COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2022
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IF 5.518
Peiying Ma,Zhou Wang,Yibei Jiang,Zongwang Huang,Lu Xia,Jinlong Jiang,Fulai Yuan,Hui Xia,Yi Zhang
Loading hydrogels with ozone for antibacterial activity is an important research topic for expanding clinical applications. In particular, hydrogel network constructs and storage and controlled release of massive ozone amounts are research emphases. In this paper, a nanoclay crosslinked nanocomposite hydrogel with a bionic three-dimensional porous network structure formed by two-dimensional lamellar montmorillonite was incorporated into polyacrylamide through a crosslinking reaction, which provided enhanced mechanical properties and abundant ozone adsorption sites. The clay-based nanocomposite hydrogel had the enlarged pore structure (11.7 µm) and a stable Young's modulus (75.82 GPa), which also provided a guarantee for the highly ozone adsorption capacity. The nanocomposite exhibited timely bactericidal and long-term antibacterial effects on Staphylococcus aureus , which provides ideas for the development and application of inexpensive clay minerals in the biomedical antibacterial field.
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NEW JOURNAL OF CHEMISTRY
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2022
·Vol. 46
·期 15
·7279-7289
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IF 3.925
Zhengrong Yin,Xiangli Zhang,Yan Bai,Yanwei Yang,Bin Liu,Zengjie Fan
Conventional topical medications for recurrent aphthous ulcers (RAU) are limited due to the washing effects of saliva and activities of masticatory muscles decreasing the local effective drug concentration. To overcome this drawback, a dissolvable and layered hyaluronate (HA) microneedle (MN) patch loading recombinant bovine basic fibroblast growth factor (rbFGF) and cetylpyridinium chloride (CPC) was prepared and used for the treatment of RAU. The MN patch was prepared via a two-step casting method and subsequently characterized using fluorescence microscopy, scanning electron microscopy (SEM), and stereomicroscopy. Moreover, its mechanical properties, penetrating ability, dissolution behavior, antibacterial performance, cytotoxicity as well as ulcer healing efficacy on the rat model were determined. The results revealed that the prepared MNs possessed uniformly arranged conical needles with the drug centrally distributed in the tips. The rbFGF/CPC-loaded HA MN patch presented favorable mechanical, dissolving, and antibacterial properties and biocompatibility, increasing the growth and proliferation of fibroblasts. More importantly, this MN patch showed a higher healing effect in promoting the healing of chemical-induced RAU within five days than the control group and the conventional treatment group. The novel MN patch will have potential application prospects in the treatment of oral ulcer.
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JOURNAL OF HAZARDOUS MATERIALS
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2022
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IF 14.224
Ying Liu,Jingfeng Gao,Yuwei Wang,Wanjun Duan,Yi Zhang,Haoran Zhang,Mingyan Zhao
Antibiotic resistance genes (ARGs) and antibiotic resistant bacteria (ARB) are widespread in urban wastewater treatment plants (UWTPs). In this research, a horizontal transfer model of recipient ( Pseudomonas . HLS-6) and donor ( Escherichia coli DH5α carries RP4 plasmid) was constructed to explore the effect of sulfidated nanoscale zerovalent iron (S-nZVI) on the efficiency of plasmid-mediated horizontal transfer. When the S/Fe was 0.1, the inactivation efficiency of 1120 mg/L S-nZVI on the donor and recipient bacteria were 2.36 ± 0.03 log and 3.50 ± 0.17 log after 30 min, respectively (initial ARB concentration ≈ 5 ×10 7 CFU/mL). Effects of treatment time, S/Fe molar ratio, S-nZVI dosage and initial bacterial concentration were systemically studied. S-nZVI treatment could increase the extracellular alkaline phosphatase and malondialdehyde content of the ARB, cause oxidative stress in the bacteria, destroy the cell structure and damage the intracellular DNA. This study provided evidence and insights into possible underlying mechanisms for reducing conjugative transfer, such as hindering cell membrane repair, inducing the overproduction of reactive oxygen species , inhibiting the SOS response, reducing the expression of ARGs and related transfer genes. S-nZVI could inhibit the gene conjugative transfer while inactivating the ARB. The findings provided an alternative method for controlling antibiotic resistance.
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DALTON TRANSACTIONS
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2022
·Vol. 51
·期 17
·6817-6824
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IF 4.569
Ye Zhang,Dan Yang,Wei Guo,Feng Zhang,Huiming Lin,Kai Yu,Chunyu Yang,Fengyu Qu
We have developed a multifunctional hydrogel dressing (denoted as dressing-2 : 1) using silver-doped yolk-like nickel sulfide (Ag(8.5%)@NiS2−x), polyacrylamide (PAM), and chitosan (CS). Ag(8.5%)@NiS2−x has tremendous potential in antibacterial applications mainly due to the following advantages: (i) it has excellent optical absorption in the 200–2500 nm range and can be combined with near-infrared laser for photothermal therapy; (ii) it possesses peroxidase characteristic, which can catalyze low-concentration hydrogen peroxide to produce highly effective bactericidal hydroxyl radicals; (iii) silver doping gives it the ability to destroy the inherent components of bacteria. Moreover, the PAM/CS hydrogel can adsorb both bacteria and inflammatory secretions, enhancing the sterilization ability of Ag(8.5%)@NiS2−x and promoting tissue healing. Our work highlights the great potential of dressing-2 : 1 as a multifunctional hydrogel dressing for effective antibacterial wound healing.
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POLYMER TESTING
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2022
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IF 4.931
Xuefeng Li,Lingli Shang,Dapeng Li,Wei Wang,Shunlan Chen,Hanwen Zhong,Yiwan Huang,Shijun Long
Naturally occurring polysaccharide-based polyelectrolyte complex (PEC) physical hydrogels have broad applications in biomedicine. Yet, obtaining high-strength, strong-adhesion, and antibacterial PEC hydrogels via physically crosslinking of natural polysaccharides still remains a challenge. In this work, a chitosan (CS)/sodium alginate (SA) PEC physical hydrogel film was developed by using two oppositely charged natural polysaccharides, CS and SA, of equivalently high molecular weight ( M w , approx. 10 5 Da), the tensile stress of which was achieved as high as 12.3 MPa due to CS-CS intermolecular hydrogen bonding and CS-SA electrostatic interaction. In addition, the hydrogel films, upon protonation at acidic conditions (e.g. pH 2.6), exhibited excellent antibacterial activity against Escherichia coli ( E. coli ) and the CS/SA hydrogel films also demonstrated strong adhesion to biological tissue. The high M w -matching, two-component natural polysaccharide approach presented in this work to preparing high-strength, strong-adhesion, and antibacterial PEC hydrogels may shed some lights on converting renewable biomass to value-added biomaterials.
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Journal of Environmental Chemical Engineering
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2022
·
IF 7.968
Jinxiu Li,Jinxin Zhao,Bing Li,Huaitian Bu,Weizhao Yin,Sihao Lv,Jinhua Wu
Activated carbon-supported goethite (α-FeOOH@AC) was prepared by a simple impregnation method to catalyze hydrogen peroxide (H 2 O 2 ) for effective inactivation of Escherichia coli ( E. coli ) with α-FeOOH and AC as controls. As expected, α-FeOOH particles were uniformly distributed on AC surfaces and surface-bound Fe(III) was partially converted to Fe(II) by structural hydroxyl groups of AC. The resultant Fe(II) catalyzed H 2 O 2 to generate hydroxyl radicals (·OH) for effective E. coli inactivation by destroying its membrane and intracellular substances. The α-FeOOH@AC-H 2 O 2 system therefore achieved an effective inactivation efficiency of 4.5 log, which was much higher than 1.6 log of the α-FeOOH-H 2 O 2 system and 1.9 log of the AC-H 2 O 2 system. Besides, due to the cycle of Fe(III)/Fe(II) redox on AC surface during reaction, high inactivation efficiency and low leaching iron concentration of 0.29 mg/L could be achieved at neutral condition. In addition, the α-FeOOH@AC showed excellent stability and reusability, and the used α-FeOOH@AC could be refreshed by eluting surface-bound iron oxides and reloading α-FeOOH particles with the above impregnation method. Our study demonstrated that α-FeOOH@AC is an effective and stable heterogeneous Fenton catalyst for the inactivation of E. coli in surface water treatment .
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Membranes
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2022
·Vol. 12
·期 2
·239
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IF 4.562
Xiaolong Sun,Longfei Yin,Huayue Zhu,Junhao Zhu,Jiahuan Hu,Xi Luo,He Huang,Yongqian Fu
In this study, chitosan and sugarcane cellulose were used as film-forming materials, while the inorganic agent zinc oxide (ZnO) and natural compound phenyllactic acid (PA) were used as the main bacteriostatic components to fabricate biodegradable antimicrobial composite membranes. The water absorption and antimicrobial properties were investigated by adjusting the concentration of PA. The scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) results demonstrated that the components of the composite membrane were successfully integrated. The addition of ZnO improved the mechanical and antimicrobial properties of the composite membrane, while the addition of PA with high crystallinity significantly reduced the water absorption and swelling. Moreover, the addition of 0.5% PA greatly improved the water absorption of the composite membrane. The results of antimicrobial experiments showed that PA improved the antimicrobial activity of the composite membrane againstStaphylococcus aureus,Escherichia coli,Aspergillus nigerandPenicillium rubens. Among them, 0.3% PA had the best antimicrobial effect againstS. aureus,E. coliandA. niger, while 0.7% PA had the best antimicrobial effect againstP. rubens.Keywords:composite membrane;phenyllactic acid;antimicrobial activity
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
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IF 8.025
Jiayao Yang,Jinfeng Dai,Xiaohuan Liu,Shenyuan Fu,Enmin Zong,Pingan Song
Lignin, as a natural polymer material, has the advantages of green safety, renewable, and pollution-free. It has a wide application prospect in the field of thermosetting. However, it has been attractive but a huge challenge to design high performance and high added-value lignin-based epoxy resin. Herein, lignin-based epoxy (LEP) was synthesized from moso bamboo-derived lignin, and then lignin-based epoxy/titanium dioxide (LEP/TiO 2 ) hybrid nanoparticle was synthesized via liquid deposition method for modifying lignin-based epoxy resin to prepare multifunctional bio-based epoxy. The results show that the LEP/TiO 2 hybrid nanoparticle exhibits a stable topological surface shape and good dispersion and uniformity. By adding 10 wt% LEP/TiO 2 hybrid nanoparticles, the multifunctional bio-based epoxy exhibits good mechanical strength and toughness, and the tensile strength and fracture toughness reach 36 MPa and 1.26 MPa·m 1/2 , respectively. In addition, the thermal stability , UV absorption and antibacterial properties of the multifunctional bio-based epoxy are further improved. This study provides a facile and efficient method for the preparation of high-performance multifunctional bio-based epoxy composite and a novel solution for the utilization of lignin.
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IEEE TRANSACTIONS ON MEDICAL IMAGING
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2022
·Vol. 41
·期 9
·2543-2555
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IF 11.037
Shuangyang Zhang,Li Qi,Xipan Li,Zhichao Liang,Xiangdong Sun,Jiaming Liu,Lijun Lu,Yanqiu Feng,Wufan Chen
As an emerging molecular imaging modality, Photoacoustic Tomography (PAT) is capable of mapping tissue physiological metabolism and exogenous contrast agent information with high specificity. Due to its ultrasonic detection mechanism, the precise localization of targeted lesions has long been a challenge for PAT imaging. The poor soft-tissue contrast of the PAT image makes this process difficult and inaccurate. To meet this challenge, in this study, we first make use of the rich and clear structural information brought about by another advanced imaging modality, Magnetic Resonance Imaging (MRI), to assist organ segmentation and correct for the light fluence attenuation of PAT. We demonstrate improved feature visibility and enhanced localization of endogenous and exogenous agents in the fluence corrected PAT images. Compared with PAT-based methods, the contrast-to-noise ratio (CNR) of our MRI-assisted method increases by 29.1% in live animal experiments. Furthermore, we show that the co-registered MRI image can also be incorporated into PAT image restoration, and achieves improved anatomical landscape and soft-tissue contrast (CNR increased by 25.36%) while preserving similar spatial resolution. This PAT-MRI combination provides excellent structural, functional and molecular images of the subject, and may enable more comprehensive analysis of various preclinical research applications.
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ACS Biomaterials Science & Engineering
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2022
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IF 5.395
Daijun Chen,Xiaoli Zhao,Han Gao,Guanglei Ren,Jinni Luo,Huanxia Wang,Chenying Zha,Kewu Yang,Pengxiang Jia
Conductive hydrogels have shown great potential in the field of flexible strain sensors. However, their application is greatly limited due to the poor antifouling and low mechanical strength. Unfortunately, it is still a challenge to improve these two distinct properties simultaneously. Herein, a hydrogel with high strength, good conductivity, and excellent antifouling and antibacterial properties was prepared through the synergistic effect of physical and chemical cross-linking. First, acrylic acid (AA), acrylamide (AM), and 2-methacryloyloxyethyl phosphorylcholine (MPC) monomers were polymerized in the presence of chitosan chains to form the hydrogel. Then, the prepared hydrogel was immersed in a ferric ion solution to further strengthen the hydrogel through ion coordination. The obtained CS-P(AM-MPC-AA0.2)-Fe0.13+ hydrogel showed outstanding tensile strength (1.03 MPa), excellent stretchability (1075%), good toughness (7.03 MJ/m3), and fatigue resistance. The CS-P(AM-MPC-AA0.2)-Fe0.13+ hydrogel also demonstrated good ion conductivity (0.42 S/m) and excellent antifouling and antibacterial properties. In addition, the strain sensor constructed by the CS-P(AM-MPC-AA0.2)-Fe0.13+ hydrogel showed high sensitivity and good stability. This work presented a facile method to construct a zwitterionic hydrogel with high-strength, conductive, antifouling, and antibacterial properties, which suggested a promising gel platform for flexible wearable sensors.
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Journal of Materials Chemistry B
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2022
·Vol. 10
·期 22
·4142-4152
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IF 7.571
Kun Fang,Qinwei Gu,Mingzhu Zeng,Zhimao Huang,Haofeng Qiu,Jiru Miao,Yue Fang,Yinyu Zhao,Ying Xiao,Ting Xu,Robert Petrovich Golodok,Vadim Victorovich Savich,Alexander Phyodorovich Ilyushchenko,Fanrong Ai,Donglei Liu,Rong Wang
Diabetic wounds remain one of the most prevalent hard-to-heal wounds in the clinic. The causative factors impeding the wound healing process include not only the elevated oxidative stress and bacterial infections but also the high and repetitive plantar stress (including compressive pressure and shear stress). Conventional hydrogel dressings are mechanically weak and fragile, limiting their applications in the high stress-loading conditions of diabetic foot ulcers. As such, mechanically tough hydrogel dressings with appropriate bioactivities are highly desirable for diabetic wound treatment. In this study, a mechanically reinforced hydrogel with multiple biofunctionalities was developed via a facile and straightforward strategy of incorporation of tannic acid (TA) in zwitterionic poly(sulfobetaine methacrylate) (polySBMA) hydrogel. The polySBMA hydrogel reinforced by TA showed excellent mechanical property, with the tensile stress and compressive stress up to 93.7 kPa and 18.4 MPa, respectively, and it could resist cyclic compressive stress at ∼200 kPa (maximum in-shoe plantar pressure) for up to 3500 cycles. The TA-reinforced zwitterionic hydrogel exhibited strong adhesion to skin tissue (20.2 kPa), which was expected to reduce the shear stress on the foot. The plantar pressure on the foot was significantly reduced by the application of the resilient hydrogel. Attributed to the antioxidant and antibacterial properties of TA, the hydrogel showed rapid radical scavenging capability and strong bactericidal efficacy against Gram-positive and Gram-negative bacteria. In vitro and in vivo studies confirmed that the hydrogel has good cytocompatibility and negligible skin irritation, and promoted healing of diabetic wounds in mice. Such tough and effective hydrogel with a straightforward preparation strategy holds great promise as wound dressings for diabetic wound treatment.
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BIORESOURCE TECHNOLOGY
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2022
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IF 11.889
Jing Liu,Guanyi Chen,Beibei Yan,Weiming Yi,Jingang Yao
Magnetic whole-cell biocatalysts (MWCBs) constructed by immobilizing Bacillus subtilis cells within ferroferric oxide-polyvinyl alcohol composite beads were developed and employed to transesterify waste frying oil to biodiesel in a magnetically fluidized bed reactor (MFBR). Effective variables including biocatalysts concentration, reactant flow rate, magnetic field intensity and temperature were evaluated to enhance the transesterification. By coupling MFBR with MWCBs, continuous biodiesel production was achieved. Response surface methodology and Box-Behnken design were employed to predict the optimal conditions and the maximum biodiesel yield reached 89.0 ± 0.6% after 48 h under the optimized conditions. Furthermore, MWCBs displayed satisfactory stability and reusability in MFBR and still maintained a biodiesel yield of more than 82.5% after 10 cycles. Lastly, the fuel properties of the obtained biodiesel met the ASTM and EN standards. The present study revealed that the route of producing biodiesel over MWCBs in the MFBR system showed great potential for industrialization.
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