FOOD CHEMISTRY
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2024
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IF 8.5
Guijiao Zhao,Chenhuan Wang,Min Kang,Lin Hao,Weihua Liu,Zhi Wang,Xiaodong Shi,Qiuhua Wu
Developing effective methods for highly sensitive detection of phenolic endocrine disruptors (EDCs) is especially urgent. Herein, a magnetic hydroxyl-functional porous organic polymer (M-FH-POP) was facilely synthesized by green diazo-couple reaction using basic fuchsin and hesperetin as monomer for the first time. M-FH-POP delivered superior adsorption performance for phenolic EDCs. The adsorption mechanism was hydrogen bonds, hydrophobic interaction and π-π interplay. With M-FH-POP as adsorbent, a magnetic solid phase extraction method was established for extracting trace phenolic EDCs (bisphenol A, 4- tert -butylphenol, bisphenol F and bisphenol B) in water and fish before ultra-high performance liquid chromatography tandem mass spectrometry analysis. The method displayed low detection limit (S/N = 3) of 0.05–0.15 ng mL −1 for water and 0.08–0.3 ng g −1 for fish. The spiked recoveries were 88.3 %–109.8 % with the relative standard deviations of 2.4 %–6.4 %. The method offers a new strategy for sensitive determination of phenolic EDCs in water and fish samples.
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Nano Today
·
2024
·
IF 13.2
Ke Zhu,Wenlei Qin,Yuwen Chen,Xiaoyin Liang,Haoran Xin,Zhihan Huang,Hector F. Garces,Yaping Gan,Mika Sillanpää,Rongliang Qiu,Guoqing Guan,Kai Yan
Constructing the coordination environment of single-atom catalysts (SACs) can be an attractive technical strategy to regulate the generation of reactive oxygen species for Fenton-like reactions. Herein, we have constructed an asymmetric coordination of Fe single-atom catalyst (Fe SA -NS-PCNS) with abundant N-Fe-S bridge (Fe SA -N 3 S 1 ) for robust Fenton-like reactions. 82.5 % of singlet oxygen ( 1 O 2 ) selectivity and high turnover frequency of bisphenol A degradation (0.568 min −1 ) were achieved at mild conditions. Experimental works and theoretical analyses illustrated that S doping breaks the inert environment of the original N-Fe-N symmetric coordination equilibrium and modulates the electron density of the atomic Fe center, which is beneficial for boosting PMS adsorption and reducing the energy barriers of vital *OH and *O intermediates. The coupling between the Fe SA -N 3 S 1 interface and peroxymonosulfate molecule boosts in-situ electron transfer through the N-Fe-S bridge, which induces more electron flow from the low valence Fe to OH* on the surface of Fe-*O-H, forming a high yield of 1 O 2 . Moreover, we designed the Fenton-like reactions by Fe SA -NS-PCNS membrane reactor for an efficient contaminant removal rate of over 90 % even after 11 cycles. This work provides a novel perspective on developing SACs with asymmetric coordination to regulate reactive oxygen species for the treatment of organic contaminants in water bodies.
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ENVIRONMENTAL TOXICOLOGY
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2024
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IF 4.4
Xuening Ma,Qianchao Shao,Shuxian Huang,Weigao Zhang,Hu Liu,Xu Jiayi,Xunan Zhao,Peiqi Li,Da Shao,YuanQing Bu,Dan Weng
The increasing incidence of cancer underscore the necessity of investigating contributors such as endocrine-disrupting chemicals (EDCs), including bisphenol A (BPA). Although BPA's risks are well-documented, comprehensive studies on its substitutes, such as bisphenol B (BPB), are limited. Dysregulated lipid metabolism is a hallmark of cancer progression. Our previous work demonstrated that BPA and bisphenol S (BPS) disrupt lipid metabolism via the peroxisome proliferator-activated receptor γ (PPARγ) pathway. We hence hypothesized that BPB might similarly perturb lipid metabolism and promote tumor growth. BPB's impact on lipid metabolism was investigated in vitro and in vivo using B16 melanoma cancer cells. Our findings indicate BPB exposure significantly increased lipid metabolism in B16 cells, enhancing cell proliferation and migration, and promoting tumor development in mice. Utilizing siRNA transfection or chemical inhibitor, we found that stearoyl-CoA desaturase-1 (SCD1), a key enzyme in lipid synthesis pathway, was required for BPB-induced lipid accumulation and cancer cell migration. Docking analysis revealed BPB may activate gene expression related to lipid metabolism and angiogenesis by interacting with PPARγ and hypoxia-inducible factor-1α (HIF-1α). This study illuminates BPB's potential role in advancing melanoma through lipid metabolism manipulation, highlighting the need for further research into the safety of BPA substitutes and their impact on cancer development.
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JOURNAL OF CHROMATOGRAPHY A
·
2024
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IF 3.8
Qidong Yu,Wenmin Zhang,Jingyi Wang,Shiye Xie,Baodi Liao,Hui Chen,Qingqing Ding,Lan Zhang
Design and preparation of fiber coatings with excellent electrochemical performance and high polarity is significant for efficient extraction of polar targets in electro-enhanced solid-phase microextraction (EE-SPME). In this work, a combination strategy for structure regulation of covalent organic framework (COF) was proposed to fabricate a nitrogen-rich thiocarbamide linked COF coating (Thiocarbamide-TZ-DHTP) via molecular design and post-synthetic thiocarbamide conversion. The prepared COF coating possesses a large number of O, N, and S functional groups, which not only endow the coating with higher polarity but also significantly enhance its electrochemical performance. The COF coating was used for EE-SPME of polar bisphenols (BPs), demonstrating excellent enrichment efficiency and durability. Subsequently, coupled with gas chromatography-tandem mass spectrometry (GC-MS/MS), a sensitive method was developed for determination of trace BPs. The established method possess wide linear ranges (2.0–800.0 ng L −1 ), good correlation coefficients (0.9985–0.9994) and low detection limits (0.1–2.0 ng L −1 ). Moreover, the established method had been successfully applied to detection of trace BPs in tea beverage with satisfactory recoveries (81.6 % to 118.6 %). This research provides a feasible pathway for preparing COF coating with excellent electrochemical performance and high polarity for EE-SPME.
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JOURNAL OF CHROMATOGRAPHY A
·
2024
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IF 3.8
Haixia Liu,Honghong Rao,Jinxin Guo,Baolan Lu,Yuyun Wang,Rongxi Zhu,Xinzhen Du
A layer-by-layer chemical bonding strategy was developed for fast in situ growth of bifunctional mesoporous covalent organic framework submicrospheres (COF SMSs) on the nickel-chromium alloy (Ni-Cr) fiber substrate via the ultrasound-assisted Schiff-base reaction for the first time. COF SMSs showed well-defined morphology, extraordinary high surface area (1211 m 2 · g −1 ) and narrow mesopore (2.50 nm) as well as excellent stability. Furthermore, the resulting Ni-Cr fiber presented outstanding adsorption capability and improved selectivity for bisphenols (BPs). Consequently, an attractive SPME-HPLC-UV approach with the Ni-Cr@Ni-Cr LDHs NSs@COF SMSs fiber was proposed for rapid preconcentration and sensitive determination of BPs. By optimizing adsorption parameters, the SPME-HPLC-UV method presented good linearity for five BPs in the ranges of 0.02–200 ng·mL −1 with coefficients of determination ( R 2 ) higher than 0.999. Limits of detection and limits of quantitation were obtained from 0.003 ng·mL −1 to 0.006 ng·mL −1 and from 0.010 to 0.019 ng·mL −1 , respectively. Moreover, the intra-day and inter-day precision expressed as relative standard deviations (RSDs) was 1.57–3.52 % and 2.65–4.38 % for the proposed method with a single fiber, respectively. RSDs of the proposed method with different duplicate fibers were 3.25–6.72 %. The proposed SPME-HPLC-UV method was available for efficient preconcentration and sensitive detection of five BPs from real water and milk samples. The relative recoveries at three spiking levels of BPs were achieved in the range of 80.00–118.8 % with RSDs below 7.81 %. In addition, the prepared fiber still exhibited satisfactory adsorption performance after 120 adsorption-desorption cycles.
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TALANTA
·
2025
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IF 6.1
Lihong Su,Luliang Wang,Lei Zhao,Yushen Liu,Chengke Wang,Chen Shao,Lu Liu,Daohong Zhang,Ibrahim A. Darwish
The development of advanced adsorbents enabling rapid and sensitive detection of endocrine-disrupting bisphenols (BPs) is essential for safeguarding ecosystems and human health. Covalent organic frameworks (COFs) hold great promise for the adsorption of BPs, but conventional rigid aromatic architectures suffer from limited molecular recognition capability. Herein, we design a hydroxyl-functionalized flexible aliphatic COF (TFT-TAH COF) via the polymerization of 2,3-dihydroxydicarbohydrazid (TAH) and 1,3,5-tris(4-formyl-phenyl) triazine (TFT) for efficient extraction and sensitive detection of BPs (BPA, BPF, BPAF, and BPF). The flexible aliphatic linker exposes more active sites, thereby displaying excellent BPs adsorption capacity (654–1111 mg g −1 ) and rapid adsorption kinetics (equilibrium within 30 s). TFT-TAH COF gave good affinity for BPs through the synergistic effects of size matching, hydrogen bonding, and π-π interactions. In addition, a novel analytical method was developed for BPs determination by coupling TFT-TAH COF-based dispersive solid-phase extraction with high-performance liquid chromatography, achieving low detection limits of 0.03–0.1 ng mL −1 and satisfactory precision with relative standard deviations≤5.7 %. Moreover, recoveries for the spiked lake, river, drinking water, bottled water, and milk samples ranged from 89.8 to 101.6 %. This work pioneers an innovative approach to fabricating flexible aliphatic-linked COFs for environmental monitoring and food safety.
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ANALYTICA CHIMICA ACTA
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2025
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IF 6
Weisheng Xue,Baoshan He,Xiaoyu Cao,Lingling Xie,Yao Liu,Wenhong Zhao,Wenjie Ren,Yiwei Xu
Background Bisphenol A (BPA) is a common monomer in polycarbonate plastics and epoxy resins that can migrate into food and water under extreme conditions, posing significant health risks including endocrine disruption, infertility, and metabolic disorders. Conventional detection techniques such as HPLC, HPLC-MS, and ELISA offer high sensitivity but suffer from costly instrumentation, complex pretreatment, and limited field applicability. Aptamer-based biosensors provide an attractive alternative due to their high specificity, low cost, and ease of use. Dual-mode platforms integrating colorimetric and fluorescent signals can overcome the limitations of single-mode detection Results Here, we developed an electrostatic–FRET coupled dual-mode aptasensor for BPA detection using cysteamine-modified gold nanoparticles (CS-AuNPs) and a FAM-labeled aptamer. In the absence of BPA, FAM-aptamer adsorbed onto CS-AuNPs, leading to fluorescence quenching and colloidal stability. Upon BPA binding, aptamer conformational change suppressed electrostatic adsorption, resulting in fluorescence recovery and nanoparticle aggregation with a visible color shift. Under optimized conditions, the fluorescence mode displayed a linear response from 10–1000 nM with a detection limit of 1.19 nM, while the colorimetric mode showed a range of 25–1000 nM with a detection limit of 2.22 nM. The dual-mode system demonstrated high selectivity against BPA analogues and reliable recoveries (92.7–109.2%) in spiked tap water, confirming its accuracy and robustness in real sample analysis Significance This study presents a cost-effective and visually responsive aptasensor that integrates electrostatic adsorption and FRET for sensitive BPA detection. By combining fluorescence and colorimetric modes, the platform achieves complementary readouts, reducing false positives and enhancing detection reliability. The work highlights the potential of positively charged AuNPs in multimodal biosensing, offering a promising tool for environmental monitoring and food safety assessment.
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MICROCHEMICAL JOURNAL
·
2025
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IF 5.1
Yao Liu,Runzi Zhang,Xiaoyu Yang,Yi He,Xiao Yang
Herein, a dual-enhanced SERS biosensor has been developed for the detection of bisphenol S (BPS) based on silver nanoflowers coated zeolitic imidazolate-based metal-organic framework (AgNFs@ZIF-8) cooperate with host-guest recognition amplification technology. The biosensor utilizes the molecularly imprinted polymer (MIP) and BPS aptamer chain (APT) as dual recognition element to achieve a significant increase in selectivity. In the presence of the target, the APT on AgNFs@ZIF-8@β-cyclodextrin(β-CD) specifically binds with BPS, which further recognized by MIP to form a sandwich structure. At this time, due to the large surface area, and stable Raman enhancement ability, AgNFs@ZIF-8@β-CD could not only provide multiple active “hot spots” as the surface-enhanced Raman scattering (SERS) enhanced substrate, but also specific capture large number of methylene blue (MB, SERS tag) through the host-guest recognition. Moreover, multiple host-guest recognition can be achieved by further addition of AgNFs@ZIF-8@β-CD and MB, which greatly improve the detection sensitivity. This SERS sensor, characterized by an extensive linear detection range from 1.00 × 10 −13 to 1.00 × 10 −6 M and an exceptionally low limit of detection (LOD) of 1.36 × 10 −14 M, has been effectively utilized for the detection of BPS in plastic pacifiers, receipts, and river water samples. As an extremely sensitive and highly specific analytical method for detecting BPS, this SERS-based method has promising applications in the fields of environmental monitoring and food safety.
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FOOD CHEMISTRY
·
2018
·
IF 4.946
Hai-Long Jiang,Yun-Liang Lin,Na Li,Zhi-Wei Wang,Meng Liu,Ru-Song Zhao,Jin-Ming Lin
Magnetic N -doped carbon nanotubes were firstly applied as adsorbent in food analysis for pre-concentration of bisphenols in fruit juices followed by ultra-high performance liquid chromatography-tandem mass spectrometry determination. The magnetic nanoparticles were characterized by X-ray diffraction, infrared spectroscopy, scanning electron microscopy and vibrating sample magnetometer. The adsorption conditions were further optimized by response surface methodology. Under optimal conditions, the method provided good linearity with correlation coefficient ( r ≥ 0.9979), excellent intermediate precisions (2.71–5.91%, n = 3), low limits of detection (LODs) ranging from 0.43 to 2.47 ng L −1 , and satisfying recoveries of three juice samples (between 90.6% and 101%).
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RAPID COMMUNICATIONS IN MASS SPECTROMETRY
·
2017
·Vol. 31
·期 11
·937-950
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IF 1.998
Na Wei,Zhenjia Zheng,Yuhua Wang,Yanduo Tao,Yun Shao,Shuyun Zhu,Jinmao You,Xian-En Zhao
Rationale Endocrine-disrupting chemicals (EDCs) in environment samples and food stuffs are an increasing serious public health issue due to their potency to interfere and deregulate several aspects of the endocrine system. Because of their extremely low abundance, it remains a challenging task to develop a sensitive detection method. Methods 4'-Carbonyl chloride rosamine (CCR) was used as a derivatization reagent for EDCs for the first time. A new ultrasound-assisted in situ derivatization/dispersive liquid-liquid microextraction (UA-DLLME with in situ derivatization) method for multiple EDCs including five estrogens, two alkylphenols, eight bisphenols, seven parabens and triclosan coupled with ultra-high-performance liquid chromatography/tandem mass spectrometry (UHPLC/MS/MS) has been developed and validated. Results The ionization efficiency of EDCs was greatly enhanced through the introduction of a permanent charged moiety of CCR into the derivatives during electrospray ionization (ESI)-MS analysis. The main variables potentially affecting the UA-DLLME with in situ derivatization process are optimized. The recoveries and matrix effects of 23 EDCs for the spiking samples were in the range of 83.0–116.0% and 85.8–114.6%, respectively. Good method reproducibility was achieved. Conclusions The limits of detection (LODs) for 23 EDCs were 0.05–0.40 ng/L and 0.03–0.25 ng/g (dry weight, d.w.) for environment samples and food stuffs, respectively. The proposed method has been demonstrated to be suitable for simultaneous determination of multiple EDCs in real samples with high sensitivity, speediness, and good sample clean-up ability. Copyright © 2017 John Wiley & Sons, Ltd.
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FOOD CHEMISTRY
·
2024
·
IF 8.5
Yukun Yang,Xiaoyi Zhang,Xiaomin Wang,Xu Jing,Ligang Yu,Baoqing Bai,Tao Bo,Jinhua Zhang,Hailong Qian,Ying Gu
As an emerging porous material, hydrogen-bonded organic framework materials (HOFs) still pose application challenges. In this work, the designed type “I + II” heterojunction extracted hot electrons from HOFs using quantum dots (QDs) and polypyrrole (Ppy), improving the stability and photoelectrochemical performance of materials. In addition to serving as a potential well, electropolymerized Ppy was used as a recognition element for bisphenol A (BPA), and a novel self-powered molecularly imprinted photoelectrochemical (MIP–PEC) sensor was designed. The sensing platform showed a linear relationship from 1 × 10 −10 to 1 × 10 −7 mol∙L −1 and from 1 × 10 −7 to 1 mol∙L −1 with an acceptable detection limit of 4.2 × 10 −11 mol∙L −1 . This is the first application of HOFs in constructing MIP–PEC sensors and a new attempt to improve the stability of HOFs for the application of porous crystal materials in the sensing field.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2025
·Vol. 26
·期 19
·9507
·
IF 4.9
Sen Zhao,Heliang Ni,Yuan Xiao,Jing Du,Yudong Han,Wenying Wang,Shuang Tang,Mingxi Yu
Accumulating evidence indicates that bisphenol A (BPA) analogs, including bisphenol B (BPB) and bisphenol S (BPS), disrupt testicular function and contribute to male reproductive dysfunction (MRD). However, whether BPA analogs are involved in MRD among middle-aged men remains inconclusive. Therefore, we selected cryptorchidism, erectile dysfunction, premature ejaculation, and testicular tumors as representative MRD conditions in middle-aged individuals, aiming to explore the molecular mechanisms that may be disrupted by bisphenols (BPs). By using GeneCards, STRING and Cytoscape, TP53, AKT1, and MYC were pinpointed as core targets associated with MRD. Enrichment analysis suggested that BPs may induce MRD by disrupting steroidogenesis. UPLC-MS/MS analysis showed that both BPB and BPS exhibit specific accumulation in the testes. Following 20-day exposure to 0.3 or 0.6 mg/kg body weight/day BPB or BPS, testosterone levels and the expression of hub genes were decreased. The molecular docking results demonstrated that both BPB and BPS can directly bind to members of the cytochrome P450 family, potentially interfering with sex hormone biosynthesis. Our study identified the targets and mechanisms through which BPB and BPS induce MRD in middle-aged males, thereby providing insights for the safety assessment of BPs.
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危险品化学品经营许可证（带存储）