INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Yao Liu,Dongshu Chen,Panpan Gu,Yue Liu,Bai Wang,Xiaoxu Xu,Jianshe Hu
With the rapid development of wearable electronic devices and smart sensors, flexible sensors have received much attention due to their excellent mechanical properties and good adaptability. However, developing a simple method to produce conductive hydrogels with excellent electrical conductivity , mechanical properties, environmental stability, and durability is still a major challenge. In this study, a novel dual-network composite flexible sensor was developed, which was mainly composed of xanthan gum (XG), sodium alginate (SA), polyacrylamide (PAAm), and gallium‑indium alloy (Ga-In). The sensor combined the good biocompatibility and thickening properties of natural polysaccharides , the flexibility of polymers, and the excellent electrical conductivity of conductive metal alloys. The sensors exhibited good mechanical properties (stress ≈ 400 KPa, strain ≈ 540 %), high fatigue resistance , recoverability and excellent environmental adaptability. In addition, the addition of liquid metal could increase the conductivity (1.83 S m −1 ) of the hydrogel while maintaining high transparency, and the flexible sensor device constructed from it had high sensitivity to strain (GF = 2.75). Therefore, the hydrogel as a flexible sensor showed promising applications in detecting human movement, which could monitor the movement of human joints, micro-expressions, and handwriting. This will provide new ideas for scientific management of sports and health monitoring.
研究领域:
生物医学工程
·
柔性电子学
·
智能传感器
·
材料科学
·
健康监测
·
人机交互
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2024
·Vol. 12
·期 44
·11347-11358
·
IF 6.1
Yukun Yan,Yuanyuan Chen,Hanqing Dai,Wanlu Zhang,Ruiqian Guo
The ionic environment has a strong influence on the bioelectricity of skin, which is also present in the wound healing process. Inspired by this, we proposed a mechanism for hydrogel-based dressings to respond to endogenous electric fields through exudate absorption and conducted a verification study using a typical hydrogel, namely, polyacrylamide and sodium alginate (PAM–SA) hydrogels, as an example. Theoretical calculations showed that the PAM–SA hydrogels could absorb and orient the various electrolytes of exudate in the hydrogel at the wound site, contributing to the reconstruction of the electric field at the wound site. During the treatment process, this effect significantly accelerated the healing process of the rat epidermis, which exceeded the conventional dressing in terms of healing speed and efficacy, and the wounds on the complete layer of rat skin (wound area: 1.13 cm2) could be rapidly repaired within 10 days. Revealing the electrophysiological behavior of PAM–SA dressings during wound healing can help further improve the design model, the optimization concept, and development paths for the bioelectrical structures of modern dressings and bioelectrical stimulation in wound healing.
研究领域:
生物医学工程
·
皮肤修复
·
生物电学
✓ 已验证
DOI
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2021
·Vol. 222
·期 13
·2100070
·
IF 2.527
Hongyang Wang,Shuai Lan,Yu Zhang,Lu Zhang,Dandan Jia,Weiguo Zhang,Chun Liu,Lei Cao,Dongjun Wang
For the unusual phenomenon of nontraditional intrinsic luminescence, a systematic fluorescence study is conducted in the phase transformation from solution through hydrogel to solid states. In this process, significant differences are found in fluorescence intensity, peak position, lifetime, and excitation-dependent emission. In particular, the samples in the hydrogel state show two fluorescent peaks at 480 and 516 nm, respectively, while only one fluorescent peak is detected in the cases of solution (at 516 nm) or solid (at around 450 nm). More interestingly, the longer wavelength peak presents excitation-dependent fluorescence, and the shorter one is excitation-independent. These unique fluorescent observations can be ascribed to the fact that the aggregates of amine groups act as the actual fluorescent centers, which are quite sensitive to their surrounding microenvironments. Based on these results, some simulation tests of sensors and intelligent hydrogels in response to water are also studied.
研究领域:
材料科学
·
光学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2020
·
IF 3.862
Liyuan Qiao,Cheng Liu,Chengde Liu,Fangyuan Hu,Xiangyu Li,Chenghao Wang,Xigao Jian
Functional hydrogels have been used in various fields, but their development might be limited due to the finite variety of crosslinking agents, complicated functional monomer design and synthesis. To address these issues, a new series of polyamino acid-based multifunctional coupling agents, polyaspartic hydrazide-co-aspartic acid polymers (PHAs), were synthesized through a very simple ring-opening reaction in a short time. The structures of these polymers with gradient content of acylhydrazine and carboxyl groups were characterized through 1 H NMR and FT-IR. The molecular weight of PHAs and the content of acylhydrazine and carboxyl groups were tested through GPC and colloidal titration method, respectively. By crosslinking between acylhydrazine groups of PHA crosslinkers and carbonyl of diacetone acrylamide (DAAM), DAPHA hydrogels with different PHA structures and contents were prepared from acrylamide (AAM), DAAM and PHA crosslinkers in a one-step reaction. Furthermore, through coordination between pendant carboxyl of PHAs and metal cations, DAPHA-Fe 3+ hydrogels were prepared by soaking DAPHA hydrogels in ferric chloride solution. And the structures and mechanical properties of both DAPHA and DAPHA-Fe 3+ hydrogels were investigated. Moreover, taking advantage of the complexation and dissociation of DAPHA hydrogel with Fe 3+ , their shape memory properties were investigated. Finally, magnetic DAPHA-Fe 3 O 4 hydrogels were prepared through in-situ precipitation method, and their magnetism has been studied.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2019
·Vol. 9
·期 6
·3407-3415
·
IF 3.049
Xinglu Jiang,Chenggui Zhao,Xiaobo Fan,Wei Xu,Rui Zhang,Hongbo Xu,Guoqiu Wu
Cell-free DNA (cfDNA) in blood, which stems from the fetus of pregnant women and tumor in cancer patients, has gained attention in molecular diagnosis. However, cfDNA is less stable, and its amount in the serum is extremely low; these are critical barriers for the utilization of this resource. In this study, a DNA-modified polyacrylamide hydrogel (DNA-Gel) was prepared, and a specialized device was designed to simultaneously catch, purify, concentrate, and detect targeted cfDNA by electrophoresis. We demonstrated that 20–1000 bp ssDNA and dsDNA could be caught and released by the DNA-Gel-based device with high specificity and sensitivity. Upon increasing the number of cycles and electrophoresis time, higher DNA purity and density were achieved, and the separation of serum proteins, untargeted cfDNA, and other charged molecules was promoted. As low as 10 pg μL−1 of DNA could be detected using the DNA-Gel after four cycles of concentration. We also detected 1 fg μL−1 of DNA in the serum with 16 cycles of concentration, followed by 25 PCR cycles. We also designed a device to obtain DNA from the DNA-Gel. We found that the DNA loss rate was around 50%, and A260/A280 was close to 1.7. Thus, we have designed a cost-effective and highly economical device to purify DNA at low concentrations with high specificity and selectivity.
研究领域:
分子生物学
·
生物医学工程
·
分析化学
·
遗传学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2015
·
IF 4.074
Chan Bai,Sufen Zhang,Lei Huang,Haiyan Wang,Wei Wang,Qingfu Ye
Starch , with properties of eco-friendliness and abundance, is one of the most important natural polymers. Starch-based hydrogels were investigated as carriers of carbendazim to combine controlled-release and water absorption (WA). Three carbendazim-loaded hydrogels (CLHs) with different WA capacities were prepared by solution polymerization. The CLHs were characterized by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and liquid-chromatography mass-spectrometry (LC–MS/MS). Release kinetics of CLHs was investigated using 14 C-labeling method. The diffusion parameters of CLHs were 0.47, 0.57 and 0.81 in deionized H 2 O (ddH 2 O). WA affected release profile significantly, the release longevity reaching 240 h when WA was 800 g/g in ddH 2 O. Solution pH influenced release profiles and the lowest release rate occurred in the lowest pH. Addition of CLH (1.3 g/kg soil) markedly increased water-holding capacity (WHC) of soil by 8.2%. The study indicated that starch-based CLH was a good controlled-release agent for carbendazim and water absorbent for soil.
研究领域:
农业科学
·
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MACROMOLECULES
·
2021
·
IF 5.985
Noy Cohen,Cong Du,Zi Liang Wu
The submersion of a polymer network with a high density of hydrogen bond based cross-links in an aqueous bath results in the formation of a rubberlike hydrogel. The cross-links, which connect chains and maintain the structure of the network, can dissociate as a result of two main factors: (1) the interactions between the hydrogen bonds and the surrounding water molecules and (2) the forces that are exerted on the cross-link from the interconnected chains. We recall that these forces depend on the ratio between the end-to-end distance and the overall contour length of the chains. The application of an external loading translates into the stretching of chains in the network and, as a consequence, an increase in the forces that are exerted. Sufficiently large external loadings can break cross-links and alter the microstructure of the network. From a macroscopic viewpoint, the breaking of cross-links leads to significant microstructural changes such as a reduction in the chain density and an entropic gain. In this work, we derive a microscopically motivated and energy-based model that captures the effects of hydration and external loadings on the overall changes in properties and mechanical response of hydrogels. We provide a systematic method to estimate the percentage of cross-links that dissociate due to hydration and application of a force and provide representative examples to highlight the influence of the orientations of the interconnected chains with respect to a cross-link. To validate the model, we carry out uniaxial tension experiments on poly(methacrylic acid) hydrogels with five different water contents and fit the model parameters. We show that the model is capable of qualitatively and quantitatively capturing the experimental results. The model is also used to approximate the number of cross-links that dissociate due to the water and the externally applied uniaxial force. This work paves the way to the efficient design of multifunctional synthetic hydrogels with programmable properties and behaviors.
研究领域:
材料科学
·
生物工程
✓ 已验证
产品关联
DOI
高影响因子
Nanomaterials
·
2021
·Vol. 11
·期 7
·1854
·
IF 5.076
Xiuru Xu,Chubin He,Feng Luo,Hao Wang,Zhengchun Peng
Robust conductive hydrogels are in great demand for the practical applications of smart soft robots, epidermal electronics, and human–machine interactions. We successfully prepared nanoparticles enhanced polyacrylamide/hydroxypropyl guar gum/acryloyl-grafted chitosan quaternary ammonium salt/calcium ions/SiO2nanoparticles (PHC/Ca2+/SiO2NPs) conductive hydrogels. Owing to the stable chemical and physical hybrid crosslinking networks and reversible non-covalent interactions, the PHC/Ca2+/SiO2NPs conductive hydrogel showed good conductivity (~3.39 S/m), excellent toughness (6.71 MJ/m3), high stretchability (2256%), fast self-recovery (80% within 10 s, and 100% within 30 s), and good fatigue resistance. The maximum gauge factor as high as 66.99 was obtained, with a wide detectable strain range (from 0.25% to 500% strain), the fast response (25.00 ms) and recovery time (86.12 ms), excellent negligible response hysteresis, and good response stability. The applications of monitoring the human’s body movements were demonstrated, such as wrist bending and pulse tracking.Keywords:hydrogels;toughness;wearable sensors
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
·
2025
·
IF 4.3
Xuena Zhang,Fengqiang Zhang,Chongwei Yin,Juan Xu,Ting Wang
Ethinylestradiol (EE) is a clinically used estrogen with antifertility effects that is poorly water soluble, limiting bioavailability and preventing long-term release when administered orally. This study addresses these challenges through the development of a novel injectable thermosensitive hydrogel that both improves hydrophobic EE dispersion and enables sustained in vivo release, presenting significant potential for long-term contraception. Carboxymethyl-β-cyclodextrin (CM-β-CD) was synthesized to encapsulate EE, thereby enhancing its solubility and distribution in the hydrogel matrix. We found that hydrogels prepared by adding 0.5% (w/v) oxidized dextran (ODex) to the chitosan/sodium β-glycerophosphate (CS/ODex/β-GP) system exhibited mechanical strength favorable for cell growth compared to conventional CS/β-GP, resolved the problems of poor stability and mechanical strength of CS/β-GP hydrogels, and ensured effective retention and delivery in vivo . A 240h drug release study demonstrated the hydrogel’s ability to sustain release, highlighting its potential to prolong contraceptive efficacy. Biocompatibility testing showed cell viability in excess of 85%. FTIR and SEM characterization further confirmed the functional structure and morphology of the hydrogel. This thermosensitive injection system provides a promising platform for the long-term release of hydrophobic drugs such as EE, providing an innovative approach to extended contraceptive delivery.
研究领域:
药剂学
·
生物材料
·
生殖医学
·
药物递送系统
·
高分子药物载体
·
转化医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Xiaotao Zhu,Qiran Yu,Wufeng Su,Na Li,Xiao Miao,Yumin Wang,Lide Xu,Jingwei Lu,Guina Ren
The development of functional hydrogels with wet adhesion strength and antiswelling properties is crucial for applications ranging from biomedicine to wearable electronics but remains difficult to realize. Herein, we developed a high-performance TA/PAAc/EMA/C-CNT (TPEC) hydrogel via a solvent displacement process. The TPEC hydrogel showed no observable swelling behavior even after 8 days of immersion in a water bath, demonstrating its excellent antiswelling property. The TPEC hydrogel possesses strong adhesive strength in the underwater environment, allowing it to adhere firmly to rigid substrates and moving fingers, and also acts as a sealing material to prevent liquid leakage underwater. In addition, the TPEC hydrogel also demonstrated improved mechanical properties, good conductivity, and antimicrobial properties. Finally, exploiting its multifunctional properties, the resulting TPEC hydrogel is utilized as a flexible wearable strain sensor for monitoring body motion in both air and water environments. This work is expected to open up new opportunities for developing future generations of high-performance adhesive hydrogels for use in wet environments.
研究领域:
生物材料
·
生物医学工程
·
柔性电子
·
组织工程
·
转化医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2018
·Vol. 16
·期 1
·1-15
·
IF 5.294
Fu Ji-jun,Chen Ming-yue,Li Jie-xia,Zhou Jun-hua,Xie Sheng-nan,Yuan Ping,Tang Bo,Liu Cheng-cheng
Background In order to explore the possibility of treating breast cancer by
local photo-therapy, a photothermal agents loaded in situ hydrogel was
established. In detail, The
Cu2MnS2 nanoplates were
prepared by one-pot synthesis and, the thermosensitive Pluronic F127 was used as
the hydrogel matrix. The Cu2MnS2
nanoplates and the hydrogel were characterized by morphous, particle size, serum
stability, photothermal performance upon repeated 808 nm laser irradiation as
well as the rheology features. The therapeutic effects of the
Cu2MnS2 nanoplates and the
hydrogel were evaluated qualitatively and quantitatively in 4T1 mouse breast
cancer cells. The retention, photothermal efficacy, therapeutic effects and
systemic toxicity of the hydrogel were assessed in tumor bearing mouse
model.Results The Cu2MnS2 nanoplates
with a diameter of about 35 nm exhibited satisfying serum stability, photo-heat
conversion ability and repeated laser exposure stability. The hydrogel
encapsulation did not negatively influence the above features of the
photothermal agent. The nanoplates loaded in situ hydrogel shows a phase
transition at body temperature and, as a result, a long retention in
vivo.Conclusion sThe photothermal agent embedded hydrogel played a promising
photothermal therapeutic effects in tumor bearing mouse model with low systemic
toxicity after peritumoral administration.
研究领域:
肿瘤学
·
纳米医学
·
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Siyu Zheng,Afei Liu,Xianhui Zhang,Wenhui Wu,Lihui Chen,Chunmei Lai,Yuekun Lai,Kai Liu
Most hydrogels rely heavily on cryoprotectants to enhance their anti-freezing capabilities; however, this approach is often accompanied by disadvantages such as altered network structures and the risk of cryoprotectant leakage in aqueous conditions. Given these challenges, an environmentally resilient diode-like hydrogel is developed, featuring a double-layer coating design inspired by the physiological characteristics of penguins. This design is achieved through plasma treatment and immersion in 3-aminopropyltriethoxysilane/butyl acetate and perfluoropolyether carboxylic acid/butyl acetate solutions, constructing a double-layer coating with stable interfacial strength. The coating not only enhances anti-dehydration performance but also imparts anti-freezing properties via N,N-dimethylformamide solution. By carefully regulating the coating thickness and polymerization duration, it has optimized the mechanical and electrical attributes of hydrogel, culminating in robust performance even at −80 °C. The hydrogel exhibits exceptional water retention capabilities, with a mere 33.4% water loss rate following 7 days of air drying. Moreover, the hydrogel demonstrates stable piezoionic output performance across various low-temperature environments, with tensile and compressive strengths of 1156 kPa and 3.45 MPa, respectively. This study presents a novel solution for the application of conductive hydrogels in smart wearable devices, underscoring their potential for use in extreme environments.
研究领域:
材料科学
·
柔性电子学
·
可穿戴传感器
·
能量收集
·
仿生材料
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）