POLYMER
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2026
·
IF 5.1
You Zhang,Wenzhong Ma,Jing Zhong,Yu Qiao,Zihao Jiang,Ning Xu,Longgui Zhang
Recent advances in mechanophores have enabled novel strategies for designing pressure-sensitive devices and force-responsive materials. In particular, mechanophores based on a molecular ring have garnered significant attention for their high reversibility and low activation energy. However, the impact of conformational changes of these mechanophores within polymer networks on the material’s mechanosensitivity remains poorly understood. We designed two fluorescent macrocycles with distinct sizes and integrated them into polycaprolactone (PCL) cross-linked networks, enabling systematic investigation of how macrocycle dimensions govern the materials’ mechanochromic response. We find that PCL networks with fluorescence macrocycles of distinct sizes exhibited different strain-dependent fluorescence quenching and that this response remained highly reversible across multiple cycles. Furthermore, introducing smaller macrocycles increased polymer chain rigidity, resulting in significantly longer fluorescence lifetimes in the fabricated samples. This work demonstrates that tuning the size of mechanochromic macrocycles can optimize the force-optical response of materials, providing a new strategy for designing highly sensitive mechanochromic systems.
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JOURNAL OF CONTROLLED RELEASE
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2026
·
IF 12.4
Chongzheng Yan,Zhichao Kong,Yuxue Pan,Zhipeng Fu,Kun Han,Xiaotian Zhao,Jing Zhang,Longyu Bo,Weiyi Sun,Jinxin Gao,Xianghui Dong,Zuolin Zheng,Xiao Yue,Peng Sun,Xinyi Jiang,Chen Chen
Chimeric antigen receptor microglia (CAR-M)-mediated amyloid-β oligomers (AβO) phagocytosis shows great promise in Alzheimer's disease (AD) treatment, however, the limited AβO degradation of CAR-M compromises their anti-AβO potency. This work here reports an in situ engineered agonistic anti-C-type lectin domain containing 7 A (CLEC7A) nanobody to accelerate AβO degradation of CAR-M, augmenting their anti-AβO efficacy. Specifically, with the intranasal-delivered microglia-targeting lipid nanoparticles (LNP), this work generates an AβO-specific degradation-potentiated CAR-M by introducing dual mRNAs encoding AβO-specific CAR and anti-CLEC7A nanobody into the cerebral microglia. These data show that these engineered CAR-M exhibited superior phagocytic function and promoted intracellular AβO degradation via activating CLEC7A-spleen tyrosine kinase (SYK) signaling pathway through the local secretion of anti-CLEC7A nanobody. In the APP/PS1 mouse model of AD, these in situ reprogrammed CAR-M significantly reduced cerebral Aβ levels, suppressed neuroinflammation, and restored cognitive function. In sum, these findings demonstrate that potentiating AβO degradation within CAR-M effectively alleviates AD pathology, providing a promising therapeutic strategy for AD with broad application in other neurodegenerative diseases.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2026
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IF 6.7
Shuang Li,Xiaoyu Chen,Zhuo Liu,Ge Song,Yan Xu
So far reported most semiconductor metal oxide-based triethylamine (TEA) gas sensors need to work at high operating temperature, which not only lead to power consumption but also shorten the service life of sensors. Therefore, there is a high requirement to develop convenient TEA sensors with low operating temperature. In this work, hierarchical radial porous GaN/ZnO n-n heterostructure was successfully prepared by surface modification of ZIF (Zeolitic Imidazolate Framework)-61 microspheres with GaN nanoparticles (NPs) via electrostatic attraction effect combined with a subsequent pyrolysis. The resultant GaN/ZnO heterostructure presents significantly improved TEA sensing performance compared with pure ZnO, reflecting in reduced operating temperature (80 ℃) and higher response value of 24.18 towards 50 ppm TEA, likewise good selectivity and stability. This can be attributed to the highly permeable structure and large surface area of GaN/ZnO heterostructure, accelerating the adsorption and diffusion of gases. The GaN NPs decorated on ZnO facilitate electron transfer and adsorption of reactive oxygen species. The in-situ DRIFTs was conducted to investigate the oxidation of TEA over GaN/ZnO surface. The work demonstrates an electrostatic interaction strategy combined with pyrolysis to obtain a novel radial porous GaN/ZnO hierarchical microspheres showing intriguing TEA sensing properties.
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BIORESOURCE TECHNOLOGY
·
2026
·
IF 8.2
Ziteng Wang,Lihui Yi,Jixiang Li,Shiyuan Wang,Xu Li,Wenge Yang,Yonghong Hu
Multidimensional score guided design and tunable boost of LPMO-chitinase complex. • It integrated CBMs substrate affinity and catalytic domains spatial proximity. • The designed fusion CBM 11 enhanced synergistic activity on α-chitin and β-chitin. • Compared to Bc Chi2, NACOS yield increased 6.33 times and 20.16 times, respectively. N- acetylchitosan oligosaccharides (NACOS) show great promise in food, medicine, and agriculture. The synergistic effect of lytic polysaccharide monooxygenases (LPMOs) and chitinases can overcome kinetic barrier and boost the yield of NACOS from crystalline chitin. However, the enhancement level is highly dependent on the enzyme combination, lacking consistency and predictability. To address this challenge, this study developed a predictable multidimensional framework based on the substrate affinity of carbohydrate-binding modules (CBMs) and the spatial proximity of catalytic domains, guiding the rational design of LPMO-chitinase complex and the tunable enhancement of synergistic effect. The designed artificial fusion CBM 11 exhibited good catalytic activity. In the α-chitin and β-chitin systems, compared with chitinase ( Bc Chi2) alone, the addition of LPMO ( Bc LPMO1_T3) increased the yield of NACOS by only 0.17-fold and 1.97-fold, while fusion CBM 11 (a multi-enzyme complex of Bc LPMO1_T3 and Bc Chi2) achieved significant increases of 6.33-fold and 20.16-fold, respectively. The degradation rate of β-chitin by 3 μmol/L fusion CBM 11 reached over 85%. In addition, the fusion enzyme exhibited good thermostability and significant tolerance to high concentrations of H 2 O 2 , further demonstrating the application potential in complex reaction systems. This work presents a rational strategy for optimizing multi-enzyme synergistic systems to efficiently degrade chitin and provides a reference for the development of biocatalysts targeting other insoluble polysaccharides. Download: Download high-res image (143KB) Download: Download full-size image
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JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
·
2022
·Vol. 98
·期 1
·204-212
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IF 3.709
Xin Guo,ChunXiao Ren,Siqi Jiang,Jisheng Li,Shuai Zhang,Yichuan Wang,Weiting Ma,Ye Yang,Chenglong Ma,Zhiyong Su,Zhiyuan Wang,Yufeng Hu,Zhichang Liu
BACKGROUND Recent works have shown how to develop methods with specific economic and environmental aspects; this is the main motivation for research on energy efficient processes and environmentally friendly materials for formaldehyde (HCHO) storage. One specific goal is to improve the adsorption capacity for HCHO by constructing closely contacted connections with absorbents. RESULTS In this study, two ionic liquids (ILs), 1-methylimidazole hydrogen sulfate [MIM][HSO 4 ] and Imidazole hydrogen sulfate [IM][HSO4] as newly developed absorbents for HCHO storage are applied for the first time. Based on thermogravimetric analysis (TGA) and nuclear magnetic resonance (NMR) results, it is concluded that their exceptional capacity for storage of HCHO is 31.07 and 34.60 (g formaldehyde)⋅(mol ionic liquid) −1 , respectively. In addition, to study the renewability of HCHO, the decomposition rates of the reaction products (as a function of decomposition time and decomposition temperature) were measured. The optimal kinetic model was selected to satisfy the formation and decomposition processes of the products. Thereafter, the activation energy ( E ), pre-finger factor ( A ), decomposition rate constant of the decomposition reaction, and the rate constant of the reaction were determined. NMR results confirmed that the higher storage capacity of HCHO in [MIM][HSO 4 ] and [IM][HSO 4 ] is mostly attributed to the stronger covalent bonds between the ionic liquids (ILs) and HCHO. CONCLUSION These ILs are, thus, promising candidates as adsorbents for the design of air depollution processes. This study may provide new insights into the use of ILs for storage of HCHO for low-cost, high-performance, and environmentally benign adsorbents for indoor air purification. © 2022 Society of Chemical Industry (SCI).
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Algal Research-Biomass Biofuels and Bioproducts
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2022
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IF 5.276
Tiancheng Tang,Benwei Zhu,Zhong Yao
Ulvan , extracted from the marine green algae belonging to the genus Ulva , is a complex water-soluble sulfated polysaccharide which mainly composed of four monosaccharides consisting of rhamnose , xylose , glucuronic acid and iduronic acid . Its complex monosaccharide composition gives ulvan great potential for application in the fields of food, pharmaceuticals, and chemistry. And it can be degraded by ulvan lyases mainly from Polysaccharide Lyases (PL) family of PL24, PL25 and PL28 through β -elimination mechanism, which cleaves the β -glycosidic bond between sulfated rhamnose and glucuronic acid or iduronic acid, thereby producing an Ulva oligosaccharide with unsaturated bond. In this study, we have identified a putative ulvan lyase from Alteromonas sp. TK-45 (2). We heterologously expressed, purified, and biochemically characterized the ulvan lyase, which has removed signal peptide . The results show that ULA-1 had best activity at 45 °C and pH 8.0. The K m and V max values were 13.25 μg·mL −1 and 1.719 μmol·min −1 ·mL −1 , respectively. The thermostability of ULA-1 was excellent, and its activity hardly decreased after incubation at 45 °C for 1 h. ESI-MS analysis showed that the primary end-product were disaccharides to tetrasaccharides . In conclusion, our research has expanded the database of ulvan lyase, and provided the possibility to make full use of ulvan, a huge marine biomass resource .
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INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
·
2022
·
IF 1.934
Xiaoyan Liu,He Zhu,Yanan Li,Hongqiang Qin,Mingliang Ye
In this study, we presented a MALDI-TOF MS based approach for the screening of recombinant protein high-yield strains. It relies on the MALDI MS analysis of the affinity tag containing peptide that released from the targe t recombinant proteins expressed in host strains. This approach was illustrated by quantifying the His-tag containing target peptide which was removed from the recombinant protein of Src Homology 2 superbinder by tobacco etch virus protease . After the specific enrichment and detection of target peptide with the theoretical molecular weight of 1895.09 Da, we could achieve the identification of strains with different expression levels of Src Homology 2 superbinder. Furthermore, the screening of strains at the absolute quantitative level was realized by adding the synthesized heavy labeled peptide as internal standards, and the quantitative results have a good linear correlation. In general, based on the virtue of high speed, accuracy and sensitivity of MALDI-TOF MS, this approach has the potential to achieve high throughput detection, and then provide powerful technical support for the screening of recombinant protein high-yield strains.
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CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Yongsheng Ma,Shuyi Xu,Pengpeng Yue,Hankun Cao,Yongkang Zou,Lizhe Wang,Haitao Long,Shuangquan Wu,Qifa Ye
Infections caused by bacteria have long constituted a major threat to human health and the economy. Therefore, there is an urgent need to design broad-spectrum antibacterial materials possessing good biocompatibility to treat such infections. Herein, inspired by the good biocompatibility of chitin and antibacterial properties of imidazolium salts, a polysaccharide-based material, imidazolium salt chitin (IMSC), was homogeneously prepared using a facile method with epichlorohydrin as a chemical crosslinker to combine chitin with imidazole to enhance Staphylococcus aureus ( S. aureus )-infected wound healing. The characteristics, antimicrobial properties, and biosafety of IMSC were evaluated. The results demonstrated successful grafting of imidazole onto chitin. Furthermore, IMSC exhibited good water solubility, broad-spectrum antimicrobial activity, hemocompatibility, and biocompatibility. Moreover, IMSC enabled complete healing of S. aureus -infected wound in Sprague–Dawley rats within 15 days of application, thus demonstrating that IMSC could reduce wound inflammation and remarkably accelerate wound healing owing to its efficient antibacterial activity and ability to promote collagen deposition in and around the wound area. Therefore, this study provides a promising and potential therapeutic strategy for infected wound healing by synthesizing a water-soluble and broad-spectrum antimicrobial material exhibiting good biocompatibility.
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MOLECULES
·
2023
·Vol. 28
·期 2
·702
·
IF 4.6
Zhiyang Feng,Jiaqing Zhu,Shen Zhuo,Jun Chen,Wenyi Huang,Hao Cheng,Lijun Li,Tai Tang,Jun Feng
A magnetically functionalized Fe3O4@ZIF−67 metal–organic framework (MOF) was prepared by electrostatic self-assembly using magnetic Fe3O4nanoparticles as the core and ZIF−67 as the shell. The composite was characterized by electron microscopy, X-ray diffraction, Fourier- transform infrared spectroscopy, and Brunauer–Emmett–Teller measurements. Magnetic solid-phase extraction (MSPE) was performed on five flavonoids fromDicranopteris pedatausing Fe3O4@ZIF−67 as an adsorbent. The developed MSPE method was combined with high-performance liquid chromatography–ultraviolet detection to preconcentrate and separate five flavonoids (rutin, quercitrin, kaempferol-3-O-α-L-rhamnoside, quercetin, and kaempferol) fromDicranopteris pedata. The factors affecting the extraction, such as the amount of Fe3O4@ZIF−67 adsorbent, salt ion concentration in the sample solution, vortex time, type and amount of desorbing solvent, concentration of formic acid to acidify the desorbing solvent, and acetonitrile ratio, were optimized. The developed method showed good linearity over the concentration range of 1.09–70.0 μg∙mL−1for the five flavonoids, with R2values between 0.9901 and 0.9945. The limits of detection and average recoveries for the five flavonoids were in the ranges of 39.5–56.2 ng∙mL−1and 92.2–100.7%, respectively. The method presented herein is simple, efficient, and sensitive; it can be used for enrichment analysis of the five flavonoids inDicranopteris pedata.Keywords:magnetic solid-phase extraction;Fe3O4@ZIF−67;Dicranopteris pedata;flavonoids;metal–organic framework materials
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Wenting Wu,Zongqi Zhang,Lipeng Sun,Ruiping Wei,Lijing Gao,Xiaomei Pan,Jin Zhang,Jin Yu,Guomin Xiao
Well-arranged photosensitive units and catalytic sites in closeness are critical for enhancing charge separation effectiveness and promoting photocatalysis. Here, a heterogeneous interface is constructed, which binds a deprotonated carboxyl group on perylene diimide (PDI) photosensitizer to unsaturated metal sites generated by etching of different Prussian blue analogues (PBAs). The atomically-dispersed metal sites and anchored photosensitive units greatly accelerate charge transfer. Typically, the S-scheme heterojunction built by etched NiCo PBA and PDI (NCSP) possesses bond of O-Ni. Density functional theory (DFT) and in-situ technology reveals the electron density of the Ni active site is optimized. Consequently, activation barrier of CO 2 on the Ni site was reduced, thus improving the CO generation (60.0 μmol g −1 ) up to about 9 times than NiCo PBA. This work reveals key insights into the precise modulation of active moiety for efficient photocatalytic CO 2 conversion.
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OPTIK
·
2022
·
IF 2.84
Ruoxian Hou,Hanzhang Chen,Defu Sun,Nana Zhang,Chuanying Shen,Duanliang Wang
Using the solvent evaporation approach at room temperature (RT), we produced transparent single crystals of two new organic-inorganic hybrid materials: (C 5 H 6 NO)SO 3 NH 2 (crystal 1: reaction by sulfamate and 4-hydroxypyridine) and (C 3 H 5 N 2 )SO 3 NH 2 (crystal 2: reaction by sulfamate and imidazole). Both crystals have the same space structure and belong to the P 2 1 / c space group of the monoclinic crystal system, according to the results of X-ray single crystal diffraction. In crystals 1 and 2, sulfamic acid and organics (4-hydroxypyridine, imidazole) are alternatively positioned by hydrogen bonds to create a layered structure. Hydrogen bonds and electrostatic Coulomb forces connect the layers to one another. Powder XRD demonstrates the remarkable phase purity of both crystals. Furthermore, the optical properties of both crystals, including IR , UV absorption, and fluorescence spectra , have been investigated in detail. The presence of functional groups such as NH 2 and C C in the grown crystals was confirmed by Fourier transform infrared analysis. The optical band gaps for crystals 1 and 2 are about 4.33 and 4.31 eV, respectively, and the UV absorption findings show a low light absorption . According to the photoluminescence spectra, the two crystals have distinct fluorescence characteristics, with emission peaks of approximately 433 nm and 442 nm, apiece.
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JOURNAL OF POLYMER SCIENCE
·
2022
·Vol. 61
·期 6
·491-502
·
IF 3.046
Lidong Cao,Xingzhong Fang,Guofei Chen
High imidization temperature of polyimides (PIs) brings great restriction to the applications in electronic industry. In this study, N,N ′-carbonyldiimidazole (CDI), a novel low-temperature imidization accelerator with the unique dual function of catalyst and dehydrating agent, was researched to solve this problem. PIs synthesized from 4,4′-(hexafluoroisopropylidene)diphthalic anhydride (6FDA) and 4,4′-oxydianiline were researched as the main object on method A and method B, two preparation methods of PIs, by introduction of CDI, which was found that the PIs prepared by method A achieved complete imidization and basically had no residual CDI and N,N -Dimethylacetamide at 180 °C under vacuum, while the completely imidized PIs prepared by method B were also obtained at 40 °C. Even prepared at low temperature, the PI films with adding CDI both showed satisfactory thermal and mechanical properties, especially in reducing coefficient of thermal expansion. In addition, the universality of the reaction between CDI and poly(amic acid) were also verified by other soluble PI systems. All these results prove the superior performance of CDI in lowering imidization temperature, showing great potentials in low-temperature cured PIs. Graphical
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