RSC Advances
·
2018
·Vol. 8
·期 11
·6110-6119
·
IF 2.936
Chengkai Pang,Yuqun Zhuo,Qiyu Weng,Zhenwu Zhu
The activity and hydrothermal stability of Cu/SAPO and xMn–2Cu/SAPO for low-temperature selective catalytic reduction of NOx with ammonia were investigated. An ion-exchanged method was employed to synthesize xMn–2Cu/SAPO, which was characterized by N2 adsorption, ICP-AES, X-ray diffraction (XRD), NH3-temperature programmed desorption (NH3-TPD), NO oxidation, X-ray photoelectron spectrum (XPS), UV-vis, H2-temperature programmed reduction (H2-TPR) and diffuse reflectance infrared Fourier transform spectra (DRIFTS). 2Mn–2Cu/SAPO and 4Mn–2Cu/SAPO showed the best SCR activity, in that at 150 °C NO conversion reached 76% and N2 selectivity was above 95% for the samples. NO oxidation results showed that the 2Mn–2Cu/SAPO had the best NO oxidation activity and the BET surface area decreased as manganese loading increased. XRD results showed that the metal species was well dispersed. NH3-TPD showed that the acid sites have no significant influence on the SCR activity of xMn–2Cu/SAPO. H2-TPR patterns showed good redox capacity for xMn–2Cu/SAPO. UV-vis and H2-TPR showed that the ratio of Mn4+ to Mn3+ increased as manganese loading increased. XPS spectra showed a significant amount of Mn3+ and Mn4+ species on the surface and addition of manganese increased the ratio of Cu2+. The promotion effect of manganese to 2Cu/SAPO comes from the generation of Mn3+ and Mn4+ species. Deduced from the DRIFTS spectra, the Elay–Rideal mechanism was effective on 4Mn–2Cu/SAPO.
研究领域:
环境科学
·
催化化学
✓ 已验证
DOI
高影响因子
JOURNAL OF CHEMICAL RESEARCH
·
2022
·
IF 1.097
Tiandi Ding,HaiJiao Chen,Yan Li,Ying Li,Ying Zhi,Zhiqiang Qu,Qiang Sun,Qingqiang Yao,Bo Liu
Sphingosine kinase is a lipid kinase that catalyzes the phosphorylation of sphingosine to sphingosine-1-phosphate. Sphingosine-1-phosphate is a bioactive lipid that regulates biological processes. The overexpression of sphingosine kinases is related to a variety of pathophysiological conditions. For example, SphK1 has been shown to be highly expressed in various cancer cells including ovarian, cervical, colon, stomach, lung, and brain cancer. Inhibition of sphingosine kinases is a promising way to treat diseases such as cancer. Through computer-aided drug design, we have discovered a new SphK1 inhibitor named Amb30572637 (SAMS10). In this report, we describe the discovery process and biological characteristics. In biochemical experiments, SAMS10 shows a prominent inhibitory effect on SphK1, with an IC50 value of 9.8 μM. Subsequent MTT experiments show that SAMS10 has anticancer effects toward A549, SKVO3, A375, and LOVO cell lines and has essentially no cytotoxicity against the healthy cell L929. SAMS10 has significant inhibitory activity against the A549 and LOVO cell lines, with IC50 values of 14.64 and 14.48 μM, respectively. It belongs to a moderately active SphK1 inhibitor with lower anticancer activity than the control compound cisplatin, but the effect of SAMS10 toward SphK1 and its anticancer activity indicate that it is a promising lead compound for the development of effective SphK1 anticancer inhibitors.
研究领域:
药理学
·
癌症研究
·
药物发现
·
生物化学
·
分子生物学
✓ 已验证
DOI
高影响因子
BMC PLANT BIOLOGY
·
2022
·Vol. 22
·期 1
·1-14
·
IF 5.26
Cheng Pengfei,Feng Liying,Zhang Shuoyu,Li Longna,Guan Rongzhan,Long Weihua,Xian Zhihui,Zhang Jiefu,Shen Wenbiao
Background Cold stress adversely influences rapeseeds ( Brassica napus L.) growth and yield during winter and spring seasons. Hydrogen (H 2 ) is a potential gasotransmitter that is used to enhance tolerance against abiotic stress, including cold stress. However, convenience and stability are two crucial limiting factors upon the application of H 2 in field agriculture. To explore the application of H 2 in field, here we evaluated the role of ammonia borane (AB), a new candidate for a H 2 donor produced by industrial chemical production, in plant cold tolerance. Results The application with AB could obviously alleviate the inhibition of rapeseed seedling growth and reduce the oxidative damage caused by cold stress. The above physiological process was closely related to the increased antioxidant enzyme system and reestablished redox homeostasis. Importantly, cold stress-triggered endogenous H 2 S biosynthesis was further stimulated by AB addition. The removal or inhibition of H 2 S synthesis significantly abolished plant tolerance against cold stress elicited by AB. Further field experiments demonstrated that the phenotypic and physiological performances of rapeseed plants after challenged with cold stress in the winter and early spring seasons were significantly improved by administration with AB. Particularly, the most studied cold-stress response pathway, the ICE1-CBF-COR transcriptional cascade, was significantly up-regulated either. Conclusion Overall, this study clearly observed the evidence that AB-increased tolerance against cold stress could be suitable for using in field agriculture by stimulation of H 2 S signaling.
研究领域:
植物学
·
农业科学
✓ 已验证
DOI
高影响因子
ATMOSPHERIC ENVIRONMENT
·
2020
·
IF 4.039
Yaxin Guo,Na Wang,Shufeng Pang,Yunhong Zhang
Although nitrates and amino acids are ubiquitous in the atmosphere, the interactions of amino acids with nitrates on the hygroscopicity of aerosols are still not clear. We studied the hygroscopic properties and compositional evolution of three atmospherically relevant species, sodium nitrate (NaNO 3 ), glycine and L-alanine (alanine). The investigations on the NaNO 3 , glycine, alanine and their internally NaNO 3 /amino acid mixed particles with molar ratios of 3:1, 1:1 and 1:3 were conducted using attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR). The mixed NaNO 3 /glycine droplets with molar ratios of 3:1, 1:1 and 1:3 exhibited efflorescence transition at 52.3%, 62.6% and 63.2%RH, respectively. For the NaNO 3 /alanine mixed systems with molar ratios of 3:1, 1:1 and 1:3, the efflorescence relative humidity (ERH) was measured to be 50.2%, 59.8% and 69.3%, respectively. These results suggested that in each of the systems studied the addition of amino acids to aerosols could promote the crystallization of mixed droplets. However, the higher deliquescence relative humidity (DRH) with increased fraction of glycine for the mixed NaNO 3 /glycine (3:1, 79.2%RH; 1:1, 86.3%RH; 1:3, 86.5%RH) also indicated that glycine could inhibit the deliquescence phase transition of mixed systems. In the case of NaNO 3 /alanine systems, the DRH for 3:1 and 1:3 mixed particles was 78.2% and 82.7% while no deliquescence transition occurred for the 1:1 mixed particles. The hygroscopic properties of mixed NaNO 3 /amino acids droplets were modified due to the formed amino acid-NaNO 3 complex salts from the interactions of amino acids with NaNO 3 in aerosols during dehydration process. The discrepancies in water content for the mixed NaNO 3 /amino acids with molar ratios of 1:1 and 1:3 between dehydration and hydration processes at high RH could be attributed to the crystallization of amino acid-NaNO 3 complex salts during dehydration and the residual amino acids.
研究领域:
大气科学
·
化学
✓ 已验证
DOI
高影响因子
BIOMACROMOLECULES
·
2021
·
IF 6.988
Yu Zhang,Bo Xia,Yanyan Li,Xianfu Lin,Qi Wu
The synthesis of optically pure polymers is one of the most challenging tasks in polymer chemistry. Herein, Novozym 435 (Lipase B from Candida antarctica, immobilized on Lewatit VP OC 1600)-catalyzed polycondensation between d-/l-aspartic acid (Asp) diester and diols for the preparation of helical chiral polyesters was reported. Compared with d-Asp diesters, the fast-reacting l-Asp diesters easily reacted with diols to provide a series of chiral polyesters containing N-substitutional l-Asp repeating units. Besides amino acid configuration, N-substituent side chains and the chain length of diols were also investigated and optimized. It was found that bulky acyl N-substitutional groups like N-Boc and N-Cbz were more favorable for this polymerization than small ones probably due to competitively binding of these small acyl groups into the active site of Novozym 435. The highest molecular weight can reach up to 39.5 × 103 g/mol (Mw,Đ = 1.64). Moreover, the slow-reacting d-Asp diesters were also successfully polymerized by modifying the substrate structure to create a “nonchiral” condensation environment artificially. These enantiocomplementary chiral polyesters are thermally stable and have specific helical structures, which was confirmed by circular dichroism (CD) spectra, scanning electron microscope (SEM), and molecular calculation.
研究领域:
高分子化学
·
生物催化
·
材料科学
✓ 已验证
DOI
高影响因子
BIOMACROMOLECULES
·
2021
·
IF 6.988
Botuo Zheng,Songyi Xu,Xufeng Ni,Jun Ling
Polymerization of N-substituted glycine N-thiocarboxyanhydrides (NNTAs) is a promising pathway to prepare functional polypeptoids benefiting from their tolerance to nucleophilic impurities. However, controlled NNTA polymerization is hard to achieve in amide polar solvents, including N,N-dimethylacetamide (DMAc), N,N-dimethylformamide (DMF), and N-methyl pyrrolidone (NMP), the only aprotic solvents for many biomacromolecules and polypeptoids. In the present work, we successfully achieve controlled NNTA polymerization in amide polar solvents by adding acetic acid as a promoter. The promotion is applied to the polymerization of sarcosine NTA, N-ethyl glycine NTA, and N-butyl glycine NTA. DMAc, DMF, and NMP are suitable solvents to prepare polypeptoids with designable molecular weights and low dispersities (1.06–1.21). The polysarcosines with high molecular weights are prepared up to 35.2 kg/mol. A kinetic investigation quantitatively reveals that the presence of acetic acid not only accelerates the polymerization, but also suppresses H2S-catalyzed decomposition of NNTAs by decreasing the concentration of H2S dissolved in polar solvents. Benzoic acid is also able to promote the polymerization, while trifluoroacetic acid, phosphoric acid, and phenol are not appropriate promoters. The moderate acidity of acids is essential. l-Methionine, l-tryptophan, and l-phenylalanine, which are dissolved in DMF, initiate the controlled polymerization of sarcosine-NTA in the presence of acetic acid and introduce functional end groups to polysarcosines quantitatively. In DMAc, hydrophilic vancomycin is grafted by poly(N-butyl glycine). The amphiphilic product dissolves in dichloromethane and stabilizes water-in-oil emulsion.
研究领域:
高分子化学
·
材料科学
·
生物技术
✓ 已验证
DOI
高影响因子
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
·
2022
·
IF 5.141
Rui Wang,Zunli Mo,Hebing Pei,Simin He,Hui Zheng,Wanjing Liu,Xuening Jin,Xuejiao Zhang,Nijuan Liu,Ruibin Guo
Sensors used to detect Fe 3+ and Cys are generally a single method. In this work, two methods of fluorescence and electrochemistry are innovatively combined to detect Fe 3+ and Cys, and the obtained Lod is basically the same. Carbon quantum dots (CQDs) with blue fluorescence were successfully prepared by hydrothermal methods using tryptophan (Trp) as carbon source, which can be used for fluorescence and electrochemical dual-channel probe quickly detecting iron ion (Fe 3+ ) and cysteine (Cys). A series of studies have been carried out on its morphology, chemical structure, and optical properties through TEM, XRD, FT-IR, XPS, UV–vis absorption spectrum, and photoluminescence spectra. And the quantum yield of CQDs was up to 52.64%. It was also analyzed in the real sample, demonstrating the feasibility and reliability of detecting Fe 3+ and Cys in the real sample. Furthermore, CQDs can also be used as fluorescent ink for information anti-counterfeiting due to their excellent fluorescent properties.
研究领域:
分析化学
·
材料科学
·
纳米技术
·
生物化学
✓ 已验证
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2018
·
IF 3.716
Liping Zhao,Juan Qiao,Ke Zhang,Dan Li,Hongyi Zhang,Li Qi
A chiral ligand exchange capillary electrochromatography (CLE-CEC) protocol was designed and implemented for d , l -amino acids enantioseparation with poly(maleic anhydride-styrene-methacryloyl- l -arginine methyl ester) as the coating. The block copolymer was synthesized through the reversible addition fragmentation chain transfer reaction. In the constructed CLE-CEC system, poly (methacryloyl- l -arginine methyl ester) moiety of the block copolymer played the role as the immobilized chiral ligand and Zn (II) was used as the central ion. Key factors, including pH of buffer solution, ratio of Zn (II) to ligands, the mass ratio of monomers in the block copolymer, which affect the enantioresolution were investigated. Comparing with the bare capillary, the CLE-CEC enantioresolution was enhanced greatly with the coating one. 5 Pairs of d , l -amino acids enantiomers obtained baseline separation with 5 pairs partly separated. The mechanism of enhancement enantioresolution of the developed CLE-CEC system was explored briefly. Further, good linearities were achieved in the range of 25.0 μM–5.0 mM for quantitative analysis of d -glutamine (r 2 = 0.997) and l -glutamine (r 2 = 0.991). Moreover, the proposed CLE-CEC assay was successfully applied in the kinetics study of glutaminase by using l -glutamine as the substrate.
研究领域:
分析化学
·
生物化学
✓ 已验证
DOI
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Wangli Dai,Shulai Liu,Yicheng Ding,Saiqi Gu,Xuxia Zhou,Yuting Ding
The flavor alterations in bighead carp subjected to varying storage temperatures and the underlying metabolic mechanism were elucidated. Analysis of volatile flavor compounds, electronic nose, free amino acids , ATP-related compounds, and sensory evaluations uncovered a progressive flavor deterioration during storage, especially at 25 °C. Metabolomics-based flavor relating component profiling analysis showed that free fatty acids formed various fatty aldehydes including (E, E)-2,4-heptadienal and nonanal under lipoxygenase catalysis. Alcohol dehydrogenase and alcohol acyltransferases were intimately involved in alcohol and ester generation, while alkaline phosphatase, 5′-nucleotidase, and acid phosphatase were closely associated with IMP, Hx, and HxR conversion, respectively. Aeromonas , Serratia , Lactococcus , Pseudomonas , and Peptostreptococcus notably influenced flavor metabolism and enzyme activities. The metabolism disparities of valine , leucine , isoleucine , lysine, and α-linolenic acid could be the primary factors contributing to flavor metabolism distinctions. This study offers novel insights into the flavor change mechanisms and potential regulation strategies of bighead carp during storage.
研究领域:
食品科学
·
生物化学
·
微生物学
·
代谢组学
✓ 已验证
DOI
PubMed
高影响因子
POLYMER DEGRADATION AND STABILITY
·
2022
·
IF 5.204
Xinming Ye,Yu Feng,Panpan Tian,Zhimao Li,Yingchun Li,Wensheng Wang,Jie Li,Liang Qiao,Kun Wang,Wenchao Zhang,Ye-Tang Pan,Rongjie Yang
Despite remarkable advances in developing flame retardants and smoke suppressants for epoxy resin (EP), engineering nitrogen-containing polyhedral oligomeric silsesquioxane (N-POSS) to impart superior fire safety properties to EP has remained an intractable challenge. In this work, two nitrogen-containing polyhedral oligomeric silsesquioxanes (N-POSSs), namely, aminoethyl-aminopropyl-hepta-phenyl polyhedral oligomeric silsesquioxane (AEAP-POSS) and aminopropyl-hepta-phenyl polyhedral oligomeric silsesquioxane (AP-POSS), were synthesized through the “corner-capping” reaction. The molecular structures of N-POSSs were fully characterized by FTIR, 1 H NMR, 29 Si NMR and MALDI-TOF MS, and the synthesized AEAP-POSS and AP-POSS were introduced into EP to solve the shortcomings of flammability. TGA results showed that the incorporation of 4 wt% N-POSS nanoparticles distinctly improved the char residue at 800 °C, which significantly enhanced the thermal stability of the EP composites. When 4 wt% of AP-POSS was introduced into EP, reductions in the peak of heat release rate (p-HRR), fire growth index (FGI), peak of smoke production rate (p-SPR), and the peak of CO production rate (p-COP) reached to 60.6%, 70.2%, 52.3% and 60.4%, respectively. Subsequently, TG-FTIR and XPS were utilized to investigate the flame retardancy and smoke suppression mechanism. Our work presented a considerable advancement for the facile fabrication of flame retardants based on nitrogen-containing polyhedral oligomeric silsesquioxane compounds.
研究领域:
材料科学
·
化学工程
·
高分子科学
·
消防安全工程
✓ 已验证
DOI
高影响因子
TALANTA
·
2017
·
IF 4.162
Qianqian Wu,Kangnan Wang,Zian Wang,Yatong Sun,Duxia Cao,Zhiqiang Liu,Ruifang Guan,Songfang Zhao,Xueying Yu
Two 3-hydroxyflavone derivatives as one- and two-photon fluorescent chemosensors for cysteine (Cys) and homocysteine (Hcy) were synthesized. The recognition properties and mechanism of the chemosensors for Cys and Hcy were investigated systematically. The experiment results indicate that 3-hydroxyflavone compound 1 (6-bromo-2-(9-ethyl-9 H -carbazol-3-yl)-3-hydroxy-chromen-4-one) after the addition of nickel ions exhibits good recognition properties for Cys and Hcy with fluorescence enhancement and 65 nm absorption peak blue shift based on nickel displacement reaction mechanism. The detection limits (DL) with fluorescence as detected signal are 4.06 × 10 −3 µM (Cys, linear range of 10–80 µM) and 5.8 × 10 −3 µM (Hcy, linear range of 10–100 µM), respectively. But acrylate substituted 3-hydroxyflavone compound 2 (4-oxo-2-(4-diethylamino-phenyl)-4 H -chromen-3-yl acrylate) can specially identify Cys with fluorescence turn-on (DL = 1.87 × 10 −3 µM, linear range of 4–22 µM) based on Cys leading to acrylate hydrolysis mechanism and succedent excited-state intramolecular proton transfer process of 3-hydroxyflavone compound. Then Cys and Hcy biological thiols can be recognized at one time by these two 3-hydroxyflavone derivatives. The bioimaging experiment indicates that both the compounds can be successfully applied to the detection of Cys/Hcy in living cells and compound 2 also can be applied to bioimaging Cys in zebrafish by one- and two-photon fluorescence mode. Then these two compounds have a potential in the application of biological sample analysis.
研究领域:
生物化学
·
分子生物学
·
医学影像学
✓ 已验证
DOI
高影响因子
Chem Catalysis
·
2025
·
IF 11.6
Yingxin Ma,Xuyun Guo,Wenfang Yuan,Peinuo Yang,Yu Zhang,Wenxuan Chen,Lejuan Cai,Valeria Nicolosi,Wenlong Wang,Yang Chai,Bocheng Qiu
Electrochemical upcycling of nitrate (NO 3 − ) wastewater to ammonia offers a sustainable route for reclaiming nitrogen resources from waste. However, its practical implementation still faces substantial obstacles, including high energy input and limited selectivity. Here, we report a paired electrochemical system that combines the anodic oxidation of polyethylene terephthalate (PET) hydrolysate, specifically its ethylene glycol (EG) monomer, to glycolic acid (GA) with the cathodic reduction of NO 3 − to ammonia. All of this is made possible by the discovery of a PdCu alloy anode and a CuCo alloy cathode. Built upon experimental demonstration and a theoretical understanding of the improved CO resistance on the PdCu alloy for EG oxidation, as well as the synergy between Cu and Co for NO 3 − reduction, our paired system enables the efficient co-production of GA and ammonia from PET hydrolysate and NO 3 − -containing wastewater. This conceptual design of paired electrochemistry provides an intriguing way to synthesize high-value chemicals from waste resources.
研究领域:
环境科学
·
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）