MICROCHEMICAL JOURNAL
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2026
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IF 5.2
Hanqing Liu,Haifeng Zhou,Jing Xu,Le Ding,Guangjun Zhou,Shiwei Chen,Youxin Lou
Excessive use of nitrite in food production and preservation causes blood and digestive system diseases, underscoring the need for rapid and accurate quantitative detection of nitrite. In this study, we developed a novel visual method for nitrite detection based on a near-infrared (NIR)-excited ratiometric fluorescent hydrogel sensor. In this sensor, NIR-excited upconversion nanoparticles (UCNPs) and basic fuchsin (BF) served as energy donors and acceptors, respectively, collectively forming an integrated ratiometric nanofluorescent probe. The upconversion optical probe was further embedded into a three-dimensional (3D) porous polyacrylamide (PAM) hydrogel to fabricate a smart hydrogel nanosensor that exhibited specific optical and colorimetric responses to nitrite. The hydrogel nanosensor demonstrated a high loading capacity for upconversion probes and provided a liquid-phase detection environment, thus significantly enhancing both fluorescence signal stability and sensing sensitivity. The NIR-excitation of the UCNPs prevented background fluorescence interference from the hydrogel and real samples. BF acted as a specific recognition unit for nitrite ions. The addition of nitrite altered the green-to-red intensity (G/R) ratio of the hydrogel sensor, facilitating real-time quantitative nitrite detection. Furthermore, the hydrogel sensor was integrated with a smartphone to create a portable platform for practical visual nitrite detection. The detection limits for nitrite using the probe and hydrogel sensor were extremely low (60.7 and 72 nM, respectively). The proposed novel UCNP-based hydrogel nanosensor provides a new sensing approach for detecting harmful substances in food, showing considerable potential to advance the applicability of portable fluorescence sensing devices in food safety monitoring.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2026
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IF 6.7
Min Luan,Sha Bao,Xueling Zhang,Yuhao Huang,Ruinan Yuan,Pengjun Zhong,Mengyuan Liu,Jue Li,Xuefei Liu,Lei Chen,Qingrong Huang,Rihui Wu
The exact mechanism through which dietary flavonoids alleviate metabolic syndrome (MetS) via the gut microbiota remains fully unclear. This study demonstrates that sinensetin markedly impeded the development of MetS and altered hepatic transcriptomic profiles by activating alternative bile acid biosynthesis signaling cascades both in vivo and in vitro. Importantly, sinensetin administration induced significant shifts in hepatic bile acid composition, notably increasing the relative abundance of non-12-hydroxy bile acids (non-12-OH BAs) in high-fat diet (HFD)-fed mice. Additionally, oral administration of sinensetin significantly relieved intestinal dysbiosis caused by HFD by altering the composition of gut microbiota in mice. The therapeutic efficacy of sinensetin against MetS was microbiota-dependent, as antibiotic-mediated depletion of gut microbiota abolished its beneficial effects, and fecal microbiota transplantation transmited this metabolic improvement. These findings suggest that sinensetin alleviated MetS by reshaping the gut microbiota to enhance non-12-OH BAs synthesis, offering novel mechanistic insights and promising avenues for therapeutic intervention.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Shuanglong Tang,Xi Wang,Jingyu Li,Xiaodan Wen,Hao Chen,Mei Yan,Xi Chen,Chongshen Guo
Although photothermal therapy (PTT) has been deemed as an effective approach for tumor ablation, the ubiquitous overheat over 50 °C in the PTT process would damage surrounding normal tissue. The combination of nutrient depletion at the tumor site with mild PTT seems like an efficient way to overcome this dilemma. In this work, cobalt-doped polydopamine (CP) behaved as both photothermal agent and glucose oxidase (GOx) carrier to achieve a starvation assisted photothermal therapy. CP possesses more weak acid sites than pure polydopamine, and it gives higher encapsulation efficiency and loading capacity of 89.71% and 47.29% towards GOx, respectively. The CPGP was prepared by coating the GOx-loaded CP with a phase change material (PCM) layer. The solidified PCM prevents the binding between the GOx and glucose, thereby inhibiting GOx activity. The PCM melts at 45 °C and then the GOx activity restores to normal level. The CPGP could cause reduction of intracellular levels of NAD + , NADH and ATP, as well as mitochondrial dysfunction and the induction of apoptosis or necrosis. Hence, CPGP-mediated starvation-photothermal combination therapy exhibits an effective tumor-killing effect. In addition, upregulated M1-polarized macrophages, CD4 + T cells and CD8 + T cells were observed in the mouse model.
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CATALYSIS LETTERS
·
2026
·Vol. 156
·期 3
·80
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IF 2.5
Li Xincheng,Huang Pengpeng,Fan Mingming,Zhang Pingbo
Isostearic acid, a bio-based and environmentally friendly chemical, has attracted considerable attention because of its high value as an oleic acid derivative. The synthesis of isostearic acid via oleic acid isomerization over commercial H-ZSM-5 zeolites is limited by low yield and acid value, mainly due to diffusion constraints. To address this issue, a hierarchical-pore H-ZSM-5 zeolite (Meso-5) was synthesized using Silicalite-1(S-1) as a seed crystal to enhance diffusion and catalytic performance. The catalyst was comprehensively characterized by XRD, SEM, BET, TGA, FT-IR, and Py-FTIR. Meso-5 efficiently catalyzed the isomerization of oleic acid, attributed to its abundant Brønsted and Lewis acid sites whose synergistic interaction significantly promoted the formation of branched-chain products. The catalyst delivered a selectivity of 87.3% with a 71.1% yield in the first run, and even after five reuse cycles it maintained 82.1% selectivity with a 55.6% yield. Evidently, the hierarchical pore structure of the catalyst significantly facilitated the diffusion of oleic acid molecules and their isomerized intermediates, thereby enhancing the overall catalytic activity. The resulting isostearic acid was purified via a simple recrystallization procedure to a purity of 83.4% and an acid value of 186.7 mg KOH/g, both meeting the standards of commercial isostearic acid. These findings provide a robust basis for further catalyst optimization and scale-up toward industrial isostearic acid production. Graphical A tandem catalytic route combining ZSM-5-driven isomerization with Ni/C-catalyzed hydrogenation enabled the efficient conversion of oleic acid to isostearic acid. The hierarchical H-ZSM-5 structure enhanced branched-chain formation, ensuring high selectivity and yield toward the desired product
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JOURNAL OF CATALYSIS
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2026
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IF 6
Jie Wang,Feng Gao,Jilei Lin,Chunjuan Zhang,Meiqing Shen,Linghui Kong,Gurong Shen
Ammonia is emerging as a promising carbon-free energy carrier. The electrocatalytic ammonia oxidation reaction (AOR), highly structure-sensitive, exhibits exceptional activity on Pt nanocubes (NCs) with (100) facets. Yet, synthesis methods employing metal carbonyl capping agents inevitably introduce residual metals, whose catalytic effects are often neglected. Here, Pt NCs synthesized with Mo(CO) 6 were found to contain trace Mo both in the bulk and at the surface. Surface Mo species, partially oxidized to MoO x , substantially modify the electronic structure of Pt(100), lowering activation barriers for rate-determining AOR steps and enhancing resistance to nitrogen poisoning. These effects collectively boost AOR performance, enabling a direct ammonia fuel cell with a Pt-154 anode to achieve a peak power density of 26.7 mW cm −2 . These results reveal the overlooked impact of capping-agent-derived contaminants in AOR and point to the deliberate incorporation of heterometallic modifiers as a viable strategy for advanced electrocatalyst design.
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ANALYTICA CHIMICA ACTA
·
2026
·
IF 6.1
Hongyu Ning,Yilei Fan,Haodong Wang,Huijun Liu,Zhongping Huang,Haixing Wang,Xing Ke,Yu Xu
Background The global increase in cannabis use has created a strong demand for reliable and efficient detection methods. Traditional urine-based assays are widely used and standardized, but suffer from complex hydrolysis requirements, long detection windows, and an inability to monitor recent use. In contrast, oral fluid testing enables non-invasive, real-time detection of parent cannabinoids, but is limited by low sample volume, matrix interference, and insufficient sensitivity in common rapid tests. It is clear that a sample preparation and detection approach is needed that is robust, highly sensitive, streamlined, and compatible with high-throughput confirmatory analysis such as LC-MS/MS. Results In this study, a magnetic solid-phase extraction (MSPE) method was developed using a novel magnetic metal–organic framework composite, Fe 3 O 4 @poly(GMA/DVB-ZIF-8), for the efficient extraction of four cannabinoids from urine and oral fluid. The sorbent uses multiple interactions—including hydrophobic, π–π, electrostatic, and Zn–O coordination—to achieve high analyte recovery (exceeding 85%). Coupled with UHPLC-MS/MS analysis, the method demonstrates wide linearity (0.05–25 ng/mL, r 2 > 0.9945), low detection limits (as low as 0.017 ng/mL), and good repeatability (RSDs <13.8%). Comparative evaluation with conventional liquid–liquid extraction showed minimal deviation (relative percent difference <6.0%), confirming high trueness and reliability for cannabinoid monitoring in biological samples. Significance This MSPE approach provides a simple, efficient and high-throughput sample preparation method for reliable and rapid forensic analysis of cannabinoids in complex biological samples.
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ACS Nano
·
2026
·
IF 17.3
Xinhua Liu,Sunli Wan,Tingting Yao,Dan Wang,Mingkang Wang,Xinlong Liu,Xiaohui Deng,Runjianya Ling,Wangshu Zhu,Ze-Jian Wang,Yuanyuan Guo,Chuan Zhang,Yuehua Li
Atherosclerosis (AS) is a key pathological basis causing major cardiovascular diseases. Its proinflammatory microenvironment, characterized by aggregated inflammatory macrophages, excessive reactive oxygen species, and deficient phagocytosis, plays a pivotal role in driving AS pathogenesis. However, given the complexity of the microenvironment inside atherosclerotic plaques, developing highly effective and comprehensive nanoplatforms for precise diagnosis, efficient therapy, and reliable prognostic evaluation remains a major challenge. Herein, we construct a biomimetic nanomodulator (FeMn/Cur@CM) with responsive T1-T2 dual-modal magnetic resonance imaging (MRI) and multifaceted regulation functionalities of the plaque microenvironment for visualized treatment of AS. Coated with a macrophage membrane, curcumin-loaded FeMn/Cur@CM nanoparticles achieve prolonged circulation and specific targeting of inflammatory plaques. Diagnostically, FeMn/Cur@CM functions as a microenvironment-responsive dual-modal MRI contrast agent, amplifying T1-T2 signals in plaques. Therapeutically, FeMn/Cur@CM multifacetedly modulates the plaque microenvironment by alleviating oxidative stress, neutralizing protons, promoting macrophage reprogramming, and restoring macrophage efferocytosis. As a result, the integrated theranostic platform demonstrates remarkable plaque regression and simultaneously realizes real-time visualization of lesion progression via dual-modal MRI, providing precise diagnosis of plaque milieu. Through inflammation-targeted intervention coupled with real-time imaging feedback, this biomimetic nanomodulator establishes a promising strategy for the precise treatment of inflammatory vascular diseases, offering translational potential for AS management.
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ACS Applied Nano Materials
·
2026
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IF 5.8
Kongfu Ou,Jinju Zheng,Jialong Zhao,Kai Wang,Xuanming Qin,Weiyou Yang,Zhentao Du,Hui Fu
Nontoxic CuGaS2 (CGS) quantum dots (QDs) are promising for next-generation displays due to their unique optical properties. However, their wide photoluminescence (PL) full width at half-maximum (FWHM), arising from intraband defect-state-mediated radiative recombination, hinders compliance with the narrow bandwidth requirements for ultrahigh-definition displays. Herein, we introduce a Ga2S3 (GaS) interlayer strategy via a hot-injection method to mitigate lattice mismatch and interface strains between the CGS core and the ZnS shell. Precisely controlling the GaS shell thickness further promotes structural ordering and suppresses sulfur vacancies (VS), thereby reducing nonradiative recombination and enhancing near-band-edge emission. Under optimized conditions, the as-prepared CGS/GaS/ZnS QDs exhibit narrow-band blue emission with a PL quantum yield (QY) of 44% and an FWHM of 24 nm, which is the narrowest value reported to date for Cu-based QDs. As integrated into solid-state light-emitting diode (LED) devices, the QDs yield narrow emission under various operating currents and demonstrate excellent operational stability. These findings highlight the critical role of multishell structures in controlling the defect states and lattice strain in CGS-based QDs, offering a design strategy for next-generation display materials demanding high color purity.
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ACS Applied Materials & Interfaces
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2026
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IF 7.8
Yunping Lang,Xinxuan Yang,Yang Shao,Lin Fan,Xiaoyan Liu,Nannan Yang,Huilian Liu,Fengyou Wang,Jinghai Yang,Lili Yang
Two-dimensional/three-dimensional (2D/3D) perovskite solar cells (PSCs) have attracted considerable attention due to their promising performance and environmental stability. However, conventional in situ grown 2D/3D perovskites form a layered structure with 2D organic spacer layers aligned parallel to the 3D perovskite, impeding out-of-plane carrier transport. Moreover, the distinct cation size between 2D and 3D perovskites triggers ion diffusion at the heterointerface, leading to the formation of a mixed-phase 2D perovskite and increased defect density, which severely limits device performance. To address these issues, we synthesized 2D perovskite quantum dots (QDs) modified with poly(3-hexylthiophene) (P3HT), acting as building blocks, which were subsequently deposited onto a 3D perovskite film to construct novel 2D QDs@P3HT/3D PSCs. This strategy effectively suppresses defect accumulation caused by mixed phases in traditional 2D/3D perovskite. Furthermore, this design facilitates additional vertical carrier transport pathways, alleviating the out-of-plane carrier transport limitation in conventional layered 2D/3D perovskite. As a result, the optimized devices achieve a power conversion efficiency of 25.04% and exhibit remarkable stability, retaining over 93% of their initial efficiency after 1200 h of aging under 85% relative humidity at 25 °C. This work offers a viable strategy to balance efficiency and stability in perovskite photovoltaics.
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MOLECULES
·
2026
·Vol. 31
·期 6
·1006
·
IF 5.1
Yiting He,Xiayu Zhu,Ajun Li,Shuyuan Lin,Bo Li,Songbin Liu,Xinyu Ye
CsPbBr3perovskite quantum dots (QDs) have attracted significant attention for optoelectronic applications owing to their outstanding optical properties, yet achieving controlled synthesis with high stability under mild conditions remains a challenge. The room-temperature synthesis of CsPbBr3perovskite quantum dots using a coprecipitation method is systematically investigated in this work, with an emphasis on how the structural and optical properties of the QDs are influenced by the Br/Pb ratio and OA/OAm ratio. The findings show that controlling the Br/Pb and OA/OAm ratios can effectively influence the size, crystalline phase, and surface passivation properties of CsPbBr3quantum dots. The photoluminescence peak shifts blue and the bandgap widens when the Br/Pb ratio rises due to a decrease in quantum dot size. This is mainly explained by more effective surface covering by Br−ions and increased quantum confinement effects. The resultant quantum dots demonstrate ideal optical performance at a Br/Pb ratio of 75 and an OA/OAm ratio of 1.5, with dense ligand coverage, superior defect passivation, and markedly improved stability under UV irradiation and in aqueous environments. Variations in the Br/Pb and OA/OAm ratios affect the binding configuration and coverage of ligands on the quantum dot surface, thereby influencing the relationship between non-radiative recombination and the quantum confinement effect. The LED fabricated with the as-synthesized high-performance quantum dots demonstrates a wide color gamut, covering 129.45% of the NTSC standard, indicating strong potential for display applications.
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ANALYTICAL CHEMISTRY
·
2026
·
IF 7.3
Lixian Huang,Jiaqi Lu,Yidong Bin,Min He,Caiying Li,Shulin Zhao,Shulong Wang,Liangliang Zhang
Oxidative stress plays a pivotal role in the onset and progression of arthritis, in which the abnormal elevation of hydroxyl radical (•OH) has been recognized as a key molecular hallmark of early inflammation. However, effective tools capable of simultaneously visualizing •OH dynamics and tracking therapeutic efficacy remain elusive. Herein, we developed a self-calibrated near-infrared II (NIR-II) ratiometric imaging probe responsive to •OH. The probe integrates downconversion nanoparticles (DCNP) as a stable internal reference (F1550nm,980Ex) and a •OH-triggered red-shiftable dye Hydro-830 (F930nm,808Ex), enabling ratiometric imaging through the signal ratio “F930nm,808Ex/F1550nm,980Ex.” The probe exhibits high sensitivity and specificity toward •OH in vitro and effectively captures the upregulation of oxidative stress at early inflammatory stages in vivo. In a longitudinal “treatment–imaging” study, the ratiometric signal gradually decreased following methotrexate (MTX) therapy, consistent with reductions in joint swelling, inflammatory cytokines, and histopathological lesions. This study establishes a self-calibrated NIR-II ratiometric imaging strategy for precise monitoring of oxidative stress, enabling early molecular diagnosis and dynamic therapeutic evaluation of arthritis, and offering a promising paradigm for imaging other ROS-related inflammatory disorders.
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ACS Nano
·
2026
·
IF 17.3
Sixia Wang,Junyan Li,Yifan Liu,Ruru Zhang,Lei Chen,Zhe Yang,Jianfeng Zeng,Shuwang Wu,Mingyuan Gao
Boron neutron capture therapy (BNCT) has received significant attention due to its effectiveness in treating tumors. Preclinical and clinical studies have sought materials with a high boron content. Meanwhile, imaging-guided BNCT can not only enable the determination of the optimal neutron irradiation time and the required dose but also hold substantial significance for evaluating the therapeutic effects. Herein, iron borate (Fe2B2O5) nanobeams were synthesized via the thermal decomposition method. First, iron borate nanobeams are rich in boron, providing sufficient boron for BNCT. Second, the magnetic properties of the nanobeams enable enhancement of magnetic resonance imaging (MRI) contrast, facilitating the monitoring of the agent’s distribution. The size and morphology of the nanobeams can be tuned by varying the synthesis temperature, time, and precursor concentration. To enhance the colloidal stability and biocompatibility, the iron borate nanobeams were coated with a layer of silica (IBNBs@SiO2). The in vitro and in vivo experiments demonstrate that IBNBs@SiO2 functions as a T1 contrast agent. Furthermore, cells and mice treated with IBNBs@SiO2 followed by thermal neutron irradiation demonstrated the effective suppression of melanoma growth. Therefore, IBNBs have potential for MRI-guided BNCT.
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