GENOME BIOLOGY
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2022
·Vol. 23
·期 1
·1-29
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IF 17.906
Li Conghui,Yin Zhinang,Xiao Ruijing,Huang Beili,Cui Yali,Wang Honghong,Xiang Ying,Wang Lingrui,Lei Lingyu,Ye Jiaqin,Li Tianyu,Zhong Youquan,Guo Fangteng,Xia Yuchen,Fang Pingping,Liang Kaiwei
Background G-quadruplexes (G4s) are unique noncanonical nucleic acid secondary structures, which have been proposed to physically interact with transcription factors and chromatin remodelers to regulate cell type-specific transcriptome and shape chromatin landscapes.Results Based on the direct interaction between G4 and natural porphyrins, we establish genome-wide approaches to profile where the iron-liganded porphyrin hemin can bind in the chromatin. Hemin promotes genome-wide G4 formation, impairs transcription initiation, and alters chromatin landscapes, including decreased H3K27ac and H3K4me3 modifications at promoters. Interestingly, G4 status is not involved in the canonical hemin-BACH1-NRF2-mediated enhancer activation process, highlighting an unprecedented G4-dependent mechanism for metabolic regulation of transcription. Furthermore, hemin treatment induces specific gene expression profiles in hepatocytes, underscoring the in vivo potential for metabolic control of gene transcription by porphyrins.Conclusion sThese studies demonstrate that G4 functions as a sensor for natural porphyrin metabolites in cells, revealing a G4-dependent mechanism for metabolic regulation of gene transcription and chromatin landscapes, which will deepen our knowledge of G4 biology and the contribution of cellular metabolites to gene regulation.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2022
·
IF 4.326
Lu Liu,Qi Wu,Shunli Wang,Wei Lai,Peijun Zheng,Can Wang,Xin Wei,Shuangjiang Luo
The recovery of helium from natural gas using membranes has attracted substantial attention, while very limited polymers were spun into hollow fibers and evaluated for realistic helium recovery. This work demonstrates the successful preparation of asymmetric and highly helium-selective hollow fiber membranes for the enrichment of helium from natural gas. A novel, aromatic copolyimide was designed and fabricated into hollow fiber membranes (HFMs) via the dry-jet/wet-quench spinning approach. The as-prepared HFMs display a He permeance of 85 GPU and high He-related gas selectivities of 140, 204, 448, and 609 for He/N2, He/CH4, He/C2H6, and He/C3H8 gas pairs, respectively. Particularly, ternary and quaternary mixed-gas permeation results reveal excellent light and heavy hydrocarbon resistance due to the competition between plasticization and gas sorption. The HFMs also demonstrated superior low-temperature gas separation performance and outstanding membrane gas separation stability, rendering them attractive for helium recovery.
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Fermentation-Basel
·
2023
·Vol. 9
·期 2
·133
·
IF 3.7
Peng Cheng,Muhammad Usman,Muhammad Arslan,Huanqing Sun,Li Zhou,Mohamed Gamal El-Din
A Gram-positive exoelectrogenRhodococcus pyridinivoranssp. strain HR-1 was cultivated from leachate-fed microbial fuel cell (MFC) to study the biodegradation effect of pyridine. In the comparison with mixed cultured MFC, HR-1 presented a remarkable electrical capacity with a maximum output of 4.33 W/m3under 30 °C in neutral anolyte with 1 g/L acetate as a substrate. Further, HR-1 demonstrated the environmental resistance as a Gram-positive strain. Microbial metabolism was evident at pH between 5–9 and temperature in the range of 20–40 °C, whereas optimal condition for pyridine degradation was observed at 30 °C. This is the first study reporting the degradation of pyridine in the bio-electrochemical system that achieved a 42% ± 5% degradation rate in a full operation cycle at 2 g/L of the concentration. Considering the nonnegligible internal resistance of HR-1-inoculated MFC, trehalose lipid was also introduced as a bio-surfactant to reduce the charge transfer obstacle between the microbes and the electrodes. The surface morphology illustrated that the strain had a plump shape with a high specific area. Accordingly, bio-surfactant addition promoted the anode biomass (1.2 ± 0.1 mg/cm2to 1.7 ± 0.2 mg/cm2) and achieved a higher degradation rate (68% ± 4%). The feasibility of electrochemical disposal on pyridine and eminent adaptability of strain sp. HR-1 as a Gram-positive exoelectrogen makes MFC a practical approach for real application.Keywords:microbial fuel cells;gram-positive exoelectrogen;pyridine;trehalose lipid;Rhodococcus pyridinivorans
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Nanoscale
·
2023
·Vol. 15
·期 8
·4114-4122
·
IF 6.7
Huiya Lan,Bin Wu,Yuye Yan,Ru Xia,Jiasheng Qian
Interfacial thermal resistance is the main barrier restricting the heat dissipation of thermal management materials in electronic equipment. The interface structure formed by covalent bonding is an effective way to promote interfacial heat transfer. Herein, an integrated composite with multi-aspect covalent bonding beneficial for heat transmission is constructed by polyimide (PI) polymerization with maleimide modified graphene nanosheets (M@GNS). The interfacial structure with low thermal resistance built by covalent bonding and oriented graphene arrangement initiated by the coating process makes the in-plane thermal conductivity of the composite as high as 16.10 W m−1 K−1. Finite element simulation and 1000 bending tests are carried out to further verify the performance advantages of the integrated structure in the internal thermal diffusion and long-term use of the composite. M@GNS/PI with integrated structure provides extra heat transfer channels for heat dissipation, possibly providing an effective way to address the traditional thermal accumulation issue of electronic devices.
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POLYMER INTERNATIONAL
·
2023
·Vol. 72
·期 5
·520-531
·
IF 3.2
Yaqing Wen,Chunshan Lu,Guofei Chen,Xingzhong Fang
Two series of poly(ester-amide-imide)s (PEsAIs) with simultaneously bulky side groups, ester and amide bonds were synthesized by copolymerization of tert -butylhydroquinone bis(trimellitate anhydride), p -phthaloyl chloride and other monomers. These PEsAIs had glass transition temperatures ( T g s) in the range of 231–301 °C, coefficients of thermal expansion (CTEs) of 17–59 ppm K −1 and displayed good mechanical properties with tensile modulus of 2.6–4.5 GPa, tensile strengths of 63–143 MPa and elongations at break of 3.0%–11.7%. All films had good transparency with transmittances at 400 nm ( T 400nm ) of 43%–80%. The introduction of p -phthaloyl chloride successfully improved the properties of the polymer with higher transmittance, higher T g and lower CTE. In particular, PEsAI-b-60 presented the best comprehensive performance with a moderate T g of 301 °C, low CTE of 17 ppm K −1 and high transmittance ( T 400nm ) of 75%. © 2023 Society of Industrial Chemistry.
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ANALYTICA CHIMICA ACTA
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2022
·
IF 6.911
Yang-Yang Hou,Wan-Zhen Xie,Ke-Jing Huang,Jing Xu
A novel self-powered biosensor is engineered by the integration of DNAzyme walker and AuNPs/graphdiyne biosensing interface, realizing sensitive detection of target microRNA . The cleverly constructed DNAzyme walker with outstanding signal transduction ability to obtain an amplified signal response. In addition, the AuNPs/graphdiyne significantly improves electron transport speed of biosensing interface for improving the sensitivity of biosensor. A dynamic linear range of 0.05 fM-10 pM with a low detection limit of 0.015 fM (S/N = 3) is obtained by utilizing the self-powered biosensor. Meanwhile, the developed self-powered biosensor is capable of assaying miRNA-21 in human serum samples with satisfactory recoveries. This strategy provides a valid method for the sensitive microRNA detection, and shows great potential in point-care detection of tumor biomarker.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2023
·
IF 6.1
Dingkai Wang,Mingyu Cui,Yanjun Li,Wei Zhao,Shangshang Ma,Zhijie Jiang,Xutang Liu,Chong Liang,Rujuan Li,Long Ma,Yanmin Song,Xian-Yong Wei
The facile, green, and efficient strategy for the separation of lignin from straw and subsequent production of value-added chemicals is crucial to the current utilization of straw. Herein, up to 23.72% of lignin was isolated from wheat stalk over cheap and green 1-(3-sulfobutyl) triethylammonium hydrogen sulfate ([BSTEA]HSO4) in aqueous ethanol (Vethanol: Vwater = 4:1). The acquired lignin was verified as a p-hydroxyphenyl-guaiacyl-syringyl type, which had a narrower molecular weight distribution, better thermal stability, and higher purity compared with those of the lignin obtained using 1-methyl-3-(4-sulfobutyl)-imidazolium hydrogen sulfate and 1-(3-sulfobutyl) pyridinium hydrogen sulfate. Moreover, a carbohydrate-rich liquid containing [BSTEA]HSO4 was obtained by water removal from the waste liquid after lignin separation and further converted to ethyl levulinate (EL) by a one-pot process in the presence of inexpensive and stable USY zeolite. The yield of EL reached 30.23% at 200 °C for 60 min over the presence of 40% [BSTEA]HSO4 and 60% USY zeolite. Under optimal conditions, the yields of lignin and EL can respectively reach 83.89 and 72.28% of those catalyzed by a fresh catalyst after five cycles. In short, the above-mentioned methods present a green, economic, and efficient route for the extraction of lignin and further treatment of the liquid waste generated during the extraction process.
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MICROPOROUS AND MESOPOROUS MATERIALS
·
2023
·
IF 5.2
Ruixue Yangcheng,Yuntong Cui,Shuang Luo,Jiansu Ran,Jianjian Wang
Developing an efficient and stable catalyst for the aqueous hydrodeoxygenation (HDO) of lignin derivatives at ambient temperature is highly desirable. Here, a novel Pd/PHS catalyst with the hierarchical structure was facilely constructed. Taking HDO of vanillin (VAN, a typical molecule of lignin derivatives) to 2-methoxy-4-methyl phenol (MMP) as a model reaction, >99% VAN conversion and 98.2% MMP yield can be achieved over Pd/PHS at ambient temperature in a water solvent, outperforming the recent works reported in the literature. We found that the hierarchal zeolitic structure could immobilize acidic P species in Pd/PHS via trapping and hydrogen-bonding, and these P species could greatly accelerate the conversion of reaction intermediate, enhancing the yield of MMP product. Pd/PHS also showed excellent activities in HDO of other lignin derivatives. We think this work will provide a new route to guide the design of stable catalyst for the efficient aqueous HDO of lignin derivatives to high value-added chemicals and biofuels at ambient temperature.
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Molecular Catalysis
·
2023
·
IF 4.6
Shuxing Zhang,Jiali Zheng,Zhihui Li,Xiaoshu Ding,Yanji Wang
Herein, we reported a green catalytic reaction system for the synthesis of 5-amino-1-pentanol with furfural and ionic liquid hydroxylamine salt as the initial raw material. In addition, the method can obtain 2-furonitrile and furfurylamine in high yields. The reaction system comprises three new reactions, including the reaction of furfural with ionic liquid hydroxylamine salt to synthesize 2-furonitrile, the hydrogenation of 2-furonitrile to prepare furfurylamine, and the hydrogenolysis of furfurylamine to prepare 5-amino-1-pentanol. For the synthesis of 2-furonitrile, ionic liquid hydroxylamine salt (NH 2 OH) 2 ·[HSO 3 - b - mim ]·HSO 4 was prepared. The ionic liquid as co-solvents, catalysts, and hydroxylamine stabilizer has recovery and reusability. For the hydrogenation of 2-furonitrile to furfurylamine, high-efficiency Ru/g-C 3 N 4 catalyst was prepared. For the hydrogenolysis of furfurylamine to 5-amino-1-pentanol, high-efficiency Pt/ZrO 2 catalyst was prepared. Finally, the yield of 5-amino-1-pentanol based on furfural was 48.7%. A potential pathway for preparing drugs from biomass has been identified in this work.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2022
·
IF 9.136
Sitan Wang,Xuan Meng,Naiwang Liu,Li Shi
Sulfated zirconia, as a promising catalyst in various acid-catalytic reactions, still suffer from unsatisfactory catalytic stability and regeneration performance due to severe leaching of sulfur species, while aluminum modification can effectively overcome these drawbacks. Unfortunately, the limited acceptability of aluminum content by co-precipitation and milling methods remains a critical issue. Herein, an effective strategy of coating sulfated zirconia on the surface of γ-Al 2 O 3 was developed to synthesize the novel Al 2 O 3 @SO 4 2- /ZrO 2 catalyst with high aluminum content. The synthesis variables were investigated and systematically optimized. The structural and acidic properties of Al 2 O 3 @SO 4 2- /ZrO 2 were determined by XRD, HR-TEM equipped with EDX, N 2 adsorption-desorption isotherms, EA, FT-IR, NH 3 -TPD and Py-FTIR. Results indicated that the unique structure constructed by sulfated zirconia coated on γ-Al 2 O 3 not only realized the stabilization of favorable tetragonal zirconia phase even at exceedingly high aluminum content but also promoted Brønsted acid sites. Accordingly, the optimal Al 2 O 3 @SO 4 2- /ZrO 2 - 50% performed outstanding catalytic activity and stability, given the olefins conversion of 98%-75% during the continuous reaction experiment. Owing to the alleviation of sulfur loss by Al-promoting effects, excellent regeneration performance, with olefins conversion only slightly declining after 4 consecutive reaction-regeneration cycles, was also obtained. The mechanistic pathway for the alkylation of olefins with aromatics over Al 2 O 3 @SO 4 2- /ZrO 2 was also investigated and proposed by GC–MS analysis.
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ACS Applied Nano Materials
·
2023
·
IF 5.9
Jingshun Zhuang,Saerona Kim,Mairui Zhang,Jiae Ryu,Jeeranan Nonkumwong,Laongnuan Srisombat,Kwang Ho Kim,Jeong Jae Wie,Gyu Leem,Chang Geun Yoo
Lignin is a promising feedstock for renewable fuels and chemicals due to its aromatic skeleton and natural abundance. Lignin can be converted to diverse aromatic monomers as well as dicarboxylic acids depending on the applied conversion technologies. Despite its great potential, its native and processing-induced heterogeneity and complexity limit the conversion efficiency and product selectivity. In this study, magnesium ferrite (MgFe2O4) nanoparticle–peracetic acid (PAA) has been investigated as an efficient catalyst–oxidant incorporation for catalytic oxidative depolymerization of lignin under mild conditions. Typically, the increase in processing severity can enhance the lignin conversion while it results in the further decomposition of aromatic compounds to dicarboxylic acids. However, in this study, the incorporation of MgFe2O4 nanoparticles and PAA not only enhanced the total product yield but also improved the selectivity of aromatic monomers. The oxidative depolymerization system using the catalyst–oxidant combination resulted in 46 wt % of total oil product with a 61% selectivity of aromatic monomers under mild temperature (90 °C). In addition, this combination catalyst showed relatively good cycling stability based on the total product yield after recycling five times via magnetic separation. Overall, MgFe2O4 nanoparticles play an important role as a co-catalyst with a PAA oxidant in the oxidative conversion of lignin with an enhanced conversion efficiency and recyclability, and it will facilitate the valorization of lignin in future bio-based fuels and chemicals.
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Environmental Technology & Innovation
·
2023
·
IF 7.1
Yi-na Tu,Die Zhou,Huaying Liu,Wei Tang,Weilin Wu,Yingjie Li
The dissolved black carbon (DBC) derived from co-pyrolysis of plastic and biomass be released into aquatic environment. DBC was an important photoactive constituent, however, the photochemical activity of DBC from the co-pyrolysis plastic and biomass remains unclear. Herein three popular plastic wastes (polystyrene, PS; polylactic acid, PLA; plastic mulch film, PMF) and pine needle biomass prepared co-pyrolysis biochar, and effects of co-pyrolysis plastics on DBC’s photogeneration ability of reactive intermediates, affecting pollutant photodegradation, were investigated. In comparison to individual DBC, the mixed DBC from co-pyrolysis biochar had a lower molecular weight and more oxygen-containing groups. Quantum yields of singlet oxygen ( 1 O 2 ) and triplet state DBC ( 3 DBC*) from mixed DBC were higher, especially PMF-DBC since its lower aromaticity and molecular weight connected with its higher E 2 / E 3 and lower SUVA 254 values. Steady-state photochemical experiment demonstrated 3 DBC* formation rates for mixed DBC were lower than individual DBC, while the second-order reaction rate constants of 3 DBC* with 2,4,6-trimethylphenol for mixed DBC were higher than that of individual DBC. Quenching experiment by sorbic acid to distinguish high/low-energy triplets revealed that contributions of low-energy triplets to 3 DBC* and 1 O 2 generation decreased relative to individual DBC, indicating the transformation of reductive groups to oxidative groups, which was supported by the phototransformation kinetics. Quantum yields of 3 DBC* and 1 O 2 were positively linear correlations with E 2 / E 3 using twenty DBC samples. These findings are helpful in understanding DBC’s photochemical activity from co-pyrolysis of plastics and biomass, especially in aquatic environments adjacent to soil amended by biochar.
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