides experimental support for the practical application of biochar-based catalytic systems in water purification. Download: Download high-res image (110KB) Download: Download full-size image
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MICROCHEMICAL JOURNAL
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2026
·
IF 5.2
Minghui Wang,Qiaolin Guo,Zhenyong Hu,Yue He,Lai Zhang,Cuifei Chen
An ultrasensitive biosensor has been developed for miR-375 detection. • HRP is embedded into COFs to form stable HRP@COFs co-precipitated nanospheres. • The HRP@COFs preserved enzymatic activity and enhanced catalytic efficiency. • The biosensor has been successfully validated using clinical samples. The dysregulated expression of microRNA (miRNA) in various cancers has attracted considerable attention owing to their crucial roles in tumor initiation and progression. Among them, miR-375 has been recognized as a prospective biomarker for early malignancy detection and therapeutic monitoring. In this study, a highly sensitive electrochemical biosensor has been developed based on horseradish peroxidase (HRP)-embedded covalent organic framework (HRP@COFs) co-precipitated nanospheres for the detection of miR-375. The HRP@COFs nanocomposite effectively preserves the enzymatic activity of HRP while providing the structural stability and high loading capacity of COFs, thereby enhancing catalytic efficiency and signal amplification. In the presence of target miR-375, the azide-modified H1 hairpin probes on the HRP@COFs surface are activated, leading to the formation of a rigid H1-H2 duplex structure through competitive hybridization with H2 hairpins. The resulting H2-H1-HRP@COFs complexes are subsequently anchored onto the electrode surface via click chemistry. Upon the addition of H 2 O 2 , HRP catalyzes aniline polymerization and deposition, resulting in a significant electrochemical response. This biosensor achieves ultrasensitive detection of miR-375 with a detection limit as low as 230 aM. It has been successfully validated using clinical samples, demonstrating great potential for reliable breast cancer diagnosis. This work highlights the synergistic advantages of integrating HRP with COFs, providing a robust and efficient platform for microRNA detection and expanding the applications of COFs-based materials in biosensing and clinical diagnostics. Download: Download high-res image (151KB) Download: Download full-size image
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Chao-Peng Liang,Fang-Fang Liu,Zhi-Xiang Zhang,Dong-Mei Cheng,Xiang-Jun Rao
The WPU matrix promotes fungal growth, spore germination, and tolerance to UV, thermal, and chemical stresses. • WPU enhances conidial retention on maize leaves and improves insecticidal efficacy. • WPU-encapsulated conidia evade host immune recognition, reducing immune clearance and facilitating infection. • Transcriptomic analysis identified key genes and pathways associated with WPU-mediated growth promotion and UV resistance. Environmental fragility and host immune clearance remain major barriers to the field efficacy of entomopathogenic fungi in agricultural pest management. In this study, we developed a bio-based nanocarrier using self-assembled, castor oil-derived waterborne polyurethane (WPU) to encapsulate Beauveria bassiana conidia. The resulting WPU nanodispersion (∼34.8 nm) formed a stable coating on the conidial surface through interfacial self-assembly. Encapsulation significantly improved conidial germination and fungal development while enhancing tolerance to ultraviolet irradiation, thermal stress, and chemical stress. Maize phylloplane assays showed that the WPU matrix acted as an adhesion-promoting coating, substantially increasing rainfastness and environmental persistence. Functional assays and microscopic observations indicated reduced hemocyte recognition and phagocytic clearance of WPU-coated conidia, suggesting attenuated early immune elimination during infection. Comparative transcriptomic analysis of encapsulated and unencapsulated conidia under basal and UV-stress conditions revealed differential expression of genes associated with DNA repair, antioxidant defense, and cuticle-degrading enzyme activity, indicating stress-related transcriptional changes. Overall, these results suggest that castor oil-based WPU functions both as a protective coating and as a biologically interactive matrix. This study provides mechanistic insight into polymer-mediated enhancement of entomopathogenic fungi and offers a practical framework for developing high-performance, environmentally stable mycoinsecticide formulations. Download: Download high-res image (337KB) Download: Download full-size image
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Yuxiang Deng,Zhenyu Cai,Libo Yang,Zhiyao Wu,Bihong Chen,Chang Gao,Xinyu Yu,Nannan Wang,Xinpeng Wang
3DOM-TiO 2 /CuO S-scheme heterojunction synthesized via hard templating • Removes 99.06% U(VI) in 120 min; capacity of 1751.33 mg/g • Dynamic Cu valence change & O-vacancy evolution restrain charge recombination. • In situ multi-spectra & DFT reveal charge transfer and U(VI) reduction mechanism. Photocatalysis offers a sustainable approach for uranium-containing wastewater remediation, yet conventional materials still suffer from limited solar-light utilization and rapid charge recombination. Herein, a three-dimensional ordered macroporous TiO 2 /CuO composite (3DOM-TC) was synthesized using resorcinol–formaldehyde resin spheres as a hard template. The ordered macroporous TiO 2 framework enables slow-photon-assisted light harvesting and multiple light scattering, while CuO coupling broadens the light-response range and constructs an S-scheme TiO 2 /CuO heterojunction to promote directional charge separation. Meanwhile, oxygen vacancies mainly serve as electron-trapping and O 2 /intermediate adsorption–activation sites, which are coupled with the dynamic Cu 2+ /Cu + variation during photocatalysis. As a result, 3DOM-TC achieves 99.06% U(VI) removal within 120 min, corresponding to a maximum extraction capacity of 1751.33 mg/g. Photoelectrochemical tests confirm enhanced photocurrent density and efficient interfacial charge transport compared with pristine TiO 2 . In situ EPR, XPS, and DFT calculations reveal the photoinduced charge-transfer pathway and illumination-enhanced oxygen-vacancy signals. Moreover, in situ FTIR spectroscopy confirms that photogenerated ·O 2 − can further convert to H 2 O 2 -related species, thereby promoting U(VI) precipitation as (UO 2 )O 2 ·4H 2 O. This work highlights the synergistic integration of 3DOM-enabled light harvesting, S-scheme charge separation, and vacancy-assisted electron transfer and O 2 activation, providing a promising strategy for efficient photocatalytic U(VI) sequestration. Download: Download high-res image (232KB) Download: Download full-size image
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JOURNAL OF MEMBRANE SCIENCE
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2026
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IF 8.8
Yanqing Qu,Jiahao Li,Xiaoyu Du,Hongge Jia,Jingyu Xu
With the acceleration of industrialization, oily wastewater poses a serious threat to the ecological environment. Membrane separation technology has emerged as a research hotspot due to its advantages of high efficiency and energy savings; however, membrane fouling significantly restricts its long term stable operation. This study introduces a 3D COFs/MXene composite membrane with photocatalytic self–cleaning capability for highly efficient oil–water separation. A well dispersed 3D COFs colloidal dispersion was prepared via oil–oil–water three phase interfacial polymerization, effectively overcoming the dispersion challenges of COFs materials. Ti 3 C 2 T x MXene nanosheets were synthesized using the LiF/HCl etching method. Using intermolecular hydrogen bonding, the two components were ultrasonically assembled, and a COFs/MXene composite membrane was fabricated via vacuum assisted filtration. The membrane exhibits excellent hydrophilicity (water contact angle as low as 54.3°) and underwater oleophobicity (underwater oil contact angle up to 144.9°). Under visible light irradiation, the MXene component generates reactive oxygen species (·O 2 − and ·OH), enabling photocatalytic degradation of oil contaminants adsorbed on the membrane surface and thereby imparting self–cleaning functionality. Separation performance tests reveal that the composite membrane achieves efficient separation of various oil–in–water emulsions, with a maximum water flux of 1918.9 L m −2 h −1 bar −1 . The flux for n –hexane emulsion increased to 2.1 times that of pure MXene membrane, while maintaining a rejection rate above 98.8%. Moreover, the membrane demonstrates excellent cycling stability and photocatalytic antifouling performance. This research offers a novel strategy for developing self–cleaning separation membranes and holds promising potential for application in oily wastewater treatment.
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MICROCHEMICAL JOURNAL
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2026
·
IF 5.2
Yinuo Liu,Zhengyuan Dai,Ying Wang,Shanshan Fu,Xiaoyu Yang,Jingcui Huang,Li Li,Yaping Ding
Ratiometric probe (blue/yellow CDs) offers visual color change and improved accuracy. • Molecularly imprinted polymers provide high selectivity against food interferents. • Smartphone with Color Picker App enables on-site visual quantitative detection. • Successfully applied to milk and ice cream with recoveries of 95.6–104.2%. A ratiometric fluorescence sensor (B-CDs@MIPs/Y-CDs) based on blue/yellow dual-emission carbon dots and molecularly imprinted polymers was constructed for visual detection of vanillin. The addition of vanillin resulted in selective quenching of the blue fluorescence of B-CDs at 438 nm via static quenching, whereas the yellow emission at 542 nm stayed constant, leading to a progressive color shift from blue to green and ultimately to yellow. Under optimized conditions, the linear range was 2.0–120.0 μM with a detection limit of 0.22 μM. Recoveries from spiked milk and ice cream samples ranged from 95.6% to 104.2% (RSD < 1.77%). Combined with a smartphone using the Color Picker App for RGB analysis, rapid visual detection was achieved. This method is low-cost, easy to operate, and sensitive, showing great potential for food safety monitoring. Download: Download high-res image (125KB) Download: Download full-size image
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CATALYSIS LETTERS
·
2026
·Vol. 156
·期 8
·220
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IF 2.5
Shi Yinhu,Ma Jiping,Zhang Yunwei,Wang Shuwei,Wang Xinhong
The selective and sustainable production of methyl lactate from biomass-derived polyols remains a significant challenge due to the frequent requirement of homogeneous bases. Herein, an integrated Au/CuO catalyst is reported for the base-free oxidative esterification of 1,2-propanediol to methyl lactate. The Au/CuO catalyst exhibits superior catalytic performance compared with Au supported on other oxides, affording high conversion and selectivity under optimized conditions. Systematic studies reveal that moderate Au loading and reaction conditions are crucial for suppressing over-oxidation and C-C bond cleavage. Mechanistic investigations suggest that the reaction proceeds via parallel oxidation pathways involving both primary and secondary hydroxyl groups, while the Au-CuO interface plays a key role in regulating intermediate oxidation and stabilizing methyl lactate. This work highlights the importance of metal-oxide interfacial effects in base-free oxidative esterification and provides a sustainable route for methyl lactate production from renewable polyols. Graphical
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Science China-Chemistry
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2026
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IF 9.8
Luo Yuxin,Zhang Yipeng,Li Ji,Wu Xinyuan,Huang Kang,Ni Zhigang,Zhu Youlong
Organic cathode materials (OCMs) with high capacity, fast-charging ability, and long-term cycling stability are crucial for advancing sustainable and high-performance lithium-ion batteries (LIBs). Herein, we report two bipolar porous organic polymers (POPs) featuring densely distributed redox-active centers and arylamine linkage as high-performance OCMs (denoted as HATN-3AQ and HATN-3AB). The deliberate incorporation of multiple redox-active sites and arylamine moieties enhances electronic delocalization and enables efficient bipolar redox activity. Meanwhile, the porous framework promotes efficient electrolyte penetration, accelerates rapid Li + transport, and exposes a large number of redox-active sites. Benefiting from these synergistic structural and electronic advantages, the HATN-3AQ cathode delivers a high reversible capacity of 219.5 mAh g −1 at 0.1 A g −1 , together with an exceptional rate capability of 136.9 mAh g −1 at a high current density of 20 A g −1 (≈68 C), enabling the fast-charging of an energy output of 249.5 Wh kg −1 within 1 min. Moreover, it exhibits outstanding cycling durability, retaining 82.1 mAh g −1 after 4000 cycles at 10 A g −1 . DFT calculations in combination with comprehensive ex situ characterizations were performed to further elucidate the dual-ion storage mechanism for both bipolar POPs during the charge-discharge process. This study establishes a general molecular-engineering approach for constructing OCMs with high capacity, ultrafast charging capability, and long cycle life, and highlights bipolar POPs as a promising and versatile platform for sustainable LIBs.
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npj Science of Food
·
2026
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IF 9.7
Shi Yuxuan,Sun Jiayi,Chen Lin,Xu Shuang,Guo Shasha,Xu Anan,Ye Qun,Wang Yuefei,Xu Ping
While black tea’s oxidized polyphenols hold potential for gut health, the specific protective mechanisms of its ethanol-soluble fraction (BES), particularly regarding host-microbiota interactions, remain poorly defined. This study elucidated the dual mechanisms through which BES ameliorates dextran sulfate sodium (DSS)-induced colitis in mice. By integrating network pharmacology, molecular docking/dynamics simulations, RT-qPCR, and Western blot analysis, we identified the PI3K/AKT signaling axis as a potential host target. Our findings suggest that key flavonoid constituents stably bind to critical nodes, potentially downregulating the expression and activation of pathway components. Concurrently, 16S rRNA sequencing and metabolomics revealed that BES reshaped gut microbiota by suppressing Akkermansia and enriching SCFA producers such as Lactobacillus , restoring fecal SCFA levels. Fecal microbiota transplantation confirmed that BES-modulated microbiota alone transferred protection. Thus, BES acts concertedly through direct PI3K/AKT inhibition and indirect microbiota-SCFA modulation, providing a mechanistic basis for targeted use of black tea fractions in intestinal inflammation.
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高影响因子
APPLIED SURFACE SCIENCE
·
2026
·
IF 6.6
Mingzhen Wu,Jiushuai Deng,Jiaozhong Cai,Hao Zhang
TP enables the selective flotation separation of hematite from quartz. • TP is selectively chemisorbed onto the hematite surface. • TP is a natural, biodegradable, and water-soluble depressant. This paper investigated the selective depression of hematite by tea polyphenols (TP) in a cationic collector dodecylamine (DDA) system. Micro-flotation results indicate that, under natural pH conditions, when the DDA concentration was 2 × 10 -4 mol/L and the TP concentration was 2 × 10 -3 mol/L, the artificially mixed ore achieved satisfactory flotation indexes: an iron grade of 65.68% and a recovery of 87.75%. Contact angle test results indicate that TP could significantly reduce the hydrophobicity of hematite surfaces while exerting a minor effect on quartz. FTIR and XPS analyses indicate that TP was chemisorbed on the surface of hematite. Frontier molecular orbital analysis shows that the phenolic hydroxyl group served as the primary reactive site of the TP molecule. Molecular dynamics simulation results reveal that TP exhibited stronger interaction with hematite than with quartz, with interaction energies of approximately −56.44 kcal/mol and −27.80 kcal/mol, respectively. Therefore, TP, as a selective and biodegradable depressant for hematite, is expected to be applicable to the flotation separation of hematite and quartz. Download: Download high-res image (96KB) Download: Download full-size image
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危险品化学品经营许可证（带存储）