JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
·
2018
·Vol. 42
·期 1
·111-115
·
IF 1.441
Hongzhi Xiao,Haoyuan Peng,Ting Zhao,Jingyuan kong,Jiao Xue,Jianzhong Wang,Yalong Lin,Suxia zhang,Xingyuan Cao
The pharmacokinetic parameters of moxidectin (MXD) after intravenous and pour-on (topical) administration were studied in sixteen pigs at a single dose of 1.25 and 2.5 mg/kg BW (body weight), respectively. Blood samples were collected at pretreatment time (0 hr) over 40 days. The plasma kinetics were analyzed by WinNonlin 6.3 software through a noncompartmental model. For intravenous administration ( n = 8), the elimination half-life (λ Z ), the apparent volume of distribution (V z ), and clearance (Cl) were 10.29 ± 1.90 days, 89.575 ± 29.856 L/kg, and 5.699 ± 2.374 L/kg, respectively. For pour-on administration ( n = 8), the maximum plasma drug concentration ( C max ), time to maximum plasma concentration ( T max ), and λ Z were 7.49 ng/ml, 1.72, and 6.20 days, respectively. MXD had a considerably low absolute pour-on bioavailability of 9.2%, but the mean residence time (MRT) for pour-on administration 10.88 ± 1.75 days was longer than 8.99 ± 2.48 days for intravenous administration. These results showed that MXD was absorbed via skin rapidly and eliminated slowly. The obtained data might contribute to refine the dosage regime for topical MXD administration.
研究领域:
兽医学
·
药理学
·
动物科学
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产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2022
·Vol. 27
·期 4
·1355
·
IF 4.927
Jiliu Pei,Shengyu Zhu,Yu Liu,Yukang Song,Feng Xue,Xiaohui Xiong,Chen Li
Riboflavin (RF) was considered to be possessed of photoactivity to generate reactive oxygen species (ROS) under ultraviolet (UV) light, which is thought to be a favorable antibacterial candidate. Herein, RF was incorporated into chitosan (CS) coatings and treated under UV with different exposure times (2, 4, and 6 h) to improve the physicochemical and antibacterial properties. The results showed that the light transmittance and antibacterial performance of chitosan coatings gradually increased with the extension of the UV irradiation time. The antibacterial ability of chitosan coatings correlated with the generation of ROS: ∙OH and H2O2, which achieved 1549.08 and 95.48 μg/g, respectively, after 6 h irradiation. Furthermore, the chitosan coatings with UV irradiation also reduced the pH value, total volatile basic nitrogen (TVB-N), ΔE, and total viable counts (TVC) and improved sensory attributes of pork. In conclusion, the UV irradiated chitosan coatings could be used as an environmentally friendly antimicrobial packaging material to effectively delay the spoilage of pork, maintain its sensory quality and prolong its shelf life.Keywords:chitosan;riboflavin;UV irradiation;pork preservation;antibacterial activity
研究领域:
食品科学
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材料科学
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生物技术
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产品关联
DOI
PubMed
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2023
·
IF 8.1
Wanmei Lin,Yifan Zhang,Jihong Huang,Zhonghong Li
A pH-responsive double-layer film comprising chitosan (CS), zein (Z), curcumin-β-cyclodextrin complex (Cur- β-CD), alizarin (AL) and cinnamaldehyde (CIN) was developed to detect spoilage and prolong the shelf life of pork. The outer Z/AL is the colorimetric responsive and highly protective outer layer, while the CS/Cur- β-CD/CIN is the fluorescence responsive and functional layer. The CS/Cur- β-CD/CIN-Z/AL film demonstrated excellent barrier properties against oxygen (8.48 × 10 -13 g (m s Pa) -1 ) and water (2.42 × 10 -11 g (m s Pa) -1 ) primarily due to the polar interactions in the Z structure and its hydrophobic nature. The addition of AL and Cur provided the CS/Cur- β-CD/CIN-Z/AL film with pH colorimetric and fluorescence response capabilities, respectively. Furthermore, the inclusion of Cur- β-CD, CIN and AL significantly enhanced the film’s antioxidant and antibacterial properties, with radical scavenging rates of 79.29 % (DPPH) and 89.84 % (ABTS), as well as antibacterial efficiencies of 96.2 % ( S. aureus ) and 85.78 % ( E. coli ). To test the effectiveness of the double-layer film, a freshness monitoring and maintenance experiment was conducted on pork stored at 4 °C for 8 days. Various parameters of pork, including surface color, pH value, total volatile bases nitrogen (TVB-N), total viable counts (TVC), thiobarbituric acid reactive substance (TBARS), hardness and springiness, were measured, along with the color and fluorescence intensity (FL) of the film. The shelf life of the pork was extended by at least 2 days compared to the control group, and the pork was considered inedible if ΔE ≥ 12 or FL intensity ≤ 2160. Overall, this food packaging film shows promise in simultaneously monitoring and maintaining the freshness of pork.
研究领域:
食品科学
·
材料科学
·
生物工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Frontiers in Veterinary Science
·
2024
·
IF 2.6
Xu Changzhi,Yang Xianshu,Sui Heming,Tong Xu,Zhang Dandan,Zheng Xianrui,Jiao Jun,Wang Chonglong,Cao Zubing,Zhang Yunhai
According to previous studies, the quality and fertilization rate of fresh sperm from boars of different ages were significantly different. However, the difference of freeze–thaw sperm quality and fertility in boars of different ages is unclear. In this study, boars of a Chinese native breed were assigned into two groups. Each group consisted of five boars aged aged either 2–3 years (young boars = YB) or 5–6 years (aging boars = AB) A total of 60 ejaculates for each group were collected and cryopreserved. Semen quality and in vitro fertility of post-thaw sperm was evaluated. The results showed that the concentration and motility of fresh sperm collected from AB were similar to YB, but their semen volume was higher than that in YB (p < 0.05). Frozen–thawed sperm of AB had lower viability than YB, and higher abnormal rate and reactive oxygen species (ROS) levels of YB (p < 0.05). There was no effect of the age on post-thaw sperm motility and time survival. Functional assessments indicated that increasing age markedly compromises the integrity of the sperm plasma membrane and acrosome, as well as mitochondrial functionality post-thaw, albeit without affecting DNA integrity. Furthermore, increasing age of boars reduces the ability of sperm to bind to the oocyte zona pellucida after thawing, delaying the time of the first embryo cleavage after fertilization. Finally, the early developmental efficiency of in vitro fertilized embryos progressing from 4-cell to blastocyst derived from post-thaw sperm in AB significantly decreased compared to those from YB (p < 0.05). Taken together, these results suggest that increasing age in boars impairs the quality and in vitro fertility of frozen thawed sperm.
研究领域:
动物科学
·
生殖生物学
·
兽医学
✓ 已验证
DOI
PubMed
高影响因子
Biochar
·
2021
·Vol. 3
·期 3
·391-405
·
IF 0
Li Chao,Sun Yifan,Zhang Lijun,Wang Changxu,Zhang Shu,Li Qiaoling,Xu Leilei,Hu Xun
Biomass and pig manure have distinct compositions and the co-pyrolysis of them has gained much attention. However, the influence of volatiles interaction on the properties of the char was still unclear. In this study, lignin was selected as the model component of biomass with pig manure for co-pyrolysis at 600 °C. The results indicate that volatiles from co-pyrolysis promoted re-condensation reaction, resulting in the higher char yield (48.0% in co-pyrolysis versus 31.0% in pyrolysis of single manure) and the formation of more aromatics in bio-oil. The co-pyrolysis also facilitated the dehydrogenation and dehydration reactions, which accounted for the elimination of oxygen and nitrogen contents and thus a higher carbon content (64.7% in the co-pyrolysis versus the averaged value of 46.4% from the pyrolysis of single feedstock), higher crystallinity and thermal stability of the char. The in-situ diffuse reflection infrared Fourier transform spectroscopy (DRIFTS) characterization results demonstrated that the functionalities abundances of char with temperature was influenced by volatiles interaction via accelerating the carbonization reaction. In addition, the high heating value (HHV) of char was obviously improved by cross-interaction of volatiles during co-pyrolysis (24.4 MJ/Kg in co-pyrolysis versus averaged value of 15.1 MJ/Kg from single pyrolysis), implying that the co-pyrolysis enhanced the energy density of the resulting char. Graphic abstract
研究领域:
能源与环境科学
·
化学工程
✓ 已验证
DOI
SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Yongqiang Shi,Zhihua Li,Jiyong Shi,Fang Zhang,Xucheng Zhou,Yahui Li,Mel Holmes,Wen Zhang,Xiaobo Zou
A novel and low-cost micro-sensor with a diameter of 12 μm was developed based on Titanium dioxide-Polyaniline/Silk fibroin fiber (TiO 2 -PANI/SFF). TiO 2 -PANI composites were deposited on surfaces of SFFs by in-situ polymerization. The microfibers were characterized by Scanning electron microscopy (SEM), Energy dispersive spectrometer (EDS), Raman spectrometer, Fourier transform infrared (FTIR) spectroscopy and X-ray diffraction (XRD), and the formation mechanism of them was illustrated in detail. With ammonia (NH 3 ) as model gas, the TiO 2 -PANI/SFF micro-sensor showed good sensing performance with response value of 0.82 and response time of 10 s to NH 3 of 100 μg/L. When the micro-sensors were applied for pork freshness evaluation, the output response values showed good correlation with the total volatile basic nitrogen (TVB-N) levels in pork (R 2 = 0.990), and the discriminant results of the micro-sensors for pork freshness based on linear discriminant analysis (LDA) showed the prediction accuracy of calibration and prediction set was 90.73% and 86.38%, respectively, which indicated the great potential of TiO 2 -PANI/SFF micro-sensor for pork freshness evaluation.
研究领域:
材料科学
·
食品科学
·
传感器技术
✓ 已验证
DOI
高影响因子
CyTA-Journal of Food
·
2025
·
IF 1.7
Ziyi Hu,Liusha Kuang,Lin Li,Enqi He,Lei Zhou,Aihua Lou,Yan Liu,Jie Luo,Wei Quan,Qingwu Shen
The correlations between meat quality, dominant microbiota, and key volatile compounds during chill storage were investigated by HS-SPME-GC-MS, Illumina sequencing and correlation analysis. The results indicated that lipid and protein oxidation of pork belly increased significantly on day 4, biogenic amine index reaching 344.07 mg/kg on day 6, the total viable count reached 7.98 log10 (CFU/g) at day 8, with Macrococcus caseolyticus (54.60%), unclassified g Acinetobacter (23.70%) and Acinetobacter bereziniae (7.75%) identified as dominant bacteria. HS-SPME-GC-MS identified 66 compounds with tetramethyl-pyrazine, acetoin, 1-hexadecanol, and hexadecanoic acid were found to be related to meat quality and influenced by microbial activity, serving as indicators of pork belly freshness. However, due to the complexity of microbial communities in aquatic products, further research is needed to explore the relationship between changes in microbial communities and the volatile organic compounds (VOCs). These findings provide valuable insight into key factors contributing to spoilage in Ningxiang pork.
研究领域:
食品科学
·
微生物学
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产品关联
DOI
高影响因子
Food Bioscience
·
2025
·
IF 5.9
Lin Liu,Tanghui Liu,Guihong Li,Qingqing Tan,Anjun Tang,TingTing Wen,Ziming Li,Hai Chi,Hongrui Chen,Jie Tang,Xingzhong Zhang
In this work, we provided a facile way to prepare composite antimicrobial films based on polyvinyl alcohol (PVA) incorporated with Zanthoxylum schinifolium essential oil/cinnamaldehyde (ZSEO/CA) Pickering emulsion, and applied them for the preservation of chilled fresh pork. The ZSEO/CA Pickering emulsions stabilized by bacterial cellulose nanofibrils/whey protein isolate (BCNFs/WPI) complexes exhibited uniform droplet size distribution (around 150 nm) and maintained the better stability with an oil phase ratio of 10 wt%, which was selected for subsequent composite film preparation. Compared to pure PVA film, the addition of ZSEO/CA Pickering emulsion in composite films reduced their transmittance, but provided a significant barrier against ultraviolet light. Moreover, the incorporation of emulsion enhanced the hydrophobicity, thermal stability, water vapor permeability (WVP) and antibacterial activity of the composite films. Among them, the composite antimicrobial film with an emulsion proportion of 30 wt% (PVA-PE(30)) showed the optimal performance characteristics, and effectively prolonged the chilled fresh pork storage period. Overall, the incorporation of ZSEO/CA Pickering emulsion into PVA-based films provided a promising strategy to construct composite antimicrobial films for food packaging and preservation.
研究领域:
食品科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Food and Bioprocess Technology
·
2025
·
IF 5.8
Fang Zhuoyu,Wang Qianqian,Sun Yue,Sun Xinyu,Long Ruixue,Zhang Hao,Jiang Wenxiang,Zhao Jiansheng,Wu Zeyu,Xu Feiran,Xu Baocai
A polyvinyl alcohol (PVA)-based intelligent food label which was added curcumin (CUR), gelatin (GEL), and carbon quantum dots (CQDs) extracted from coffee grounds was developed and characterized. The addition of GEL and CQDs made the tensile strength (TS) of the intelligent food label increase to 1.81 ± 0.07 MPa, and the elongation at break (EAB) was increased to 5.39 ± 0.41%. Benefiting from the antibacterial properties of CQDs and the sustained release properties of GEL, the PVA/CUR/GEL/CQDs label had a magnificent inhibitory effect on E. coli and S. aureus , and the bacteriostatic rates were 98.84 ± 0.41% and 98.75 ± 0.53%, respectively. In addition, the PVA/CUR/GEL/CQDs label also showed excellent pH response performance in an ammonia environment. During the storage experiment at 4 °C, the total viable count (TVC), total volatile basic nitrogen (TVB-N), and thiobarbituric acid reactive substances (TBARS) of zang scent pork loaded with intelligent food labels prepared by electrospinning were reduced to 6.58 Log CFU/g, 18.67 mg/100 g, and 0.81 mg MDA/kg, respectively, which extended the shelf life from 4 to 6 days. The intelligent food labels prepared by electrospinning had a better preservation effect than those prepared by the casting method due to their excellent sustained release properties. In general, multifunctional intelligent food labels can not only effectively reduce corruption, but also have the function of freshness detection, which has broad prospects in the cross-transport of perishable fresh meat. Graphical
研究领域:
食品科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Foods
·
2025
·Vol. 14
·期 9
·1639
·
IF 5.1
Jingjing Huang,Haiqiu Wei,Zhang Luo,Liang Li,Zhendong Liu,Ningning Xie
The mechanistic effects ofZanthoxylum bungeanumon the textural properties of Tibetan pig sausages remain inadequately elucidated. We conducted a dose–response analysis usingZ. bungeanumaqueous extraction (ZBAE) containing 36.97 mg GAE/g polyphenols, applied at concentrations from 0.125% to 1.20% in the meat paste. Optimal textural enhancement was achieved at 0.25% ZBAE, as proved by significantly improving water holding capacity (1.77% increase), hardness (139.87% increase), and gel strength (46.04% increase) relative to the control group (p< 0.05). Specifically, this concentration: (i) promoted protein molecular rearrangement of by enhancing hydrophobic interactions (33.33% increase) and hydrogen bonding (287.99% increase); (ii) induced conformational transitions fromα-helix (42.62% decrease) toβ-sheet formations (21.11% increase); and (iii) generated a homogeneous three-dimensional protein network characterized by a fractal dimension of 2.769 ± 0.006 and a porosity of 38.350 ± 0.333%. The addition of natural polyphenols from Z.bungeanummay optimize the textural quality of processed meat products.
研究领域:
食品科学
·
生物化学
✓ 已验证
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Guangzhi Wang,Yuchen Guo,Yang Yu,Yan Shi,Yuxiang Ying,Hong Men
Pork freshness is crucial for flavour, nutrition and consumer health. The current colorimetric sensor array (CSA) detection systems face challenges related to high sensor development costs, low recognition accuracy and limitations in the platform use. Herein, we developed a CSA and ColorNet framework to detect pork freshness. The 53-point CSA was designed by selecting sensitised pH indicators and aldehyde/ketone indicators. To optimize the sensor, the Euclidean distance method was used to identify 24 array points with dyes that exhibited more sensitive responses. The ColorNet captured the color information of pork freshness, allowing real-time detection with a 99.5 % accuracy. For practical deployment and mobile applications, a refined 12-point CSA was developed using gradient activation mapping, maintaining a 99 % recognition rate, which is comparable with the 24-point CSA. The proposed CSA and model ensure consumer health and safety, providing strong technical support for quality monitoring and control in the pork industry.
研究领域:
食品科学
·
人工智能
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Today Bio
·
2025
·
IF 10.2
Xiaobo Yu,Jingli Ding,Yingjie He,Shunbo Wei,Xing Chen,Qiujie Luo,Yuqing Zhang,Chen Qian,Jiahui Wang,Mengjie Hu,Xiang Zhang,Cuifen Lu,Jinping Liu,Jianliang Zhou
Valvular heart disease (VHD) poses a thorny problem in cardiovascular diseases. The most effective treatment for VHD is heart valve replacement. Biological heart valve (BHV) is more favored than mechanical heart valve due to the maturity of transcatheter heart valve replacement (THVR) and the absence of the need for lifelong anticoagulant use. However, traditional commercial BHV suffers degeneration within 10 to 15 years because of calcification caused by the cross-linking reagent, glutaraldehyde. Considering the remarkable properties of POSS, PEG, and the star-like eight-arm structure, we fabricated POSS-PEG-PP, which is a decellularized porcine pericardium (DPP) crosslinked by a star-like eight-arm cross-linker octafunctionalized POSS of benzaldehyde-terminated polyethylene glycol (POSS-PEG-CHO) based on the Schiff's base reaction. POSS-PEG-PP exhibits more intense fiber arrangement and better mechanical properties than GLUT-PP (glutaraldehyde crosslinked DPP). The results also show that the cytocompatibility, endothelialization, and hemocompatibility of POSS-PEG-PP are outstanding in vitro. Subsequently, in vivo assessments demonstrate that POSS-PEG-PP has anti-inflammatory and anti-calcification abilities. Furthermore, RNA sequencing analysis of subcutaneous implants suggests that the intervention of AMPK and IL-17 signaling pathways plays an important role in the inflammatory and immune responses regulation of POSS-PEG-PP. Therefore, POSS-PEG-PP is an excellent substitute material for BHVs and is expected to be clinically transformed.
研究领域:
心血管疾病
·
生物材料科学
·
组织工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）