JOURNAL OF CHROMATOGRAPHY A
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2024
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IF 3.8
Haidong Gao,Shucai Gao,Ming Lv,Yeru Liu,Jingjing Yao,Hongwei Liu,Fayun Wang,Mantang Chen,Libin Wan
Polycyclic aromatic hydrocarbons (PAHs) have been classified as the earliest discovered class of environmental carcinogens, seriously endangering human health and ecological safety, and the hydroxylpolycyclic aromatic hydrocarbons (OH-PAHs) in human urine are considered as the main biomarkers to evaluate the exposure levels of PAHs in human body. Therefore, it is necessary to develop an accurate and sensitive method for the determination of urinary OH-PAHs. Herein, we proposed electromembrane extraction (EME) as a simple, effective and ecofriendly sample pretreatment technique for selective extraction, purification and enrichment of four typical OH-PAHs (2-naphthol, 2- and 3-phenanthrol, 2-hydroxyfluorene) in human urine for the first time. Under the optimum conditions, an analytical method of EME coupled with HPLC was established, which provided wide linear ranges for four OH-PAHs from 1 to 500 ng mL -1 with low LODs of 0.05–0.3 ng mL -1 . The average recoveries of four OH-PAHs at three spiked levels in human urine were 81.6–102.5% with RSDs all below 9.4%. The present method has been successfully applied for the sensitive determination of trace four OH-PAHs in urine samples from non-smokers and smokers with a maximum concentration of 2.24 and 3.56 ng mL -1 , respectively, which showed a great potential for the analysis of trace OH-PAHs in biological samples.
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JOURNAL OF MOLECULAR LIQUIDS
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2024
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IF 5.3
Yujie Zhen,Qingqing Yin,Fangyu Zhang,Anle Zhang,Wenxue Lu,Tao Li,Yiwu Lu,Yingmin Yu
To explore the effective treatment of acrylic acid wastewater, liquid–liquid equilibrium (LLE) data for water + acrylic acid + {n-propyl acetate, n-butyl acetate, n-heptanol, and methyl isopropyl ketone} at 303.2 K and 101.3 kPa were measured respectively. The distribution coefficients ( D ) and separation factors ( S ) were used to assess the extraction effectiveness of the four solvents, and the results of the comparative data showed that the D values of the four solvents for acrylic acid ranged from 1.6 to 4.4, and the S values were in the order of n-butyl acetate > n-propyl acetate > MIPK > n-heptanol. The experimental data were fitted by NRTL and UNIQUAC models to obtain the binary interaction parameters, and the obtained above parameters were proved reliable by the mixing surface analysis method of Gibbs energy topology. The root mean square deviation ( RMSD ) of both models did not exceed 0.0051 and 0.0077, respectively. In addition, σ-profiles analyzed the differences in extraction effects in terms of interactions and interaction energies, and the analyses showed that the theoretical calculations are in agreement with the experimental results.
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ANALYTICAL LETTERS
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2024
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IF 1.6
Yelu Wu,Weiyang Tang,Jian-Liang Zhou,Tian Xie
3,4-Dihydroxybenzaldehyde (DHB) is a highly effective water-soluble compound in the traditional Chinese medicine Salvia miltiorrhiza Bge. Which demonstrates clear therapeutic effects against a variety of diseases. Therefore, the development of a selective approach for the separation of 3,4-dihydroxybenzaldehyde is of great significance. In this study, electro-driven extraction combined with multi-stage extraction technology was employed for the first time to separate 3,4-dihydroxybenzaldehyde from S. miltiorrhiza Bge. Decoction (Recovery ≥ 46.09%). Five long-chain fatty alcohols were selected as the supported liquid membrane (SLM) in the electro-driven extraction. Factors influencing extraction efficiency, including pH, voltage, and extraction time, were optimized using a design of experiments. Under the optimal conditions, the linearity of 3,4-dihydroxybenzaldehyde ranged from 0.01 to 100 μg·mL−1), with limits of detection (LOD) and quantification (LOQ) of 5 and 17 ng·mL−1, respectively. The precision of electro-driven liquid membrane extraction for 3,4-dihydroxybenzaldehyde was below 8.42%. This paper reports novel electro-driven liquid membrane extraction for selectively isolating 3,4-dihydroxybenzaldehyde from S. miltiorrhiza Bge.
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JOURNAL OF CHROMATOGRAPHY A
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2025
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IF 4
Mantang Chen,Linping Shi,Fuwei Xie,Xiaoyu Wang,Cong Nie,Sheng Wang,Kejian Liu,Jingjing Yu,Libin Wan
A flat membrane–based liquid-phase microextraction (FM-LPME) method was developed for the first time to simultaneously separate and extract basic and acidic pesticide analytes from the same sample. Using carbendazim and pirimicarb as representative basic pesticides, along with bromacil, diflubenzuron and 1,2-dibenzoyl-1-tert-butylhydrazine (RH-5849) as representative acidic pesticides, the performance of FM-LPME for the extraction of these model pesticides has been optimised individually. Under optimal extraction conditions, the developed FM-LPME-LC–MS/MS method exhibited excellent linearity, with R 2 values exceeding 0.9903 in concentration ranges of 0.1–1400 ng mL −1 for carbendazim and pirimicarb, and 1–1400 ng mL −1 for bromacil, diflubenzuron and RH-5849. The limits of detection ranged from 0.01 to 0.09 ng mL −1 . The recoveries and relative standard deviations of all the tested pesticides at three spiked concentrations (100, 500 and 1200 ng mL −1 ) were in the ranges of 80.0%–125.0% and 0.3%–9.3%, respectively. The FM-LPME-LC–MS/MS method demonstrated advantages in terms of being environmentally friendly, possessing a wide linear range, high sensitivity, high precision and satisfactory recoveries, thus highlighting its notable potential for the separation and extraction of basic and acidic pesticide residues in water samples.
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MACROMOLECULAR RAPID COMMUNICATIONS
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2025
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IF 4.3
Ming Yang,Ni Yao,Roman A. Surmenev,Xinxin Zhang,Jianyong Yu,Shichao Zhang,Bin Ding
Electrospun fibrous materials with fine fibers and small pores are fundamental for particulate matter (PM) filtration, addressing its harmful environmental and health impacts. However, the existing electrospun fibers are still limited to their sub-micron diameters and unstable surface electrostatic effect, leading to deteriorated filtration performance after prolonged storage or wetting. Herein, the study creates nanofibrous membranes with long-time stable electrostatics by electret-enhanced electrospinning. The phase separation and polarization of the charged jet are manipulated to achieve rapid stretch and strong electret. The obtained membrane exhibits nanosized structures with fiber diameters of ≈220 nm, pore size <1 µm, as well as robust surface potential of 0.4 kV. By virtue of the synergistic effects of sieving and adsorption, the nanofibrous membrane showed a remarkable PM 0.3 filtration efficiency of 96.6% and pressure drop of 140 Pa, even reaching the N90 standard after five wetting cycles. The design of such durable membranes will offer a new sight in the functional filtration materials.
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CATALYSIS TODAY
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2024
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IF 5.2
Xing Zhang,Guangyi Li,Hailu Yu,Lianqi Xing,Aiqin Wang,Wei Wang,Zhitong Zhao,Ning Li
In recent years, numerous methods have been reported for the preparation of bio-jet fuel. However, the cost remained the most vital determinant for the practical application of these methods. In 2019, our research team reported a synthetic process for bio-JP-10 fuel. It was suggested the production cost of bio-JP-10 fuel can be greatly reduced to $2547/ton that is significantly lower than the market price (∼7091 US$/ton) of fossil energy-based JP-10 fuel. However, energy consumption constituted as much as 42 % of the bio-JP-10 fuel production cost. In the present work, the initial 1,3-cyclopentanediol concentration in the dehydration step of the original route was amplified by six-fold by the optimization of solvent. Upon further optimization of reaction conditions, higher than 80 % cyclopentadiene carbon yields were achieved. Furthermore, a tandem reaction process involving the dehydration, Diels-Alder reaction and hydrogenation steps was developed, eliminating the need to separate the products. Both innovations considerably enhanced the production efficiency of bio-JP-10 fuel. Following the process simulation and energy balance of Aspen Plus 11, the energy consumption cost of bio-JP-10 fuel can be reduced by 67 %.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2024
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IF 2
Mai Han,Yujie Zhen,Fangyu Zhang,Anle Zhang,Jiajun Wei,Wei Wang,Zhiwei Zhang,Wenxue Lu,Tao Li,Qingsong Li
The development and research of biomass fuels have been paid more and more attention. The production of methacrylic acid is accompanied by a large amount of water and environmental pollution. Therefore, the separation of methacrylic acid from aqueous solution is of great significance for industrial production and environmental protection. The liquid–liquid equilibrium (LLE) for ternary systems of water + methacrylic acid + alcohol solvents at 303.2 K and 101.3 kPa was investigated. Thermodynamic models (NRTL and UNIQUAC) were used to correlate and regress the experimental data. The root-mean-square deviation (RMSD %) was used to evaluate the deviation between the experimental value and the calculated value, which were 1 and 1, respectively, indicating that the extractants selected in the experiment could well separate methacrylic acid from the aqueous solution, and 1-octanol exhibits better extraction performance. The correlation of LLE data is proven by MATLAB. In addition, the binary interactive parameters of the model regression are verified by MATLAB.
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MICROCHEMICAL JOURNAL
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2025
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IF 5.1
Jing Wang,Hong-li Guo,Yun-feng Liu,Li Yang,Run-qin Wang,Rong-rong Xing,Xuan Chen,Shuang Hu
In this study, a ternary switchable deep eutectic supramolecular polymer (sDESP) based homogeneous liquid–liquid microextraction (HLLME) was established and applied to the preconcentration and determination of six main hepatotoxic ingredients in “Psoraleae Fructus” combined with high performance liquid chromatography-ultraviolet detection (HPLC-UVD). A hydrophilic switchable DESP with diethanolamine-heptanol deep eutectic solvent (DES) loaded into hydroxypropyl-β-cyclodextrin was used as an extraction solvent in the HLLME method, that could be converted into the hydrophobic form by injecting a phase-switching trigger. Then, the upper hydrophobic phase concentrating the target analytes was collected for chromatographic analysis after a centrifugation. Several key factors affecting the experiment, including the type of both DES and macrocyclic host molecule, the consumption of DESP, the type and volume of phase-switching trigger, the concentration of sodium chloride in the sample phase and extraction time were optimized. And the DESP extractant was characterized by Fourier transform infrared spectroscopy and proton nuclear magnetic resonance spectroscopy. Under the optimum conditions, the enrichment factors for six analytes by the sDESP were between 65 and 352, which were 1.1–1.2 times higher than those by pure DES. Good linearity ( r ≥ 0.9972), low detection limits of 0.03–0.6 ng/mL, and satisfactory precisions (relative standard deviation <9.9 %) and spiked recoveries (86.7 %–100.7 %) were obtained. The hydrophilic sDESP as a novel extractant has a good extraction efficiency for six hepatotoxic ingredients in traditional Chinese medicine “Psoraleae Fructus”. This method is a promising sample pre-treatment method owing to the advantages of dispersant free, low organic solvent consumption and simple operation.
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MICROCHEMICAL JOURNAL
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2025
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IF 5.1
Run-qin Wang,Jia Chen,Bei-bei Guo,Li Yang,Shuang Hu
A dispersive liquid–liquid microextraction utilizing alkanolamine-based deep eutectic solvent was firstly proposed and introduced to preconcentrate trace level of digoxin in human plasma prior to high performance liquid chromatography analysis with deslanoside as the internal standard. In the procedure, a deep eutectic solvent was prepared with N,N-dimethylethanolamine as a hydrogen bond acceptor and n -heptanol as a hydrogen bond donor. Chemical structures of the prepared deep eutectic solvent were characterized by infrared spectroscopy and proton nuclear magnetic resonance spectroscopy. The experimental parameters affecting the extraction performance, including deep eutectic solvent composition, volume of extraction solvent, pH of aqueous sample solution, salt concentration and extraction time, were investigated and optimized. Under the optimum conditions, the method showed good linearity in the range of 0.32–80 ng/mL, precision (relative standard deviations 1.0 %–15 %), accuracy (relative errors −6.4 %–8.5 %) and acceptable extraction recoveries (80.3 %–81.4 %). In addition, satisfactory lower limit of quantification (0.32 ng/mL) and stability were achieved, while matrix effect was not observed in human plasma for the proposed method. It showed that the developed method was efficient, fast and eco-friendly, which provides a potential alternative for the preconcentration and determination of digoxin in complex biological matrices.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
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IF 9.4
Ximeng Liu,Jingwen Chen,Fan Xia,Jian Yang,Chun Feng,Jinlou Gu
The design and construction of MOFs with flower-like structure could afford sufficient space for the immobilization of guests with large size and interconnected transport channels for their mass diffusion although it remains a challenge. Herein, wrinkled Ce-based hierarchically porous UiO-66 (Ce-WUiO-66) with good crystallinity was successfully synthesized for the first time using bicontinuous emulsion composed of 1-heptanol, water and F127 (PEO 106 PPO 70 PEO 106 ) surfactant as a template. F127 played a key role in the formation of emulsions as a stabilizer, and meanwhile its PEO segments interacted with MOF precursors to guide the evolvement of crystallized pore walls. Through controlling the ratios of heptanol to water and the salinity, the distances of the pleat openings and the morphology of the resultant Ce-WUiO-66 were facilely regulated. In virtue of its highly open radial structure, Ce-WUiO-66 could serve as an ideal platform for loading multiple substances to build a cascade sensing system. As a proof of concept, we designed an amino acid (AA) cascade probe by co-immobilizing gold nanoclusters (AuNCs) and LAA oxidase into Ce-WUiO-66. The aggregation-induced-emission enhancement resulted from the encapsulation of AuNCs into Ce-WUiO-66 significantly improved the detection sensitivity and the detection limit of corresponding substrates reached as low as 10 -8 M. The proposed biphasic interface assembly strategy is hopefully to provide a new route for the rational design of MOFs with various open pore structure and broaden their potential applications with multiple large-size substances involved besides the currently exemplified cascade sensing platform.
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JOURNAL OF HAZARDOUS MATERIALS
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2024
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IF 12.2
Yaxing Ma,Li Chen,Ying Luo,Chuixiu Huang,Xiantao Shen
Lead (Pb) poisoning is estimated to account for 1 % of the global disease burden. The gold standard for diagnosing lead poisoning in human body relies on blood lead level (BLL), which is always performed in hospitals using expensive instruments. However, there are still many countries and regions with a lack of medical resources (without enough professional medical staff and analytical instruments). To achieve a facile diagnosis of lead poisoning by ordinary residents (without any expertise), this study conducted a research study on 810 participants to discover and validate a new lead poisoning indicator (creatinine-corrected urinary lead level, cULL) beyond BLL in non-invasive samples. A point-of-care testing (POCT) device to measure cULL was developed, equipped with liquid-phase microextraction and electromembrane extraction on a paper-based analytical device for on-site separation of lead and creatinine in the urine, using a smartphone for the quantification of analytes. The cULL as a novel indicator and the POCT device developed could be effective in reducing the risk of damage from lead contamination.
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FOOD CHEMISTRY
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2024
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IF 8.5
Guanmian Wei,Ziyi Zhang,Feiran Zhao,Yaxin Sang,Joe M. Regenstein,Peng Zhou
The characteristic aroma compounds of Chinese steamed bread (CSB) fermented with different starters were studied using HS-SPME-GC/MS, aroma recombination and omission experiments. The dynamic changes of the microbiota and their function and metabolites during fermentation were analyzed using metagenomics and non-targeted metabolomics. Forty-nine volatile flavor compounds were identified, while 5 characteristic aroma-active compounds were investigated in CSB fermented with commercial dry yeast (AQ-CSB), and 10 were investigated in CSB fermented with traditional starter (NY-CSB). Microbial structure and function analysis showed that Saccharomyces cerevisiae dominated during AQ-CSB fermentation and contributed >95% to its KEGG pathways, while Pediococcus pentosaceus , unclassified Pediococcus , Lactobacillus plantarum , Lactobacillus brevis and unclassified Lactobacillus were predominant in NY-CSB and together had an ~96% contribution to these pathways. NY-CSB showed higher metabolic activity during fermentation, and the characteristic metabolites were mainly involved in carbohydrate, amino acid and lipid metabolism. The characteristic aroma compounds were identified and increased the understanding of the contributions of the microbiota. This may be useful for designing starter cultures that produce CSB with desirable aroma properties.
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