MICROCHEMICAL JOURNAL
·
2026
·
IF 5.1
Jiarong Chen,Hao yang,Hongyun Li,Qiang Wu,Yibo Wang,Wen Zeng,Zhen Han,Quansheng Ouyang,Cheng Chen
A hierarchical modification strategy involving In doping and subsequent PdO loading was developed to significantly enhance the acetone sensing properties of BiVO 4 . The pristine BiVO 4 (BVO), In-doped BiVO 4 (In-BVO), and PdO-loaded In-BiVO 4 (Pd/In-BVO) were systematically synthesized and evaluated. The gas sensing results demonstrated that the response to 100 ppm acetone was substantially improved from 10 (BVO) to 15 (In-BVO) and further to 22 (Pd/In-BVO). Notably, the operating temperatures of BVO and In-BVO were both 310 °C, while that of Pd/In-BVO was meaningfully reduced to 270 °C. Furthermore, the theoretical limit of detection was lowered to 50 ppb for the Pd/In-BVO, compared to 199 ppb for pure BVO. Combined characterizations revealed that In doping introduced acidic sites to enhance acetone adsorption, while simultaneously lowering the oxygen desorption temperature. The subsequent PdO loading not only amplified these effects but also introduced a PdO/BiVO 4 heterojunction along with metallic Pd, which collectively promoted carrier separation, increased charge carrier concentration, and facilitated the adsorption and activation of oxygen species. This work provides a profound insight into the design of high-performance gas sensors through multi-step engineering.
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Toxins
·
2026
·Vol. 18
·期 1
·39
·
IF 4
Yichao Li,Huarong Xiao,Jun Xie,Liping Liu,Fajun Jiang,Jingqiu Liao,Ermeng Yu
This study investigated the effects of chronic MC-LR exposure (0 μg/L [Control], 1 μg/L [M1], 3 μg/L [M3], 10 μg/L [M10], and 30 μg/L [M30]) on the muscle nutrient composition, meat quality, and muscle proteomic profile of Nile tilapia (Oreochromis niloticus). In the high-dose group (M30), MC-LR exposure compromised the muscle antioxidant status of Nile tilapia, resulting in reduced meat quality, as evidenced by decreased pH value and water-holding capacity, elevated lipid/protein oxidation, and altered texture parameters (shear force and fragmentation index). Proteomic analysis further revealed a downregulation of proteins associated with ribosomes, suggesting an impairment of muscle protein synthesis in the M30 group. Moreover, despite chronic exposure, only low levels of MC-LR accumulated in the muscle tissue, indicating a negligible health risk to consumers. Collectively, these findings offered valuable insights into the impact of environmental MC-LR contamination on fish muscle quality and nutritional value.
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Desalination and Water Treatment
·
2026
·
IF 1
Dezhi Zhao,Haiping Chen,Yuyang Tian,Yuan Liu
The COVID-19 pandemic has brought about increasing demand of face masks, however, due to the inadequate disposal, it has caused great environmental problems. In this study, we try to recycle these wastes to fabricate chelating materials for the potential application in heavy metal removal from wastewater. Surface characteristics of the prepared amine-modified polypropylene (AMP) adsorbent were identified by advanced methods. The introduced amino groups endowed AMP a more basic and hydrophilic surface, which facilitated electrostatic attraction with cations in acidic to neutral conditions. Moreover, batch experiments showed the adsorption of heavy metals onto the AMP was pH dependent and followed pseudo-second-order kinetic model and Langmuir adsorption isotherm model, and the theoretical adsorption capacities were 58.275, 62.500 and 58.207 mg/g for Pb 2 + , Cu 2+ and Zn 2+ , respectively. In particular, the prepared AMP can be regenerated for 10 cycles with relatively stable heavy metal absorption capacity. Chemical adsorption was proposed as the main adsorption mechanism, as N worked as electron donor to form complex with metal ions, and metal salt crystal growth was also observed on AMP surface. The favorable adsorption capacity and reusability of AMP demonstrated the potential of upcycling the waste masks in wastewater treatment.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.5
Huiqi Wang,Xinmin Fang,Yuemou Zhao,Wennian Li,Longyan Zhao,Xinzhou Yang,Qingxia Yuan
Stemona tuberosa Lour., a noted traditional Chinese medicine, exerts potent pharmacological effects, yet its key pectic polysaccharides, especially their chemical structures, remain poorly understood, impeding further investigation and development. In this study, two pectin polysaccharides (STP-3-1 and STP-3-2) were isolated from the roots for the first time. Using HPLC, methylation-GC–MS, and 1D/2D NMR, their structures were elucidated. Both contain a rhamnogalacturonan I (RG-I) backbone with 1,5-α-arabinan and 1,4-β-galactan side chains; STP-3-1 is exclusively RG-I with higher galactose content, whereas STP-3-2 also harbors an α-1,4-homogalacturonan segment, α-L-Rha p -(1→, Δ4,5-α-D-Gal p A-(1 → residues, and methyl-esterified →4)-α-Gal p A-(1 → units. Immunological assays showed both polymers dose-dependently induced NO, TNF-α, and IL-6 production and their mRNA expression via the TLR pathway, with STP-3-2 displaying stronger activity, likely due to its lower molecular weight and higher homogalacturonan content. These findings reveal S. tuberosa polysaccharides as promising immunopotentiators. Their rigorously defined architectures offer exact molecular blueprints for mechanistic and pharmaceutical studies, while their exceptionally clear NMR spectra set a high-confidence reference for future pectic-polysaccharide research.
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INFLAMMATION
·
2026
·
IF 5.4
Wang Dongyan,Shi Yihai,Lu Jie,Bao Wen,Wang Nan,Shen Qiuteng,Lin Zhenyu,Qian Lijuan,Zhu Chang
Chronic pancreatitis (CP) is characterized by chronic pancreatic inflammation and progressive fibrosis. This study investigated the role of ubiquitin-specific peptidase 1 (USP1), a protein-stabilizing deubiquitinase, in CP. C57BL/6J mice were given 8-week repetitive intraperitoneal cerulein (50 µg/kg) injections to establish the CP model. USP1 expression in CP mouse pancreatic tissues was 3-fold higher than in controls. Lentivirus-mediated Usp1 knockdown reduced pancreatic inflammatory cell infiltration, trypsin activity, and proinflammatory cytokine levels. Additionally, Usp1 knockdown inhibits collagen deposition and fibrosis of the pancreas. In vitro, USP1 was upregulated in activated pancreatic stellate cells (PSCs) induced by TGF-β1 (5 ng/mL). USP1 knockdown decreased the expressions of collagen type I alpha 1 chain (COL1A1), COL1A2, fibronectin, and α-smooth muscle actin (α-SMA), suppressing PSC activation and extracellular matrix production. Immunoprecipitation-liquid chromatography/mass spectrometry (IP-LC/MS) and label-free proteomics identified integrin subunit beta 5 (ITGB5) as a potential target protein of USP1. USP1 promoted ITGB5 deubiquitination/stabilization, while USP1 knockdown reduced ITGB5 expression. Rescue experiments showed ITGB5 overexpression reversed the inhibitory effect of USP1 knockdown on PSC activation. Moreover, ITGB5 knockdown inhibited PSC activation via suppressing PI3K/AKT pathway. In conclusion, USP1 knockdown inhibits PSC activation by suppressing the ITGB5-PI3K-AKT axis, thereby alleviating the pathological progression of CP.
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Journal of Analysis and Testing
·
2026
·
IF 9.4
Zheng Desheng,Zhu Jianping,Tang Wenqi,Xu Ming,Gu Zhiyuan
Stationary phase optimization is crucial for enhancing gas chromatography (GC) separation performance, yet coating process engineering remains overlooked despite its significant impact on stationary phase loading and distribution. Coating process engineering directly impacts the loading amount and the stacking mode of the stationary phase materials on the inner wall of the chromatographic columns. Uneven coating can result in insufficient stationary phase loading and severe material aggregation, ultimately preventing the material from achieving its full separation potential. Herein, we proposed a solvent polarity matching strategy and successfully fabricated an evenly distributed MIL-125-NH 2 stationary phase for GC separation. Compared to uneven stationary phases, the evenly distributed GC stationary phase obviously eliminated peak tailing in substituted benzene separation and demonstrated a remarkable improvement in separation resolution. Furthermore, validation with UiO-66 confirmed the universality of this strategy. This work established coating engineering as vital as material design, offering a practical approach to unlock the full separation potential of high-performance GC stationary phases.
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Materials Today Bio
·
2026
·
IF 11
Longqing Hu,Zhongyuan Yin,Songwei Tan,Yu Deng,Xincai Qu,Ting Hu,Qiong Wang
Triple-negative breast cancer (TNBC) derives only limited clinical benefit from radiotherapy (RT), partly due to abnormalities in the tumor microenvironment and dysregulated signaling pathways. By integrating TNBC cases from the METABRIC and TCGA cohorts, we implemented an analysis framework centered on RT-by-gene interaction terms, implicating TNF-α–NF-κB signaling and inflammatory response as potential effect modifiers of RT benefit. Based on a pathway-guided polyphenol–gene interaction screen, curcumin (Cur) was prioritized as a modulator of TNF-α–NF-κB/inflammation-related programs. We then engineered a multifunctional nanoplatform (TCC) that couples catalytic modulation of the tumor microenvironment with suppression of adaptive pro-survival programs. TCC was built on pH-responsive nanoceria (CeO 2 nanozymes) to modulate redox homeostasis and alleviate hypoxia, loaded with Cur, and coated with D-α-tocopherol polyethylene glycol succinate (TPGS) to improve stability and cellular uptake; cRGD was further introduced to generate cRGD-TCC for enhanced tumor targeting. In vitro and in vivo, TCC promoted G 2 /M-phase arrest, amplified RT-induced reactive oxygen species generation and DNA damage, and attenuated TNF-α–NF-κB/inflammatory programs and markers of inflammation, survival, and invasion. Collectively, TCC provides an integrated radiosensitization strategy that addresses microenvironmental barriers and adaptive tumor signaling, thereby potentially enhancing RT response in TNBC.
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METABOLIC BRAIN DISEASE
·
2026
·Vol. 41
·期 1
·153
·
IF 3.8
Li Chunlei,Li Yuan,Liu Tongyan,Zong Yue,Zhou Lingyun
Spinal cord injury (SCI) is a highly disabling condition affecting the central nervous system (CNS). Neuroinflammation and neuronal apoptosis are two critical factors in the pathological process of SCI. Although electroacupuncture (EA) has been reported to alleviate neuroinflammation in brain injury, the underlying molecular mechanism remains unclear. Transcriptome sequencing of spinal cord tissues was performed to identify potential key factors and pathways involved in EA post-SCI. DHCR24, a cholesterol synthesis regulator, was selected as a key candidate and DHCR24 was downregulated after SCI (log 2 FC = -1.6, P < 0.01), and this downregulation was notably reversed by EA treatment (log 2 FC = 1.04, P < 0.01). We investigated the neuroprotective effect of DHCR24 against neuron death and neuroinflammation in SCI, with a particular focus on its effects on the Wnt signaling pathway. SCI-induced DHCR24 downregulation was associated with decreased expression of the axonal regeneration marker NF and increased activation of Iba1/CCR7-positive microglia, accompanied by enhanced neuronal apoptosis and inflammatory factor release. Importantly, functional validation experiments demonstrated that DHCR24 was required for the therapeutic effects of EA. Complementary in vitro studies in LPS/IFN-γ-stimulated BV2 microglia cells confirmed the role of DHCR24 in microglial polarization and neuronal survival, likely via Wnt signaling activation. Integrating transcriptomic and mechanistic evidence, we demonstrate that DHCR2 promotes Wnt pathway activation, reduces neuronal apoptosis and neuroinflammation, and ultimately enhances spinal cord repair. This study provides evidence supporting the potential clinical application of EA in SCI recovery and identifies DHCR24 may be a key mechanistic target underlying its therapeutic effects. Graphical
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Human Cell
·
2025
·Vol. 38
·期 6
·1-17
·
IF 3.1
Li Qingsheng,Liu Yuxi,Zhang Lin,Zheng Yi,Feng Xiaofan,Wang Yanjie
The occurrence of tumor metastasis is associated with the phenotype of tumor-associated macrophages (TAMs). Within the tumor microenvironment, TAMs undergo metabolic reprogramming. Aerobic glycolysis contributes to TAM polarization into an M2-like phenotype. Cedrol is a component extracted from herbal medicines. Anti-cancer activities of cedrol have been reported, however, its effect on the metabolic reprogramming and pro-metastatic ability of TAMs remains unclear. Here, we found that cedrol reduced THP-1-derived macrophage polarization into M2-like phenotypes. Cedrol impaired the promoting effects of TAMs on the migration and invasion of lung cancer cells. Tumor metastasis in C57BL/6 mice was reduced following cedrol treatment, accompanied by decreases in M2-like TAMs in the lung tissues. Cedrol treatment decreased glucose consumption and lactate production and downregulated glycolysis-associated gene expression. A glycolytic inhibitor (2-DG) was utilized to confirm that suppression of glycolysis in TAMs limited the metastasis of lung cancer cells. MYC was identified as a downregulated gene in cedrol-treated TAMs based on the mRNA sequencing analysis. MYC overexpression could reverse the effects of cedrol on TAMs. Cedrol treatment reduced MYC expression at least partly via the PI3K-Akt pathway. These findings suggest that cedrol exerts anti-tumor effects by inhibiting TAM polarization into an M2-like phenotype by modulating MYC-mediated aerobic glycolysis, indicating cedrol as a potential drug for lung cancer treatment.
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EUROPEAN POLYMER JOURNAL
·
2023
·
IF 6
Muyao Gao,Tianhao Li,Wenjing Kong,Xun Sun,Li Liu,Bing Li,Yujie Song,Ming Liu
Phthalonitrile resins are one of the high temperature resistant polymers which can be potentially used for harsh environments in both military and domestic fields. The high melting points of the monomers led to short processing windows and made processing procedure challenging and energy intensive. To solve this problem, liquid phthalonitrile monomers containing flexible siloxane segments were designed and synthesized. The long bond length and large bond angle of Si-O-Si chain segments introduced flexibility into the monomers and effectively reduced the melting point to −35.9 °C. Meanwhile, the high bond energy preserved the thermal stability of the resulting cured resin. The high fluidity (viscosity of ∼ 2 Pa·s at 30 °C) allows the monomers to be processed at room temperature without additional heating. In addition, the monomers can be dissolved in common organic solvents, such as ethyl acetate and ethanol. The resins cured at 250 °C demonstrated good thermal and thermal oxygen stability. The weight loss of 5 % in argon and air at temperatures of 428.6 °C and 434.9 °C, respectively. Furthermore, blending this liquid monomer blended with powdered monomers improved both the processibility of the high melting monomers and the overall temperature resistance of the cured resin. The resin showed a weight loss of 5 % in argon and air of 534.4 °C and 532.3 °C, respectively.
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JOURNAL OF POLYMERS AND THE ENVIRONMENT
·
2023
·Vol. 31
·期 8
·3551-3564
·
IF 5.3
Zhang Chen,Qi Yuhong,Zhang Zhanping
Marine biofouling has become the main factor of marine economic loss. In this article, we studied the relationship between the PS-PEG hydrogels properties and the anti-bio adhesive behavior, such as amphiphilic, swelling degree, elastic modulus and roughness. Testing the adhesion behavior of marine bacteria and benthic diatom on PS-PEG hydrogel with different polystyrene microspheres content. Meanwhile, the influence of polystyrene microsphere content on the antifouling performance of hydrogel was emphatically analyzed and proposed the anti-bio adhesive behavior mechanism of PS-PEG hydrogels. The results showed that the antifouling performance of PS-PEG hydrogels was significantly enhanced by adding polystyrene microspheres. In the marine bacterial adhesion behavior, when polystyrene microspheres were added at 14.2 wt.%, the bacterial adhesion rate was respectively 3.85% and 0.01% for rinsing and washing samples, and the bacterial removal rate was 99.74%. In addition, in the benthic diatom adhesion behavior, the chlorophyll concentration a-values after rinsing and washing samples were only 0.019 mg/L and 0.002 mg/L with the same content of polystyrene microspheres, and the removal rate was 89.6%. At the same time, polystyrene microspheres enable PS-PEG hydrogels to exhibit amphiphilic, which could form a hydration layer by surface reorganization in seawater, the hardness and toughness of PS-PEG hydrogel substrate can be increased by adding appropriate polystyrene microspheres, and it also reduced the surface roughness of hydrogels after swelling in seawater. Accordingly, PS-PEG hydrogels can achieve efficient anti-bio adhesive behavior mainly through the synergistic effect of a highly hydrated layer, unstable surface and low roughness.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2023
·Vol. 140
·期 19
·e53838
·
IF 3
Xuhui Zhang,Guangyao Ji,Jianing Yang,Jie Jiang,Jianzhong He,Ting Li,Jing Huang,Mingqing Chen,Weifu Dong
Strong, tough, and biodegradable polymers from renewable raw materials are of great importance in circumventing environmental issues. Poly(propylene carbonate) (PPC), a biodegradable carbon dioxide (CO 2 )/propylene oxide copolymer, has been simultaneously strengthened and toughened by incorporating a hybrid natural filler (CNF@xyl). The CNF@xyl is formed by coating cellulose nanofibril (CNF) with small xylitol (xyl) particles using evaporation-induced self-assembly. In CNF@xyl, the xyl cladding around CNF can improve the dispersion of CNF in PPC by inhibiting the contact among CNF, and can enhance the interfacial interaction by providing high-density hydrogen bonds. Meanwhile, the CNF can minimize the size of xyl particles by being a substrate for xyl spreading. Consequently, by incorporating the hybrid fillers at small fraction, PPC/(CNF0.4@xyl2.0) exhibits a Young's modulus of 1318 ± 65 MPa, a tensile strength of 19.07 ± 0.98 MPa, and a toughness of 77.64 ± 3.21 MJ/m 3 , which is 161%, 145%, and 130% of that of neat PPC, respectively. More importantly, CNF, xyl, and PPC are fully biodegradable while CNF and xyl are renewable. This work offers a novel yet green method for optimizing the mechanical properties of biodegradable polymers and provides an alternative way to circumvent environmental issues.
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危险品化学品经营许可证（带存储）